Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions
Vogel, Peter, Donoviel, Michael S, Read, Robert, Hansen, Gwenn M, Hazlewood, Jill, Anderson, Stephen J, Sun, Weimei, Swaffield, Jonathan, Oravecz, Tamas
Published in PloS one (2009)
Published in PloS one (2009)
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Discovery and Characterization of Novel Tryptophan Hydroxylase Inhibitors That Selectively Inhibit Serotonin Synthesis in the Gastrointestinal Tract
Liu, Qingyun, Yang, Qi, Sun, Weimei, Vogel, Pete, Heydorn, William, Yu, Xiang-Qing, Hu, Zhixiang, Yu, Wangsheng, Jonas, Brandie, Pineda, Randy, Calderon-Gay, Valerie, Germann, Michael, O'Neill, Emily, Brommage, Robert, Cullinan, Emily, Platt, Ken, Wilson, Alan, Powell, Dave, Sands, Arthur, Zambrowicz, Brian, Shi, Zhi-Cai
Published in The Journal of pharmacology and experimental therapeutics (01.04.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2008)
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A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency
Salojin, Konstantin V., Cabrera, Robert M., Sun, Weimei, Chang, Wei Chun, Lin, Colin, Duncan, Lindsay, Platt, Ken A., Read, Robert, Vogel, Peter, Liu, Qingyun, Finnell, Richard H., Oravecz, Tamas
Published in Blood (05.05.2011)
Published in Blood (05.05.2011)
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Inhibition of Sphingosine-1-Phosphate Lyase for the Treatment of Autoimmune Disorders
Bagdanoff, Jeffrey T, Donoviel, Michael S, Nouraldeen, Amr, Tarver, James, Fu, Qinghong, Carlsen, Marianne, Jessop, Theodore C, Zhang, Haiming, Hazelwood, Jill, Nguyen, Huy, Baugh, Simon D. P, Gardyan, Michael, Terranova, Kristen M, Barbosa, Joseph, Yan, Jack, Bednarz, Mark, Layek, Suman, Courtney, Lawrence F, Taylor, Jerry, Digeorge-Foushee, Ann Marie, Gopinathan, Suma, Bruce, Debra, Smith, Traci, Moran, Liam, O’Neill, Emily, Kramer, Jeff, Lai, Zhong, Kimball, S. David, Liu, Qingyun, Sun, Weimei, Yu, Sean, Swaffield, Jonathan, Wilson, Alan, Main, Alan, Carson, Kenneth G, Oravecz, Tamas, Augeri, David J
Published in Journal of medicinal chemistry (09.07.2009)
Published in Journal of medicinal chemistry (09.07.2009)
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Modulation of Peripheral Serotonin Levels by Novel Tryptophan Hydroxylase Inhibitors for the Potential Treatment of Functional Gastrointestinal Disorders
Shi, Zhi-Cai, Devasagayaraj, Arokiasamy, Gu, Kunjian, Jin, Haihong, Marinelli, Brett, Samala, Lakshman, Scott, Sheldon, Stouch, Terry, Tunoori, Ashok, Wang, Ying, Zang, Yi, Zhang, Chengmin, Kimball, S. David, Main, Alan J, Sun, Weimei, Yang, Qi, Nouraldeen, Amr, Yu, Xiang-Qing, Buxton, Eric, Patel, Shiv, Nguyen, Nghi, Swaffield, Jon, Powell, David R, Wilson, Alan, Liu, Qingyun
Published in Journal of medicinal chemistry (10.07.2008)
Published in Journal of medicinal chemistry (10.07.2008)
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Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors
Jin, Haihong, Cianchetta, Giovanni, Devasagayaraj, Arokiasamy, Gu, Kunjian, Marinelli, Brett, Samala, Lakshman, Scott, Sheldon, Stouch, Terry, Tunoori, Ashok, Wang, Ying, Zang, Yi, Zhang, Chengmin, David Kimball, S., Main, Alan J., Ding, Zhi-Ming, Sun, Weimei, Yang, Qi, Yu, Xiang-Qing, Powell, David R., Wilson, Alan, Liu, Qingyun, Shi, Zhi-Cai
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Targeting Enteropeptidase with Reversible Covalent Inhibitors To Achieve Metabolic Benefits
Sun, Weimei, Zhang, Xuqing, Cummings, Maxwell D, Albarazanji, Kamal, Wu, Jiejun, Wang, Mina, Alexander, Richard, Zhu, Bin, Zhang, YueMei, Leonard, James, Lanter, James, Lenhard, James
Published in The Journal of pharmacology and experimental therapeutics (01.12.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2020)
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Synthesis and Reactivity of Spirocarbocycles as Scaffolds for Nucleoside Analogues
Verhoeven, Jonas, Deraet, Xavier, Pande, Vineet, Sun, Weimei, Alonso, Mercedes, De Proft, Frank, Meerpoel, Lieven, Thuring, Jan Willem, Verniest, Guido
Published in Journal of organic chemistry (04.12.2020)
Published in Journal of organic chemistry (04.12.2020)
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Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity
Brehmer, Dirk, Beke, Lijs, Wu, Tongfei, Millar, Hillary J, Moy, Christopher, Sun, Weimei, Mannens, Geert, Pande, Vineet, Boeckx, An, van Heerde, Erika, Nys, Thomas, Gustin, Emmanuel M, Verbist, Bie, Zhou, Longen, Fan, Yue, Bhargava, Vipul, Safabakhsh, Pegah, Vinken, Petra, Verhulst, Tinne, Gilbert, Angelique, Rai, Sumit, Graubert, Timothy A, Pastore, Friederike, Fiore, Danilo, Gu, Junchen, Johnson, Amy, Philippar, Ulrike, Morschhäuser, Barbara, Walker, David, De Lange, Desiree, Keersmaekers, Vikki, Viellevoye, Marcel, Diels, Gaston, Schepens, Wim, Thuring, Jan Willem, Meerpoel, Lieven, Packman, Kathryn, Lorenzi, Matthew V, Laquerre, Sylvie
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Discovery of a novel series of guanidinebenzoates as gut-restricted enteropeptidase and trypsin dual inhibitors for the treatment of metabolic syndrome
Zhang, Xuqing, Zhu, Bin, Sun, Weimei, Wang, Mina, Albarazanji, Kamal, Ghosh, Brahma, Cummings, Maxwell, Lenhard, James, Leonard, James, Macielag, Mark, Lanter, James
Published in Bioorganic & medicinal chemistry letters (15.05.2021)
Published in Bioorganic & medicinal chemistry letters (15.05.2021)
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Preparation of 4′‐Spirocyclobutyl Nucleoside Analogues as Novel and Versatile Adenosine Scaffolds
Verhoeven, Jonas, De Vleeschouwer, Freija, Kong, Hanchu, Van Hecke, Kristof, Pande, Vineet, Sun, Weimei, Vos, Ann, Wu, Tongfei, Meerpoel, Lieven, Thuring, Jan Willem, Verniest, Guido
Published in Chemistry : a European journal (02.12.2019)
Published in Chemistry : a European journal (02.12.2019)
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Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease
Lu, Tianbao, Connolly, Peter J., Philippar, Ulrike, Sun, Weimei, Cummings, Maxwell D., Barbay, Kent, Gys, Luc, Van Nuffel, Luc, Austin, Nigel, Bekkers, Mariette, Shen, Fang, Cai, Ann, Attar, Ricardo, Meerpoel, Lieven, Edwards, James
Published in Bioorganic & medicinal chemistry letters (01.12.2019)
Published in Bioorganic & medicinal chemistry letters (01.12.2019)
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A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding Mode
Pande, Vineet, Sun, Weimei, Beke, Lijs, Berthelot, Didier, Brehmer, Dirk, Brown, David, Corbera, Jordi, Irving, Steve, Meerpoel, Lieven, Nys, Thomas, Parade, Marc, Robinson, Colin, Sommen, Cois, Viellevoye, Marcel, Wu, Tongfei, Thuring, Jan Willem
Published in ACS medicinal chemistry letters (12.11.2020)
Published in ACS medicinal chemistry letters (12.11.2020)
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Abstract 5690: Discovery of JNJ-67856633: A novel, first-in-class MALT1 protease inhibitor for the treatment of B cell lymphomas
Philippar, Ulrike, Lu, Tianbao, Vloemans, Nele, Bekkers, Mariette, Van Nuffel, Luc, Gaudiano, Marcello, Wnuk-Lipinska, Katarzyna, Van Der Leede, Bas-jan, Amssoms, Katie, Kimpe, Kristof, Medaer, Bart, Greway, Tony, Abraham, Yann, Cummings, Max, Trella, Emanuele, Vanhoof, Greet, Sun, Weimei, Thuring, Jan Willem, Connolly, Peter, Linders, Jan, Rui, Haopeng, Balasubramanian, Sriram, Johnson, Amy, Gerecitano, John, Goldberg, Jenna, Edwards, James P., Elsayed, Yusri, Smit, Jennifer, Bussolari, Jaqueline, Attar, Ricardo
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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The Role of Glycine 99 in l-Lactate Monooxygenase from Mycobacterium smegmatis
Sun, Weimei, Williams, Charles H., Massey, Vincent
Published in The Journal of biological chemistry (24.10.1997)
Published in The Journal of biological chemistry (24.10.1997)
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Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer models
Wu, Tongfei, Millar, Hillary, Gaffney, Dana, Beke, Lijs, Mannens, Geert, Vinken, Petra, Sommers, Ivan, Thuring, Jan-Willem, Sun, Weimei, Moy, Christopher, Pande, Vineet, Zhou, Junguo, Haddish-Berhane, Nahor, Salvati, Mark, Laquerre, Sylvie, Lorenzi, Matthew V., Brehmer, Dirk
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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