Structural Hot Spots Determine Functional Diversity of the Candida glabrata Epithelial Adhesin Family
Diderrich, Rike, Kock, Michael, Maestre-Reyna, Manuel, Keller, Petra, Steuber, Holger, Rupp, Steffen, Essen, Lars-Oliver, Mösch, Hans-Ulrich
Published in The Journal of biological chemistry (07.08.2015)
Published in The Journal of biological chemistry (07.08.2015)
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Journal Article
BAY-7081: A Potent, Selective, and Orally Bioavailable Cyanopyridone-Based PDE9A Inhibitor
Meibom, Daniel, Micus, Sina, Andreevski, Anna Lena, Anlauf, Sonja, Bogner, Pamela, von Buehler, Clemens-Jeremias, Dieskau, André P., Dreher, Jan, Eitner, Frank, Fliegner, Daniela, Follmann, Markus, Gericke, Kersten Matthias, Maassen, Stefanie, Meyer, Jutta, Schlemmer, Karl-Heinz, Steuber, Holger, Tersteegen, Adrian, Wunder, Frank
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
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Journal Article
Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
Graham, Keith, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Naujoks, Jan, Lesche, Ralf, Weiske, Joerg, Kuehnlenz, Julia, Brzezinka, Krzysztof, Potze, Lisette, Zanconato, Francesca, Nicke, Barbara, Montebaur, Anna, Bone, Wilhelm, Golfier, Sven, Kaulfuss, Stefan, Kopitz, Charlotte, Pilari, Sabine, Steuber, Holger, Hayat, Sikander, Kamburov, Atanas, Steffen, Andreas, Schlicker, Andreas, Buchgraber, Philipp, Braeuer, Nico, Font, Nuria Aiguabella, Heinrich, Tobias, Kuhnke, Lara, Nowak-Reppel, Katrin, Stresemann, Carlo, Steigemann, Patrick, Walter, Annette O., Blotta, Simona, Ocker, Matthias, Lakner, Ashley, von Nussbaum, Franz, Mumberg, Dominik, Eis, Knut, Piccolo, Stefano, Lange, Martin
Published in Cell chemical biology (18.07.2024)
Published in Cell chemical biology (18.07.2024)
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Journal Article
Privileged Structures Meet Human T‑Cell Leukemia Virus‑1 (HTLV-1): C2‑Symmetric 3,4-Disubstituted Pyrrolidines as Nonpeptidic HTLV‑1 Protease Inhibitors
Kuhnert, Maren, Blum, Andreas, Steuber, Holger, Diederich, Wibke E
Published in Journal of medicinal chemistry (11.06.2015)
Published in Journal of medicinal chemistry (11.06.2015)
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Journal Article
Expect the Unexpected or Caveat for Drug Designers: Multiple Structure Determinations Using Aldose Reductase Crystals Treated under Varying Soaking and Co-crystallisation Conditions
Steuber, Holger, Zentgraf, Matthias, Gerlach, Christof, Sotriffer, Christoph A., Heine, Andreas, Klebe, Gerhard
Published in Journal of molecular biology (13.10.2006)
Published in Journal of molecular biology (13.10.2006)
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Journal Article
Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor
Ferreira de Freitas, Renato, Eram, Mohammad S, Szewczyk, Magdalena M, Steuber, Holger, Smil, David, Wu, Hong, Li, Fengling, Senisterra, Guillermo, Dong, Aiping, Brown, Peter J, Hitchcock, Marion, Moosmayer, Dieter, Stegmann, Christian M, Egner, Ursula, Arrowsmith, Cheryl, Barsyte-Lovejoy, Dalia, Vedadi, Masoud, Schapira, Matthieu
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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Journal Article
Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics
Sutherland, Mathew, Li, Alice, Kaghad, Anissa, Panagopoulos, Dimitrios, Li, Fengling, Szewczyk, Magdalena, Smil, David, Scholten, Cora, Bouché, Léa, Stellfeld, Timo, Arrowsmith, Cheryl H., Barsyte, Dalia, Vedadi, Masoud, Hartung, Ingo V., Steuber, Holger, Britton, Robert, Santhakumar, Vijayaratnam
Published in ChemMedChem (08.04.2021)
Published in ChemMedChem (08.04.2021)
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Journal Article
Abstract 1887: Preclinical evaluation of a novel interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor in combination with PI3K inhibitor copanlisib or BTK inhibitors in ABC-DLBCL
Lange, Martin, Wengner, Antje Margret, Bothe, Ulrich, Boemer, Ulf, Nubbemeyer, Reinhard, Siebeneicher, Holger, Steuber, Holger, Guenther, Judith, Potze, Lisette, Schmidt, Nicole, Politz, Oliver, Doecke, Wolf-Dietrich, Lagkadinou, Eleni, Zollner, Thomas M., Nussbaum, Franz von, Mumberg, Dominik, Steinmeyer, Andreas, Brands, Michael, Ziegelbauer, Karl
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 1646: Discovery and characterization of BAY-6035, a novel benzodiazepine-based SMYD3 inhibitor
Gradl, Stefan, Steuber, Holger, Weiske, Jörg, Schmees, Norbert, Siegel, Stephan, Stoeckigt, Detlef, Christ, Clara D., Li, Fengling, Organ, Shawna, Barsyte-Lovejoy, Dalia, Szewczyk, Magdalena M., Kennedy, Steven, Trush, Viacheslav, Vedadi, Masoud, Arrowsmith, Cheryl H., Brown, Peter J., Husemann, Manfred, Fernandez-Montalvan, Amaury E., Badock, Volker, Bauser, Marcus, Haegebarth, Andrea, Hartung, Ingo V., Stresemann, Carlo
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Identification of azabenzimidazoles as potent JAK1 selective inhibitors
Vasbinder, Melissa M., Alimzhanov, Marat, Augustin, Martin, Bebernitz, Geraldine, Bell, Kirsten, Chuaqui, Claudio, Deegan, Tracy, Ferguson, Andrew D., Goodwin, Kelly, Huszar, Dennis, Kawatkar, Aarti, Kawatkar, Sameer, Read, Jon, Shi, Jie, Steinbacher, Stefan, Steuber, Holger, Su, Qibin, Toader, Dorin, Wang, Haixia, Woessner, Richard, Wu, Allan, Ye, Minwei, Zinda, Michael
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
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Journal Article
Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening
Gradl, Stefan, Steuber, Holger, Weiske, Joerg, Szewczyk, Magda M., Schmees, Norbert, Siegel, Stephan, Stoeckigt, Detlef, Christ, Clara D., Li, Fengling, Organ, Shawna, Abbey, Megha, Kennedy, Steven, Chau, Irene, Trush, Viacheslav, Barsyte-Lovejoy, Dalia, Brown, Peter J., Vedadi, Masoud, Arrowsmith, Cheryl, Husemann, Manfred, Badock, Volker, Bauser, Marcus, Haegebarth, Andrea, Hartung, Ingo V., Stresemann, Carlo
Published in SLAS discovery (01.09.2021)
Published in SLAS discovery (01.09.2021)
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Journal Article
Abstract 4584: Novel YAP1/TAZ pathway inhibitors identified through phenotypic screening with potent anti-tumor activity via blockade of GGTase-I and Rho-GTPase signaling
Graham, Keith, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Naujoks, Jan, Lesche, Ralf, Nicke, Barbara, Bone, Wilhelm, Golfier, Sven, Brzezinka, Krzysztof, Kaulfuss, Stefan, Kopitz, Charlotte, Steuber, Holger, Braeuer, Nico, Nowak-Reppel, Katrin, Stresemann, Carlo, Steigemann, Patrick, Kuehnlenz, Julia, Potze, Lisette, Zanconato, Francesca, Montebaur, Anna, Pilari, Sabine, Hayat, Sikander, Kamburov, Atanas, Steffen, Andreas, Schlicker, Andreas, Buchgraber, Philipp, Font, Nuria Aiguabella, Heinrich, Tobias, Kuhnke, Lara, Walter, Annette O., Blotta, Simona, Ocker, Matthias, Lakner, Ashley, Mumberg, Dominik, Eis, Knut, Piccolo, Stefano, Lange, Martin
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
How Reliable Are Current Docking Approaches for Structure-Based Drug Design? Lessons from Aldose Reductase
Zentgraf, Matthias, Steuber, Holger, Koch, Cornelia, La Motta, Concettina, Sartini, Stefania, Sotriffer, Christoph A., Klebe, Gerhard
Published in Angewandte Chemie International Edition (01.01.2007)
Published in Angewandte Chemie International Edition (01.01.2007)
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Journal Article
High-resolution Crystal Structure of Aldose Reductase Complexed with the Novel Sulfonyl-pyridazinone Inhibitor Exhibiting an Alternative Active Site Anchoring Group
Steuber, Holger, Zentgraf, Matthias, Podjarny, Alberto, Heine, Andreas, Klebe, Gerhard
Published in Journal of molecular biology (10.02.2006)
Published in Journal of molecular biology (10.02.2006)
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Journal Article
Non‐ATP‐Mimetic Organometallic Protein Kinase Inhibitor
Wähler, Kathrin, Kräling, Katja, Steuber, Holger, Meggers, Eric
Published in ChemistryOpen (Weinheim) (01.12.2013)
Published in ChemistryOpen (Weinheim) (01.12.2013)
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Journal Article
[8--3,8-디아자비사이클로[3.2.1]옥트-3-일](1H-1,2,3-트리아졸-4-일)메타논
BADER BENJAMIN, SIEBENEICHER HOLGER, TEREBESI ILDIKO, ROTTMANN ANTJE, KOPPITZ MARCUS, PETERS MICHAELE, WAGENFELD ANDREA, IRLBACHER HORST, NUBBEMEYER REINHARD, TER LAAK ANTONIUS, STEUBER HOLGER
Year of Publication 28.01.2019
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Year of Publication 28.01.2019
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