Engineering yeast endosymbionts as a step toward the evolution of mitochondria
Mehta, Angad P., Supekova, Lubica, Chen, Jian-Hua, Pestonjamasp, Kersi, Webster, Paul, Ko, Yeonjin, Henderson, Scott C., McDermott, Gerry, Supek, Frantisek, Schultz, Peter G.
Published in Proceedings of the National Academy of Sciences - PNAS (13.11.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (13.11.2018)
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Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin
Hoepfner, Dominic, McNamara, Case W., Lim, Chek Shik, Studer, Christian, Riedl, Ralph, Aust, Thomas, McCormack, Susan L., Plouffe, David M., Meister, Stephan, Schuierer, Sven, Plikat, Uwe, Hartmann, Nicole, Staedtler, Frank, Cotesta, Simona, Schmitt, Esther K., Petersen, Frank, Supek, Frantisek, Glynne, Richard J., Tallarico, John A., Porter, Jeffrey A., Fishman, Mark C., Bodenreider, Christophe, Diagana, Thierry T., Movva, N. Rao, Winzeler, Elizabeth A.
Published in Cell host & microbe (14.06.2012)
Published in Cell host & microbe (14.06.2012)
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Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design
Harbut, Michael B., Patel, Bhumit A., Yeung, Bryan K. S., McNamara, Case W., Bright, A. Taylor, Ballard, Jaime, Supek, Frantisek, Golde, Todd E., Winzeler, Elizabeth A., Diagana, Thierry T., Greenbaum, Doron C.
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2012)
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Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis
Nagle, Advait S., Khare, Shilpi, Kumar, Arun Babu, Supek, Frantisek, Buchynskyy, Andriy, Mathison, Casey J. N., Chennamaneni, Naveen Kumar, Pendem, Nagendar, Buckner, Frederick S., Gelb, Michael H., Molteni, Valentina
Published in Chemical reviews (26.11.2014)
Published in Chemical reviews (26.11.2014)
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Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease
Khare, Shilpi, Roach, Steven L, Barnes, S Whitney, Hoepfner, Dominic, Walker, John R, Chatterjee, Arnab K, Neitz, R Jeffrey, Arkin, Michelle R, McNamara, Case W, Ballard, Jaime, Lai, Yin, Fu, Yue, Molteni, Valentina, Yeh, Vince, McKerrow, James H, Glynne, Richard J, Supek, Frantisek
Published in PLoS pathogens (01.07.2015)
Published in PLoS pathogens (01.07.2015)
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A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating Mycobacterium tuberculosis
Mak, Puiying A, Rao, Srinivasa P. S, Ping Tan, Mai, Lin, Xiuhua, Chyba, Jason, Tay, Joann, Ng, Seow Hwee, Tan, Bee Huat, Cherian, Joseph, Duraiswamy, Jeyaraj, Bifani, Pablo, Lim, Vivian, Lee, Boon Heng, Ling Ma, Ngai, Beer, David, Thayalan, Pamela, Kuhen, Kelli, Chatterjee, Arnab, Supek, Frantisek, Glynne, Richard, Zheng, Jun, Boshoff, Helena I, Barry, Clifton E, Dick, Thomas, Pethe, Kevin, Camacho, Luis R
Published in ACS chemical biology (20.07.2012)
Published in ACS chemical biology (20.07.2012)
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Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors
Saldivia, Manuel, Fang, Eric, Ma, Xiaolei, Myburgh, Elmarie, Carnielli, Juliana B. T., Bower-Lepts, Christopher, Brown, Elaine, Ritchie, Ryan, Lakshminarayana, Suresh B., Chen, Yen-Liang, Patra, Debjani, Ornelas, Elizabeth, Koh, Hazel X. Y., Williams, Sarah L., Supek, Frantisek, Paape, Daniel, McCulloch, Richard, Kaiser, Marcel, Barrett, Michael P., Jiricek, Jan, Diagana, Thierry T., Mottram, Jeremy C., Rao, Srinivasa P. S.
Published in Nature microbiology (01.10.2020)
Published in Nature microbiology (01.10.2020)
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Identification of Human Kinases Involved in Hepatitis C Virus Replication by Small Interference RNA Library Screening
Supekova, Lubica, Supek, Frantisek, Lee, Jongkook, Chen, Shawn, Gray, Nathanael, Pezacki, John P., Schlapbach, Achim, Schultz, Peter G.
Published in The Journal of biological chemistry (04.01.2008)
Published in The Journal of biological chemistry (04.01.2008)
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Gene Expression Profiling of Endoplasmic Reticulum Stress in Hepatitis C Virus-Containing Cells Treated with an Inhibitor of Protein Disulfide Isomerases
Özcelik, Dennis, Seto, Andrew, Rakic, Bojana, Farzam, Ali, Supek, Frantisek, Pezacki, John Paul
Published in ACS omega (31.12.2018)
Published in ACS omega (31.12.2018)
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Anti-trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of African trypanosomiasis
Rao, Srinivasa P S, Lakshminarayana, Suresh B, Jiricek, Jan, Kaiser, Marcel, Ritchie, Ryan, Myburgh, Elmarie, Supek, Frantisek, Tuntland, Tove, Nagle, Advait, Molteni, Valentina, Mäser, Pascal, Mottram, Jeremy C, Barrett, Michael P, Diagana, Thierry T
Published in Tropical medicine and infectious disease (01.03.2020)
Published in Tropical medicine and infectious disease (01.03.2020)
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Sec16p Potentiates the Action of COPII Proteins to Bud Transport Vesicles
Supek, Frantisek, Madden, David T., Hamamoto, Susan, Orci, Lelio, Schekman, Randy
Published in The Journal of cell biology (16.09.2002)
Published in The Journal of cell biology (16.09.2002)
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Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
Khare, Shilpi, Nagle, Advait S., Biggart, Agnes, Lai, Yin H., Liang, Fang, Davis, Lauren C., Barnes, S. Whitney, Mathison, Casey J. N., Myburgh, Elmarie, Gao, Mu-Yun, Gillespie, J. Robert, Liu, Xianzhong, Tan, Jocelyn L., Stinson, Monique, Rivera, Ianne C., Ballard, Jaime, Yeh, Vince, Groessl, Todd, Federe, Glenn, Koh, Hazel X. Y., Venable, John D., Bursulaya, Badry, Shapiro, Michael, Mishra, Pranab K., Spraggon, Glen, Brock, Ansgar, Mottram, Jeremy C., Buckner, Frederick S., Rao, Srinivasa P. S., Wen, Ben G., Walker, John R., Tuntland, Tove, Molteni, Valentina, Glynne, Richard J., Supek, Frantisek
Published in Nature (London) (08.09.2016)
Published in Nature (London) (08.09.2016)
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Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease
Khare, Shilpi, Liu, Xianzhong, Stinson, Monique, Rivera, Ianne, Groessl, Todd, Tuntland, Tove, Yeh, Vince, Wen, Ben, Molteni, Valentina, Glynne, Richard, Supek, Frantisek
Published in Antimicrobial agents and chemotherapy (01.10.2015)
Published in Antimicrobial agents and chemotherapy (01.10.2015)
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Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases
Nagle, Advait, Biggart, Agnes, Be, Celine, Srinivas, Honnappa, Hein, Andreas, Caridha, Diana, Sciotti, Richard J, Pybus, Brandon, Kreishman-Deitrick, Mara, Bursulaya, Badry, Lai, Yin H, Gao, Mu-Yun, Liang, Fang, Mathison, Casey J. N, Liu, Xiaodong, Yeh, Vince, Smith, Jeffrey, Lerario, Isabelle, Xie, Yongping, Chianelli, Donatella, Gibney, Michael, Berman, Ashley, Chen, Yen-Liang, Jiricek, Jan, Davis, Lauren C, Liu, Xianzhong, Ballard, Jaime, Khare, Shilpi, Eggimann, Fabian Kurt, Luneau, Alexandre, Groessl, Todd, Shapiro, Michael, Richmond, Wendy, Johnson, Kevin, Rudewicz, Patrick J, Rao, Srinivasa P. S, Thompson, Christopher, Tuntland, Tove, Spraggon, Glen, Glynne, Richard J, Supek, Frantisek, Wiesmann, Christian, Molteni, Valentina
Published in Journal of medicinal chemistry (08.10.2020)
Published in Journal of medicinal chemistry (08.10.2020)
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Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT)
Koester, Dennis C., Marx, Vanessa M., Williams, Sarah, Jiricek, Jan, Dauphinais, Maxime, René, Olivier, Miller, Sarah L., Zhang, Lei, Patra, Debjani, Chen, Yen-Liang, Cheung, Harry, Gable, Jonathan, Lakshminarayana, Suresh B., Osborne, Colin, Galarneau, Jean-Rene, Kulkarni, Upendra, Richmond, Wendy, Bretz, Angela, Xiao, Linda, Supek, Frantisek, Wiesmann, Christian, Honnappa, Srinivas, Be, Celine, Mäser, Pascal, Kaiser, Marcel, Ritchie, Ryan, Barrett, Michael P., Diagana, Thierry T., Sarko, Christopher, Rao, Srinivasa P. S.
Published in Journal of medicinal chemistry (08.09.2022)
Published in Journal of medicinal chemistry (08.09.2022)
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Journal Article
Engineering yeast endosymbionts as a step toward the evolution of mitochondria
Mehta, Angad P., Supekova, Lubica, Chen, Jian-Hua, Pestonjamasp, Kersi, Webster, Paul, Ko, Yeonjin, Henderson, Scott C., McDermott, Gerry, Supek, Frantisek, Schultz, Peter G.
Published in Proceedings of the National Academy of Sciences - PNAS (29.10.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (29.10.2018)
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