PAM-Antagonists: A Better Way to Block Pathological Receptor Signaling?
Kenakin, Terry, Strachan, Ryan T.
Published in Trends in pharmacological sciences (Regular ed.) (01.08.2018)
Published in Trends in pharmacological sciences (Regular ed.) (01.08.2018)
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TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome
Olsen, Reid H J, DiBerto, Jeffrey F, English, Justin G, Glaudin, Alexis M, Krumm, Brian E, Slocum, Samuel T, Che, Tao, Gavin, Ariana C, McCorvy, John D, Roth, Bryan L, Strachan, Ryan T
Published in Nature chemical biology (01.08.2020)
Published in Nature chemical biology (01.08.2020)
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Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
Staus, Dean P, Strachan, Ryan T, Manglik, Aashish, Pani, Biswaranjan, Kahsai, Alem W, Kim, Tae Hun, Wingler, Laura M, Ahn, Seungkirl, Chatterjee, Arnab, Masoudi, Ali, Kruse, Andrew C, Pardon, Els, Steyaert, Jan, Weis, William I, Prosser, R Scott, Kobilka, Brian K, Costa, Tommaso, Lefkowitz, Robert J
Published in Nature (London) (21.07.2016)
Published in Nature (London) (21.07.2016)
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Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor
Che, Tao, Majumdar, Susruta, Zaidi, Saheem A., Ondachi, Pauline, McCorvy, John D., Wang, Sheng, Mosier, Philip D., Uprety, Rajendra, Vardy, Eyal, Krumm, Brian E., Han, Gye Won, Lee, Ming-Yue, Pardon, Els, Steyaert, Jan, Huang, Xi-Ping, Strachan, Ryan T., Tribo, Alexandra R., Pasternak, Gavril W., Carroll, F. Ivy, Stevens, Raymond C., Cherezov, Vadim, Katritch, Vsevolod, Wacker, Daniel, Roth, Bryan L.
Published in Cell (11.01.2018)
Published in Cell (11.01.2018)
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Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors
Pironti, Gianluigi, Strachan, Ryan T, Abraham, Dennis, Mon-Wei Yu, Samuel, Chen, Minyong, Chen, Wei, Hanada, Kenji, Mao, Lan, Watson, Lewis J, Rockman, Howard A
Published in Circulation (New York, N.Y.) (16.06.2015)
Published in Circulation (New York, N.Y.) (16.06.2015)
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VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells
English, Justin G., Olsen, Reid H.J., Lansu, Katherine, Patel, Michael, White, Karoline, Cockrell, Adam S., Singh, Darshan, Strachan, Ryan T., Wacker, Daniel, Roth, Bryan L.
Published in Cell (25.07.2019)
Published in Cell (25.07.2019)
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Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library
Ahn, Seungkirl, Kahsai, Alem W., Pani, Biswaranjan, Wang, Qin-Ting, Zhao, Shuai, Wall, Alissa L., Strachan, Ryan T., Staus, Dean P., Wingler, Laura M., Sun, Lillian D., Sinnaeve, Justine, Choi, Minjung, Cho, Ted, Xu, Thomas T., Hansen, Gwenn M., Burnett, Michael B., Lamerdin, Jane E., Bassoni, Daniel L., Gavino, Bryant J., Husemoen, Gitte, Olsen, Eva K., Franch, Thomas, Costanzi, Stefano, Chen, Xin, Lefkowitz, Robert J.
Published in Proceedings of the National Academy of Sciences - PNAS (14.02.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (14.02.2017)
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Rapid modulation of spine morphology by the 5-HT₂A serotonin receptor through kalirin-7 signaling
Jones, Kelly A, Srivastava, Deepak P, Allen, John A, Strachan, Ryan T, Roth, Bryan L, Penzes, Peter
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2009)
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Journal Article
Ribosomal S6 Kinase 2 Directly Phosphorylates the 5-Hydroxytryptamine 2A (5-HT2A) Serotonin Receptor, Thereby Modulating 5-HT2A Signaling
Strachan, Ryan T., Sheffler, Douglas J., Willard, Belinda, Kinter, Michael, Kiselar, Janna G., Roth, Bryan L.
Published in The Journal of biological chemistry (27.02.2009)
Published in The Journal of biological chemistry (27.02.2009)
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Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor
Kahsai, Alem W, Wisler, James W, Lee, Jungmin, Ahn, Seungkirl, Cahill Iii, Thomas J, Dennison, S Moses, Staus, Dean P, Thomsen, Alex R B, Anasti, Kara M, Pani, Biswaranjan, Wingler, Laura M, Desai, Hemant, Bompiani, Kristin M, Strachan, Ryan T, Qin, Xiaoxia, Alam, S Munir, Sullenger, Bruce A, Lefkowitz, Robert J
Published in Nature chemical biology (11.07.2016)
Published in Nature chemical biology (11.07.2016)
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Journal Article
Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors
Foster, Simon R., Hauser, Alexander S., Vedel, Line, Strachan, Ryan T., Huang, Xi-Ping, Gavin, Ariana C., Shah, Sushrut D., Nayak, Ajay P., Haugaard-Kedström, Linda M., Penn, Raymond B., Roth, Bryan L., Bräuner-Osborne, Hans, Gloriam, David E.
Published in Cell (31.10.2019)
Published in Cell (31.10.2019)
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GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling
Thomsen, Alex R.B., Plouffe, Bianca, Cahill, Thomas J., Shukla, Arun K., Tarrasch, Jeffrey T., Dosey, Annie M., Kahsai, Alem W., Strachan, Ryan T., Pani, Biswaranjan, Mahoney, Jacob P., Huang, Liyin, Breton, Billy, Heydenreich, Franziska M., Sunahara, Roger K., Skiniotis, Georgios, Bouvier, Michel, Lefkowitz, Robert J.
Published in Cell (11.08.2016)
Published in Cell (11.08.2016)
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Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin
Nobles, Kelly N, Xiao, Kunhong, Ahn, Seungkirl, Shukla, Arun K, Lam, Christopher M, Rajagopal, Sudarshan, Strachan, Ryan T, Huang, Teng-Yi, Bressler, Erin A, Hara, Makoto R, Shenoy, Sudha K, Gygi, Steven P, Lefkowitz, Robert J
Published in Science signaling (09.08.2011)
Published in Science signaling (09.08.2011)
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A stress response pathway regulates DNA damage through β2―adrenoreceptors and β―arrestin―1
HARA, Makoto R, KOVACS, Jeffrey J, SHENOY, Sudha K, GREGORY, Simon G, AHN, Seungkirl, DUCKETT, Derek R, LEFKOWITZ, Robert J, WHALEN, Erin J, RAJAGOPAL, Sudarshan, STRACHAN, Ryan T, GRANT, Wayne, TOWERS, Aaron J, WILLIAMS, Barbara, LAM, Christopher M, XIAO, Kunhong
Published in Nature (London) (21.08.2011)
Published in Nature (London) (21.08.2011)
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Journal Article
Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor
Levit Kaplan, Anat, Strachan, Ryan T, Braz, Joao M, Craik, Veronica, Slocum, Samuel, Mangano, Thomas, Amabo, Vanessa, O'Donnell, Henry, Lak, Parnian, Basbaum, Allan I, Roth, Bryan L, Shoichet, Brian K
Published in Journal of medicinal chemistry (10.03.2022)
Published in Journal of medicinal chemistry (10.03.2022)
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Journal Article
Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR)
Strachan, Ryan T., Sun, Jin-peng, Rominger, David H., Violin, Jonathan D., Ahn, Seungkirl, Rojas Bie Thomsen, Alex, Zhu, Xiao, Kleist, Andrew, Costa, Tommaso, Lefkowitz, Robert J.
Published in The Journal of biological chemistry (16.05.2014)
Published in The Journal of biological chemistry (16.05.2014)
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Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator
Krumm, Brian E., DiBerto, Jeffrey F., Olsen, Reid H. J., Kang, Hye Jin, Slocum, Samuel T., Zhang, Shicheng, Strachan, Ryan T., Huang, Xi-Ping, Slosky, Lauren M., Pinkerton, Anthony B., Barak, Lawrence S., Caron, Marc G., Kenakin, Terry, Fay, Jonathan F., Roth, Bryan L.
Published in Biochemistry (Easton) (04.04.2023)
Published in Biochemistry (Easton) (04.04.2023)
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