The Additive Effects of Low Dose Intake of Ferulic Acid, Phosphatidylserine and Curcumin, Not Alone, Improve Cognitive Function in APPswe/PS1dE9 Transgenic Mice
Okuda, Michiaki, Fujita, Yuki, Sugimoto, Hachiro
Published in Biological & pharmaceutical bulletin (01.10.2019)
Published in Biological & pharmaceutical bulletin (01.10.2019)
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Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation
Okuda, Michiaki, Fujita, Yuki, Takada-Takatori, Yuki, Sugimoto, Hachiro, Urakami, Katsuya
Published in PloS one (14.10.2020)
Published in PloS one (14.10.2020)
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Flavonols and flavones as BACE-1 inhibitors: Structure–activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features
Shimmyo, Yoshiari, Kihara, Takeshi, Akaike, Akinori, Niidome, Tetsuhiro, Sugimoto, Hachiro
Published in Biochimica et biophysica acta (01.05.2008)
Published in Biochimica et biophysica acta (01.05.2008)
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Glutathione Biosynthesis via Activation of the Nuclear Factor E2–Related Factor 2 (Nrf2) – Antioxidant-Response Element (ARE) Pathway Is Essential for Neuroprotective Effects of Sulforaphane and 6-(Methylsulfinyl) Hexyl Isothiocyanate
Mizuno, Keita, Kume, Toshiaki, Muto, Chie, Takada-Takatori, Yuki, Izumi, Yasuhiko, Sugimoto, Hachiro, Akaike, Akinori
Published in Journal of Pharmacological Sciences (2011)
Published in Journal of Pharmacological Sciences (2011)
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Development of a brain-permeable peptide nanofiber that prevents aggregation of Alzheimer pathogenic proteins
Tanaka, Naoki, Okuda, Michiaki, Nishigaki, Tatsutoshi, Tsuchiya, Nobuhiko, Kobayashi, Yukako, Uemura, Takuya, Kumo, Sayaka, Sugimoto, Hachiro, Miyata, Seiji, Waku, Tomonori
Published in PloS one (24.07.2020)
Published in PloS one (24.07.2020)
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LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11
Sagane, Koji, Ishihama, Yasushi, Sugimoto, Hachiro
Published in International journal of biological sciences (01.01.2008)
Published in International journal of biological sciences (01.01.2008)
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Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade
Takada-Takatori, Yuki, Kume, Toshiaki, Sugimoto, Mitsuhiro, Katsuki, Hiroshi, Sugimoto, Hachiro, Akaike, Akinori
Published in Neuropharmacology (01.09.2006)
Published in Neuropharmacology (01.09.2006)
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Three distinct neuroprotective functions of myricetin against glutamate-induced neuronal cell death: Involvement of direct inhibition of caspase-3
Shimmyo, Yoshiari, Kihara, Takeshi, Akaike, Akinori, Niidome, Tetsuhiro, Sugimoto, Hachiro
Published in Journal of neuroscience research (01.06.2008)
Published in Journal of neuroscience research (01.06.2008)
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Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis
Kato, Hajime, Sato, Hiroyasu, Okuda, Michiaki, Wu, Jun, Koyama, Shingo, Izumi, Yasuhiko, Waku, Tomonori, Iino, Mitsuyoshi, Aoki, Masashi, Arawaka, Shigeki, Ohta, Yasuyuki, Ishizawa, Kenichi, Kawasaki, Kanan, Urano, Yasuomi, Miyasaka, Tomohiro, Noguchi, Noriko, Kume, Toshiaki, Akaike, Akinori, Sugimoto, Hachiro, Kato, Takeo
Published in Amyotrophic lateral sclerosis and frontotemporal degeneration (02.10.2022)
Published in Amyotrophic lateral sclerosis and frontotemporal degeneration (02.10.2022)
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PE859, a novel tau aggregation inhibitor, reduces aggregated tau and prevents onset and progression of neural dysfunction in vivo
Okuda, Michiaki, Hijikuro, Ichiro, Fujita, Yuki, Wu, Xiaofeng, Nakayama, Shinichi, Sakata, Yoko, Noguchi, Yuji, Ogo, Makoto, Akasofu, Shigeru, Ito, Yoshimasa, Soeda, Yoshiyuki, Tsuchiya, Nobuhiko, Tanaka, Naoki, Takahashi, Takashi, Sugimoto, Hachiro
Published in PloS one (06.02.2015)
Published in PloS one (06.02.2015)
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Long-Term Ultra-High Hydrostatic Pressurized Brown Rice Intake Prevents Bone Mineral Density Decline in Elderly Japanese Individuals
MATSUZAKI, Kentaro, YANO, Shozo, SUMIYOSHI, Eri, SHIDO, Osamu, KATSUBE, Takuya, TABATA, Mitsumasa, OKUDA, Michiaki, SUGIMOTO, Hachiro, YOSHINO, Katsumi, HASHIMOTO, Michio
Published in Journal of Nutritional Science and Vitaminology (11.10.2019)
Published in Journal of Nutritional Science and Vitaminology (11.10.2019)
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Invasion Precedes Tumor Mass Formation in a Malignant Brain Tumor Model of Genetically Modified Neural Stem Cells
Sampetrean, Oltea, Saga, Isako, Nakanishi, Masaya, Sugihara, Eiji, Fukaya, Raita, Onishi, Nobuyuki, Osuka, Satoru, Akahata, Masaki, Kai, Kazuharu, Sugimoto, Hachiro, Hirao, Atsushi, Saya, Hideyuki
Published in Neoplasia (New York, N.Y.) (01.09.2011)
Published in Neoplasia (New York, N.Y.) (01.09.2011)
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Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis)
Izumi, Yasuhiko, Matsumura, Atsuko, Wakita, Seiko, Akagi, Ken-ichi, Fukuda, Hiroyuki, Kume, Toshiaki, Irie, Kazuhiro, Takada-Takatori, Yuki, Sugimoto, Hachiro, Hashimoto, Tadashi, Akaike, Akinori
Published in Free radical biology & medicine (15.08.2012)
Published in Free radical biology & medicine (15.08.2012)
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Influence of Ultra-High Hydrostatic Pressurizing Brown Rice on Cognitive Functions and Mental Health of Elderly Japanese Individuals: A 2-Year Randomized and Controlled Trial
KURODA, Yoko, MATSUZAKI, Kentaro, WAKATSUKI, Harumi, SHIDO, Osamu, HARAUMA, Akiko, MORIGUCHI, Toru, SUGIMOTO, Hachiro, YAMAGUCHI, Shuhei, YOSHINO, Katsumi, HASHIMOTO, Michio
Published in Journal of Nutritional Science and Vitaminology (11.10.2019)
Published in Journal of Nutritional Science and Vitaminology (11.10.2019)
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Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation
Urano, Yasuomi, Takahachi, Mina, Higashiura, Ryo, Fujiwara, Hitomi, Funamoto, Satoru, Imai, So, Futai, Eugene, Okuda, Michiaki, Sugimoto, Hachiro, Noguchi, Noriko
Published in Cells (Basel, Switzerland) (03.02.2020)
Published in Cells (Basel, Switzerland) (03.02.2020)
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Amyloid precursor protein promotes endoplasmic reticulum stress‐induced cell death via C/EBP homologous protein‐mediated pathway
Takahashi, Keita, Niidome, Tetsuhiro, Akaike, Akinori, Kihara, Takeshi, Sugimoto, Hachiro
Published in Journal of neurochemistry (01.06.2009)
Published in Journal of neurochemistry (01.06.2009)
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Decreased proliferation of hippocampal progenitor cells in APPswe/PS1dE9 transgenic mice
Taniuchi, Nobuhiko, Niidome, Tetsuhiro, Goto, Yasuaki, Akaike, Akinori, Kihara, Takeshi, Sugimoto, Hachiro
Published in Neuroreport (19.11.2007)
Published in Neuroreport (19.11.2007)
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Distinct mechanisms underlie distinct polyphenol-induced neuroprotection
Yazawa, Keiko, Kihara, Takeshi, Shen, Huilian, Shimmyo, Yoshiari, Niidome, Tetsuhiro, Sugimoto, Hachiro
Published in FEBS letters (11.12.2006)
Published in FEBS letters (11.12.2006)
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