Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features
Azab, Abdel Kareem, Hu, Jinsong, Quang, Phong, Azab, Feda, Pitsillides, Costas, Awwad, Rana, Thompson, Brian, Maiso, Patricia, Sun, Jessica D., Hart, Charles P., Roccaro, Aldo M., Sacco, Antonio, Ngo, Hai T., Lin, Charles P., Kung, Andrew L., Carrasco, Ruben D., Vanderkerken, Karin, Ghobrial, Irene M.
Published in Blood (14.06.2012)
Published in Blood (14.06.2012)
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Journal Article
Selective Tumor Hypoxia Targeting by Hypoxia-Activated Prodrug TH-302 Inhibits Tumor Growth in Preclinical Models of Cancer
SUN, Jessica D, QIAN LIU, HART, Charles P, JINGLI WANG, AHLUWALIA, Dharmendra, FERRARO, Damien, YAN WANG, DUAN, Jian-Xin, STEVE AMMONS, W, CURD, John G, MATTEUCCI, Mark D
Published in Clinical cancer research (01.02.2012)
Published in Clinical cancer research (01.02.2012)
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Journal Article
Partial ablation of the orexin field induces a sub-narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration
Black, Sarah Wurts, Sun, Jessica D, Santiago, Pamela, Laihsu, Alex, Kimura, Nikki, Yamanaka, Akihiro, Bersot, Ross, Humphries, Paul S
Published in Sleep (New York, N.Y.) (01.09.2018)
Published in Sleep (New York, N.Y.) (01.09.2018)
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Journal Article
Comparison of hypoxia-activated prodrug evofosfamide (TH-302) and ifosfamide in preclinical non-small cell lung cancer models
Sun, Jessica D., Liu, Qian, Ahluwalia, Dharmendra, Ferraro, Damien J., Wang, Yan, Jung, Don, Matteucci, Mark D., Hart, Charles P.
Published in Cancer biology & therapy (02.04.2016)
Published in Cancer biology & therapy (02.04.2016)
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Journal Article
Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition
Meng, Fanying, Bhupathi, Deepthi, Sun, Jessica D, Liu, Qian, Ahluwalia, Dharmendra, Wang, Yan, Matteucci, Mark D, Hart, Charles P
Published in BMC cancer (21.05.2015)
Published in BMC cancer (21.05.2015)
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Journal Article
Hypoxia-Targeting Drug Evofosfamide (TH-302) Enhances Sunitinib Activity in Neuroblastoma Xenograft Models
Kumar, Sushil, Sun, Jessica D., Zhang, Libo, Mokhtari, Reza Bayat, Wu, Bing, Meng, Fanying, Liu, Qian, Bhupathi, Deepthi, Wang, Yan, Yeger, Herman, Hart, Charles, Baruchel, Sylvain
Published in Translational oncology (01.08.2018)
Published in Translational oncology (01.08.2018)
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Journal Article
Correction: Selective Tumor Hypoxia Targeting by Hypoxia-Activated Prodrug TH-302 Inhibits Tumor Growth in Preclinical Models of Cancer
Sun, Jessica D, Liu, Qian, Wang, Jingli, Ahluwalia, Dharmendra, Ferraro, Damien, Wang, Yan, Duan, Jian-Xin, Ammons, W Steve, Curd, John G, Matteucci, Mark D, Hart, Charles P
Published in Clinical cancer research (15.05.2024)
Published in Clinical cancer research (15.05.2024)
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Journal Article
TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [18F]HX4 Hypoxia PET Imaging
Peeters, Sarah G J A, Zegers, Catharina M L, Biemans, Rianne, Lieuwes, Natasja G, van Stiphout, Ruud G P M, Yaromina, Ala, Sun, Jessica D, Hart, Charles P, Windhorst, Albert D, van Elmpt, Wouter, Dubois, Ludwig J, Lambin, Philippe
Published in Clinical cancer research (01.07.2015)
Published in Clinical cancer research (01.07.2015)
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Journal Article
Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug
Hu, Jinsong, Handisides, Damian R., Van Valckenborgh, Els, De Raeve, Hendrik, Menu, Eline, Vande Broek, Isabelle, Liu, Qian, Sun, Jessica D., Van Camp, Ben, Hart, Charles P., Vanderkerken, Karin
Published in Blood (02.09.2010)
Published in Blood (02.09.2010)
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Journal Article
Hypoxia-activated evofosfamide for treatment of recurrent bevacizumab-refractory glioblastoma: a phase I surgical study
Brenner, Andrew, Zuniga, Richard, Sun, Jessica D, Floyd, John, Hart, Charles P, Kroll, Stew, Fichtel, Lisa, Cavazos, David, Caflisch, Laura, Gruslova, Aleksandra, Huang, Shiliang, Liu, Yichu, Lodi, Alessia, Tiziani, Stefano
Published in Neuro-oncology (Charlottesville, Va.) (02.08.2018)
Published in Neuro-oncology (Charlottesville, Va.) (02.08.2018)
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Journal Article
Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer
Sun, Jessica D, Liu, Qian, Ahluwalia, Dharmendra, Li, Wenwu, Meng, Fanying, Wang, Yan, Bhupathi, Deepthi, Ruprell, Ayesha S, Hart, Charles P
Published in Cancer biology & therapy (04.03.2015)
Published in Cancer biology & therapy (04.03.2015)
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Journal Article
TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules
Liu, Qian, Sun, Jessica D., Wang, Jingli, Ahluwalia, Dharmendra, Baker, Amanda F., Cranmer, Lee D., Ferraro, Damien, Wang, Yan, Duan, Jian-Xin, Ammons, W. Steve, Curd, John G., Matteucci, Mark D., Hart, Charles P.
Published in Cancer chemotherapy and pharmacology (01.06.2012)
Published in Cancer chemotherapy and pharmacology (01.06.2012)
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Journal Article
Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer
Duran, Rafael, Mirpour, Sahar, Pekurovsky, Vasily, Ganapathy-Kanniappan, Shanmugasundaram, Brayton, Cory F, Cornish, Toby C, Gorodetski, Boris, Reyes, Juvenal, Chapiro, Julius, Schernthaner, Rüdiger E, Frangakis, Constantine, Lin, MingDe, Sun, Jessica D, Hart, Charles P, Geschwind, Jean-François
Published in Clinical cancer research (15.01.2017)
Published in Clinical cancer research (15.01.2017)
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Journal Article
ORIC-101, a Glucocorticoid Receptor Antagonist, in Combination with Nab-Paclitaxel in Patients with Advanced Solid Tumors
Chen, Christopher T, Khanna, Vishesh, Kummar, Shivaani, Abdul-Karim, Raghad M, Sommerhalder, David, Tolcher, Anthony W, Ueno, Naoto T, Davis, Sarah Lindsey, Orr, Douglas W, Hamilton, Erika, Patel, Manish R, Spira, Alexander I, Jauhari, Shekeab, Florou, Vaia, Duff, Maureen, Xu, Rongda, Wang, Jian, Barkund, Shravani R, Zhou, Haiying, Pankov, Aleksandr, Kong, Wayne, Jahchan, Nadine S, Jackson, Erica L, Sun, Jessica D, Junttila, Melissa R, Multani, Pratik S, Daemen, Anneleen, Chow Maneval, Edna, Munster, Pamela N
Published in Cancer research communications (01.09.2024)
Published in Cancer research communications (01.09.2024)
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Journal Article
14-Aminocamptothecins: Their Synthesis, Preclinical Activity, and Potential Use for Cancer Treatment
Duan, Jian-Xin, Cai, Xiaohong, Meng, Fanying, Sun, Jessica D, Liu, Qian, Jung, Donald, Jiao, Hailong, Matteucci, Jackson, Jung, Brian, Bhupathi, Deepthi, Ahluwalia, Dharmendra, Huang, Heli, Hart, Charles P, Matteucci, Mark
Published in Journal of medicinal chemistry (24.03.2011)
Published in Journal of medicinal chemistry (24.03.2011)
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Journal Article
Combination treatment with hypoxia-activated prodrug evofosfamide (TH-302) and mTOR inhibitors results in enhanced antitumor efficacy in preclinical renal cell carcinoma models
Sun, Jessica D, Ahluwalia, Dharmendra, Liu, Qian, Li, Wenwu, Wang, Yan, Meng, Fanying, Bhupathi, Deepthi, Matteucci, Mark D, Hart, Charles P
Published in American journal of cancer research (01.01.2015)
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Published in American journal of cancer research (01.01.2015)
Journal Article
Abstract P6-03-24: ORIC-101 robustly inhibits the glucocorticoid pathway and overcomes chemoresistance in triple-negative breast cancer
Zhou, Haiying, Ye, Qiuping, Pankov, Aleksandr, Kong, Wayne, Barkund, Shravani, Friedman, Lori S., Sun, Jessica D., Kabbarah, Omar
Published in Cancer research (Chicago, Ill.) (15.02.2020)
Published in Cancer research (Chicago, Ill.) (15.02.2020)
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Journal Article
Abstract 4121: ORIC-101 overcomes resistance to diverse chemotherapeutics across cancer types
Zhou, Haiying, Barkund, Shravani, Pankov, Aleksandr, Hegde, Ganapati, Kong, Wayne, Narayanan, Padmini, Sun, Jessica D., Kabbarah, Omar, Friedman, Lori S., Daemen, Anneleen
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 4123: ORIC-101 overcomes glucocorticoid receptor-mediated chemoresistance in pancreatic cancer models
Sun, Jessica D., Zhou, Haiying, Kong, Wayne, Yuen, Natalie, Duong, Frank L., Barkund, Shravani, Pankov, Aleksandr, McWeeney, Dan, Ye, Qiuping, Kabbarah, Omar, Friedman, Lori S., Daemen, Anneleen, Junttila, Melissa
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Rapid, noninvasive, and unsupervised detection of sleep/wake using piezoelectric monitoring for pharmacological studies in narcoleptic mice
Sarah Wurts Black, Sun, Jessica D, Laihsu, Alex, Kimura, Nikki, Santiago, Pamela, Donohue, Kevin D, O'hara, Bruce F, Bersot, Ross, Humphries, Paul S
Published in bioRxiv (25.09.2018)
Published in bioRxiv (25.09.2018)
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