Heteroarylation of Azine N-Oxides
Gosselin, Francis, Savage, Scott J, Blaquiere, Nicole, Staben, Steven T
Published in Organic letters (03.02.2012)
Published in Organic letters (03.02.2012)
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Primary Amine Tethered Small Molecules Promote the Degradation of X‑Linked Inhibitor of Apoptosis Protein
Besten, Willem den, Verma, Kshitij, Yamazoe, Sayumi, Blaquiere, Nicole, Phung, Wilson, Izrael-Tomasevic, Anita, Mulvihill, Melinda M, Helgason, Elizabeth, Prakash, Sumit, Goncharov, Tatiana, Vucic, Domagoj, Dueber, Erin, Fairbrother, Wayne J, Wertz, Ingrid, Yu, Kebing, Staben, Steven T
Published in Journal of the American Chemical Society (21.07.2021)
Published in Journal of the American Chemical Society (21.07.2021)
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Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors
Hu, Dennis X., Patel, Snahel, Chen, Huifen, Wang, Shumei, Staben, Steven T., Dimitrova, Yoana N., Wallweber, Heidi Ackerly, Lee, Joanna Y., Chan, Grace Ka Yan, Sneeringer, Christopher J., Prangley, Madeleine S., Moffat, John G., Wu, Kai C., Schutt, Leah K., Salphati, Laurent, Pang, Jodie, McNamara, Erin, Huang, Haochu, Chen, Yong, Wang, Yunli, Zhao, Wensheng, Lim, Junghyun, Murthy, Aditya, Siu, Michael
Published in Journal of medicinal chemistry (08.09.2022)
Published in Journal of medicinal chemistry (08.09.2022)
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The Rational Design of Selective Benzoxazepin Inhibitors of the α‑Isoform of Phosphoinositide 3‑Kinase Culminating in the Identification of (S)‑2-((2-(1-Isopropyl‑1H‑1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2‑d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)
Heffron, Timothy P, Heald, Robert A, Ndubaku, Chudi, Wei, BinQing, Augistin, Martin, Do, Steven, Edgar, Kyle, Eigenbrot, Charles, Friedman, Lori, Gancia, Emanuela, Jackson, Philip S, Jones, Graham, Kolesnikov, Aleksander, Lee, Leslie B, Lesnick, John D, Lewis, Cristina, McLean, Neville, Mörtl, Mario, Nonomiya, Jim, Pang, Jodie, Price, Steve, Prior, Wei Wei, Salphati, Laurent, Sideris, Steve, Staben, Steven T, Steinbacher, Stefan, Tsui, Vickie, Wallin, Jeffrey, Sampath, Deepak, Olivero, Alan G
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands
Steffek, Micah, Helgason, Elizabeth, Popovych, Nataliya, Rougé, Lionel, Bruning, John M., Li, Ke Sherry, Burdick, Daniel J., Cai, Jianping, Crawford, Terry, Xue, Jing, Decurtins, Willy, Fang, Chunlin, Grubers, Felix, Holliday, Michael J., Langley, Allyson, Petersen, Ann, Satz, Alexander Lee, Song, Aimin, Stoffler, Daniel, Strebel, Quentin, Tom, Jeffrey Y. K., Skelton, Nicholas, Staben, Steven T., Wichert, Moreno, Mulvihill, Melinda M., Dueber, Erin C.
Published in Biochemistry (Easton) (07.02.2023)
Published in Biochemistry (Easton) (07.02.2023)
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Gold(I)-Catalyzed Cyclizations of Silyl Enol Ethers: Application to the Synthesis of (+)-Lycopladine A
Staben, Steven T., Kennedy-Smith, Joshua J., Huang, David, Corkey, Britton K., LaLonde, Rebecca L., Toste, F. Dean
Published in Angewandte Chemie International Edition (11.09.2006)
Published in Angewandte Chemie International Edition (11.09.2006)
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Preclinical Assessment of the PI3Kα Selective Inhibitor Inavolisib and Prediction of Its Pharmacokinetics and Efficacious Dose in Human
Salphati, Laurent, Pang, Jodie, Plise, Emile G, Cheong, Jonathan, Braun, Marie-Gabrielle, Friedman, Lori S, Hong Thibodeau, Rebecca, Jaochico, Allan, Johnson, Ryan, Liu, Ning, Nannini, Michelle, Sampath, Deepak, Song, Kyung, Hannan, Emily J, Staben, Steven T
Published in Xenobiotica (10.10.2024)
Published in Xenobiotica (10.10.2024)
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Gold(I)-Catalyzed Ring Expansion of Cyclopropanols and Cyclobutanols
Markham, Jordan P, Staben, Steven T, Toste, F. Dean
Published in Journal of the American Chemical Society (13.07.2005)
Published in Journal of the American Chemical Society (13.07.2005)
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Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition
Walle, Lieselotte Vande, Stowe, Irma B, Šácha, Pavel, Lee, Bettina L, Demon, Dieter, Fossoul, Amelie, Van Hauwermeiren, Filip, Saavedra, Pedro H V, Šimon, Petr, Šubr, Vladimír, Kostka, Libor, Stivala, Craig E, Pham, Victoria C, Staben, Steven T, Yamazoe, Sayumi, Konvalinka, Jan, Kayagaki, Nobuhiko, Lamkanfi, Mohamed
Published in PLoS biology (16.10.2019)
Published in PLoS biology (16.10.2019)
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Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase
Blaquiere, Nicole, Castanedo, Georgette M, Burch, Jason D, Berezhkovskiy, Leonid M, Brightbill, Hans, Brown, Suzanne, Chan, Connie, Chiang, Po-Chang, Crawford, James J, Dong, Teresa, Fan, Peter, Feng, Jianwen, Ghilardi, Nico, Godemann, Robert, Gogol, Emily, Grabbe, Alice, Hole, Alison J, Hu, Baihua, Hymowitz, Sarah G, Alaoui Ismaili, Moulay Hicham, Le, Hoa, Lee, Patrick, Lee, Wyne, Lin, Xingyu, Liu, Ning, McEwan, Paul A, McKenzie, Brent, Silvestre, Hernani L, Suto, Eric, Sujatha-Bhaskar, Swathi, Wu, Guosheng, Wu, Lawren C, Zhang, Yamin, Zhong, Zoe, Staben, Steven T
Published in Journal of medicinal chemistry (09.08.2018)
Published in Journal of medicinal chemistry (09.08.2018)
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Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K)
Castanedo, Georgette M, Blaquiere, Nicole, Beresini, Maureen, Bravo, Brandon, Brightbill, Hans, Chen, Jacob, Cui, Hai-Feng, Eigenbrot, Charles, Everett, Christine, Feng, Jianwen, Godemann, Robert, Gogol, Emily, Hymowitz, Sarah, Johnson, Adam, Kayagaki, Nobuhiko, Kohli, Pawan Bir, Knüppel, Kathleen, Kraemer, Joachim, Krüger, Susan, Loke, Pui, McEwan, Paul, Montalbetti, Christian, Roberts, David A, Smith, Myron, Steinbacher, Stefan, Sujatha-Bhaskar, Swathi, Takahashi, Ryan, Wang, Xiaolu, Wu, Lawren C, Zhang, Yamin, Staben, Steven T
Published in Journal of medicinal chemistry (26.01.2017)
Published in Journal of medicinal chemistry (26.01.2017)
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Gold(I)-Catalyzed Conia-Ene Reaction of β-Ketoesters with Alkynes
Kennedy-Smith, Joshua J, Staben, Steven T, Toste, F. Dean
Published in Journal of the American Chemical Society (14.04.2004)
Published in Journal of the American Chemical Society (14.04.2004)
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The Crystal Structure of the Catalytic Domain of the NF-κB Inducing Kinase Reveals a Narrow but Flexible Active Site
de Leon-Boenig, Gladys, Bowman, Krista K., Feng, Jianwen A., Crawford, Terry, Everett, Christine, Franke, Yvonne, Oh, Angela, Stanley, Mark, Staben, Steven T., Starovasnik, Melissa A., Wallweber, Heidi J.A., Wu, Jiansheng, Wu, Lawren C., Johnson, Adam R., Hymowitz, Sarah G.
Published in Structure (London) (10.10.2012)
Published in Structure (London) (10.10.2012)
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Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design
Crawford, James J., Feng, Jianwen, Brightbill, Hans D., Johnson, Adam R., Wright, Matthew, Kolesnikov, Aleksandr, Lee, Wendy, Castanedo, Georgette M., Do, Steven, Blaquiere, Nicole, Staben, Steven T., Chiang, Po-Chang, Fan, Peter W., Baumgardner, Matt, Wong, Susan, Godemann, Robert, Grabbe, Alice, Wiegel, Catharina, Sujatha-Bhaskar, Swathi, Hymowitz, Sarah G., Liau, Nicholas, Hsu, Peter L., McEwan, Paul A., Ismaili, Moulay Hicham Alaoui, Landry, Matthew L.
Published in Bioorganic & medicinal chemistry letters (01.06.2023)
Published in Bioorganic & medicinal chemistry letters (01.06.2023)
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Gold(I)-Catalyzed 5-endo-dig Carbocyclization of Acetylenic Dicarbonyl Compounds
Staben, Steven T., Kennedy-Smith, Joshua J., Toste, F. Dean
Published in Angewandte Chemie International Edition (11.10.2004)
Published in Angewandte Chemie International Edition (11.10.2004)
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Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors
Staben, Steven T, Feng, Jianwen A, Lyle, Karen, Belvin, Marcia, Boggs, Jason, Burch, Jason D, Chua, Ching-ching, Cui, Haifeng, DiPasquale, Antonio G, Friedman, Lori S, Heise, Christopher, Koeppen, Hartmut, Kotey, Adrian, Mintzer, Robert, Oh, Angela, Roberts, David Allen, Rouge, Lionel, Rudolph, Joachim, Tam, Christine, Wang, Weiru, Xiao, Yisong, Young, Amy, Zhang, Yamin, Hoeflich, Klaus P
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
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Rational Design of Phosphoinositide 3-Kinase α Inhibitors That Exhibit Selectivity over the Phosphoinositide 3-Kinase β Isoform
Heffron, Timothy P, Wei, BinQing, Olivero, Alan, Staben, Steven T, Tsui, Vickie, Do, Steven, Dotson, Jennafer, Folkes, Adrian J, Goldsmith, Paul, Goldsmith, Richard, Gunzner, Janet, Lesnick, John, Lewis, Cristina, Mathieu, Simon, Nonomiya, Jim, Shuttleworth, Stephen, Sutherlin, Daniel P, Wan, Nan Chi, Wang, Shumei, Wiesmann, Christian, Zhu, Bing-Yan
Published in Journal of medicinal chemistry (24.11.2011)
Published in Journal of medicinal chemistry (24.11.2011)
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Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1)
Feng, Jianwen A, Lee, Patrick, Alaoui, Moulay Hicham, Barrett, Kathy, Castanedo, Georgette, Godemann, Robert, McEwan, Paul, Wang, Xiaolu, Wu, Ping, Zhang, Yamin, Harris, Seth F, Staben, Steven T
Published in ACS medicinal chemistry letters (12.09.2019)
Published in ACS medicinal chemistry letters (12.09.2019)
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