Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin‑1
Casimiro-Garcia, Agustin, Allais, Christophe, Brennan, Agnes, Choi, Chulho, Dower, Gabriela, Farley, Kathleen A, Fleming, Margaret, Flick, Andrew, Frisbie, Richard K, Hall, Justin, Hepworth, David, Jones, Hannah, Knafels, John D, Kortum, Steve, Lovering, Frank E, Mathias, John P, Mohan, Sashi, Morgan, Paul M, Parng, Chuenlei, Parris, Kevin, Pullen, Nick, Schlerman, Franklin, Stansfield, John, Strohbach, Joseph W, Vajdos, Felix F, Vincent, Fabien, Wang, Hong, Wang, Xiaolun, Webster, Robert, Wright, Stephen W
Published in Journal of medicinal chemistry (13.01.2022)
Published in Journal of medicinal chemistry (13.01.2022)
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Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases
Vazquez, Michael L, Kaila, Neelu, Strohbach, Joseph W, Trzupek, John D, Brown, Matthew F, Flanagan, Mark E, Mitton-Fry, Mark J, Johnson, Timothy A, TenBrink, Ruth E, Arnold, Eric P, Basak, Arindrajit, Heasley, Steven E, Kwon, Soojin, Langille, Jonathan, Parikh, Mihir D, Griffin, Sarah H, Casavant, Jeffrey M, Duclos, Brian A, Fenwick, Ashley E, Harris, Thomas M, Han, Seungil, Caspers, Nicole, Dowty, Martin E, Yang, Xin, Banker, Mary Ellen, Hegen, Martin, Symanowicz, Peter T, Li, Li, Wang, Lu, Lin, Tsung H, Jussif, Jason, Clark, James D, Telliez, Jean-Baptiste, Robinson, Ralph P, Unwalla, Ray
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells
Offensperger, Fabian, Tin, Gary, Duran-Frigola, Miquel, Hahn, Elisa, Dobner, Sarah, Ende, Christopher W Am, Strohbach, Joseph W, Rukavina, Andrea, Brennsteiner, Vincenth, Ogilvie, Kevin, Marella, Nara, Kladnik, Katharina, Ciuffa, Rodolfo, Majmudar, Jaimeen D, Field, S Denise, Bensimon, Ariel, Ferrari, Luca, Ferrada, Evandro, Ng, Amanda, Zhang, Zhechun, Degliesposti, Gianluca, Boeszoermenyi, Andras, Martens, Sascha, Stanton, Robert, Müller, André C, Hannich, J Thomas, Hepworth, David, Superti-Furga, Giulio, Kubicek, Stefan, Schenone, Monica, Winter, Georg E
Published in Science (American Association for the Advancement of Science) (26.04.2024)
Published in Science (American Association for the Advancement of Science) (26.04.2024)
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Development of an Efficient Synthesis of the Pyrrolquinolone PHA-529311
Dorow, R. L, Herrinton, Paul M, Hohler, Richard A, Maloney, Mark T, Mauragis, Michael A, McGhee, William E, Moeslein, Jeffery A, Strohbach, Joseph W, Veley, Michael F
Published in Organic process research & development (01.05.2006)
Published in Organic process research & development (01.05.2006)
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Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors
Lovering, Frank, Morgan, Paul, Allais, Christophe, Aulabaugh, Ann, Brodfuehrer, Joanne, Chang, Jeanne, Coe, Jotham, Ding, WeiDong, Dowty, Heather, Fleming, Margaret, Frisbie, Richard, Guzova, Julia, Hepworth, David, Jasti, Jayasankar, Kortum, Steve, Kurumbail, Ravi, Mohan, Shashi, Papaioannou, Nikolaos, Strohbach, Joseph W., Vincent, Fabien, Lee, Katherine, Zapf, Christoph W.
Published in European journal of medicinal chemistry (10.02.2018)
Published in European journal of medicinal chemistry (10.02.2018)
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Microfluidic-Enabled Intracellular Delivery of Membrane Impermeable Inhibitors to Study Target Engagement in Human Primary Cells
Li, Jing, Wang, Bu, Juba, Brian M, Vazquez, Michael, Kortum, Steve W, Pierce, Betsy S, Pacheco, Michael, Roberts, Lee, Strohbach, Joseph W, Jones, Lyn H, Hett, Erik, Thorarensen, Atli, Telliez, Jean-Baptiste, Sharei, Armon, Bunnage, Mark, Gilbert, Jonathan Brian
Published in ACS chemical biology (15.12.2017)
Published in ACS chemical biology (15.12.2017)
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Structure-Based Design of Novel HIV Protease Inhibitors: Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors
Thaisrivongs, Suvit, Janakiraman, Musiri N, Chong, Kong-Teck, Tomich, Paul K, Dolak, Lester A, Turner, Steve R, Strohbach, Joseph W, Lynn, Janet C, Horng, Miao-Miao, Hinshaw, Roger R, Watenpaugh, Keith D
Published in Journal of medicinal chemistry (07.06.1996)
Published in Journal of medicinal chemistry (07.06.1996)
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The design and development of 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides as inhibitors of human cytomegalovirus polymerase
TANIS, Steven P, STROHBACH, Joseph W, STEPHANSKI, Kevin J, WATHEN, Michael W, PARKER, Timothy T, MOON, Malcom W, THAISRIVONGS, Suvit, PERRAULT, William R, HOPKINS, Todd A, KNECHTEL, Mary L, OIEN, Nancee L, WIEBER, Janet L
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
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Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class
Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Aristoff, Paul A, Johnson, Paul D, Skulnick, Harvey I, Dolak, Lester A, Seest, Eric P, Tomich, Paul K, Bohanon, Michael J, Horng, Miao-Miao, Lynn, Janet C, Chong, Kong-Teck, Hinshaw, Roger R, Watenpaugh, Keith D, Janakiraman, Musiri N, Thaisrivongs, Suvit
Published in Journal of medicinal chemistry (27.08.1998)
Published in Journal of medicinal chemistry (27.08.1998)
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Non-peptidic HIV protease inhibitors
Chrusciel, R Alan, Strohbach, Joseph W
Published in Current topics in medicinal chemistry (01.01.2004)
Published in Current topics in medicinal chemistry (01.01.2004)
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Journal Article
Structure-Based Design of HIV Protease Inhibitors: 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Non-peptidic Inhibitors
Thaisrivongs, Suvit, Tomich, Paul K, Watenpaugh, Keith D, Chong, Kong-Teck, Howe, W. Jeffrey, Yang, Chih-Ping, Strohbach, Joseph W, Turner, Steve R, McGrath, James P
Published in Journal of medicinal chemistry (01.09.1994)
Published in Journal of medicinal chemistry (01.09.1994)
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Journal Article
Structure-Based Design of HIV Protease Inhibitors: Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors
Thaisrivongs, Suvit, Skulnick, Harvey I, Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Johnson, Paul D, Aristoff, Paul A, Judge, Thomas M, Gammill, Ronald B, Morris, Jeanette K, Romines, Karen R, Chrusciel, Robert A, Hinshaw, Roger R, Chong, Kong-Teck, Tarpley, W. Gary, Poppe, Susan M, Slade, David E, Lynn, Janet C, Horng, Miao-Miao, Tomich, Paul K, Seest, Eric P, Dolak, Lester A, Howe, W. Jeffrey, Howard, Gina M, Schwende, Francis J, Toth, Lisa N, Padbury, Guy E, Wilson, Grace J, Shiou, Lihua, Zipp, Gail L, Wilkinson, Karen F, Rush, Bob D, Ruwart, Mary J, Koeplinger, Kenneth A, Zhao, Zhiyang, Cole, Serena, Zaya, Renee M, Kakuk, Thomas J, Janakiraman, Musiri N, Watenpaugh, Keith D
Published in Journal of medicinal chemistry (25.10.1996)
Published in Journal of medicinal chemistry (25.10.1996)
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Structure-Based Design of HIV Protease Inhibitors: 5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors
Thaisrivongs, Suvit, Romero, Donna L, Tommasi, Ruben A, Janakiraman, Musiri N, Strohbach, Joseph W, Turner, Steve R, Biles, Carolyn, Morge, Raymond R, Johnson, Paul D, Aristoff, Paul A, Tomich, Paul K, Lynn, Janet C, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Howe, W. Jeffrey, Finzel, Barry C, Watenpaugh, Keith D
Published in Journal of medicinal chemistry (08.11.1996)
Published in Journal of medicinal chemistry (08.11.1996)
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Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design
Lee, Katherine L, Ambler, Catherine M, Anderson, David R, Boscoe, Brian P, Bree, Andrea G, Brodfuehrer, Joanne I, Chang, Jeanne S, Choi, Chulho, Chung, Seungwon, Curran, Kevin J, Day, Jacqueline E, Dehnhardt, Christoph M, Dower, Ken, Drozda, Susan E, Frisbie, Richard K, Gavrin, Lori K, Goldberg, Joel A, Han, Seungil, Hegen, Martin, Hepworth, David, Hope, Heidi R, Kamtekar, Satwik, Kilty, Iain C, Lee, Arthur, Lin, Lih-Ling, Lovering, Frank E, Lowe, Michael D, Mathias, John P, Morgan, Heidi M, Murphy, Elizabeth A, Papaioannou, Nikolaos, Patny, Akshay, Pierce, Betsy S, Rao, Vikram R, Saiah, Eddine, Samardjiev, Ivan J, Samas, Brian M, Shen, Marina W. H, Shin, Julia H, Soutter, Holly H, Strohbach, Joseph W, Symanowicz, Peter T, Thomason, Jennifer R, Trzupek, John D, Vargas, Richard, Vincent, Fabien, Yan, Jiangli, Zapf, Christoph W, Wright, Stephen W
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
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Non-peptidic HIV protease inhibitors : C2-SYMMETRY-BASED design of bis-sulfonamide dihydropyrones
JANAKIRAMAN, M. N, WATENPAUGH, K. D, TOMICH, P. K, CHONG, K.-T, TURNER, S. R, TOMMASI, R. A, THAISRIVONGS, S, STROHBACH, J. W
Published in Bioorganic & medicinal chemistry letters (19.05.1998)
Published in Bioorganic & medicinal chemistry letters (19.05.1998)
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HETERO BICYCLIC CARBOXAMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS
RUMINSKI PETER G, HANAU CATHLEEN E, STROHBACH JOSEPH W, SCHNUTE MARK E, CARROLL JEFFERY N, SAMPLE KIRBY
Year of Publication 11.03.2010
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Year of Publication 11.03.2010
Patent
Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity
Thaisrivongs, Suvit, Tomasselli, Alfredo G, Moon, Joseph B, Hui, John, McQuade, Thomas J, Turner, Steve R, Strohbach, Joseph W, Howe, W. Jeffrey, Tarpley, W. Gary, Heinrikson, Robert L
Published in Journal of medicinal chemistry (01.08.1991)
Published in Journal of medicinal chemistry (01.08.1991)
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Journal Article
Cycloalkylpyranones and Cycloalkyldihydropyrones as HIV Protease Inhibitors: Exploring the Impact of Ring Size on Structure−Activity Relationships
Romines, Karen R, Morris, Jeanette K, Howe, W. Jeffrey, Tomich, Paul K, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Anderson, David J, Strohbach, Joseph W, Turner, Steve R, Mizsak, Steve A
Published in Journal of medicinal chemistry (27.09.1996)
Published in Journal of medicinal chemistry (27.09.1996)
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Journal Article
Peptidomimetic HIV protease inhibitors: phosphate prodrugs with improved biological activities
Chong, Kong Teck, Ruwart, Mary J, Hinshaw, Roger R, Wilkinson, Karen F, Rush, Bob D, Yancey, Mark F, Strohbach, Joseph W, Thaisrivongs, Suvit
Published in Journal of medicinal chemistry (20.08.1993)
Published in Journal of medicinal chemistry (20.08.1993)
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