Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer
Duncan, James S., Whittle, Martin C., Nakamura, Kazuhiro, Abell, Amy N., Midland, Alicia A., Zawistowski, Jon S., Johnson, Nancy L., Granger, Deborah A., Jordan, Nicole Vincent, Darr, David B., Usary, Jerry, Kuan, Pei-Fen, Smalley, David M., Major, Ben, He, Xiaping, Hoadley, Katherine A., Zhou, Bing, Sharpless, Norman E., Perou, Charles M., Kim, William Y., Gomez, Shawn M., Chen, Xin, Jin, Jian, Frye, Stephen V., Earp, H. Shelton, Graves, Lee M., Johnson, Gary L.
Published in Cell (13.04.2012)
Published in Cell (13.04.2012)
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Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia
Xu, Bowen, On, Doan M., Ma, Anqi, Parton, Trevor, Konze, Kyle D., Pattenden, Samantha G., Allison, David F., Cai, Ling, Rockowitz, Shira, Liu, Shichong, Liu, Ying, Li, Fengling, Vedadi, Masoud, Frye, Stephen V., Garcia, Benjamin A., Zheng, Deyou, Jin, Jian, Wang, Gang Greg
Published in Blood (08.01.2015)
Published in Blood (08.01.2015)
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Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP
Liu, Feng, Barsyte-Lovejoy, Dalia, Li, Fengling, Xiong, Yan, Korboukh, Victoria, Huang, Xi-Ping, Allali-Hassani, Abdellah, Janzen, William P, Roth, Bryan L, Frye, Stephen V, Arrowsmith, Cheryl H, Brown, Peter J, Vedadi, Masoud, Jin, Jian
Published in Journal of medicinal chemistry (14.11.2013)
Published in Journal of medicinal chemistry (14.11.2013)
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An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1
Konze, Kyle D, Ma, Anqi, Li, Fengling, Barsyte-Lovejoy, Dalia, Parton, Trevor, MacNevin, Christopher J, Liu, Feng, Gao, Cen, Huang, Xi-Ping, Kuznetsova, Ekaterina, Rougie, Marie, Jiang, Alice, Pattenden, Samantha G, Norris, Jacqueline L, James, Lindsey I, Roth, Bryan L, Brown, Peter J, Frye, Stephen V, Arrowsmith, Cheryl H, Hahn, Klaus M, Wang, Gang Greg, Vedadi, Masoud, Jin, Jian
Published in ACS chemical biology (21.06.2013)
Published in ACS chemical biology (21.06.2013)
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Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing
Moussa, Hagar F., Bsteh, Daniel, Yelagandula, Ramesh, Pribitzer, Carina, Stecher, Karin, Bartalska, Katarina, Michetti, Luca, Wang, Jingkui, Zepeda-Martinez, Jorge A., Elling, Ulrich, Stuckey, Jacob I., James, Lindsey I., Frye, Stephen V., Bell, Oliver
Published in Nature communications (29.04.2019)
Published in Nature communications (29.04.2019)
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MERTK activation drives osimertinib resistance in EGFR-mutant non-small cell lung cancer
Yan, Dan, Huelse, Justus M, Kireev, Dmitri, Tan, Zikang, Chen, Luxiao, Goyal, Subir, Wang, Xiaodong, Frye, Stephen V, Behera, Madhusmita, Schneider, Frank, Ramalingam, Suresh S, Owonikoko, Taofeek, Earp, H Shelton, DeRyckere, Deborah, Graham, Douglas K
Published in The Journal of clinical investigation (01.08.2022)
Published in The Journal of clinical investigation (01.08.2022)
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The Lipid Kinase PIP5K1C Regulates Pain Signaling and Sensitization
Wright, Brittany D., Loo, Lipin, Street, Sarah E., Ma, Anqi, Taylor-Blake, Bonnie, Stashko, Michael A., Jin, Jian, Janzen, William P., Frye, Stephen V., Zylka, Mark J.
Published in Neuron (Cambridge, Mass.) (21.05.2014)
Published in Neuron (Cambridge, Mass.) (21.05.2014)
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A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1
Stuckey, Jacob I, Dickson, Bradley M, Cheng, Nancy, Liu, Yanli, Norris, Jacqueline L, Cholensky, Stephanie H, Tempel, Wolfram, Qin, Su, Huber, Katherine G, Sagum, Cari, Black, Karynne, Li, Fengling, Huang, Xi-Ping, Roth, Bryan L, Baughman, Brandi M, Senisterra, Guillermo, Pattenden, Samantha G, Vedadi, Masoud, Brown, Peter J, Bedford, Mark T, Min, Jinrong, Arrowsmith, Cheryl H, James, Lindsey I, Frye, Stephen V
Published in Nature chemical biology (01.03.2016)
Published in Nature chemical biology (01.03.2016)
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An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering
Cui, Gaofeng, Botuyan, Maria Victoria, Drané, Pascal, Hu, Qi, Bragantini, Benoît, Thompson, James R., Schuller, David J., Detappe, Alexandre, Perfetti, Michael T., James, Lindsey I., Frye, Stephen V., Chowdhury, Dipanjan, Mer, Georges
Published in Nature communications (29.09.2023)
Published in Nature communications (29.09.2023)
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Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7
Lamb, Kelsey N, Bsteh, Daniel, Dishman, Sarah N, Moussa, Hagar F, Fan, Huitao, Stuckey, Jacob I, Norris, Jacqueline L, Cholensky, Stephanie H, Li, Dongxu, Wang, Jingkui, Sagum, Cari, Stanton, Benjamin Z, Bedford, Mark T, Pearce, Kenneth H, Kenakin, Terry P, Kireev, Dmitri B, Wang, Gang Greg, James, Lindsey I, Bell, Oliver, Frye, Stephen V
Published in Cell chemical biology (17.10.2019)
Published in Cell chemical biology (17.10.2019)
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Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines
Liu, Feng, Barsyte-Lovejoy, Dalia, Allali-Hassani, Abdellah, He, Yunlong, Herold, J. Martin, Chen, Xin, Yates, Christopher M, Frye, Stephen V, Brown, Peter J, Huang, Jing, Vedadi, Masoud, Arrowsmith, Cheryl H, Jin, Jian
Published in Journal of medicinal chemistry (08.09.2011)
Published in Journal of medicinal chemistry (08.09.2011)
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Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8
Ma, Anqi, Yu, Wenyu, Li, Fengling, Bleich, Rachel M, Herold, J. Martin, Butler, Kyle V, Norris, Jacqueline L, Korboukh, Victoria, Tripathy, Ashutosh, Janzen, William P, Arrowsmith, Cheryl H, Frye, Stephen V, Vedadi, Masoud, Brown, Peter J, Jin, Jian
Published in Journal of medicinal chemistry (14.08.2014)
Published in Journal of medicinal chemistry (14.08.2014)
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Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a
Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M, Wasney, Gregory A, Dong, Aiping, Barsyte, Dalia, Kozieradzki, Ivona, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Kireev, Dmitri B, Jadhav, Ajit, Herold, J. Martin, Frye, Stephen V, Arrowsmith, Cheryl H, Brown, Peter J, Simeonov, Anton, Vedadi, Masoud, Jin, Jian
Published in Journal of medicinal chemistry (24.12.2009)
Published in Journal of medicinal chemistry (24.12.2009)
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MERTK receptor tyrosine kinase is a therapeutic target in melanoma
Schlegel, Jennifer, Sambade, Maria J, Sather, Susan, Moschos, Stergios J, Tan, Aik-Choon, Winges, Amanda, DeRyckere, Deborah, Carson, Craig C, Trembath, Dimitri G, Tentler, John J, Eckhardt, S Gail, Kuan, Pei-Fen, Hamilton, Ronald L, Duncan, Lyn M, Miller, C Ryan, Nikolaishvili-Feinberg, Nana, Midkiff, Bentley R, Liu, Jing, Zhang, Weihe, Yang, Chao, Wang, Xiaodong, Frye, Stephen V, Earp, H Shelton, Shields, Janiel M, Graham, Douglas K
Published in The Journal of clinical investigation (01.05.2013)
Published in The Journal of clinical investigation (01.05.2013)
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Inhibition of MERTK Promotes Suppression of Tumor Growth in BRAF Mutant and BRAF Wild-Type Melanoma
Sinik, Lenka, Minson, Katherine A, Tentler, John J, Carrico, Jacqueline, Bagby, Stacey M, Robinson, William A, Kami, Rotem, Burstyn-Cohen, Tal, Eckhardt, S Gail, Wang, Xiaodong, Frye, Stephen V, Earp, H Shelton, DeRyckere, Deborah, Graham, Douglas K
Published in Molecular cancer therapeutics (01.02.2019)
Published in Molecular cancer therapeutics (01.02.2019)
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Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines
Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M, Wigle, Tim J, Wasney, Gregory A, Dong, Aiping, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Norris, Jacqueline L, Kireev, Dmitri B, Jadhav, Ajit, Herold, J. Martin, Janzen, William P, Arrowsmith, Cheryl H, Frye, Stephen V, Brown, Peter J, Simeonov, Anton, Vedadi, Masoud, Jin, Jian
Published in Journal of medicinal chemistry (12.08.2010)
Published in Journal of medicinal chemistry (12.08.2010)
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Small Molecule Inhibition of MERTK Is Efficacious in Non-Small Cell Lung Cancer Models Independent of Driver Oncogene Status
Cummings, Christopher T, Zhang, Weihe, Davies, Kurtis D, Kirkpatrick, Gregory D, Zhang, Dehui, DeRyckere, Deborah, Wang, Xiaodong, Frye, Stephen V, Earp, H Shelton, Graham, Douglas K
Published in Molecular cancer therapeutics (01.09.2015)
Published in Molecular cancer therapeutics (01.09.2015)
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Inhibiting efferocytosis reverses macrophage-mediated immunosuppression in the leukemia microenvironment
Cruz Cruz, Joselyn, Allison, Kristen C, Page, Lauren S, Jenkins, Alexis J, Wang, Xiaodong, Earp, H Shelton, Frye, Stephen V, Graham, Douglas K, Verneris, Michael R, Lee-Sherick, Alisa B
Published in Frontiers in immunology (07.03.2023)
Published in Frontiers in immunology (07.03.2023)
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Structure–Activity Relationships and Kinetic Studies of Peptidic Antagonists of CBX Chromodomains
Stuckey, Jacob I, Simpson, Catherine, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Lee, Junghyun, Pasca, Ryan, Cheng, Nancy, Dickson, Bradley M, Pearce, Kenneth H, Frye, Stephen V, James, Lindsey I
Published in Journal of medicinal chemistry (13.10.2016)
Published in Journal of medicinal chemistry (13.10.2016)
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