A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner
Stemmer, Willem P C, Schellenberger, Volker, Wang, Chia-wei, Geething, Nathan C, Spink, Benjamin J, Campbell, Andrew, To, Wayne, Scholle, Michael D, Yin, Yong, Yao, Yi, Bogin, Oren, Cleland, Jeffrey L, Silverman, Joshua
Published in Nature biotechnology (01.12.2009)
Published in Nature biotechnology (01.12.2009)
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Journal Article
GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohn's disease model
Alters, Susan E, McLaughlin, Bryant, Spink, Benjamin, Lachinyan, Tigran, Wang, Chia-wei, Podust, Vladimir, Schellenberger, Volker, Stemmer, Willem P C
Published in PloS one (26.11.2012)
Published in PloS one (26.11.2012)
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Journal Article
A Novel Long-Acting Human Growth Hormone Fusion Protein (VRS-317): Enhanced In Vivo Potency and Half-Life
Cleland, Jeffrey L., Geething, Nathan C., Moore, Jerome A., Rogers, Brian C., Spink, Benjamin J., Wang, Chai-Wei, Alters, Susan E., Stemmer, Willem P.C., Schellenberger, Volker
Published in Journal of pharmaceutical sciences (01.08.2012)
Published in Journal of pharmaceutical sciences (01.08.2012)
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Journal Article
DNA shuffling of a family of genes from diverse species accelerates directed evolution
Stemmer, Willem P. C, Crameri, Andreas, Raillard, Sun-Ai, Bermudez, Ericka
Published in Nature (London) (15.01.1998)
Published in Nature (London) (15.01.1998)
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Journal Article
Genome shuffling leads to rapid phenotypic improvement in bacteria
del Cardayré, Stephen B, Zhang, Ying-Xin, Perry, Kim, Vinci, Victor A, Powell, Keith, Stemmer, Willem P. C
Published in Nature (London) (07.02.2002)
Published in Nature (London) (07.02.2002)
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Journal Article
Gcg-XTEN: an improved glucagon capable of preventing hypoglycemia without increasing baseline blood glucose
Geething, Nathan C, To, Wayne, Spink, Benjamin J, Scholle, Michael D, Wang, Chia-wei, Yin, Yong, Yao, Yi, Schellenberger, Volker, Cleland, Jeffrey L, Stemmer, Willem P C, Silverman, Joshua
Published in PloS one (14.04.2010)
Published in PloS one (14.04.2010)
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Journal Article
Genome shuffling of Lactobacillus for improved acid tolerance
del Cardayré, Stephen, Gavrilovic, Vesna, Ryan, Chris M, Patnaik, Ranjan, Louie, Susan, Stemmer, Willem P.C, Perry, Kim
Published in Nature biotechnology (01.07.2002)
Published in Nature biotechnology (01.07.2002)
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Journal Article
Improving the Catalytic Activity of a Thermophilic Enzyme at Low Temperatures
Merz, Astrid, Yee, Muh-ching, Szadkowski, Halina, Pappenberger, Günter, Crameri, Andreas, Stemmer, Willem P. C, Yanofsky, Charles, Kirschner, Kasper
Published in Biochemistry (Easton) (08.02.2000)
Published in Biochemistry (Easton) (08.02.2000)
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Journal Article
Directed Evolution and Biocatalysis
Powell, Keith A., Ramer, Sandra W., del Cardayré, Stephen B., Stemmer, Willem P. C., Tobin, Matthew B., Longchamp, Pascal F., Huisman, Gjalt W.
Published in Angewandte Chemie (International ed.) (05.11.2001)
Published in Angewandte Chemie (International ed.) (05.11.2001)
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Journal Article
Correction: GLP2-2G-XTEN: A Pharmaceutical Protein with Improved Serum Half-Life and Efficacy in a Rat Crohn’s Disease Model
Alters, Susan E., McLaughlin, Bryant, Spink, Benjamin, Lachinyan, Tigran, Wang, Chia-wei, Podust, Vladimir, Schellenberger, Volker, Stemmer, Willem P. C.
Published in PloS one (10.06.2013)
Published in PloS one (10.06.2013)
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Journal Article
Evolution of a Human Immunodeficiency Virus Type 1 Variant with Enhanced Replication in Pig-Tailed Macaque Cells by DNA Shuffling
Pekrun, Katja, Shibata, Riri, Igarashi, Tatsuhiko, Reed, Margaret, Sheppard, Liana, Patten, Philip A, Stemmer, Willem P C, Martin, Malcolm A, Soong, Nay-Wei
Published in Journal of Virology (01.03.2002)
Published in Journal of Virology (01.03.2002)
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Journal Article
EXTENDED RECOMBINANT POLYPEPTIDES AND COMPOSITIONS COMPRISING THE SAME
VOLKER SCHELLENBERGER, JOSHUA SILVERMAN, BENJAMIN SPINK, NATHAN GEETHING, WANG CHIA-WEI, TO WAYNE, STEMMER WILLEM P, JEFFREY L CLELAND
Year of Publication 18.06.2024
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Year of Publication 18.06.2024
Patent
GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohn's. PLoS One. 2012; 7(11): e50630
Alters, Susan E, McLaughlin, Bryant, Spink, Benjamin, Lachinyan, Tigran, Wang, Chia-Wei, Podust, Vladimir, Schellenberger, Volker, Stemmer, Willem P C
Published in PloS one (2013)
Published in PloS one (2013)
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