Structural analysis of human KDM5B guides histone demethylase inhibitor development
Johansson, Catrine, Velupillai, Srikannathasan, Tumber, Anthony, Szykowska, Aleksandra, Hookway, Edward S, Nowak, Radoslaw P, Strain-Damerell, Claire, Gileadi, Carina, Philpott, Martin, Burgess-Brown, Nicola, Wu, Na, Kopec, Jola, Nuzzi, Andrea, Steuber, Holger, Egner, Ursula, Badock, Volker, Munro, Shonagh, LaThangue, Nicholas B, Westaway, Sue, Brown, Jack, Athanasou, Nick, Prinjha, Rab, Brennan, Paul E, Oppermann, Udo
Published in Nature chemical biology (01.07.2016)
Published in Nature chemical biology (01.07.2016)
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Journal Article
Novel dengue virus NS2B/NS3 protease inhibitors
Wu, Hongmei, Bock, Stefanie, Snitko, Mariya, Berger, Thilo, Weidner, Thomas, Holloway, Steven, Kanitz, Manuel, Diederich, Wibke E, Steuber, Holger, Walter, Christof, Hofmann, Daniela, Weißbrich, Benedikt, Spannaus, Ralf, Acosta, Eliana G, Bartenschlager, Ralf, Engels, Bernd, Schirmeister, Tanja, Bodem, Jochen
Published in Antimicrobial agents and chemotherapy (01.02.2015)
Published in Antimicrobial agents and chemotherapy (01.02.2015)
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Structure and functionality in flavivirus NS-proteins: Perspectives for drug design
Bollati, Michela, Alvarez, Karin, Assenberg, René, Baronti, Cécile, Canard, Bruno, Cook, Shelley, Coutard, Bruno, Decroly, Etienne, de Lamballerie, Xavier, Gould, Ernest A., Grard, Gilda, Grimes, Jonathan M., Hilgenfeld, Rolf, Jansson, Anna M., Malet, Hélène, Mancini, Erika J., Mastrangelo, Eloise, Mattevi, Andrea, Milani, Mario, Moureau, Grégory, Neyts, Johan, Owens, Raymond J., Ren, Jingshan, Selisko, Barbara, Speroni, Silvia, Steuber, Holger, Stuart, David I., Unge, Torsten, Bolognesi, Martino
Published in Antiviral research (01.08.2010)
Published in Antiviral research (01.08.2010)
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Journal Article
The E. coli effector protein NleF is a caspase inhibitor
Blasche, Sonja, Mörtl, Mario, Steuber, Holger, Siszler, Gabriella, Nisa, Shahista, Schwarz, Frank, Lavrik, Inna, Gronewold, Thomas M A, Maskos, Klaus, Donnenberg, Michael S, Ullmann, Dirk, Uetz, Peter, Kögl, Manfred
Published in PloS one (14.03.2013)
Published in PloS one (14.03.2013)
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Journal Article
Tracing Binding Modes in Hit-to-Lead Optimization: Chameleon-Like Poses of Aspartic Protease Inhibitors
Kuhnert, Maren, Köster, Helene, Bartholomäus, Ruben, Park, Ah Young, Shahim, Amir, Heine, Andreas, Steuber, Holger, Klebe, Gerhard, Diederich, Wibke E.
Published in Angewandte Chemie International Edition (23.02.2015)
Published in Angewandte Chemie International Edition (23.02.2015)
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Journal Article
A combined spectroscopic and crystallographic approach to probing drug–human serum albumin interactions
Buttar, David, Colclough, Nicola, Gerhardt, Stefan, MacFaul, Philip A., Phillips, Scott D., Plowright, Alleyn, Whittamore, Paul, Tam, Kin, Maskos, Klaus, Steinbacher, Stefan, Steuber, Holger
Published in Bioorganic & medicinal chemistry (01.11.2010)
Published in Bioorganic & medicinal chemistry (01.11.2010)
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Journal Article
Identification of Small Molecules that Modulate Mutant p53 Condensation
Lemos, Clara, Schulze, Luise, Weiske, Joerg, Meyer, Hanna, Braeuer, Nico, Barak, Naomi, Eberspächer, Uwe, Werbeck, Nicolas, Stresemann, Carlo, Lange, Martin, Lesche, Ralf, Zablowsky, Nina, Juenemann, Katrin, Kamburov, Atanas, Luh, Laura Martina, Leissing, Thomas Markus, Mortier, Jeremie, Steckel, Michael, Steuber, Holger, Eis, Knut, Eheim, Ashley, Steigemann, Patrick
Published in iScience (25.09.2020)
Published in iScience (25.09.2020)
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Journal Article
Factorizing Selectivity Determinants of Inhibitor Binding toward Aldose and Aldehyde Reductases: Structural and Thermodynamic Properties of the Aldose Reductase Mutant Leu300Pro−Fidarestat Complex
Petrova, Tatiana, Steuber, Holger, Hazemann, Isabelle, Cousido-Siah, Alexandra, Mitschler, Andre, Chung, Roland, Oka, Mitsuru, Klebe, Gerhard, El-Kabbani, Ossama, Joachimiak, Andrzej, Podjarny, Alberto
Published in Journal of medicinal chemistry (08.09.2005)
Published in Journal of medicinal chemistry (08.09.2005)
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Journal Article
Thermodynamic Inhibition Profile of a Cyclopentyl and a Cyclohexyl Derivative towards Thrombin: The Same but for Different Reasons
Gerlach, Christof, Smolinski, Michael, Steuber, Holger, Sotriffer, Christoph A, Heine, Andreas, Hangauer, David G, Klebe, Gerhard
Published in Angewandte Chemie (International ed.) (01.01.2007)
Published in Angewandte Chemie (International ed.) (01.01.2007)
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Journal Article
Macrocyclic Statine-Based Inhibitors of BACE-1
Barazza, Alessandra, Götz, Marion, Cadamuro, Sergio A, Goettig, Peter, Willem, Michael, Steuber, Holger, Kohler, Tanja, Jestel, Anja, Reinemer, Peter, Renner, Christian, Bode, Wolfram, Moroder, Luis
Published in Chembiochem : a European journal of chemical biology (23.11.2007)
Published in Chembiochem : a European journal of chemical biology (23.11.2007)
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Journal Article
Darolutamide is a potent androgen receptor antagonist with strong efficacy in prostate cancer models
Sugawara, Tatsuo, Baumgart, Simon J., Nevedomskaya, Ekaterina, Reichert, Kristin, Steuber, Holger, Lejeune, Pascale, Mumberg, Dominik, Haendler, Bernard
Published in International journal of cancer (01.09.2019)
Published in International journal of cancer (01.09.2019)
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Journal Article
Privileged Structures Meet Human T-Cell Leukemia Virus-1 (HTLV-1): C 2 -Symmetric 3,4-Disubstituted Pyrrolidines as Nonpeptidic HTLV-1 Protease Inhibitors
Kuhnert, Maren, Blum, Andreas, Steuber, Holger, Diederich, Wibke E.
Published in Journal of medicinal chemistry (11.06.2015)
Published in Journal of medicinal chemistry (11.06.2015)
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Journal Article
Structural Basis for HTLV‑1 Protease Inhibition by the HIV‑1 Protease Inhibitor Indinavir
Kuhnert, Maren, Steuber, Holger, Diederich, Wibke E
Published in Journal of medicinal chemistry (24.07.2014)
Published in Journal of medicinal chemistry (24.07.2014)
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Journal Article
XanthomoninsI-III: A New Class of Lasso Peptides with a Seven-Residue Macrolactam Ring
Hegemann, Julian D, Zimmermann, Marcel, Zhu, Shaozhou, Steuber, Holger, Harms, Klaus, Xie, Xiulan, Marahiel, Mohamed A
Published in Angewandte Chemie International Edition (17.02.2014)
Published in Angewandte Chemie International Edition (17.02.2014)
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Journal Article
Xanthomonins I-III: A New Class of Lasso Peptides with a Seven-Residue Macrolactam Ring
Hegemann, Julian D., Zimmermann, Marcel, Zhu, Shaozhou, Steuber, Holger, Harms, Klaus, Xie, Xiulan, Marahiel, Mohamed A.
Published in Angewandte Chemie International Edition (17.02.2014)
Published in Angewandte Chemie International Edition (17.02.2014)
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Journal Article
Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839
Bothe, Ulrich, Günther, Judith, Nubbemeyer, Reinhard, Siebeneicher, Holger, Ring, Sven, Bömer, Ulf, Peters, Michaele, Rausch, Alexandra, Denner, Karsten, Himmel, Herbert, Sutter, Andreas, Terebesi, Ildiko, Lange, Martin, Wengner, Antje M., Guimond, Nicolas, Thaler, Tobias, Platzek, Johannes, Eberspächer, Uwe, Schäfer, Martina, Steuber, Holger, Zollner, Thomas M., Steinmeyer, Andreas, Schmidt, Nicole
Published in Journal of medicinal chemistry (25.01.2024)
Published in Journal of medicinal chemistry (25.01.2024)
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