Phase I Study of Recombinant Interleukin-21 in Patients With Metastatic Melanoma and Renal Cell Carcinoma
THOMPSON, John A, CURTI, Brendan D, REDMAN, Bruce G, BHATIA, Shailender, WEBER, Jeffrey S, AGARWALA, Sanjiv S, SIEVERS, Eric L, HUGHES, Steven D, DEVRIES, Todd A, HAUSMAN, Diana F
Published in Journal of clinical oncology (20.04.2008)
Published in Journal of clinical oncology (20.04.2008)
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Platelet-Derived Growth Factor C Induces Liver Fibrosis, Steatosis, and Hepatocellular Carcinoma
Campbell, Jean S., Hughes, Steven D., Gilbertson, Debra G., Palmer, Thomas E., Holdren, Matthew S., Haran, Aaron C., Odell, Melissa M., Bauer, Renay L., Ren, Hong-Ping, Haugen, Harald S., Yeh, Matthew M., Fausto, Nelson, Krebs, Edwin G.
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2005)
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Interleukin-21 enhances rituximab activity in a cynomolgus monkey model of B cell depletion and in mouse B cell lymphoma models
Krejsa, Cecile M, Holly, Rick D, Heipel, Mark, Bannink, Ken M, Johnson, Rebecca, Roque, Richard, Heffernan, Jane, Hill, Julie, Chin, Lay, Wagener, Felecia, Shiota, Faith, Henderson, Katherine, Sivakumar, Pallavur V, Ren, Hong-Ping, Barahmand-Pour, Fariba, Foster, Don, Clegg, Chris, Kindsvogel, Wayne, Ponce, Rafael, Hughes, Steven D, Waggie, Kim
Published in PloS one (25.06.2013)
Published in PloS one (25.06.2013)
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Toxicity as a result of immunostimulation by biologics
Gribble, Elizabeth J, Sivakumar, Pallavar V, Ponce, Rafael A, Hughes, Steven D
Published in Expert opinion on drug metabolism & toxicology (01.04.2007)
Published in Expert opinion on drug metabolism & toxicology (01.04.2007)
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Journal Article
IL-21 induces in vivo immune activation of NK cells and CD8+ T cells in patients with metastatic melanoma and renal cell carcinoma
Frederiksen, Klaus Stensgaard, Lundsgaard, Dorthe, Freeman, Jeremy A., Hughes, Steven D., Holm, Thomas L., Skrumsager, Birte K., Petri, Andreas, Hansen, Lasse T., McArthur, Grant A., Davis, Ian D., Skak, Kresten
Published in Cancer Immunology, Immunotherapy (01.10.2008)
Published in Cancer Immunology, Immunotherapy (01.10.2008)
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Comparison of Vascular Leak Syndrome in Mice Treated with IL21 or IL2
Sivakumar, Pallavur V, Garcia, Richard, Waggie, Kimberly S, Anderson-Haley, Monica, Nelson, Andrew, Hughes, Steven D
Published in Comparative medicine (01.02.2013)
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Published in Comparative medicine (01.02.2013)
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Comparison of the ability of wild type and stabilized human IgG(4) to undergo Fab arm exchange with endogenous IgG(4)in vitro and in vivo
Lewis, Kenneth B, Meengs, Brent, Bondensgaard, Kent, Chin, Lay, Hughes, Steven D, Kjaer, Birgitte, Lund, Søren, Wang, Liping
Published in Molecular immunology (01.10.2009)
Published in Molecular immunology (01.10.2009)
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Interleukin-21 augments the efficacy of T-cell therapy by eliciting concurrent cellular and humoral responses
Iuchi, Takekazu, Teitz-Tennenbaum, Seagal, Huang, Jianhua, Redman, Bruce G, Hughes, Steven D, Li, Mu, Jiang, Guihua, Chang, Alfred E, Li, Qiao
Published in Cancer research (Chicago, Ill.) (01.06.2008)
Published in Cancer research (Chicago, Ill.) (01.06.2008)
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Immune activation in advanced cancer patients treated with recombinant IL-21: multianalyte profiling of serum proteins
Dodds, Michael G, Frederiksen, Klaus Stensgaard, Skak, Kresten, Hansen, Lasse Tengbjerg, Lundsgaard, Dorthe, Thompson, John A, Hughes, Steven D
Published in Cancer Immunology, Immunotherapy (01.06.2009)
Published in Cancer Immunology, Immunotherapy (01.06.2009)
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Exogenous PDGF-D is a potent mesangial cell mitogen and causes a severe mesangial proliferative glomerulopathy
HUDKINS, Kelly L, GILBERTSON, Debra G, ALPERS, Charles E, CARLING, Matthew, TANEDA, Sekiko, HUGHES, Steven D, HOLDREN, Matthew S, PALMER, Thomas E, TOPOUZIS, Stavros, HARAN, Aaron C, FELDHAUS, Andrew L
Published in Journal of the American Society of Nephrology (01.02.2004)
Published in Journal of the American Society of Nephrology (01.02.2004)
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Topical recombinant thrombin at a concentration of 1000 IU/mL reliably shortens in vivo TTH and delivers durable hemostasis in the presence of heparin anticoagulation and clopidogrel platelet inhibition in a rabbit model of vascular bleeding
Hughes, Steven D, Bishop, Paul D, Garcia, Richard, Zhang, Tracy, Alexander, W Allan
Published in Annals of surgical innovation and research (19.11.2009)
Published in Annals of surgical innovation and research (19.11.2009)
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Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism
Morrison, John R., Pászty, Chris, Stevens, Mary E., Hughes, Steven D., Forte, Trudy, Scott, James, Rubin, Edward M.
Published in Proceedings of the National Academy of Sciences - PNAS (09.07.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (09.07.1996)
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Comparison of the ability of wild type and stabilized human IgG4 to undergo Fab arm exchange with endogenous IgG4 in vitro and in vivo
Lewis, Kenneth B., Meengs, Brent, Bondensgaard, Kent, Chin, Lay, Hughes, Steven D., Kjær, Birgitte, Lund, Søren, Wang, Liping
Published in Molecular immunology (01.10.2009)
Published in Molecular immunology (01.10.2009)
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Apolipoprotein(a) Yeast Artificial Chromosome Transgenic Rabbits
Rouy, Didier, Duverger, Nicolas, Lin, Sluan D., Emmanuel, Florence, Houdebine, Louis-Marie, Denefle, Patrice, Viglietta, Celine, Gong, Elaine, Rubin, Edward M., Hughes, Steven D.
Published in The Journal of biological chemistry (09.01.1998)
Published in The Journal of biological chemistry (09.01.1998)
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Comparison of the ability of wild type and stabilized human IgG sub(4) to undergo Fab arm exchange with endogenous IgG sub(4) in vitro and in vivo
Lewis, Kenneth B, Meengs, Brent, Bondensgaard, Kent, Chin, Lay, Hughes, Steven D, Kjaer, Birgitte, Lund, Soeren, Wang, Liping
Published in Molecular immunology (01.10.2009)
Published in Molecular immunology (01.10.2009)
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Journal Article
Comparison of the ability of wild type and stabilized human IgG 4 to undergo Fab arm exchange with endogenous IgG 4 in vitro and in vivo
Lewis, Kenneth B., Meengs, Brent, Bondensgaard, Kent, Chin, Lay, Hughes, Steven D., Kjær, Birgitte, Lund, Søren, Wang, Liping
Published in Molecular immunology (2009)
Published in Molecular immunology (2009)
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Journal Article
IL-21 augments the efficacy of T cell therapy by eliciting concurrent cellular and humoral responses1
Iuchi, Takekazu, Teitz-Tennenbaum, Seagal, Huang, Jianhua, Redman, Bruce G., Hughes, Steven D., Li, Mu, Jiang, Guihua, Chang, Alfred E., Li, Qiao
Published in Cancer research (Chicago, Ill.) (01.06.2008)
Published in Cancer research (Chicago, Ill.) (01.06.2008)
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Journal Article
IL-21 Improves Rituximab-Mediated B Cell Depletion
Hughes, Steven D., Ponce, Rafael A., Krejsa, Cecile, Frings, Werner, Bartsch, Stephanie, Hill, Julie P., Rogge, Mark C.
Published in Blood (16.11.2005)
Published in Blood (16.11.2005)
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