Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
Liu, Jun, Pan, Shifeng, Hsieh, Mindy H., Ng, Nicholas, Sun, Fangxian, Wang, Tao, Kasibhatla, Shailaja, Schuller, Alwin G., Li, Allen G., Cheng, Dai, Li, Jie, Tompkins, Celin, Pferdekamper, AnneMarie, Steffy, Auzon, Cheng, Jane, Kowal, Colleen, Van Phung, Guo, Guirong, Wang, Yan, Graham, Martin P., Flynn, Shannon, Brenner, J. Chad, Li, Chun, Villarroel, M. Cristina, Schultz, Peter G., Xu Wu, McNamara, Peter, Sellers, William R., Petruzzelli, Lilli, Boral, Anthony L., Seidel, H. Martin, McLaughlin, Margaret E., Che, Jianwei, Carey, Thomas E., Vanasse, Gary, Harris, Jennifer L.
Published in Proceedings of the National Academy of Sciences - PNAS (10.12.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (10.12.2013)
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Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors
Ding, Qiang, Jahnke, Wolfgang, Adrián, Francisco J, Guo, Gui-Rong, Warmuth, Markus, Deng, Xianming, Grzesiek, Stephan, Bursulaya, Badry, Gray, Nathanael S, Okram, Barun, Tuntland, Tove, Azam, Mohammad, Li, Allen G, Powers, John, Dierks, Christine, Strauss, André, Engen, John R, Cowan-Jacob, Sandra W, Wojciechowski, Amy, Liu, Yi, Fendrich, Gabriele, Iacob, Roxana E, Sim, Taebo, Sun, Fangxian, Vajpai, Navratna, Zhang, Jianming, Liu, Guoxun, Daley, George Q, Manley, Paul W, Choi, Yongmun
Published in Nature (London) (28.01.2010)
Published in Nature (London) (28.01.2010)
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Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers
Koundinya, Malvika, Sudhalter, Judith, Courjaud, Albane, Lionne, Bruno, Touyer, Gaetan, Bonnet, Luc, Menguy, Isabelle, Schreiber, Isabelle, Perrault, Christelle, Vougier, Stephanie, Benhamou, Brigitte, Zhang, Bailin, He, Timothy, Gao, Qiang, Gee, Patricia, Simard, Daniel, Castaldi, M. Paola, Tomlinson, Ronald, Reiling, Stephan, Barrague, Matthieu, Newcombe, Richard, Cao, Hui, Wang, Yanjun, Sun, Fangxian, Murtie, Joshua, Munson, Mark, Yang, Eric, Harper, David, Bouaboula, Monsif, Pollard, Jack, Grepin, Claudine, Garcia-Echeverria, Carlos, Cheng, Hong, Adrian, Francisco, Winter, Christopher, Licht, Stuart, Cornella-Taracido, Ivan, Arrebola, Rosalia, Morris, Aaron
Published in Cell chemical biology (21.06.2018)
Published in Cell chemical biology (21.06.2018)
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Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents
Griebel, Guy, Pichat, Philippe, Beeské, Sandra, Leroy, Thibaud, Redon, Nicolas, Jacquet, Agnès, Françon, Dominique, Bert, Lionel, Even, Luc, Lopez-Grancha, Mati, Tolstykh, Tatiana, Sun, Fangxian, Yu, Qunyan, Brittain, Scott, Arlt, Heike, He, Timothy, Zhang, Bailin, Wiederschain, Dmitri, Bertrand, Thomas, Houtmann, Jacques, Rak, Alexey, Vallée, François, Michot, Nadine, Augé, Franck, Menet, Véronique, Bergis, Olivier E., George, Pascal, Avenet, Patrick, Mikol, Vincent, Didier, Michel, Escoubet, Johanna
Published in Scientific reports (06.01.2015)
Published in Scientific reports (06.01.2015)
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Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK
Galkin, Anna V, Melnick, Jonathan S, Kim, Sungjoon, Hood, Tami L, Li, Nanxin, Li, Lintong, Xia, Gang, Steensma, Ruo, Chopiuk, Greg, Jiang, Jiqing, Wan, Yongqin, Ding, Peter, Liu, Yi, Sun, Fangxian, Schultz, Peter G, Gray, Nathanael S, Warmuth, Markus
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2007)
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Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist
Pan, Shifeng, Wu, Xu, Jiang, Jiqing, Gao, Wenqi, Wan, Yongqin, Cheng, Dai, Han, Dong, Liu, Jun, Englund, Nathan P, Wang, Yan, Peukert, Stefan, Miller-Moslin, Karen, Yuan, Jing, Guo, Ribo, Matsumoto, Melissa, Vattay, Anthony, Jiang, Yun, Tsao, Jeffrey, Sun, Fangxian, Pferdekamper, AnneMarie C, Dodd, Stephanie, Tuntland, Tove, Maniara, Wieslawa, Kelleher, Joseph F, Yao, Yung-mae, Warmuth, Markus, Williams, Juliet, Dorsch, Marion
Published in ACS medicinal chemistry letters (10.06.2010)
Published in ACS medicinal chemistry letters (10.06.2010)
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Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells
Wagenaar, Timothy R, Tolstykh, Tatiana, Shi, Chaomei, Jiang, Lan, Zhang, JingXin, Li, Zhifang, Yu, Qunyan, Qu, Hui, Sun, Fangxian, Cao, Hui, Pollard, Jack, Dai, Shujia, Gao, Qiang, Zhang, Bailin, Arlt, Heike, Cindhuchao, May, Hoffmann, Dietmar, Light, Madelyn, Jensen, Karin, Hopke, Joern, Newcombe, Richard, Garcia-Echeverria, Carlos, Winter, Christopher, Zabludoff, Sonya, Wiederschain, Dmitri
Published in Nucleic acids research (30.01.2015)
Published in Nucleic acids research (30.01.2015)
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An experimental model of anti-PD-1 resistance exhibits activation of TGFß and Notch pathways and is sensitive to local mRNA immunotherapy
Bernardo, Marie, Tolstykh, Tatiana, Zhang, Yu-an, Bangari, Dinesh S., Cao, Hui, Heyl, Kerstin A., Lee, Joon Sang, Malkova, Natalia V., Malley, Katie, Marquez, Eladio, Pollard, Jack, Qu, Hui, Roberts, Errin, Ryan, Sue, Singh, Kuldeep, Sun, Fangxian, Wang, Emma, Bahjat, Keith, Wiederschain, Dmitri, Wagenaar, Timothy R.
Published in Oncoimmunology (01.01.2021)
Published in Oncoimmunology (01.01.2021)
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Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models
Hotz, Christian, Wagenaar, Timothy R, Gieseke, Friederike, Bangari, Dinesh S, Callahan, Michelle, Cao, Hui, Diekmann, Jan, Diken, Mustafa, Grunwitz, Christian, Hebert, Andy, Hsu, Karl, Bernardo, Marie, Karikó, Katalin, Kreiter, Sebastian, Kuhn, Andreas N, Levit, Mikhail, Malkova, Natalia, Masciari, Serena, Pollard, Jack, Qu, Hui, Ryan, Sue, Selmi, Abderaouf, Schlereth, Julia, Singh, Kuldeep, Sun, Fangxian, Tillmann, Bodo, Tolstykh, Tatiana, Weber, William, Wicke, Lena, Witzel, Sonja, Yu, Qunyan, Zhang, Yu-An, Zheng, Gang, Lager, Joanne, Nabel, Gary J, Sahin, Ugur, Wiederschain, Dmitri
Published in Science translational medicine (08.09.2021)
Published in Science translational medicine (08.09.2021)
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In vivo selection for metastasis promoting genes in the mouse
Gumireddy, Kiranmai, Sun, Fangxian, Klein-Szanto, Andres J, Gibbins, Jonathan M, Gimotty, Phyllis A, Saunders, Aleister J, Schultz, Peter G, Huang, Qihong
Published in Proceedings of the National Academy of Sciences - PNAS (17.04.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (17.04.2007)
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Combination of PIM and JAK2 inhibitors synergistically suppresses cell proliferation and overcomes drug resistance of myeloproliferative neoplasms
Huang, Shih-Min A., Wang, Anlai, Greco, Rita, Li, Zhifang, Sun, Fangxian, Barberis, Claude, Tabart, Michel, Patel, Vinod, Schio, Laurent, Hurley, Raelene, Chen, Bo, Cheng, Hong, Lengauer, Christoph, Pollard, Jack, Watters, James, Garcia-Echeverria, Carlos, Wiederschain, Dmitri, Adrian, Francisco, Zhang, JingXin
Published in Oncotarget (08.05.2014)
Published in Oncotarget (08.05.2014)
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Optically imageable metastatic model of human breast cancer
Li, Xiaoming, Wang, Jinwei, An, Zili, Yang, Meng, Baranov, Eugene, Jiang, Ping, Sun, Fangxian, Moossa, A R, Hoffman, Robert M
Published in Clinical & experimental metastasis (01.01.2002)
Published in Clinical & experimental metastasis (01.01.2002)
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Abstract 2712: Donor selection strategies to optimize humanized mouse models for the evaluation of T cell engagers
Cheng, Liqing, Chen, Jane, Yu, Qunyan, Malkova, Natalia, Cortez-Retamozo, Virna F., Sun, Fangxian, Sidhu, Sukhvinder
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models
Shomali, Maysoun, Cheng, Jane, Sun, Fangxian, Koundinya, Malvika, Guo, Zhuyan, Hebert, Andrew T, McManus, Jessica, Levit, Mikhail N, Hoffmann, Dietmar, Courjaud, Albane, Arrebola, Rosalia, Cao, Hui, Pollard, Jack, Lee, Joon Sang, Besret, Laurent, Caron, Anne, Bangari, Dinesh S, Abecassis, Pierre-Yves, Schio, Laurent, El-Ahmad, Youssef, Halley, Frank, Tabart, Michel, Certal, Victor, Thompson, Fabienne, McCort, Gary, Filoche-Rommé, Bruno, Cheng, Hong, Garcia-Echeverria, Carlos, Debussche, Laurent, Bouaboula, Monsif
Published in Molecular cancer therapeutics (01.02.2021)
Published in Molecular cancer therapeutics (01.02.2021)
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Abstract P4-02-08: Amcenestrant in combination with CDK4/6 inhibitor palbociclib demonstrates synergistic anti-tumor activity in ER+ endocrine-resistant breast cancer xenograft models
Shomali, Maysoun, Guo, Zhuyan, Cheng, Jane, Sullivan, Amy, El-Ahmad, Youssef, Sun, Fangxian, Sidhu, Sukhvinder, Lee, Joon Sang, Cai, Hui, Pollard, Jack, Debussche, Laurent, Soria, Chris, Bouaboula, Monsif
Published in Cancer research (Chicago, Ill.) (15.02.2022)
Published in Cancer research (Chicago, Ill.) (15.02.2022)
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Discovery of 6‑(2,4-Dichlorophenyl)-5-[4-[(3S)‑1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro‑7H‑benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer
El-Ahmad, Youssef, Tabart, Michel, Halley, Frank, Certal, Victor, Thompson, Fabienne, Filoche-Rommé, Bruno, Gruss-Leleu, Florence, Muller, Claire, Brollo, Maurice, Fabien, Laurence, Loyau, Véronique, Bertin, Luc, Richepin, Patrick, Pilorge, Fabienne, Desmazeau, Pascal, Girardet, Chrystelle, Beccari, Sylvie, Louboutin, Audrey, Lebourg, Gilles, Le-Roux, Jacques, Terrier, Corinne, Vallée, François, Steier, Valérie, Mathieu, Magali, Rak, Alexey, Abecassis, Pierre-Yves, Vicat, Pascale, Benard, Tsiala, Bouaboula, Monsif, Sun, Fangxian, Shomali, Maysoun, Hebert, Andrew, Levit, Mikhail, Cheng, Hong, Courjaud, Albane, Ginesty, Celine, Perrault, Christelle, Garcia-Echeverria, Carlos, McCort, Gary, Schio, Laurent
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
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Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3 S )-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7 H -benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer
El-Ahmad, Youssef, Tabart, Michel, Halley, Frank, Certal, Victor, Thompson, Fabienne, Filoche-Rommé, Bruno, Gruss-Leleu, Florence, Muller, Claire, Brollo, Maurice, Fabien, Laurence, Loyau, Véronique, Bertin, Luc, Richepin, Patrick, Pilorge, Fabienne, Desmazeau, Pascal, Girardet, Chrystelle, Beccari, Sylvie, Louboutin, Audrey, Lebourg, Gilles, Le-Roux, Jacques, Terrier, Corinne, Vallée, François, Steier, Valérie, Mathieu, Magali, Rak, Alexey, Abecassis, Pierre-Yves, Vicat, Pascale, Benard, Tsiala, Bouaboula, Monsif, Sun, Fangxian, Shomali, Maysoun, Hebert, Andrew, Levit, Mikhail, Cheng, Hong, Courjaud, Albane, Ginesty, Celine, Perrault, Christelle, Garcia-Echeverria, Carlos, McCort, Gary, Schio, Laurent
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
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Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation
Wu, Lan, Seung, Edward, Xu, Ling, Rao, Ercole, Lord, Dana M, Wei, Ronnie R, Cortez-Retamozo, Virna, Ospina, Beatriz, Posternak, Valeriya, Ulinski, Gregory, Piepenhagen, Peter, Francesconi, Elisa, El-Murr, Nizar, Beil, Christian, Kirby, Patrick, Li, Aiqun, Fretland, Jennifer, Vicente, Rita, Deng, Gejing, Dabdoubi, Tarik, Cameron, Beatrice, Bertrand, Thomas, Ferrari, Paul, Pouzieux, Stéphanie, Lemoine, Cendrine, Prades, Catherine, Park, Anna, Qiu, Huawei, Song, Zhili, Zhang, Bailin, Sun, Fangxian, Chiron, Marielle, Rao, Srinivas, Radošević, Katarina, Yang, Zhi-Yong, Nabel, Gary J
Published in Nature cancer (01.01.2020)
Published in Nature cancer (01.01.2020)
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Abstract PS17-16: Sar439859, a novel selective estrogen receptor degrader (serd), demonstrates effective and broad antitumor activity in wild-type and mutant er-positive breast cancer models
Shomali, Maysoun, Sun, Fangxian, Levit, Mikhail, Pollard, Jack, Lee, Joon Sang, Schio, Laurent, El-Ahmad, Youssef, Soria, Chris, Cohen, Patrick, Debussche, Laurent, Bouaboula, Monsif
Published in Cancer research (Chicago, Ill.) (15.02.2021)
Published in Cancer research (Chicago, Ill.) (15.02.2021)
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