Broad Application of CYP3A4 Liquid Chromatography-Mass Spectrometry Protein Quantification in Hepatocyte Cytochrome P450 Induction Assays Identifies Nonuniformity in mRNA and Protein Induction Responses
Savaryn, John Paul, Sun, Jun, Ma, Junli, Jenkins, Gary J, Stresser, David M
Published in Drug metabolism and disposition (01.02.2022)
Published in Drug metabolism and disposition (01.02.2022)
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In Vitro Drug Metabolism Using Liver Microsomes
Knights, Kathleen M, Stresser, David M, Miners, John O, Crespi, Charles L
Published in Current protocols in pharmacology (01.09.2016)
Published in Current protocols in pharmacology (01.09.2016)
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Evaluation of Multiple in Vitro Systems for Assessment of CYP3A4 Induction in Drug Discovery: Human Hepatocytes, Pregnane X Receptor Reporter Gene, and Fa2N-4 and HepaRG Cells
MCGINNITY, Dermot F, ZHANG, George, KENNY, Jane R, HAMILTON, Geraldine A, OTMANI, Sara, STAMS, Karen R, HANEY, Suzzette, BRASSIL, Patrick, STRESSER, David M, RILEY, Robert J
Published in Drug metabolism and disposition (01.06.2009)
Published in Drug metabolism and disposition (01.06.2009)
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Plasma protein-mediated uptake and contradictions to the free drug hypothesis: a critical review
Schulz, Julia Annette, Stresser, David M., Kalvass, John Cory
Published in Drug metabolism reviews (03.07.2023)
Published in Drug metabolism reviews (03.07.2023)
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Hepatocyte Uptake and Loss Assay (HUpLA): Proof-of-Concept of an All-in-One System for Measuring Hepatic Influx, Egress, and Metabolic Clearance Based on the Extended Clearance Concept
Schulz Pauly, Julia A, Sande, Elizabeth, Feng, Mei, Wang, Yue-Ting, Stresser, David M, Kalvass, John Cory
Published in Drug metabolism and disposition (02.08.2024)
Published in Drug metabolism and disposition (02.08.2024)
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Substrate-Dependent Modulation of CYP3A4 Catalytic Activity: Analysis of 27 Test Compounds with Four Fluorometric Substrates
STRESSER, David M, BLANCHARD, Andrew P, TURNER, Stephanie D, ERVE, John C. L, DANDENEAU, Andre A, MILLER, Vaughn P, CRESPI, Charles L
Published in Drug metabolism and disposition (01.12.2000)
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Published in Drug metabolism and disposition (01.12.2000)
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Towards in vitro models for reducing or replacing the use of animals in drug testing
Stresser, David M, Kopec, Anna K, Hewitt, Philip, Hardwick, Rhiannon N, Van Vleet, Terry R, Mahalingaiah, Prathap Kumar S, O'Connell, Denice, Jenkins, Gary J, David, Rhiannon, Graham, Jessica, Lee, Donna, Ekert, Jason, Fullerton, Aaron, Villenave, Remi, Bajaj, Piyush, Gosset, James R, Ralston, Sherry L, Guha, Manti, Amador-Arjona, Alejandro, Khan, Kainat, Agarwal, Saket, Hasselgren, Catrin, Wang, Xiaoting, Adams, Khary, Kaushik, Gaurav, Raczynski, Arkadiusz, Homan, Kimberly A
Published in Nature biomedical engineering (01.08.2024)
Published in Nature biomedical engineering (01.08.2024)
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HIGHLY SELECTIVE INHIBITION OF HUMAN CYP3A IN VITRO BY AZAMULIN AND EVIDENCE THAT INHIBITION IS IRREVERSIBLE
STRESSER, David M, BROUDY, Marc I, PATTEN, Christopher J, DEHAL, Shangara S, CRESPI, Charles L, THUY HO, CARGILL, Catherine E, BLANCHARD, Andrew P, SHARMA, Raman, DANDENEAU, Andre A, GOODWIN, Joseph J, TURNER, Stephanie D, ERVE, John C. L
Published in Drug metabolism and disposition (01.01.2004)
Published in Drug metabolism and disposition (01.01.2004)
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Cytochrome P450 Fluorometric Substrates: Identification of Isoform-Selective Probes for Rat CYP2D2 and Human CYP3A4
STRESSER, David M, TURNER, Stephanie D, BLANCHARD, Andrew P, MILLER, Vaughn P, CRESPI, Charles L
Published in Drug metabolism and disposition (01.07.2002)
Published in Drug metabolism and disposition (01.07.2002)
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High-Throughput SFC-MS/MS Method to Measure EPSA and Predict Human Permeability
Wang, Yue-Ting, Price, Edward, Feng, Mei, Hulen, Jason, Doktor, Stella, Stresser, David M., Maes, Estelle M., Ji, Qin C., Jenkins, Gary J.
Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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Journal Article
Enrichment-free High-throughput Liquid Chromatography–Multiple-Reaction Monitoring Quantification of Cytochrome P450 Proteins in Plated Human Hepatocytes Direct from 96-Well Plates Enables Routine Protein Induction Measurements
Savaryn, John P., Liu, Ning, Sun, Jun, Ma, Junli, Stresser, David M., Jenkins, Gary
Published in Drug metabolism and disposition (01.07.2020)
Published in Drug metabolism and disposition (01.07.2020)
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Differential Time- and NADPH-Dependent Inhibition of CYP2C19 by Enantiomers of Fluoxetine
STRESSER, David M, MASON, Andrew K, PERLOFF, Elke S, HO, Thuy, CRESPI, Charles L, DANDENEAU, Andre A, MORGAN, Ling, DEHAL, Shangara S
Published in Drug metabolism and disposition (01.04.2009)
Published in Drug metabolism and disposition (01.04.2009)
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Cardiovascular microphysiological systems (CVMPS) for safety studies - a pharma perspective
Pointon, Amy, Maher, Jonathan, Davis, Myrtle, Baker, Thomas, Cichocki, Joseph, Ramsden, Diane, Hale, Christopher, Kolaja, Kyle L, Levesque, Paul, Sura, Radhakrishna, Stresser, David M, Gintant, Gary
Published in Lab on a chip (09.02.2021)
Published in Lab on a chip (09.02.2021)
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HUMAN CYTOCHROME P450 INDUCTION AND INHIBITION POTENTIAL OF CLEVIDIPINE AND ITS PRIMARY METABOLITE H152/81
ZHANG, J. George, DEHAL, Shangara S, HO, Thuy, JOHNSON, Jennifer, CHANDLER, Catherine, BLANCHARD, Andrew P, CLARK, Robert J, CRESPI, Charles L, STRESSER, David M, WONG, James
Published in Drug metabolism and disposition (01.05.2006)
Published in Drug metabolism and disposition (01.05.2006)
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Exploring concepts of in vitro time-dependent CYP inhibition assays
Stresser, David M, Mao, Jialin, Kenny, Jane R, Jones, Barry C, Grime, Kenneth
Published in Expert opinion on drug metabolism & toxicology (01.02.2014)
Published in Expert opinion on drug metabolism & toxicology (01.02.2014)
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Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole
Stresser, David M, Perloff, Elke S, Mason, Andrew K, Blanchard, Andrew P, Dehal, Shangara S, Creegan, Timothy P, Singh, Ritu, Gangl, Eric T
Published in Drug metabolism and disposition (01.08.2016)
Published in Drug metabolism and disposition (01.08.2016)
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