Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase
Schulze, Volker K, Klar, Ulrich, Kosemund, Dirk, Wengner, Antje M, Siemeister, Gerhard, Stöckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Holton, Simon J, Briem, Hans, Marquardt, Tobias, Schirok, Hartmut, Jautelat, Rolf, Bohlmann, Rolf, Nguyen, Duy, Fernández-Montalván, Amaury E, Bömer, Ulf, Eberspaecher, Uwe, Brüning, Michael, Döhr, Olaf, Raschke, Marian, Kreft, Bertolt, Mumberg, Dominik, Ziegelbauer, Karl, Brands, Michael, von Nussbaum, Franz, Koppitz, Marcus
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
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Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2
Eggert, Erik, Hillig, Roman C, Koehr, Silke, Stöckigt, Detlef, Weiske, Jörg, Barak, Naomi, Mowat, Jeffrey, Brumby, Thomas, Christ, Clara D, ter Laak, Antonius, Lang, Tina, Fernandez-Montalvan, Amaury E, Badock, Volker, Weinmann, Hilmar, Hartung, Ingo V, Barsyte-Lovejoy, Dalia, Szewczyk, Magdalena, Kennedy, Steven, Li, Fengling, Vedadi, Masoud, Brown, Peter J, Santhakumar, Vijayaratnam, Arrowsmith, Cheryl H, Stellfeld, Timo, Stresemann, Carlo
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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Journal Article
Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor
Lefranc, Julien, Schulze, Volker Klaus, Hillig, Roman Christian, Briem, Hans, Prinz, Florian, Mengel, Anne, Heinrich, Tobias, Balint, Jozsef, Rengachari, Srinivasan, Irlbacher, Horst, Stöckigt, Detlef, Bömer, Ulf, Bader, Benjamin, Gradl, Stefan Nikolaus, Nising, Carl Friedrich, von Nussbaum, Franz, Mumberg, Dominik, Panne, Daniel, Wengner, Antje Margret
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
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A miniaturized mode-of-action profiling platform enables high throughput characterization of the molecular and cellular dynamics of EZH2 inhibition
Falkenstern, Lilia, Georgi, Victoria, Bunse, Stefanie, Badock, Volker, Husemann, Manfred, Roehn, Ulrike, Stellfeld, Timo, Fitzgerald, Mark, Ferrara, Steven, Stöckigt, Detlef, Stresemann, Carlo, Hartung, Ingo V., Fernández-Montalván, Amaury
Published in Scientific reports (19.01.2024)
Published in Scientific reports (19.01.2024)
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Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains
Bouché, Léa, Christ, Clara D, Siegel, Stephan, Fernández-Montalván, Amaury E, Holton, Simon J, Fedorov, Oleg, ter Laak, Antonius, Sugawara, Tatsuo, Stöckigt, Detlef, Tallant, Cynthia, Bennett, James, Monteiro, Octovia, Díaz-Sáez, Laura, Siejka, Paulina, Meier, Julia, Pütter, Vera, Weiske, Jörg, Müller, Susanne, Huber, Kilian V. M, Hartung, Ingo V, Haendler, Bernard
Published in Journal of medicinal chemistry (11.05.2017)
Published in Journal of medicinal chemistry (11.05.2017)
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Journal Article
Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action
Fernández-Montalván, Amaury E, Berger, Markus, Kuropka, Benno, Koo, Seong Joo, Badock, Volker, Weiske, Joerg, Puetter, Vera, Holton, Simon J, Stöckigt, Detlef, ter Laak, Antonius, Centrella, Paolo A, Clark, Matthew A, Dumelin, Christoph E, Sigel, Eric A, Soutter, Holly H, Troast, Dawn M, Zhang, Ying, Cuozzo, John W, Keefe, Anthony D, Roche, Didier, Rodeschini, Vincent, Chaikuad, Apirat, Díaz-Sáez, Laura, Bennett, James M, Fedorov, Oleg, Huber, Kilian V. M, Hübner, Jan, Weinmann, Hilmar, Hartung, Ingo V, Gorjánácz, Mátyás
Published in ACS chemical biology (17.11.2017)
Published in ACS chemical biology (17.11.2017)
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A Method for High-Throughput Screening of Enantioselective Catalysts
Reetz, Manfred T., Becker, Michael H., Klein, Heinz-Werner, Stöckigt, Detlef
Published in Angewandte Chemie International Edition (14.06.1999)
Published in Angewandte Chemie International Edition (14.06.1999)
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Liquid Chromatography/Mass Spectrometry and Liquid Chromatography/Nuclear Magnetic Resonance as Complementary Analytical Techniques for Unambiguous Identification of Polymethoxylated Flavones in Residues from Molecular Distillation of Orange Peel Oils (Citrus sinensis)
Weber, Berthold, Hartmann, Beate, Stöckigt, Detlef, Schreiber, Klaus, Roloff, Michael, Bertram, Heinz-Jürgen, Schmidt, Claus O
Published in Journal of agricultural and food chemistry (25.01.2006)
Published in Journal of agricultural and food chemistry (25.01.2006)
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Exposure–Response Relationship of the Synthetic Epothilone Sagopilone in a Peripheral Neurotoxicity Rat Model
Chiorazzi, Alessia, Höchel, Joachim, Stöckigt, Detlef, Canta, Annalisa, Carozzi, Valentina Alda, Meregalli, Cristina, Avezza, Federica, Crippa, Luca, Sala, Barbara, Ceresa, Cecilia, Oggioni, Norberto, Cavaletti, Guido
Published in Neurotoxicity research (01.08.2012)
Published in Neurotoxicity research (01.08.2012)
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Journal Article
Extensive study on the minor constituents of the essential oil of Eucalyptus dives Schau. type
Weber, B, Hartmann, B, Stockigt, D, Kohlenberg, B, Schmidt, C.O, Bertram, H.J, Holscher, B
Published in The Journal of essential oil research (01.11.2006)
Published in The Journal of essential oil research (01.11.2006)
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Journal Article
COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING HEMATOLOGICAL CANCERS
JANZER, ANDREAS, MEYER, HANNA, STOCKIGT, DETLEF, SCADDEN, DAVID, SYKES, DAVID B, LEWIS, TIMOTHY A
Year of Publication 17.10.2023
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Year of Publication 17.10.2023
Patent
Abstract 980: BAY-299, a novel chemical probe for in-depth analysis of the function of the bromodomain proteins BRPF2 and TAF1
Bouche, Lea, Christ, Clara D., Siegel, Stephan, Tallant, Cynthia, Fernández-Montalván, Amaury E., Huber, Kilian V., Pütter, Verra, Müller, Susanne, Fedorov, Oleg, Laak, Antonius ter, Sugawara, Tatsuo, Stöckigt, Detlef, Meier, Julia, Holton, Simon J., Hartung, Ingo V., Haendler, Bernard
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
2-HETEROARYL-3-OXO-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES FOR THE TREATMENT OF CANCER
Platten, Michael, Rose, Lars, Zorn, Ludwig, Stockigt, Detlef, Gutcher, Ilona, Rohn, Ulrike, Schmees, Norbert, Karretero, Rafael, Kober, Christina, Irlbacher, Horst, Bader, Benjamin
Year of Publication 10.08.2021
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Year of Publication 10.08.2021
Patent