Sugar phosphate activation of the stress sensor eIF2B
Hao, Qi, Heo, Jin-Mi, Nocek, Boguslaw P., Hicks, Kevin G., Stoll, Vincent S., Remarcik, Clint, Hackett, Sean, LeBon, Lauren, Jain, Rinku, Eaton, Dan, Rutter, Jared, Wong, Yao Liang, Sidrauski, Carmela
Published in Nature communications (08.06.2021)
Published in Nature communications (08.06.2021)
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Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding
Huerta, Carlos, Jiang, Xin, Trevino, Isaac, Bender, Christopher F., Ferguson, Deborah A., Probst, Brandon, Swinger, Kerren K., Stoll, Vincent S., Thomas, Philip J., Dulubova, Irina, Visnick, Melean, Wigley, W. Christian
Published in Biochimica et biophysica acta (01.11.2016)
Published in Biochimica et biophysica acta (01.11.2016)
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Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site
Goedken, Eric R., Argiriadi, Maria A., Dietrich, Justin D., Petros, Andrew M., Krishnan, Navasona, Panchal, Sanjay C., Qiu, Wei, Wu, Haihong, Zhu, Haizhong, Adams, Ashley M., Bodelle, Pierre M., Goguen, Lucas, Richardson, Paul L., Slivka, Peter F., Srikumaran, Myron, Upadhyay, Anup K., Wu, Bainan, Judge, Russell A., Vasudevan, Anil, Gopalakrishnan, Sujatha M., Cox, Philip B., Stoll, Vincent S., Sun, Chaohong
Published in Scientific reports (26.08.2022)
Published in Scientific reports (26.08.2022)
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Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition
Sridar, Janani, Mafi, Amirhossein, Judge, Russell A., Xu, Jun, Kong, Kailyn A., Wang, John C. K., Stoll, Vincent S., Koukos, Georgios, Simon, Reyna J., Eaton, Dan, Bratkowski, Matthew, Hao, Qi
Published in Communications chemistry (28.10.2023)
Published in Communications chemistry (28.10.2023)
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Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex
Hao, Qi, Rathinaswamy, Manoj K., Klinge, Kelly L., Bratkowski, Matthew, Mafi, Amirhossein, Baumgartner, Christina K., Hamel, Keith M., Veits, Gesine K., Jain, Rinku, Catalano, Claudio, Fitzgerald, Mark, Hird, Alexander W., Park, Eunice, Vora, Harit U., Henderson, James A., Longenecker, Kenton, Hutchins, Charles W., Qiu, Wei, Scapin, Giovanna, Sun, Qi, Stoll, Vincent S., Sun, Chaohong, Li, Ping, Eaton, Dan, Stokoe, David, Fisher, Stewart L., Nasveschuk, Christopher G., Paddock, Marcia, Kort, Michael E.
Published in Communications chemistry (16.08.2024)
Published in Communications chemistry (16.08.2024)
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Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo
Luo, Yan, Shoemaker, Alexander R, Liu, Xuesong, Woods, Keith W, Thomas, Sheela A, de Jong, Ron, Han, Edward K, Li, Tongmei, Stoll, Vincent S, Powlas, Jessica A, Oleksijew, Anatol, Mitten, Michael J, Shi, Yan, Guan, Ran, McGonigal, Thomas P, Klinghofer, Vered, Johnson, Eric F, Leverson, Joel D, Bouska, Jennifer J, Mamo, Mulugeta, Smith, Richard A, Gramling-Evans, Emily E, Zinker, Bradley A, Mika, Amanda K, Nguyen, Phong T, Oltersdorf, Tilman, Rosenberg, Saul H, Li, Qun, Giranda, Vincent L
Published in Molecular cancer therapeutics (01.06.2005)
Published in Molecular cancer therapeutics (01.06.2005)
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A potent erythropoietin-mimicking human antibody interacts through a novel binding site
Liu, Zhihong, Stoll, Vincent S., DeVries, Peter J., Jakob, Clarissa G., Xie, Nancy, Simmer, Robert L., Lacy, Susan E., Egan, David A., Harlan, John E., Lesniewski, Richard R., Reilly, Edward B.
Published in Blood (01.10.2007)
Published in Blood (01.10.2007)
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Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors
Longenecker, Kenton L, Stewart, Kent D, Madar, David J, Jakob, Clarissa G, Fry, Elizabeth H, Wilk, Sherwin, Lin, Chun W, Ballaron, Stephen J, Stashko, Michael A, Lubben, Thomas H, Yong, Hong, Pireh, Daisy, Pei, Zhonghua, Basha, Fatima, Wiedeman, Paul E, von Geldern, Thomas W, Trevillyan, James M, Stoll, Vincent S
Published in Biochemistry (Easton) (20.06.2006)
Published in Biochemistry (Easton) (20.06.2006)
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Synthesis and structure–activity relationship of 3,4′-bispyridinylethylenes: Discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer
Li, Qun, Woods, Keith W., Thomas, Sheela, Zhu, Gui-Dong, Packard, Garrick, Fisher, John, Li, Tongmei, Gong, Jianchun, Dinges, Jurgen, Song, Xiaohong, Abrams, Jason, Luo, Yan, Johnson, Eric F., Shi, Yan, Liu, Xuesong, Klinghofer, Vered, Des Jong, Ron, Oltersdorf, Tilman, Stoll, Vincent S., Jakob, Clarissa G., Rosenberg, Saul H., Giranda, Vincent L.
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
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Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design
Dietrich, Justin D, Longenecker, Kenton L, Wilson, Noel S, Goess, Christian, Panchal, Sanjay C, Swann, Steven L, Petros, Andrew M, Hobson, Adrian D, Ihle, David, Song, Danying, Richardson, Paul, Comess, Kenneth M, Cox, Philip B, Dombrowski, Amanda, Sarris, Kathy, Donnelly-Roberts, Diana L, Duignan, David B, Gomtsyan, Arthur, Jung, Paul, Krueger, A Chris, Mathieu, Suzanne, McClure, Andrea, Stoll, Vincent S, Wetter, Jill, Mankovich, John A, Hajduk, Philip J, Vasudevan, Anil, Stoffel, Robert H, Sun, Chaohong
Published in Journal of medicinal chemistry (14.01.2021)
Published in Journal of medicinal chemistry (14.01.2021)
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Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer
Petros, Andrew M, Korepanova, Alla, Jakob, Clarissa G, Qiu, Wei, Panchal, Sanjay C, Wang, Jie, Dietrich, Justin D, Brewer, Jason T, Pohlki, Frauke, Kling, Andreas, Wilcox, Kyle, Lakics, Viktor, Bahnassawy, Lamiaa, Reinhardt, Peter, Partha, Sarathy Karunan, Bodelle, Pierre M, Lake, Marc, Charych, Erik I, Stoll, Vincent S, Sun, Chaohong, Mohler, Eric G
Published in Journal of medicinal chemistry (25.04.2019)
Published in Journal of medicinal chemistry (25.04.2019)
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In Vitro Selection and Characterization of Influenza A (A/N9) Virus Variants Resistant to a Novel Neuraminidase Inhibitor, A-315675
Molla, Akhteruzzaman, Kati, Warren, Carrick, Robert, Steffy, Kevin, Shi, Yan, Montgomery, Debra, Gusick, Nanette, Stoll, Vincent S, Stewart, Kent D, Ng, Teresa I, Maring, Clarence, Kempf, Dale J, Kohlbrenner, William
Published in Journal of Virology (01.06.2002)
Published in Journal of Virology (01.06.2002)
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Novel α- and β-Amino Acid Inhibitors of Influenza Virus Neuraminidase
KATI, Warren M, MONTGOMERY, Debra, MARING, Clarence, STOLL, Vincent S, GIRANDA, Vincent, XIAOQI CHEN, LAVER, W. Graeme, KOHLBRENNER, William, NORBECK, Daniel W
Published in Antimicrobial Agents and Chemotherapy (01.09.2001)
Published in Antimicrobial Agents and Chemotherapy (01.09.2001)
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Discovery of N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitor
Dai, Yujia, Hartandi, Kresna, Ji, Zhiqin, Ahmed, Asma A, Albert, Daniel H, Bauch, Joy L, Bouska, Jennifer J, Bousquet, Peter F, Cunha, George A, Glaser, Keith B, Harris, Christopher M, Hickman, Dean, Guo, Jun, Li, Junling, Marcotte, Patrick A, Marsh, Kennan C, Moskey, Maria D, Martin, Ruth L, Olson, Amanda M, Osterling, Donald J, Pease, Lori J, Soni, Niru B, Stewart, Kent D, Stoll, Vincent S, Tapang, Paul, Reuter, David R, Davidsen, Steven K, Michaelides, Michael R
Published in Journal of medicinal chemistry (05.04.2007)
Published in Journal of medicinal chemistry (05.04.2007)
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Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases
Tao, Zhi-Fu, Hasvold, Lisa A, Leverson, Joel D, Han, Edward K, Guan, Ran, Johnson, Eric F, Stoll, Vincent S, Stewart, Kent D, Stamper, Geoff, Soni, Nirupama, Bouska, Jennifer J, Luo, Yan, Sowin, Thomas J, Lin, Nan-Horng, Giranda, Vincent S, Rosenberg, Saul H, Penning, Thomas D
Published in Journal of medicinal chemistry (12.11.2009)
Published in Journal of medicinal chemistry (12.11.2009)
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Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate
Judge, Russell A., Vasudevan, Anil, Scott, Victoria E., Simler, Gricelda H., Pratt, Steve D., Namovic, Marian T., Putman, C. Brent, Aguirre, Ana, Stoll, Vincent S., Mamo, Mulugeta, Swann, Steven I., Cassar, Steven C., Faltynek, Connie R., Kage, Karen L., Boyce‐Rustay, Janel M., Hobson, Adrian D.
Published in Chembiochem : a European journal of chemical biology (16.03.2018)
Published in Chembiochem : a European journal of chemical biology (16.03.2018)
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Corrigendum: Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate
Judge, Russell A., Vasudevan, Anil, Scott, Victoria E., Simler, Gricelda H., Pratt, Steve D., Namovic, Marian T., Putman, C. Brent, Aguirre, Ana, Stoll, Vincent S., Mamo, Mulugeta, Swann, Steven I., Cassar, Steven C., Faltynek, Connie R., Kage, Karen L., Boyce‐Rustay, Janel M., Hobson, Adrian D.
Published in Chembiochem : a European journal of chemical biology (16.04.2018)
Published in Chembiochem : a European journal of chemical biology (16.04.2018)
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Design and synthesis of pyridine–pyrazolopyridine-based inhibitors of protein kinase B/Akt
Zhu, Gui-Dong, Gong, Jianchun, Gandhi, Viraj B., Woods, Keith, Luo, Yan, Liu, Xuesong, Guan, Ran, Klinghofer, Vered, Johnson, Eric F., Stoll, Vincent S., Mamo, Mulugeta, Li, Qun, Rosenberg, Saul H., Giranda, Vincent L.
Published in Bioorganic & medicinal chemistry (15.03.2007)
Published in Bioorganic & medicinal chemistry (15.03.2007)
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