Pharmacological comparison of muscarinic ligands : Historical versus more recent muscarinic M1-preferring receptor agonists
HEINRICH, Julia N, BUTERA, John A, TSENG, Eugene, UVEGES, Albert J, MAYER, Scott C, CARRICK, Tikva, KRAMER, Angela, KOWAL, Dianne, LOCK, Tim, MARQUIS, Karen L, PAUSCH, Mark H, POPIOLEK, Mike, SUN, Shaiu-Ching
Published in European journal of pharmacology (01.03.2009)
Published in European journal of pharmacology (01.03.2009)
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Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease
Martone, Robert L, Zhou, Hua, Atchison, Kevin, Comery, Thomas, Xu, Jane Z, Huang, Xinyi, Gong, Xioahai, Jin, Mei, Kreft, Anthony, Harrison, Boyd, Mayer, Scott C, Aschmies, Suzan, Gonzales, Cathleen, Zaleska, Margaret M, Riddell, David R, Wagner, Erik, Lu, Peimin, Sun, Shaiu-Ching, Sonnenberg-Reines, June, Oganesian, Aram, Adkins, Karissa, Leach, Michael W, Clarke, David W, Huryn, Donna, Abou-Gharbia, Magid, Magolda, Ronald, Bard, Jonathan, Frick, Glen, Raje, Sangeeta, Forlow, S Bradley, Balliet, Carrie, Burczynski, Michael E, Reinhart, Peter H, Wan, Hong I, Pangalos, Menelas N, Jacobsen, J Steven
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
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Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease
Mayer, Scott C, Kreft, Anthony F, Harrison, Boyd, Abou-Gharbia, Magid, Antane, Madelene, Aschmies, Suzan, Atchison, Kevin, Chlenov, Michael, Cole, Derek C, Comery, Thomas, Diamantidis, George, Ellingboe, John, Fan, Kristi, Galante, Rocco, Gonzales, Cathleen, Ho, Douglas M, Hoke, Molly E, Hu, Yun, Huryn, Donna, Jain, Uday, Jin, Mei, Kremer, Kenneth, Kubrak, Dennis, Lin, Melissa, Lu, Peimin, Magolda, Ron, Martone, Robert, Moore, William, Oganesian, Aram, Pangalos, Menelas N, Porte, Alex, Reinhart, Peter, Resnick, Lynn, Riddell, David R, Sonnenberg-Reines, June, Stock, Joseph R, Sun, Shaiu-Ching, Wagner, Erik, Wang, Ting, Woller, Kevin, Xu, Zheng, Zaleska, Margaret M, Zeldis, Joseph, Zhang, Minsheng, Zhou, Hua, Jacobsen, J. Steven
Published in Journal of medicinal chemistry (11.12.2008)
Published in Journal of medicinal chemistry (11.12.2008)
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Discovery of a novel series of Notch-sparing γ-secretase inhibitors
Kreft, Anthony, Harrison, Boyd, Aschmies, Suzan, Atchison, Kevin, Casebier, David, Cole, Derek C., Diamantidis, George, Ellingboe, John, Hauze, Diane, Hu, Yun, Huryn, Donna, Jin, Mei, Kubrak, Dennis, Lu, Peimin, Lundquist, Joseph, Mann, Charles, Martone, Robert, Moore, William, Oganesian, Aram, Porte, Alex, Riddell, Dave R., Sonnenberg-Reines, June, Stock, Joseph R., Sun, Shaiu-Ching, Wagner, Erik, Woller, Kevin, Xu, Zheng, Zhou, Hua, Steven Jacobsen, J.
Published in Bioorganic & medicinal chemistry (15.07.2008)
Published in Bioorganic & medicinal chemistry (15.07.2008)
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( S) -N-(5-Chlorothiophene-2-sulfonyl)-β,β-diethylalaninol a Notch-1-sparing γ-secretase inhibitor
Cole, Derek C., Stock, Joseph R., Kreft, Anthony F., Antane, Madelene, Aschmies, Suzan H., Atchison, Kevin P., Casebier, David S., Comery, Thomas A., Diamantidis, George, Ellingboe, John W., Harrison, Boyd L., Hu, Yun, Jin, Mei, Kubrak, Dennis M., Lu, Peimin, Mann, Charles W., Martone, Robert L., Moore, William J., Oganesian, Aram, Riddell, David R., Sonnenberg-Reines, June, Sun, Shaiu-Ching, Wagner, Erik, Wang, Zheng, Woller, Kevin R., Xu, Zheng, Zhou, Hua, Jacobsen, J. Steven
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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Synthesis and structure–activity relationship of a novel series of heterocyclic sulfonamide γ-secretase inhibitors
Pu, Jun, Kreft, Anthony F., Aschmies, Suzan H., Atchison, Kevin P., Berkowitz, Joshua, Caggiano, Thomas J., Chlenov, Micheal, Diamantidis, George, Harrison, Boyd L., Hu, Yun, Huryn, Donna, Steven Jacobsen, J., Jin, Mei, Lipinski, Kerri, Lu, Peimin, Martone, Robert L., Morris, Koi, Sonnenberg-Reines, June, Riddell, Dave R., Sabalski, Joan, Sun, Shaiu-Ching, Wagner, Erik, Wang, Yiqun, Xu, Zheng, Zhou, Hua, Resnick, Lynn
Published in Bioorganic & medicinal chemistry (01.07.2009)
Published in Bioorganic & medicinal chemistry (01.07.2009)
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Molecular-modeling based design, synthesis, and activity of substituted piperidines as γ-secretase inhibitors
Gundersen, Eric, Fan, Kristi, Haas, Kimberly, Huryn, Donna, Steven Jacobsen, J., Kreft, Anthony, Martone, Robert, Mayer, Scott, Sonnenberg-Reines, June, Sun, Shaiu-Ching, Zhou, Hua
Published in Bioorganic & medicinal chemistry letters (01.04.2005)
Published in Bioorganic & medicinal chemistry letters (01.04.2005)
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Pharmacological Characterization of the Muscarinic Agonist (3R,4R)-3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane (WAY-132983) in in Vitro and in Vivo Models of Chronic Pain
Sullivan, Nicole R, Leventhal, Liza, Harrison, James, Smith, Valerie A, Cummons, Terri A, Spangler, Taylor B, Sun, Shaiu-Ching, Lu, Peimin, Uveges, Albert J, Strassle, Brian W, Piesla, Michael J, Ramdass, Rana, Barry, Alena, Schantz, Jonathan, Adams, William, Whiteside, Garth T, Adedoyin, Adedayo, Jones, Philip G
Published in The Journal of pharmacology and experimental therapeutics (01.09.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2007)
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Journal Article
Pharmacological comparison of muscarinic ligands: Historical versus more recent muscarinic M 1-preferring receptor agonists
Heinrich, Julia N., Butera, John A., Carrick, Tikva, Kramer, Angela, Kowal, Dianne, Lock, Tim, Marquis, Karen L., Pausch, Mark H., Popiolek, Mike, Sun, Shaiu-Ching, Tseng, Eugene, Uveges, Albert J., Mayer, Scott C.
Published in European journal of pharmacology (01.03.2009)
Published in European journal of pharmacology (01.03.2009)
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Journal Article
Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein γ-Secretase for the Treatment of Alzheimer's Disease
Robert L. Martone, Hua Zhou, Kevin Atchison, Thomas Comery, Jane Z. Xu, Xinyi Huang, Xioahai Gong, Mei Jin, Anthony Kreft, Boyd Harrison, Scott C. Mayer, Suzan Aschmies, Cathleen Gonzales, Margaret M. Zaleska, David R. Riddell, Erik Wagner, Peimin Lu, Shaiu-Ching Sun, June Sonnenberg-Reines, Aram Oganesian, Karissa Adkins, Michael W. Leach, David W. Clarke, Donna Huryn, Magid Abou-Gharbia, Ronald Magolda, Jonathan Bard, Glen Frick, Sangeeta Raje, S. Bradley Forlow, Carrie Balliet, Michael E. Burczynski, Peter H. Reinhart, Hong I. Wan, Menelas N. Pangalos, J. Steven Jacobsen
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
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Journal Article
P4-244: Discovery of a novel series of notch-sparing γ-secretase inhibitors
Harrison, Boyd L., Kreft, Anthony, Aschmies, Susan, Atchison, Kevin, Cole, Derek, Ellingboe, John, Hauze, Diane, Hu, Yun, Huryn, Donna, Jin, Mei, Kubrak, Dennis, Lu, Peimin, Mann, Charles, Martone, Robert, Moore, William, Porte, Alex, Riddell, David, Sonnenberg-Reines, June, Stock, Joseph, Sun, Shaiu-Ching, Wagner, Erik, Woller, Kevin, Xu, Zheng, Zhou, Hua, Jacobsen, Steven
Published in Alzheimer's & dementia (01.07.2006)
Published in Alzheimer's & dementia (01.07.2006)
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