Sotatercept, a novel transforming growth factor β ligand trap, improves anemia in β-thalassemia: a phase II, open-label, dose-finding study
Cappellini, Maria Domenica, Porter, John, Origa, Raffaella, Forni, Gian Luca, Voskaridou, Ersi, Galactéros, Frédéric, Taher, Ali T, Arlet, Jean-Benoît, Ribeil, Jean-Antoine, Garbowski, Maciej, Graziadei, Giovanna, Brouzes, Chantal, Semeraro, Michaela, Laadem, Abderrahmane, Miteva, Dimana, Zou, Jun, Sung, Victoria, Zinger, Tatiana, Attie, Kenneth M, Hermine, Olivier
Published in Haematologica (Roma) (01.03.2019)
Published in Haematologica (Roma) (01.03.2019)
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Journal Article
RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan anemia through antagonizing lefty1
Ear, Jason, Huang, Haigen, Wilson, Tianna, Tehrani, Zahra, Lindgren, Anne, Sung, Victoria, Laadem, Abderrahmane, Daniel, Thomas O., Chopra, Rajesh, Lin, Shuo
Published in Blood (13.08.2015)
Published in Blood (13.08.2015)
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Activin receptor antagonists for cancer-related anemia and bone disease
Fields, Scott Z, Parshad, Shiroo, Anne, Madhurima, Raftopoulos, Haralambos, Alexander, Mark J, Sherman, Matthew L, Laadem, Abderrahmane, Sung, Victoria, Terpos, Evangelos
Published in Expert opinion on investigational drugs (01.01.2013)
Published in Expert opinion on investigational drugs (01.01.2013)
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A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure
Ear, Jason, Hsueh, Jessica, Nguyen, Melinda, Zhang, QingHua, Sung, Victoria, Chopra, Rajesh, Sakamoto, Kathleen M., Lin, Shuo
Published in Journal of genetics and genomics (20.05.2016)
Published in Journal of genetics and genomics (20.05.2016)
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Journal Article
RAP‐011, an activin receptor ligand trap, increases hemoglobin concentration in hepcidin transgenic mice
Langdon, Jacqueline M., Barkataki, Sangjucta, Berger, Alan E., Cheadle, Chris, Xue, Qian‐Li, Sung, Victoria, Roy, Cindy N.
Published in American journal of hematology (01.01.2015)
Published in American journal of hematology (01.01.2015)
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Histone deacetylase inhibitor MGCD0103 synergizes with gemcitabine in human pancreatic cells
Sung, Victoria, Richard, Normand, Brady, Helen, Maier, Armin, Kelter, Gerhard, Heise, Carla
Published in Cancer science (01.06.2011)
Published in Cancer science (01.06.2011)
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Pharmacokinetic characterization of amrubicin cardiac safety in an ex vivo human myocardial strip model. II. Amrubicin shows metabolic advantages over doxorubicin and epirubicin
Salvatorelli, Emanuela, Menna, Pierantonio, Gonzalez Paz, Odalys, Surapaneni, Sekhar, Aukerman, Sharon L, Chello, Massimo, Covino, Elvio, Sung, Victoria, Minotti, Giorgio
Published in The Journal of pharmacology and experimental therapeutics (01.05.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2012)
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Abstract 3629: BLZ945, a selective c-fms (CSF-1R) kinase inhibitor for the suppression of tumor-induced osteolytic lesions in bone
Wiesmann, Marion, Daniel, Dylan L., Pryer, Nancy, Sutton, James, Sung, Victoria, Wang, Tao, Jeffry, Ursula, Oei, Yoko, Kaufman, Susan, Lenahan, William, Lee, Isabelle, Huh, Kay, Sim, Janet
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Recent Pharmacological Advances: Focus on Small-cell Lung Cancer
Galustian, Christine, Sung, Victoria, Bartlett, Blake, Rolfe, Lindsey, Dalgleish, Angus
Published in Clinical Medicine Insights: Therapeutics (01.01.2010)
Published in Clinical Medicine Insights: Therapeutics (01.01.2010)
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Book Review
Stromal cell-mediated inhibition of erythropoiesis can be attenuated by Sotatercept (ACE-011), an activin receptor type II ligand trap
Iancu-Rubin, Camelia, Mosoyan, Goar, Wang, Jiapeng, Kraus, Thomas, Sung, Victoria, Hoffman, Ronald
Published in Experimental hematology (01.02.2013)
Published in Experimental hematology (01.02.2013)
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An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia
Dussiot, Michael, Maciel, Thiago T, Fricot, Aurélie, Chartier, Céline, Negre, Olivier, Veiga, Joel, Grapton, Damien, Paubelle, Etienne, Payen, Emmanuel, Beuzard, Yves, Leboulch, Philippe, Ribeil, Jean-Antoine, Arlet, Jean-Benoit, Coté, Francine, Courtois, Geneviève, Ginzburg, Yelena Z, Daniel, Thomas O, Chopra, Rajesh, Sung, Victoria, Hermine, Olivier, Moura, Ivan C
Published in Nature medicine (01.04.2014)
Published in Nature medicine (01.04.2014)
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An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin
Carrancio, Soraya, Markovics, Jennifer, Wong, Piu, Leisten, Jim, Castiglioni, Paola, Groza, Matthew C., Raymon, Heather K., Heise, Carla, Daniel, Tom, Chopra, Rajesh, Sung, Victoria
Published in British journal of haematology (01.06.2014)
Published in British journal of haematology (01.06.2014)
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Journal Article
Abstract LB171: The differentiated CD47 monoclonal antibody AO-176 exhibits significant in vivo activity against xenograft models of pediatric acute lymphoblastic leukemia (ALL)
Lock, Richard B., Evans, Kathryn, El-Zein, Narimanne, Earley, Eric J., Erickson, Stephen W., Teicher, Beverly A., Sung, Victoria, Smith, Malcolm A.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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AO-176, a Highly Differentiated Clinical Stage Anti-CD47 Antibody, Exerts Potent Anti-Tumor Activity in Preclinical Models of Multiple Myeloma As a Single Agent and in Combination with Approved Therapeutics
Wilson, William Casey, Richards, John, Puro, Robyn J, Andrejeva, Gabriela, Capoccia, Ben J, Donio, Mike J, Hiebsch, Ronald R, Chakraborty, Prabir, Sung, Victoria, Pereira, Daniel S
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Investigating macrophage function as a mechanism of resistance to daratumumab in relapsed refractory multiple myeloma patients
Kambhampati, Swetha, Wen, Kwun Wah, Sung, Victoria, Wong, Sandy Wai Kuan, Martin, Thomas G., Wolf, Jeffrey Lee, Shah, Nina, Wiita, Arun
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease
Sugatani, Toshifumi, Agapova, Olga A., Fang, Yifu, Berman, Alycia G., Wallace, Joseph M., Malluche, Hartmut H., Faugere, Marie-Claude, Smith, William, Sung, Victoria, Hruska, Keith A.
Published in Kidney international (01.01.2017)
Published in Kidney international (01.01.2017)
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Highly Differentiated Anti-CD47 Antibody, AO-176, Potently Inhibits Hematologic Malignancies Alone and in Combination
Richards, John, Bouchlaka, Myriam N, Puro, Robyn J, Capoccia, Ben J, Hiebsch, Ronald R, Donio, Michael J, Wilson, W. Casey, Chakraborty, Prabir, Sung, Victoria, Pereira, Daniel S
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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A first-in-human study of AO-176, a highly differentiated anti-CD47 antibody, in patients with advanced solid tumors
Burris III, Howard A., Spira, Alexander I., Taylor, Matthew H., Yeku, Oladapo O., Liu, Joyce F., Munster, Pamela N., Hamilton, Erika P., Thomas, Jacob Stephen, Gatlin, Frances, Penson, Richard T., Abrams, Thomas Adam, Dhawan, Mallika Sachdev, Walling, Jacqueline M., Frye, John W., Romanko, Kevin, Sung, Victoria, Brachmann, Carrie, El-Khoueiry, Anthony B.
Published in Journal of clinical oncology (20.05.2021)
Published in Journal of clinical oncology (20.05.2021)
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ACTRII ACTIVIN-ACTRII ANTAGONISTS AND USES FOR TREATING BONE AND OTHER DISORDERS
SLOAN VICTOR SCHORR, HRUSKA KEITH, FANG YIFU, SMITH WILLIAM, SUNG VICTORIA, STEVENS RANDALL M
Year of Publication 28.11.2022
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Year of Publication 28.11.2022
Patent
Abstract 2009: CC-90002 (anti-CD47 antibody) in vivo anti-tumor activity is associated with an increase in M1-polarized macrophages
Zheng, Bing, Wong, Piu, Yang, WenQing, Narla, Rama, Burgess, Michael, Escoubet, Laure, Raymon, Heather, Hariharan, Kandasamy, Boylan, John, Hege, Kristen, Sung, Victoria
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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