Cheminformatic Tools for Medicinal Chemists
Muchmore, Steven W, Edmunds, Jeremy J, Stewart, Kent D, Hajduk, Philip J
Published in Journal of medicinal chemistry (08.07.2010)
Published in Journal of medicinal chemistry (08.07.2010)
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Journal Article
Drug Guru: A computer software program for drug design using medicinal chemistry rules
Stewart, Kent D., Shiroda, Melisa, James, Craig A.
Published in Bioorganic & medicinal chemistry (15.10.2006)
Published in Bioorganic & medicinal chemistry (15.10.2006)
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Journal Article
Discovery of potent and selective thienopyrimidine inhibitors of Aurora kinases
McClellan, William J., Dai, Yujia, Abad-Zapatero, Cele, Albert, Daniel H., Bouska, Jennifer J., Glaser, Keith B., Magoc, Terry J., Marcotte, Patrick A., Osterling, Donald J., Stewart, Kent D., Davidsen, Steven K., Michaelides, Michael R.
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Journal Article
Mutations Conferring Resistance to a Hepatitis C Virus (HCV) RNA-Dependent RNA Polymerase Inhibitor Alone or in Combination with an HCV Serine Protease Inhibitor In Vitro
Mo, Hongmei, Lu, Liangjun, Pilot-Matias, Tami, Pithawalla, Ron, Mondal, Rubina, Masse, Sherie, Dekhtyar, Tatyana, Ng, Teresa, Koev, Gennadiy, Stoll, Vincent, Stewart, Kent D, Pratt, John, Donner, Pam, Rockway, Todd, Maring, Clarence, Molla, Akhteruzzaman
Published in Antimicrobial Agents and Chemotherapy (01.10.2005)
Published in Antimicrobial Agents and Chemotherapy (01.10.2005)
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Journal Article
Mutations Conferring Resistance to a Potent Hepatitis C Virus Serine Protease Inhibitor In Vitro
Lu, Liangjun, Pilot-Matias, Tami J, Stewart, Kent D, Randolph, John T, Pithawalla, Ron, He, Wenping, Huang, Peggy P, Klein, Larry L, Mo, Hongmei, Molla, Akhteruzzaman
Published in Antimicrobial Agents and Chemotherapy (01.06.2004)
Published in Antimicrobial Agents and Chemotherapy (01.06.2004)
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Journal Article
Structure-Based Design, Synthesis, and Biological Evaluation of Potent and Selective Macrocyclic Checkpoint Kinase 1 Inhibitors
Tao, Zhi-Fu, Wang, Le, Stewart, Kent D, Chen, Zehan, Gu, Wendy, Bui, Mai-Ha, Merta, Philip, Zhang, Haiying, Kovar, Peter, Johnson, Eric, Park, Chang, Judge, Russell, Rosenberg, Saul, Sowin, Thomas, Lin, Nan-Horng
Published in Journal of medicinal chemistry (05.04.2007)
Published in Journal of medicinal chemistry (05.04.2007)
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Journal Article
Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195
Tong, Yunsong, Stewart, Kent D, Florjancic, Alan S, Harlan, John E, Merta, Philip J, Przytulinska, Magdalena, Soni, Nirupama, Swinger, Kerren K, Zhu, Haizhong, Johnson, Eric F, Shoemaker, Alexander R, Penning, Thomas D
Published in ACS medicinal chemistry letters (14.02.2013)
Published in ACS medicinal chemistry letters (14.02.2013)
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Journal Article
Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[b,e][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors
Wang, Le, Sullivan, Gerard M, Hexamer, Laura A, Hasvold, Lisa A, Thalji, Reema, Przytulinska, Magdalena, Tao, Zhi-Fu, Li, Gaoquan, Chen, Zehan, Xiao, Zhan, Gu, Wen-Zhen, Xue, John, Bui, Mai-Ha, Merta, Philip, Kovar, Peter, Bouska, Jennifer J, Zhang, Haiying, Park, Chang, Stewart, Kent D, Sham, Hing L, Sowin, Thomas J, Rosenberg, Saul H, Lin, Nan-Horng
Published in Journal of medicinal chemistry (23.08.2007)
Published in Journal of medicinal chemistry (23.08.2007)
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Journal Article
Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors
Dai, Yujia, Hartandi, Kresna, Soni, Niru B., Pease, Lori J., Reuter, David R., Olson, Amanda M., Osterling, Donald J., Doktor, Stella Z., Albert, Daniel H., Bouska, Jennifer J., Glaser, Keith B., Marcotte, Patrick A., Stewart, Kent D., Davidsen, Steven K., Michaelides, Michael R.
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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Journal Article
Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors
Ji, Zhiqin, Dai, Yujia, Abad-Zapatero, Cele, Albert, Daniel H., Bouska, Jennifer J., Glaser, Keith B., Marcotte, Patrick A., Soni, Nirupama B., Magoc, Terry J., Stewart, Kent D., Wei, Ru-Qi, Davidsen, Steve K., Michaelides, Michael R.
Published in Bioorganic & medicinal chemistry letters (15.07.2012)
Published in Bioorganic & medicinal chemistry letters (15.07.2012)
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Journal Article
Discovery of ((4R,5S)-5-Amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a Highly Potent, Selective, Orally Efficacious, and Safe Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
Pei, Zhonghua, Li, Xiaofeng, von Geldern, Thomas W, Madar, David J, Longenecker, Kenton, Yong, Hong, Lubben, Thomas H, Stewart, Kent D, Zinker, Bradley A, Backes, Bradley J, Judd, Andrew S, Mulhern, Mathew, Ballaron, Stephen J, Stashko, Michael A, Mika, Amanda K, Beno, David W. A, Reinhart, Glenn A, Fryer, Ryan M, Preusser, Lee C, Kempf-Grote, Anita J, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (02.11.2006)
Published in Journal of medicinal chemistry (02.11.2006)
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Journal Article
Identification and Structural Characterization of I84C and I84A Mutations That Are Associated with High-Level Resistance to Human Immunodeficiency Virus Protease Inhibitors and Impair Viral Replication
HONGMEI MO, PARKIN, Neil, STEWART, Kent D, LIANGJUN LU, DEKHTYAR, Tatyana, KEMPF, Dale J, MOLLA, Akhteruzzaman
Published in Antimicrobial Agents and Chemotherapy (01.02.2007)
Published in Antimicrobial Agents and Chemotherapy (01.02.2007)
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Journal Article
Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors
Longenecker, Kenton L, Stewart, Kent D, Madar, David J, Jakob, Clarissa G, Fry, Elizabeth H, Wilk, Sherwin, Lin, Chun W, Ballaron, Stephen J, Stashko, Michael A, Lubben, Thomas H, Yong, Hong, Pireh, Daisy, Pei, Zhonghua, Basha, Fatima, Wiedeman, Paul E, von Geldern, Thomas W, Trevillyan, James M, Stoll, Vincent S
Published in Biochemistry (Easton) (20.06.2006)
Published in Biochemistry (Easton) (20.06.2006)
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Journal Article
Discovery of 4′-(1,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-benzonitriles and 4′-(1,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-pyridine-2′-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors
Tao, Zhi-Fu, Li, Gaoquan, Tong, Yunsong, Stewart, Kent D., Chen, Zehan, Bui, Mai-Ha, Merta, Philip, Park, Chang, Kovar, Peter, Zhang, Haiying, Sham, Hing L., Rosenberg, Saul H., Sowin, Thomas J., Lin, Nan-Horng
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
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Journal Article
X-ray crystallographic structure of ABT-378 (lopinavir) bound to HIV-1 protease
STOLL, Vincent, WENYING QIN, KEMPF, Dale, SHAM, Hing L, NORBECK, Daniel W, STEWART, Kent D, JAKOB, Clarissa, CHANG PARK, WALTER, K, SIMMER, R. L, HELFRICH, Rosalind, BUSSIERE, Dirk, KAO, J
Published in Bioorganic & medicinal chemistry (01.08.2002)
Published in Bioorganic & medicinal chemistry (01.08.2002)
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Journal Article
Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder
Boateng, Comfort A., Nilson, Ashley N., Placide, Rebekah, Pham, Mimi L., Jakobs, Franziska M., Boldizsar, Noelia, McIntosh, Scot, Stallings, Leia S., Korankyi, Ivana V., Kelshikar, Shreya, Shah, Nisha, Panasis, Diandra, Muccilli, Abigail, Ladik, Maria, Maslonka, Brianna, McBride, Connor, Sanchez, Moises Ximello, Akca, Ebrar, Alkhatib, Mohammad, Saez, Julianna, Nguyen, Catherine, Kurtyan, Emily, DePierro, Jacquelyn, Crowthers, Raymond, Brunt, Dylan, Bonifazi, Alessandro, Newman, Amy Hauck, Rais, Rana, Slusher, Barbara S., Free, R. Benjamin, Sibley, David R., Stewart, Kent D., Wu, Chun, Hemby, Scott E., Keck, Thomas M.
Published in Journal of medicinal chemistry (14.09.2023)
Published in Journal of medicinal chemistry (14.09.2023)
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Journal Article
Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors
Kurukulasuriya, Ravi, Rohde, Jeffrey J., Szczepankiewicz, Bruce G., Basha, Fatima, Lai, Chunqui, Jae, Hwan-Soo, Winn, Martin, Stewart, Kent D., Longenecker, Kenton L., Lubben, Thomas W., Ballaron, Stephen J., Sham, Hing L., von Geldern, Thomas W.
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
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Journal Article
In Vitro Selection and Characterization of Influenza A (A/N9) Virus Variants Resistant to a Novel Neuraminidase Inhibitor, A-315675
Molla, Akhteruzzaman, Kati, Warren, Carrick, Robert, Steffy, Kevin, Shi, Yan, Montgomery, Debra, Gusick, Nanette, Stoll, Vincent S, Stewart, Kent D, Ng, Teresa I, Maring, Clarence, Kempf, Dale J, Kohlbrenner, William
Published in Journal of Virology (01.06.2002)
Published in Journal of Virology (01.06.2002)
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Journal Article
Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability
Randolph, John T, Krueger, A. Chris, Donner, Pamela L, Pratt, John K, Liu, Dachun, Motter, Christopher E, Rockway, Todd W, Tufano, Michael D, Wagner, Rolf, Lim, Hock B, Beyer, Jill M, Mondal, Rubina, Panchal, Neeta S, Colletti, Lynn, Liu, Yaya, Koev, Gennadiy, Kati, Warren M, Hernandez, Lisa E, Beno, David W. A, Longenecker, Kenton L, Stewart, Kent D, Dumas, Emily O, Molla, Akhteruzzaman, Maring, Clarence J
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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