Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases
Carrieri, Antonio, Barbarossa, Alexia, de Candia, Modesto, Samarelli, Francesco, Damiano Altomare, Cosimo, Czarnota-Łydka, Kinga, Sudoł-Tałaj, Sylwia, Latacz, Gniewomir, Handzlik, Jadwiga, Brunetti, Leonardo, Piemontese, Luca, Limongelli, Francesco, Lentini, Giovanni, Carocci, Alessia
Published in Bioorganic & medicinal chemistry (01.08.2024)
Published in Bioorganic & medicinal chemistry (01.08.2024)
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Journal Article
First-in-Class Selenium-Containing Potent Serotonin Receptor 5‑HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer’s Disease
Pyka, Patryk, Haberek, Wawrzyniec, Więcek, Małgorzata, Szymanska, Ewa, Ali, Wesam, Cios, Agnieszka, Jastrzębska-Więsek, Magdalena, Satała, Grzegorz, Podlewska, Sabina, Di Giacomo, Silvia, Di Sotto, Antonella, Garbo, Sabrina, Karcz, Tadeusz, Lambona, Chiara, Marocco, Francesco, Latacz, Gniewomir, Sudoł-Tałaj, Sylwia, Mordyl, Barbara, Głuch-Lutwin, Monika, Siwek, Agata, Czarnota-Łydka, Kinga, Gogola, Dawid, Olejarz-Maciej, Agnieszka, Wilczyńska-Zawal, Natalia, Honkisz-Orzechowska, Ewelina, Starek, Małgorzata, Dąbrowska, Monika, Kucwaj-Brysz, Katarzyna, Fioravanti, Rossella, Nasim, Muhammad Jawad, Hittinger, Marius, Partyka, Anna, Wesołowska, Anna, Battistelli, Cecilia, Zwergel, Clemens, Handzlik, Jadwiga
Published in Journal of medicinal chemistry (25.01.2024)
Published in Journal of medicinal chemistry (25.01.2024)
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Journal Article
The Phenoxyalkyltriazine Antagonists for 5-HT6 Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases
Sudoł, Sylwia, Cios, Agnieszka, Jastrzębska-Więsek, Magdalena, Honkisz-Orzechowska, Ewelina, Mordyl, Barbara, Wilczyńska-Zawal, Natalia, Satała, Grzegorz, Kucwaj-Brysz, Katarzyna, Partyka, Anna, Latacz, Gniewomir, Olejarz-Maciej, Agnieszka, Wesołowska, Anna, Handzlik, Jadwiga
Published in International journal of molecular sciences (01.10.2021)
Published in International journal of molecular sciences (01.10.2021)
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Journal Article
Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease
Czarnota-Łydka, Kinga, Sudoł-Tałaj, Sylwia, Kucwaj-Brysz, Katarzyna, Kurczab, Rafał, Satała, Grzegorz, de Candia, Modesto, Samarelli, Francesco, Altomare, Cosimo Damiano, Carocci, Alessia, Barbarossa, Alexia, Żesławska, Ewa, Głuch-Lutwin, Monika, Mordyl, Barbara, Kubacka, Monika, Wilczyńska-Zawal, Natalia, Jastrzębska-Więsek, Magdalena, Partyka, Anna, Khan, Nadia, Więcek, Małgorzata, Nitek, Wojciech, Honkisz-Orzechowska, Ewelina, Latacz, Gniewomir, Wesołowska, Anna, Carrieri, Antonio, Handzlik, Jadwiga
Published in European journal of medicinal chemistry (05.11.2023)
Published in European journal of medicinal chemistry (05.11.2023)
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Journal Article
Hydrophobicity modulation via the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer's disease for potent serotonin 5-HT6R agents
Sudoł-Tałaj, Sylwia, Kucwaj-Brysz, Katarzyna, Podlewska, Sabina, Kurczab, Rafał, Satała, Grzegorz, Mordyl, Barbara, Głuch-Lutwin, Monika, Wilczyńska-Zawal, Natalia, Jastrzębska-Więsek, Magdalena, Czarnota-Łydka, Kinga, Kurowska, Kinga, Kubacka, Monika, Żesławska, Ewa, Nitek, Wojciech, Olejarz-Maciej, Agnieszka, Doroz-Płonka, Agata, Partyka, Anna, Latacz, Gniewomir, Wesołowska, Anna, Handzlik, Jadwiga
Published in European journal of medicinal chemistry (15.11.2023)
Published in European journal of medicinal chemistry (15.11.2023)
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Journal Article
Chlorine substituents and linker topology as factors of 5-HT6R activity for novel highly active 1,3,5-triazine derivatives with procognitive properties in vivo
Sudoł, Sylwia, Kucwaj-Brysz, Katarzyna, Kurczab, Rafał, Wilczyńska, Natalia, Jastrzębska-Więsek, Magdalena, Satała, Grzegorz, Latacz, Gniewomir, Głuch-Lutwin, Monika, Mordyl, Barbara, Żesławska, Ewa, Nitek, Wojciech, Partyka, Anna, Buzun, Kamila, Doroz-Płonka, Agata, Wesołowska, Anna, Bielawska, Anna, Handzlik, Jadwiga
Published in European journal of medicinal chemistry (01.10.2020)
Published in European journal of medicinal chemistry (01.10.2020)
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Journal Article
Rational design of new multitarget histamine H-3 receptor ligands as potential candidates for treatment of Alzheimer's disease
Lazewska, Dorota, Bajda, Marek, Kaleta, Maria, Zareba, Paula, Doroz-Plonka, Agata, Siwek, Agata, Alachkar, Alaa, Mogilski, Szczepan, Saad, Ali, Kuder, Kamil, Olejarz-Maciej, Agnieszka, Godyn, Justyna, Stary, Dorota, Sudol, Sylwia, Wiecek, Malgorzata, Latacz, Gniewomir, Walczak, Maria, Handzlik, Jadwiga, Sadek, Bassem, Malawska, Barbara, Kiec-Kononowicz, Katarzyna
Published in European journal of medicinal chemistry (01.12.2020)
Published in European journal of medicinal chemistry (01.12.2020)
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Journal Article
An exit beyond the pharmacophore model for 5-HT6R agents - a new strategy to gain dual 5-HT6/5-HT2A action for triazine derivatives with procognitive potential
Kucwaj-Brysz, Katarzyna, Ali, Wesam, Kurczab, Rafał, Sudoł-Tałaj, Sylwia, Wilczyńska-Zawal, Natalia, Jastrzębska-Więsek, Magdalena, Satała, Grzegorz, Mordyl, Barbara, Żesławska, Ewa, Agnieszka-Olejarz-Maciej, Czarnota, Kinga, Latacz, Gniewomir, Partyka, Anna, Wesołowska, Anna, Nitek, Wojciech, Handzlik, Jadwiga
Published in Bioorganic chemistry (01.04.2022)
Published in Bioorganic chemistry (01.04.2022)
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Journal Article
Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6
Ali, Wesam, Więcek, Małgorzata, Łażewska, Dorota, Kurczab, Rafał, Jastrzębska-Więsek, Magdalena, Satała, Grzegorz, Kucwaj-Brysz, Katarzyna, Lubelska, Annamaria, Głuch-Lutwin, Monika, Mordyl, Barbara, Siwek, Agata, Nasim, Muhammad Jawad, Partyka, Anna, Sudoł, Sylwia, Latacz, Gniewomir, Wesołowska, Anna, Kieć-Kononowicz, Katarzyna, Handzlik, Jadwiga
Published in European journal of medicinal chemistry (15.09.2019)
Published in European journal of medicinal chemistry (15.09.2019)
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Journal Article
Benzophenone Derivatives with Histamine H 3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease
Godyń, Justyna, Zaręba, Paula, Stary, Dorota, Kaleta, Maria, Kuder, Kamil J, Latacz, Gniewomir, Mogilski, Szczepan, Reiner-Link, David, Frank, Annika, Doroz-Płonka, Agata, Olejarz-Maciej, Agnieszka, Sudoł-Tałaj, Sylwia, Nolte, Tobias, Handzlik, Jadwiga, Stark, Holger, Więckowska, Anna, Malawska, Barbara, Kieć-Kononowicz, Katarzyna, Łażewska, Dorota, Bajda, Marek
Published in Molecules (Basel, Switzerland) (01.01.2023)
Published in Molecules (Basel, Switzerland) (01.01.2023)
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Journal Article
Histamine H3 Receptor Ligands—KSK-59 and KSK-73—Reduce Body Weight Gain in a Rat Model of Excessive Eating
Mika, Kamil, Szafarz, Małgorzata, Bednarski, Marek, Latacz, Gniewomir, Sudoł, Sylwia, Handzlik, Jadwiga, Pociecha, Krzysztof, Knutelska, Joanna, Nicosia, Noemi, Szczepańska, Katarzyna, Kuder, Kamil J., Kieć-Kononowicz, Katarzyna, Kotańska, Magdalena
Published in Pharmaceuticals (Basel, Switzerland) (25.10.2021)
Published in Pharmaceuticals (Basel, Switzerland) (25.10.2021)
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Journal Article
Benzophenone Derivatives with Histamine H3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer’s Disease
Godyń, Justyna, Zaręba, Paula, Stary, Dorota, Kaleta, Maria, Kuder, Kamil J., Latacz, Gniewomir, Mogilski, Szczepan, Reiner-Link, David, Frank, Annika, Doroz-Płonka, Agata, Olejarz-Maciej, Agnieszka, Sudoł-Tałaj, Sylwia, Nolte, Tobias, Handzlik, Jadwiga, Stark, Holger, Więckowska, Anna, Malawska, Barbara, Kieć-Kononowicz, Katarzyna, Łażewska, Dorota, Bajda, Marek
Published in Molecules (Basel, Switzerland) (28.12.2022)
Published in Molecules (Basel, Switzerland) (28.12.2022)
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Journal Article
인터페론 유전자 자극인자(STING)의 차세대 조절제
CWIERTNIA GRZEGORZ WOJCIECH, GIBAS AGNIESZKA JUSTYNA, FABRITIUS CHARLES HENRY, DOBRZANSKA MONIKA PATRYCJA, SUDOL SYLWIA, STASI LUIGI PIERO, DUDEK LUKASZ PIOTR, ZAWADZKA MAGDALENA IZABELA, RAJDA ANNA, GLUZA KAROLINA MARIA, TOPOLNICKI GRZEGORZ WITOLD, ROGACKI MACIEJ KRZYSZTOF
Year of Publication 03.03.2022
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Year of Publication 03.03.2022
Patent
Rational design of new multitarget histamine H3 receptor ligands as potential candidates for treatment of Alzheimer’s disease
Łażewska, Dorota, Bajda, Marek, Kaleta, Maria, Zaręba, Paula, Doroz-Płonka, Agata, Siwek, Agata, Alachkar, Alaa, Mogilski, Szczepan, Saad, Ali, Kuder, Kamil, Olejarz-Maciej, Agnieszka, Godyń, Justyna, Stary, Dorota, Sudoł, Sylwia, Więcek, Małgorzata, Latacz, Gniewomir, Walczak, Maria, Handzlik, Jadwiga, Sadek, Bassem, Malawska, Barbara, Kieć-Kononowicz, Katarzyna
Published in European journal of medicinal chemistry (01.12.2020)
Published in European journal of medicinal chemistry (01.12.2020)
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Journal Article
Abstract 1281: Development and characterization of small molecule HPK1 inhibitors
Kujawa, Maciej, Zimoląg, Eliza, Gałęzowski, Michał, Guzik, Paweł, Dudek, Agata, Gondela, Andrzej, Nowogródzki, Marcin, Girardi, Marianna, Krolenko, Kostiantyn, Bugaj, Marta, Sudoł, Sylwia, Gibas, Agnieszka, Szeremeta-Spisak, Joanna, Bobowska, Aneta, Zastawna, Magdalena, Wyrębek, Przemysław, Boutard, Nicolas, Więckowska, Aleksandra, Jasnosz, Wojciech, Schonemann, Wojciech, Zuchowicz, Karol, Synak, David, Kulesza, Urszula, Leventes, Oleksandr, Świrski, Mateusz, Sasmal, Sujit, Gluza, Karolina, Kret, Patryk, Ogórek, Mateusz, Michalik, Kinga, Banaszak, Katarzyna, Podkowa, Adrian, Wnuk-Lipińska, Katarzyna, Dobrzańska, Monika, Littlewood, Peter, Brzózka, Krzysztof, Bartosik, Anna, Chmielewski, Stefan
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 4532A: Development of selective small molecule STING agonists suitable for systemic administration
Chmielewski, Stefan, Zawadzka, Magdalena, Mazurek, Jolanta, Rogacki, Maciej K., Gluza, Karolina, Wójcik-Jaszczyńska, Katarzyna, Poczkaj, Aleksandra, Ćwiertnia, Grzegorz, Topolnicki, Grzegorz, Kujawa, Maciej, Zimoląg, Eliza, Głowniak-Kwitek, Urszula, Mroczkowska, Magdalena, Gibas, Agnieszka, Leś, Marcin, Sudoł, Sylwia, Wronowski, Marek, Michalik, Kinga, Banaszak, Katarzyna, Wiklik, Katarzyna, Malusa, Federico, Combik, Michał, Wiatrowska, Karolina, Dudek, Łukasz, Alvarez, Jose, Rajda, Anna, Gajdosz, Faustyna, Gołas, Aniela, Wnuk-Lipińska, Katarzyna, Kuś, Kamil, Gabor-Worwa, Ewelina, Fabritius, Charles, Stasi, Luigi, Littlewood, Peter, Brzózka, Krzysztof, Dobrzańska, Monika
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 1947: Development and characterization of small molecule HPK1 inhibitors
Chmielewski, Stefan, Kujawa, Maciej, Zimoląg, Eliza, Guzik, Paweł, Dudek, Agata, Topolnicki, Grzegorz, Sudoł, Sylwia, Gibas, Agnieszka, Bugaj, Marta, Krolenko, Kostiantyn, Nowogródzki, Marcin, Janiga, Anita, Wyrębek, Przemysław, Pięta, Jakub, Brzdonkiewicz, Aleksandra, Wilkowski, Grzegorz, Walczak, Marcin, Maciejewska, Katarzyna, Radzimierski, Adam, Jasnosz, Wojciech, Mahajan, Tushar, Bartolotta, Roberta, Gluza, Karolina, Kret, Patryk, Rutkowska, Ewelina, Michalik, Kinga, Banaszak, Katarzyna, Podkowa, Adrian, Gołas, Aniela, Wnuk-Lipińska, Katarzyna, Fabritius, Charles, Stasi, Luigi, Littlewood, Peter, Brzózka, Krzysztof, Bartosik, Anna, Dobrzańska, Monika
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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