Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction
England, Elizabeth, Rees, D. Gareth, Scott, Ian Christopher, Carmen, Sara, Chan, Denice T. Y., Chaillan Huntington, Catherine E., Houslay, Kirsty F., Erngren, Teodor, Penney, Mark, Majithiya, Jayesh B., Rapley, Laura, Sims, Dorothy A., Hollins, Claire, Hinchy, Elizabeth C., Strain, Martin D., Kemp, Benjamin P., Corkill, Dominic J., May, Richard D., Vousden, Katherine A., Butler, Robin J., Mustelin, Tomas, Vaughan, Tristan J., Lowe, David C., Colley, Caroline, Cohen, E. Suzanne
Published in Scientific reports (17.06.2023)
Published in Scientific reports (17.06.2023)
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Journal Article
Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation
Cohen, E. Suzanne, Scott, Ian C., Majithiya, Jayesh B., Rapley, Laura, Kemp, Benjamin P., England, Elizabeth, Rees, D. Gareth, Overed-Sayer, Catherine L., Woods, Joanne, Bond, Nicholas J., Veyssier, Christel Séguy, Embrey, Kevin J., Sims, Dorothy A., Snaith, Michael R., Vousden, Katherine A., Strain, Martin D., Chan, Denice T. Y., Carmen, Sara, Huntington, Catherine E., Flavell, Liz, Xu, Jianqing, Popovic, Bojana, Brightling, Christopher E., Vaughan, Tristan J., Butler, Robin, Lowe, David C., Higazi, Daniel R., Corkill, Dominic J., May, Richard D., Sleeman, Matthew A., Mustelin, Tomas
Published in Nature communications (14.09.2015)
Published in Nature communications (14.09.2015)
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Journal Article
신규한 IL33 형태, IL33의 돌연변이된 형태, 항체, 검정 및 이의 이용 방법
LOWE DAVID C, KEMP BENJAMIN P, OVERED SAYER CATHERINE L, ENGLAND ELIZABETH H, VOUSDEN KATHERINE A, MUSTELIN TOMAS M, REES DAVID G, COHEN EMMA S, BUTLER ROBIN, SLEEMAN MATTHEW, STRAIN MARTIN D, HOUSLAY KIRSTY, SCOTT IAN C, CARMEN SARA
Year of Publication 04.12.2017
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Year of Publication 04.12.2017
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A NOVEL IL33 FORM, MUTATED FORMS OF IL33, ANTIBODIES, ASSAYS AND METHODS OF USING THE SAME
LOWE, David, C, ENGLAND, Elizabeth, H, STRAIN, Martin, D, VOUSDEN, Katherine, A, MUSTELIN, Tomas, M, SCOTT, Ian, C, KEMP, Benjamin, P, COHEN, Emma, S, BUTLER, Robin, REES, David, G, OVERED-SAYER, Catherine, L, CARMEN, Sara, HOUSLAY, Kirsty, SLEEMAN, Matthew
Year of Publication 28.08.2024
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Year of Publication 28.08.2024
Patent
A NOVEL IL33 FORM, MUTATED FORMS OF IL33, ANTIBODIES, ASSAYS AND METHODS OF USING THE SAME
LOWE, David, C, ENGLAND, Elizabeth, H, STRAIN, Martin, D, VOUSDEN, Katherine, A, MUSTELIN, Tomas, M, SCOTT, Ian, C, KEMP, Benjamin, P, COHEN, Emma, S, BUTLER, Robin, REES, David, G, OVERED-SAYER, Catherine, L, CARMEN, Sara, HOUSLAY, Kirsty, SLEEMAN, Matthew
Year of Publication 29.05.2024
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Year of Publication 29.05.2024
Patent
IL33 ANTIBODIES AND METHODS OF USING THE SAME
ENGLAND, Elizabeth H, STRAIN, Martin D, COHEN, Emma S, SCOTT, Ian C, BUTLER, Robin, CARMEN, Sara, LOWE, David C, OVERED-SAYER, Catherine L, HOUSLAY, Kirsty, KEMP, Benjamin P, SLEEMAN, Matthew, VOUSDEN, Katherine A, REES, David G, MUSTELIN, Tomas M
Year of Publication 18.01.2024
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Year of Publication 18.01.2024
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A NOVEL IL33 FORM, MUTATED FORMS OF IL33, ANTIBODIES, ASSAYS AND METHODS OF USING THE SAME
STRAIN, MARTIN D, CARMEN, SARA, OVERED-SAYER, CATHERINE L, SCOTT, IAN C, MUSTELIN, TOMAS M, KEMP, BENJAMIN P, REES, DAVID G, LOWE, DAVID C, VOUSDEN, KATHERINE A, HOUSLAY, KIRSTY, COHEN, EMMA S, ENGLAND, ELIZABETH H, SLEEMAN, MATTHEW, BUTLER, ROBIN
Year of Publication 24.10.2023
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Year of Publication 24.10.2023
Patent
Polynucleotides encoding IL33 antibodies and methods of using the same
Butler, Robin, Carmen, Sara, Scott, Ian C, Overed-Sayer, Catherine L, Kemp, Benjamin P, Strain, Martin D, Lowe, David C, Vousden, Katherine A, Sleeman, Matthew, Cohen, Emma S, Rees, David G, Mustelin, Tomas M, England, Elizabeth H, Houslay, Kirsty
Year of Publication 29.08.2023
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Year of Publication 29.08.2023
Patent
A NOVEL IL33 FORM, MUTATED FORMS OF IL33, ANTIBODIES, ASSAYS AND METHODS OF USING THE SAME
ENGLAND, Elizabeth H, STRAIN, Martin D, LOWE, David Christopher, SCOTT, Ian C, COHEN, Emma Suzanne, BUTLER, Robin, CARMEN, Sara, OVERED-SAYER, Catherine L, HOUSLAY, Kirsty, KEMP, Benjamin P, SLEEMAN, Matthew, VOUSDEN, Katherine A, REES, David G, MUSTELIN, Tomas M
Year of Publication 29.06.2022
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Year of Publication 29.06.2022
Patent
A NOVEL IL33 FORM, MUTATED FORMS OF IL33, ANTIBODIES, ASSAYS AND METHODS OF USING THE SAME
CARMEN, SARA, OVERED-SAYER, CATHERINE, L, SCOTT, IAN, C, STRAIN, MARTIN, D, KEMP, BENJAMIN, P, SLEEMAN, MATTHEW, ENGLAND, ELIZABETH, H, HOUSLAY, KIRTSTY, MUSTELIN, TOMAS, M, LOWE, DAVID, C, COHEN, EMMA, S, VOUSDEN, KATHERINE, A, REES, DAVID, G, BUTLER, ROBIN
Year of Publication 05.04.2022
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Year of Publication 05.04.2022
Patent
A NOVEL IL33 FORM, MUTATED FORMS OF IL33, ANTIBODIES, ASSAYS AND METHODS OF USING THE SAME
Butler, Robin, Carmen, Sara, Scott, Ian C, Overed-Sayer, Catherine L, Kemp, Benjamin P, Strain, Martin D, Lowe, David C, Vousden, Katherine A, Sleeman, Matthew, Cohen, Emma S, Rees, David G, Mustelin, Tomas M, England, Elizabeth H, Houslay, Kirsty
Year of Publication 17.02.2022
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Year of Publication 17.02.2022
Patent
A NOVEL IL33 FORM, MUTATED FORMS OF IL33, ANTIBODIES, ASSAYS AND METHODS OF USING THE SAME
Butler, Robin, Carmen, Sara, Scott, Ian C, Overed-Sayer, Catherine L, Kemp, Benjamin P, Strain, Martin D, Lowe, David C, Vousden, Katherine A, Sleeman, Matthew, Cohen, Emma S, Rees, David G, Mustelin, Tomas M, England, Elizabeth H, Houslay, Kirsty
Year of Publication 02.12.2021
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Year of Publication 02.12.2021
Patent
A NOVEL IL33 FORM, MUTATED FORMS OF IL33, ANTIBODIES, ASSAYS AND METHODS OF USING THE SAME
Butler, Robin, Carmen, Sara, Scott, Ian C, Overed-Sayer, Catherine L, Kemp, Benjamin P, Strain, Martin D, Lowe, David C, Vousden, Katherine A, Sleeman, Matthew, Cohen, Emma S, Rees, David G, Mustelin, Tomas M, England, Elizabeth H, Houslay, Kirsty
Year of Publication 18.11.2021
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Year of Publication 18.11.2021
Patent
Tozorakimab (MEDI3506): a dual-pharmacology anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction
England, Elizabeth, Rees, D Gareth, Scott, Ian Christopher, Carmen, Sara, Chan, Denice T Y, Chaillan Huntington, Catherine E, Houslay, Kirsty F, Erngren, Teodor, Penney, Mark, Majithiya, Jayesh B, Rapley, Laura, Sims, Dorothy A, Hollins, Claire, Hinchy, Elizabeth C, Strain, Martin D, Kemp, Benjamin P, Corkill, Dominic J, May, Richard D, Vousden, Katherine A, Butler, Robin J, Mustelin, Tomas, Vaughan, Tristan J, Lowe, David C, Colley, Caroline, Cohen, E Suzanne
Published in bioRxiv (01.03.2023)
Published in bioRxiv (01.03.2023)
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Paper
A NOVEL IL33 FORM, MUTATED FORMS OF IL33, ANTIBODIES, ASSAYS AND METHODS OF USING THE SAME
STRAIN, MARTIN D, CARMEN, SARA, OVERED-SAYER, CATHERINE L, SCOTT, IAN C, MUSTELIN, TOMAS M, KEMP, BENJAMIN P, REES, DAVID G, LOWE, DAVID C, VOUSDEN, KATHERINE A, HOUSLAY, KIRSTY, COHEN, EMMA S, ENGLAND, ELIZABETH H, SLEEMAN, MATTHEW, BUTLER, ROBIN
Year of Publication 31.05.2021
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Year of Publication 31.05.2021
Patent
A NOVEL IL33 FORM, MUTATED FORMS OF IL33, ANTIBODIES, ASSAYS AND METHODS OF USING THE SAME
CARMEN, SARA, OVERED-SAYER, CATHERINE, L, SCOTT, IAN, C, STRAIN, MARTIN, D, HOUSLAY, KIRSTY, KEMP, BENJAMIN, P, SLEEMAN, MATTHEW, ENGLAND, ELIZABETH, H, MUSTELIN, TOMAS, M, LOWE, DAVID, C, COHEN, EMMA, S, VOUSDEN, KATHERINE, A, REES, DAVID, G, BUTLER, ROBIN
Year of Publication 31.03.2021
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Year of Publication 31.03.2021
Patent
A NOVEL IL33 FORM, MUTATED FORMS OF IL33, ANTIBODIES, ASSAYS AND METHODS OF USING THE SAME
BUTLER Robin, VOUSDEN Katherine A, CARMEN Sara, STRAIN Martin D, MUSTELIN Tomas M, REES David G, SLEEMAN Matthew, KEMP Benjamin P, SCOTT Ian C, LOWE David C, OVERED-SAYER Catherine L, COHEN Emma S, ENGLAND Elizabeth H, HOUSLAY Kirsty
Year of Publication 31.03.2021
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Year of Publication 31.03.2021
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A NOVEL IL33 FORM, MUTATED FORMS OF IL33, ANTIBODIES, ASSAYS AND METHODS OF USING THE SAME
Butler, Robin, Carmen, Sara, Scott, Ian C, Lowe, David, Overed-Sayer, Catherine L, Voudsen, Katherine A, Kemp, Benjamin P, Strain, Martin D, Sleeman, Matthew, Cohen, Emma S, Rees, David G, Mustelin, Tomas M, England, Elizabeth H, Houslay, Kirsty
Year of Publication 05.03.2021
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Year of Publication 05.03.2021
Patent
EN HIDTIL UKENDT IL33-FORM, MUTEREDE FORMER AF IL33, ANTISTOFFER, ASSAYS OG FREMGANGSMÅDER TIL ANVENDELSE DERAF
LOWE, David, C, ENGLAND, Elizabeth, H, STRAIN, Martin, D, VOUSDEN, Katherine, A, MUSTELIN, Tomas, M, SCOTT, Ian, C, KEMP, Benjamin, P, COHEN, Emma, S, BUTLER, Robin, REES, David, G, OVERED-SAYER, Catherine, L, CARMEN, Sara, HOUSLAY, Kirsty, SLEEMAN, Matthew
Year of Publication 01.02.2021
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Year of Publication 01.02.2021
Patent
A NOVEL IL33 FORM, MUTATED FORMS OF IL33, ANTIBODIES, ASSAYS AND METHODS OF USING THE SAME
LOWE, David, C, ENGLAND, Elizabeth, H, STRAIN, Martin, D, VOUSDEN, Katherine, A, MUSTELIN, Tomas, M, SCOTT, Ian, C, KEMP, Benjamin, P, COHEN, Emma, S, BUTLER, Robin, REES, David, G, OVERED-SAYER, Catherine, L, CARMEN, Sara, HOUSLAY, Kirsty, SLEEMAN, Matthew
Year of Publication 18.11.2020
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Year of Publication 18.11.2020
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