Impaired Responsiveness to the Platelet P2Y12 Receptor Antagonist Clopidogrel in Patients With Type 2 Diabetes and Coronary Artery Disease
Angiolillo, Dominick J., MD, PhD, Jakubowski, Joseph A., PhD, Ferreiro, José Luis, MD, Tello-Montoliu, Antonio, MD, PhD, Rollini, Fabiana, MD, Franchi, Francesco, MD, Ueno, Masafumi, MD, Darlington, Andrew, MD, Desai, Bhaloo, PhD, Moser, Brian A., MS, Sugidachi, Atsuhiro, PhD, Guzman, Luis A., MD, Bass, Theodore A., MD
Published in Journal of the American College of Cardiology (09.09.2014)
Published in Journal of the American College of Cardiology (09.09.2014)
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Patients With Poor Responsiveness to Thienopyridine Treatment or With Diabetes Have Lower Levels of Circulating Active Metabolite, but Their Platelets Respond Normally to Active Metabolite Added Ex Vivo
Erlinge, David, MD, PhD, Varenhorst, Christoph, MD, Braun, Oscar Ö., MD, PhD, James, Stefan, MD, PhD, Winters, Kenneth J., MD, Jakubowski, Joseph A., PhD, Brandt, John T., MD, Sugidachi, Atsuhiro, PhD, Siegbahn, Agneta, MD, PhD, Wallentin, Lars, MD, PhD
Published in Journal of the American College of Cardiology (09.12.2008)
Published in Journal of the American College of Cardiology (09.12.2008)
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Journal Article
A Novel Model of Intravital Platelet Imaging Using CD41-ZsGreen1 Transgenic Rats
Mizuno, Makoto, Tomizawa, Atsuyuki, Ohno, Kousaku, Jakubowski, Joseph A, Sugidachi, Atsuhiro
Published in PloS one (29.04.2016)
Published in PloS one (29.04.2016)
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Prevention of occlusive arterial thrombus formation by a single loading dose of prasugrel suppresses neointimal hyperplasia in mice
Ohno, Kousaku, Tomizawa, Atsuyuki, Jakubowski, Joseph A, Mizuno, Makoto, Sugidachi, Atsuhiro
Published in Thrombosis research (01.12.2015)
Published in Thrombosis research (01.12.2015)
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Journal Article
Regulation of Functionally Active P2Y12 ADP Receptors by Thrombin in Human Smooth Muscle Cells and the Presence of P2Y12 in Carotid Artery Lesions
Rauch, Bernhard H, Rosenkranz, Anke C, Ermler, Swen, Böhm, Andreas, Driessen, Julia, Fischer, Jens W, Sugidachi, Atsuhiro, Jakubowski, Joseph A, Schrör, Karsten
Published in Arteriosclerosis, thrombosis, and vascular biology (01.12.2010)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.12.2010)
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Comparison of antiplatelet effects of prasugrel and ticagrelor in cynomolgus monkeys by an ELISA-based VASP phosphorylation assay and platelet aggregation
Tomizawa, Atsuyuki, Ohno, Kousaku, Jakubowski, Joseph A, Mizuno, Makoto, Sugidachi, Atsuhiro
Published in Thrombosis and haemostasis (01.10.2013)
Published in Thrombosis and haemostasis (01.10.2013)
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Prasugrel, a Platelet P2Y12 Receptor Antagonist, Improves Abnormal Gait in a Novel Murine Model of Thrombotic Hindlimb Ischemia
Ohno, Kousaku, Tomizawa, Atsuyuki, Mizuno, Makoto, Jakubowski, Joseph A., Sugidachi, Atsuhiro
Published in Journal of the American Heart Association (06.04.2016)
Published in Journal of the American Heart Association (06.04.2016)
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Stereoselective inhibition of human platelet aggregation by R-138727, the active metabolite of CS-747 (prasugrel, LY640315), a novel P2Y12 receptor inhibitor
Hasegawa, Michihiro, Sugidachi, Atsuhiro, Ogawa, Taketoshi, Isobe, Takashi, Jakubowski, Joseph A, Asai, Fumitoshi
Published in Thrombosis and haemostasis (01.09.2005)
Published in Thrombosis and haemostasis (01.09.2005)
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Repeat oral dosing of prasugrel, a novel P2Y12 receptor inhibitor, results in cumulative and potent antiplatelet and antithrombotic activity in several animal species
NIITSU, Yoichi, SUGIDACHI, Atsuhiro, OGAWA, Taketoshi, JAKUBOWSKI, Joseph A, HASHIMOTO, Masami, ISOBE, Takashi, OTSUGURO, Ken-Ichi, ASAI, Fumitoshi
Published in European journal of pharmacology (28.01.2008)
Published in European journal of pharmacology (28.01.2008)
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Journal Article
Selective blockade of P2Y12 receptors by prasugrel inhibits myocardial infarction induced by thrombotic coronary artery occlusion in rats
Sugidachi, Atsuhiro, Yamaguchi, Shinji, Jakubowski, Joseph A, Ohno, Kosaku, Tomizawa, Atsuyuki, Hashimoto, Masami, Niitsu, Yoichi
Published in Journal of cardiovascular pharmacology (01.09.2011)
Published in Journal of cardiovascular pharmacology (01.09.2011)
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The influence of P2Y12 receptor deficiency on the platelet inhibitory activities of prasugrel in a mouse model: Evidence for specific inhibition of P2Y12 receptors by prasugrel
Hashimoto, Masami, Sugidachi, Atsuhiro, Isobe, Takashi, Niitsu, Yoichi, Ogawa, Taketoshi, Jakubowski, Joseph A., Asai, Fumitoshi
Published in Biochemical pharmacology (01.10.2007)
Published in Biochemical pharmacology (01.10.2007)
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Antiplatelet action of R‐99224, an active metabolite of a novel thienopyridine‐type Gi‐linked P2T antagonist, CS‐747
Sugidachi, Atsuhiro, Asai, Fumitoshi, Yoneda, Kenji, Iwamura, Ryo, Ogawa, Taketoshi, Otsuguro, Ken‐ichi, Koike, Hiroyuki
Published in British journal of pharmacology (01.01.2001)
Published in British journal of pharmacology (01.01.2001)
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The active metabolite of prasugrel inhibits ADP-stimulated thrombo-inflammatory markers of platelet activation: Influence of other blood cells, calcium, and aspirin
Frelinger, 3rd, Andrew L, Jakubowski, Joseph A, Li, Youfu, Barnard, Marc R, Fox, Marsha L, Linden, Matthew D, Sugidachi, Atsuhiro, Winters, Kenneth J, Furman, Mark I, Michelson, Alan D
Published in Thrombosis and haemostasis (01.07.2007)
Published in Thrombosis and haemostasis (01.07.2007)
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Effects of prasugrel, a novel P2Y12 inhibitor, in rat models of cerebral and peripheral artery occlusive diseases
OGAWA, Taketoshi, HASHIMOTO, Masami, NIITSU, Yoichi, JAKUBOWSKI, Joseph A, TANI, Yoshiro, OTSUGURO, Ken-Ichi, ASAI, Fumitoshi, SUGIDACHI, Atsuhiro
Published in European journal of pharmacology (01.06.2009)
Published in European journal of pharmacology (01.06.2009)
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Journal Article
Discovery of R-142086 as a Factor Xa (FXa) Inhibitor: Syntheses and Structure–Activity Relationships of Cinnamyl Derivatives
Noguchi, Tetsuji, Tanaka, Naoki, Nishimata, Toyoki, Goto, Riki, Hayakawa, Miho, Sugidachi, Atsuhiro, Ogawa, Taketoshi, Niitsu, Yoichi, Asai, Fumitoshi, Ishizuka, Tomoko, Fujimoto, Koichi
Published in Chemical & pharmaceutical bulletin (01.01.2009)
Published in Chemical & pharmaceutical bulletin (01.01.2009)
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Journal Article
Cinnamylindoline Derivatives: Synthesis and Factor Xa (FXa) Inhibitory Activities
Noguchi, Tetsuji, Tanaka, Naoki, Nishimata, Toyoki, Goto, Riki, Hayakawa, Miho, Sugidachi, Atsuhiro, Ogawa, Taketoshi, Asai, Fumitoshi, Fujimoto, Koichi
Published in Chemical & pharmaceutical bulletin (01.10.2007)
Published in Chemical & pharmaceutical bulletin (01.10.2007)
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Journal Article
Cinnamyl Derivatives: Synthesis and Factor Xa (FXa) Inhibitory Activities
Noguchi, Tetsuji, Tanaka, Naoki, Nishimata, Toyoki, Goto, Riki, Hayakawa, Miho, Sugidachi, Atsuhiro, Ogawa, Taketoshi, Asai, Fumitoshi, Fujimoto, Koichi
Published in Chemical & pharmaceutical bulletin (01.06.2008)
Published in Chemical & pharmaceutical bulletin (01.06.2008)
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