Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
Grimm, Dirk, Streetz, Konrad L, Marion, Patricia, Storm, Theresa A, Salazar, Felix, Davis, Corrine R, Pandey, Kusum, Kay, Mark A, Jopling, Catherine L
Published in Nature (25.05.2006)
Published in Nature (25.05.2006)
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Journal Article
In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses
GRIMM, Dirk, LEE, Joyce S, WANG, Lora, DESAI, Tushar, AKACHE, Bassel, STORM, Theresa A, KAY, Mark A
Published in Journal of Virology (01.06.2008)
Published in Journal of Virology (01.06.2008)
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Journal Article
Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver
Grimm, Dirk, Wang, Lora, Lee, Joyce S, Schürmann, Nina, Gu, Shuo, Börner, Kathleen, Storm, Theresa A, Kay, Mark A
Published in The Journal of clinical investigation (01.09.2010)
Published in The Journal of clinical investigation (01.09.2010)
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Journal Article
Three differentiation states risk-stratify bladder cancer into distinct subtypes
Volkmer, Jens-Peter, Sahoo, Debashis, Chin, Robert K., Ho, Philip Levy, Tang, Chad, Kurtova, Antonina V., Willingham, Stephen B., Pazhanisamy, Senthil K., Contreras-Trujillo, Humberto, Storm, Theresa A., Lotan, Yair, Beck, Andrew H., Chung, Benjamin I., Alizadeh, Ash A., Godoy, Guilherme, Lerner, Seth P., van de Rijn, Matt, Shortliffe, Linda D., Weissman, Irving L., Chan, Keith S.
Published in Proceedings of the National Academy of Sciences - PNAS (07.02.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (07.02.2012)
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Journal Article
Expression of shRNA From a Tissue-specific pol II Promoter Is an Effective and Safe RNAi Therapeutic
Giering, Jeffery C, Grimm, Dirk, Storm, Theresa A, Kay, Mark A
Published in Molecular therapy (01.09.2008)
Published in Molecular therapy (01.09.2008)
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Journal Article
Silencing of Hepatic Fatty Acid Transporter Protein 5 in Vivo Reverses Diet-induced Non-alcoholic Fatty Liver Disease and Improves Hyperglycemia
Doege, Holger, Grimm, Dirk, Falcon, Alaric, Tsang, Bernice, Storm, Theresa A., Xu, Hui, Ortegon, Angelica M., Kazantzis, Melissa, Kay, Mark A., Stahl, Andreas
Published in The Journal of biological chemistry (08.08.2008)
Published in The Journal of biological chemistry (08.08.2008)
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Journal Article
Unrestricted Hepatocyte Transduction with Adeno-Associated Virus Serotype 8 Vectors in Mice
NAKAI, Hiroyuki, FUESS, Sally, STORM, Theresa A, MURAMATSU, Shin-Ichi, NARA, Yuko, KAY, Mark A
Published in Journal of Virology (01.01.2005)
Published in Journal of Virology (01.01.2005)
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Journal Article
Large-Scale Molecular Characterization of Adeno-Associated Virus Vector Integration in Mouse Liver
NAKAI, Hiroyuki, XIAOLIN WU, FUESS, Sally, STORM, Theresa A, MUNROE, David, MONTINI, Eugenio, BURGESS, Shawn M, GROMPE, Markus, KAY, Mark A
Published in Journal of Virology (01.03.2005)
Published in Journal of Virology (01.03.2005)
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Journal Article
The Role of DNA-PKcs and Artemis in Opening Viral DNA Hairpin Termini in Various Tissues in Mice
INAGAKI, Katsuya, CONGRONG MA, STORM, Theresa A, KAY, Mark A, NAKAI, Hiroyuki
Published in Journal of Virology (01.10.2007)
Published in Journal of Virology (01.10.2007)
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Journal Article
DNA Palindromes with a Modest Arm Length of ≳20 Base Pairs Are a Significant Target for Recombinant Adeno-Associated Virus Vector Integration in the Liver, Muscles, and Heart in Mice
INAGAKI, Katsuya, LEWIS, Susanna M, XIAOLIN WU, CONGRONG MA, MUNROE, David J, FUESS, Sally, STORM, Theresa A, KAY, Mark A, NAKAI, Hiroyuki
Published in Journal of Virology (15.10.2007)
Published in Journal of Virology (15.10.2007)
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Journal Article
Low-level shRNA Cytotoxicity Can Contribute to MYC-induced Hepatocellular Carcinoma in Adult Mice
Beer, Shelly, Bellovin, David I, Lee, Joyce S, Komatsubara, Kimberly, Wang, Lora S, Koh, Huishan, Börner, Kathleen, Storm, Theresa A, Davis, Corrine R, Kay, Mark A, Felsher, Dean W, Grimm, Dirk
Published in Molecular therapy (01.01.2010)
Published in Molecular therapy (01.01.2010)
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Journal Article
Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors
Gholamin, Sharareh, Mitra, Siddhartha S, Feroze, Abdullah H, Liu, Jie, Kahn, Suzana A, Zhang, Michael, Esparza, Rogelio, Richard, Chase, Ramaswamy, Vijay, Remke, Marc, Volkmer, Anne K, Willingham, Stephen, Ponnuswami, Anitha, McCarty, Aaron, Lovelace, Patricia, Storm, Theresa A, Schubert, Simone, Hutter, Gregor, Narayanan, Cyndhavi, Chu, Pauline, Raabe, Eric H, Harsh, 4th, Griffith, Taylor, Michael D, Monje, Michelle, Cho, Yoon-Jae, Majeti, Ravi, Volkmer, Jens P, Fisher, Paul G, Grant, Gerald, Steinberg, Gary K, Vogel, Hannes, Edwards, Michael, Weissman, Irving L, Cheshier, Samuel H
Published in Science translational medicine (15.03.2017)
Published in Science translational medicine (15.03.2017)
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Journal Article
CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
Willingham, Stephen B, Volkmer, Jens-Peter, Gentles, Andrew J, Sahoo, Debashis, Dalerba, Piero, Mitra, Siddhartha S, Wang, Jian, Contreras-Trujillo, Humberto, Martin, Robin, Cohen, Justin D, Lovelace, Patricia, Scheeren, Ferenc A, Chao, Mark P, Weiskopf, Kipp, Tang, Chad, Volkmer, Anne Kathrin, Naik, Tejaswitha J, Storm, Theresa A, Mosley, Adriane R, Edris, Badreddin, Schmid, Seraina M, Sun, Chris K, Chua, Mei-Sze, Murillo, Oihana, Rajendran, Pradeep, Cha, Adriel C, Chin, Robert K, Kim, Dongkyoon, Adorno, Maddalena, Raveh, Tal, Tseng, Diane, Jaiswal, Siddhartha, Enger, Per Øyvind, Steinberg, Gary K, Li, Gordon, So, Samuel K, Majeti, Ravindra, Harsh, Griffith R, van de Rijn, Matt, Teng, Nelson N. H, Sunwoo, John B, Alizadeh, Ash A, Clarke, Michael F, Weissman, Irving L
Published in Proceedings of the National Academy of Sciences - PNAS (24.04.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (24.04.2012)
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Journal Article
A Limited Number of Transducible Hepatocytes Restricts a Wide-Range Linear Vector Dose Response in Recombinant Adeno-Associated Virus-Mediated Liver Transduction
Nakai, Hiroyuki, Thomas, Clare E, Storm, Theresa A, Fuess, Sally, Powell, Sharon, Wright, J Fraser, Kay, Mark A
Published in Journal of Virology (01.11.2002)
Published in Journal of Virology (01.11.2002)
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Journal Article
Robust Systemic Transduction with AAV9 Vectors in Mice: Efficient Global Cardiac Gene Transfer Superior to That of AAV8
Inagaki, Katsuya, Fuess, Sally, Storm, Theresa A, Gibson, Gregory A, Mctiernan, Charles F, Kay, Mark A, Nakai, Hiroyuki
Published in Molecular therapy (01.07.2006)
Published in Molecular therapy (01.07.2006)
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Journal Article
AAV serotype 2 vectors preferentially integrate into active genes in mice
Kay, Mark A, Nakai, Hiroyuki, Montini, Eugenio, Fuess, Sally, Storm, Theresa A, Grompe, Markus
Published in Nature genetics (01.07.2003)
Published in Nature genetics (01.07.2003)
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Journal Article
Extrachromosomal Recombinant Adeno-Associated Virus Vector Genomes Are Primarily Responsible for Stable Liver Transduction In Vivo
Nakai, H, Yant, S R, Storm, T A, Fuess, S, Meuse, L, Kay, M A
Published in Journal of Virology (01.08.2001)
Published in Journal of Virology (01.08.2001)
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Journal Article