Scalable Synthesis and Isolation of the Four Stereoisomers of Methyl 1-Amino-3-(4-bromophenyl)cyclopentanecarboxylate, Useful Intermediates for the Synthesis of S1P1 Receptor Agonists
Wallace, Grier A, Gordon, Thomas D, Hayes, Martin E, Konopacki, Donald B, Fix-Stenzel, Shannon R, Zhang, Xiaolei, Grongsaard, Pintipa, Cusack, Kevin P, Schaffter, Lisa M, Henry, Rodger F, Stoffel, Robert H
Published in Journal of organic chemistry (03.07.2009)
Published in Journal of organic chemistry (03.07.2009)
Get full text
Journal Article
Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads
Hobson, Adrian D, McPherson, Michael J, Waegell, Wendy, Goess, Christian A, Stoffel, Robert H, Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Hernandez, Axel, Bryant, Shaughn H, Mathieu, Suzanne L, Bischoff, Agnieszka K, Fitzgibbons, Julia, Pawlikowska, Martyna, Puthenveetil, Sujiet, Santora, Ling C, Wang, Lu, Wang, Lu, Marvin, Christopher C, Hayes, Martin E, Shrestha, Anurupa, Sarris, Kathy A, Li, Biqin
Published in Journal of medicinal chemistry (24.03.2022)
Published in Journal of medicinal chemistry (24.03.2022)
Get full text
Journal Article
Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design
Dietrich, Justin D, Longenecker, Kenton L, Wilson, Noel S, Goess, Christian, Panchal, Sanjay C, Swann, Steven L, Petros, Andrew M, Hobson, Adrian D, Ihle, David, Song, Danying, Richardson, Paul, Comess, Kenneth M, Cox, Philip B, Dombrowski, Amanda, Sarris, Kathy, Donnelly-Roberts, Diana L, Duignan, David B, Gomtsyan, Arthur, Jung, Paul, Krueger, A Chris, Mathieu, Suzanne, McClure, Andrea, Stoll, Vincent S, Wetter, Jill, Mankovich, John A, Hajduk, Philip J, Vasudevan, Anil, Stoffel, Robert H, Sun, Chaohong
Published in Journal of medicinal chemistry (14.01.2021)
Published in Journal of medicinal chemistry (14.01.2021)
Get full text
Journal Article
Correction to “Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads”
Hobson, Adrian D., McPherson, Michael J., Waegell, Wendy, Goess, Christian A., Stoffel, Robert H., Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Hernandez, Axel, Bryant, Shaughn H., Mathieu, Suzanne L., Bischoff, Agnieszka K., Fitzgibbons, Julia, Pawlikowska, Martyna, Puthenveetil, Sujiet, Santora, Ling C., Wang, Lu, Wang, Lu, Marvin, Christopher C., Hayes, Martin E., Shrestha, Anurupa, Sarris, Kathy A., Li, Biqin
Published in Journal of medicinal chemistry (27.04.2023)
Published in Journal of medicinal chemistry (27.04.2023)
Get full text
Journal Article
Eleven Amino Acid Glucagon-like Peptide-1 Receptor Agonists with Antidiabetic Activity
Mapelli, Claudio, Natarajan, Sesha I, Meyer, Jean-Philippe, Bastos, Margarita M, Bernatowicz, Michael S, Lee, Ving G, Pluscec, Jelka, Riexinger, Douglas J, Sieber-McMaster, Ellen S, Constantine, Keith L, Smith-Monroy, Constance A, Golla, Rajasree, Ma, Zhengping, Longhi, Daniel A, Shi, Dan, Xin, Li, Taylor, Joseph R, Koplowitz, Barry, Chi, Cecilia L, Khanna, Ashish, Robinson, Gordon W, Seethala, Ramakrishna, Antal-Zimanyi, Ildiko A, Stoffel, Robert H, Han, Songping, Whaley, Jean M, Huang, Christine S, Krupinski, John, Ewing, William R
Published in Journal of medicinal chemistry (10.12.2009)
Published in Journal of medicinal chemistry (10.12.2009)
Get full text
Journal Article
Discovery of small molecule benzimidazole antagonists of the chemokine receptor CXCR3
Hayes, Martin E., Wallace, Grier A., Grongsaard, Pintipa, Bischoff, Agnieszka, George, Dawn M., Miao, Wenyan, McPherson, Michael J., Stoffel, Robert H., Green, David W., Roth, Gregory P.
Published in Bioorganic & medicinal chemistry (01.03.2008)
Published in Bioorganic & medicinal chemistry (01.03.2008)
Get full text
Journal Article
A stereoselective and scalable synthesis of a conformationally constrained S1P1 agonist
Fix-Stenzel, Shannon R., Hayes, Martin E., Zhang, Xiaolei, Wallace, Grier A., Grongsaard, Pintipa, Schaffter, Lisa M., Hannick, Steven M., Franczyk, Thaddeus S., Stoffel, Robert H., Cusack, Kevin P.
Published in Tetrahedron letters (01.07.2009)
Published in Tetrahedron letters (01.07.2009)
Get full text
Journal Article
Receptor and Gβγ isoform-specific interactions with G protein-coupled receptor kinases
Daaka, Yehia, Pitcher, Julie A., Richardson, Mark, Stoffel, Robert H., Robishaw, Janet D., Lefkowitz, Robert J.
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.1997)
Get full text
Journal Article
Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3
Hayes, Martin E., Breinlinger, Eric C., Wallace, Grier A., Grongsaard, Pintipa, Miao, Wenyan, McPherson, Michael J., Stoffel, Robert H., Green, David W., Roth, Gregory P.
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
Get full text
Journal Article
A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
Chen, Jianqiang, DeVivo, Michael, Dingus, Jane, Harry, Anya, Li, Jingrong, Sui, Jinliang, Carty, Donna J., Blank, Jonathan L., Exton, John H., Stoffel, Robert H., Inglese, James, Lefkowitz, Robert J., Logothetis, Diomedes E., Hildebrandt, John D., Lyengar, Ravi
Published in Science (American Association for the Advancement of Science) (26.05.1995)
Published in Science (American Association for the Advancement of Science) (26.05.1995)
Get full text
Journal Article
Phosphatidylinositol 4,5-Bisphosphate (PIP2)-enhanced G Protein-coupled Receptor Kinase (GRK) Activity: LOCATION, STRUCTURE, AND REGULATION OF THE PIP2 BINDING SITE DISTINGUISHES THE GRK SUBFAMILIES
Pitcher, J A, Fredericks, Z L, Stone, W C, Premont, R T, Stoffel, R H, Koch, W J, Lefkowitz, R J
Published in The Journal of biological chemistry (04.10.1996)
Published in The Journal of biological chemistry (04.10.1996)
Get full text
Journal Article
Discovery of a Potent and Novel Motilin Agonist
Li, James J, Chao, Hann-Guang, Wang, Haixia, Tino, Joseph A, Lawrence, R. Michael, Ewing, William R, Ma, Zhengping, Yan, Mujing, Slusarchyk, Dorothy, Seethala, Ramakrishna, Sun, Huabin, Li, Danshi, Burford, Neil T, Stoffel, Robert H, Salyan, Mary Ellen, Li, Cindy Y, Witkus, Michael, Zhao, Ning, Rich, Adam, Gordon, David A
Published in Journal of medicinal chemistry (25.03.2004)
Published in Journal of medicinal chemistry (25.03.2004)
Get full text
Journal Article
S1P(1) receptor agonists: Assessment of selectivity and current clinical activity
Cusack, Kevin P, Stoffel, Robert H
Published in Current opinion in drug discovery & development (01.07.2010)
Get more information
Published in Current opinion in drug discovery & development (01.07.2010)
Journal Article
NOVEL OXADIAZOLE COMPOUNDS
FIX STENZEL SHANNON, WOLLER KEVIN R, GRONGSAARD PINTIPA, BREINLINGER ERIC C, ANSELL GRAHAM K, HOBSON ADRIAN D, CUSACK KEVIN P, STOFFEL ROBERT H
Year of Publication 09.09.2009
Get full text
Year of Publication 09.09.2009
Patent
Characterization of the G Protein-coupled Receptor Kinase GRK4
Premont, Richard T., Macrae, Alexander D., Stoffel, Robert H., Chung, Namjin, Pitcher, Julie A., Ambrose, Christine, Inglese, James, MacDonald, Marcy E., Lefkowitz, Robert J.
Published in The Journal of biological chemistry (01.03.1996)
Published in The Journal of biological chemistry (01.03.1996)
Get full text
Journal Article
A stereoselective and scalable synthesis of a conformationally constrained S1P(1) agonist
Fix-Stenzel, Shannon R., Hayes, Martin E., Zhang, Xiaolei, Wallace, Grier A., Grongsaard, Pintipa, Schaffter, Lisa M., Hannick, Steven M., Franczyk, Thaddeus S., Stoffel, Robert H., Cusack, Kevin P.
Published in Tetrahedron letters (15.07.2009)
Published in Tetrahedron letters (15.07.2009)
Get full text
Journal Article
Receptor and Gβ γ Isoform-Specific Interactions with G Protein-Coupled Receptor Kinases
Daaka, Yehia, Pitcher, Julie A., Richardson, Mark, Stoffel, Robert H., Robishaw, Janet D., Lefkowitz, Robert J.
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.1997)
Get full text
Journal Article
Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity
Freedman, N J, Ament, A S, Oppermann, M, Stoffel, R H, Exum, S T, Lefkowitz, R J
Published in The Journal of biological chemistry (11.07.1997)
Published in The Journal of biological chemistry (11.07.1997)
Get full text
Journal Article