Quantitative Proteomics of the Cancer Cell Line Encyclopedia
Nusinow, David P., Szpyt, John, Ghandi, Mahmoud, Rose, Christopher M., McDonald, E. Robert, Kalocsay, Marian, Jané-Valbuena, Judit, Gelfand, Ellen, Schweppe, Devin K., Jedrychowski, Mark, Golji, Javad, Porter, Dale A., Rejtar, Tomas, Wang, Y. Karen, Kryukov, Gregory V., Stegmeier, Frank, Erickson, Brian K., Garraway, Levi A., Sellers, William R., Gygi, Steven P.
Published in Cell (23.01.2020)
Published in Cell (23.01.2020)
Get full text
Journal Article
Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition
Hata, Aaron N, Niederst, Matthew J, Archibald, Hannah L, Gomez-Caraballo, Maria, Siddiqui, Faria M, Mulvey, Hillary E, Maruvka, Yosef E, Ji, Fei, Bhang, Hyo-eun C, Krishnamurthy Radhakrishna, Viveksagar, Siravegna, Giulia, Hu, Haichuan, Raoof, Sana, Lockerman, Elizabeth, Kalsy, Anuj, Lee, Dana, Keating, Celina L, Ruddy, David A, Damon, Leah J, Crystal, Adam S, Costa, Carlotta, Piotrowska, Zofia, Bardelli, Alberto, Iafrate, Anthony J, Sadreyev, Ruslan I, Stegmeier, Frank, Getz, Gad, Sequist, Lecia V, Faber, Anthony C, Engelman, Jeffrey A
Published in Nature medicine (01.03.2016)
Published in Nature medicine (01.03.2016)
Get full text
Journal Article
Studying clonal dynamics in response to cancer therapy using high-complexity barcoding
Bhang, Hyo-eun C, Ruddy, David A, Krishnamurthy Radhakrishna, Viveksagar, Caushi, Justina X, Zhao, Rui, Hims, Matthew M, Singh, Angad P, Kao, Iris, Rakiec, Daniel, Shaw, Pamela, Balak, Marissa, Raza, Alina, Ackley, Elizabeth, Keen, Nicholas, Schlabach, Michael R, Palmer, Michael, Leary, Rebecca J, Chiang, Derek Y, Sellers, William R, Michor, Franziska, Cooke, Vesselina G, Korn, Joshua M, Stegmeier, Frank
Published in Nature medicine (01.05.2015)
Published in Nature medicine (01.05.2015)
Get full text
Journal Article
An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide)
Korpal, Manav, Korn, Joshua M, Gao, Xueliang, Rakiec, Daniel P, Ruddy, David A, Doshi, Shivang, Yuan, Jing, Kovats, Steve G, Kim, Sunkyu, Cooke, Vesselina G, Monahan, John E, Stegmeier, Frank, Roberts, Thomas M, Sellers, William R, Zhou, Wenlai, Zhu, Ping
Published in Cancer discovery (01.09.2013)
Published in Cancer discovery (01.09.2013)
Get full text
Journal Article
CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions
Munoz, Diana M, Cassiani, Pamela J, Li, Li, Billy, Eric, Korn, Joshua M, Jones, Michael D, Golji, Javad, Ruddy, David A, Yu, Kristine, McAllister, Gregory, DeWeck, Antoine, Abramowski, Dorothee, Wan, Jessica, Shirley, Matthew D, Neshat, Sarah Y, Rakiec, Daniel, de Beaumont, Rosalie, Weber, Odile, Kauffmann, Audrey, McDonald, 3rd, E Robert, Keen, Nicholas, Hofmann, Francesco, Sellers, William R, Schmelzle, Tobias, Stegmeier, Frank, Schlabach, Michael R
Published in Cancer discovery (01.08.2016)
Published in Cancer discovery (01.08.2016)
Get full text
Journal Article
KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer
Krall, Elsa B, Wang, Belinda, Munoz, Diana M, Ilic, Nina, Raghavan, Srivatsan, Niederst, Matthew J, Yu, Kristine, Ruddy, David A, Aguirre, Andrew J, Kim, Jong Wook, Redig, Amanda J, Gainor, Justin F, Williams, Juliet A, Asara, John M, Doench, John G, Janne, Pasi A, Shaw, Alice T, McDonald Iii, Robert E, Engelman, Jeffrey A, Stegmeier, Frank, Schlabach, Michael R, Hahn, William C
Published in eLife (01.02.2017)
Published in eLife (01.02.2017)
Get full text
Journal Article
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
Hoffman, Gregory R., Rahal, Rami, Buxton, Frank, Xiang, Kay, McAllister, Gregory, Frias, Elizabeth, Bagdasarian, Linda, Huber, Janina, Lindeman, Alicia, Chen, Dongshu, Romero, Rodrigo, Ramadan, Nadire, Phadke, Tanushree, Haas, Kristy, Jaskelioff, Mariela, Wilson, Boris G., Meyer, Matthew J., Saenz-Vash, Veronica, Zhai, Huili, Myer, Vic E., Porter, Jeffrey A., Keen, Nicholas, McLaughlin, Margaret E., Mickanin, Craig, Roberts, Charles W. M., Stegmeier, Frank, Jagani, Zainab
Published in Proceedings of the National Academy of Sciences - PNAS (25.02.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (25.02.2014)
Get full text
Journal Article
PTEN-deficient cancers depend on PIK3CB
Wee, Susan, Wiederschain, Dmitri, Maira, Sauveur-Michel, Loo, Alice, Miller, Christine, deBeaumont, Rosalie, Stegmeier, Frank, Yao, Yung-Mae, Lengauer, Christoph
Published in Proceedings of the National Academy of Sciences - PNAS (02.09.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (02.09.2008)
Get full text
Journal Article
PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers
Wee, Susan, Jagani, Zainab, Xiang, Kay Xiaoqin, Loo, Alice, Dorsch, Marion, Yao, Yung-Mae, Sellers, William R, Lengauer, Christoph, Stegmeier, Frank
Published in Cancer research (Chicago, Ill.) (15.05.2009)
Published in Cancer research (Chicago, Ill.) (15.05.2009)
Get full text
Journal Article
MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells
Wang, Yubao, Lee, Young-Mi, Baitsch, Lukas, Huang, Alan, Xiang, Yi, Tong, Haoxuan, Lako, Ana, Von, Thanh, Choi, Christine, Lim, Elgene, Min, Junxia, Li, Li, Stegmeier, Frank, Schlegel, Robert, Eck, Michael J, Gray, Nathanael S, Mitchison, Timothy J, Zhao, Jean J
Published in eLife (20.05.2014)
Published in eLife (20.05.2014)
Get full text
Journal Article
Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia
Jaffe, Jacob D, Wang, Yan, Chan, Ho Man, Zhang, Jinghui, Huether, Robert, Kryukov, Gregory V, Bhang, Hyo-eun C, Taylor, Jordan E, Hu, Min, Englund, Nathan P, Yan, Feng, Wang, Zhaofu, Robert McDonald, E, Wei, Lei, Ma, Jing, Easton, John, Yu, Zhengtian, deBeaumount, Rosalie, Gibaja, Veronica, Venkatesan, Kavitha, Schlegel, Robert, Sellers, William R, Keen, Nicholas, Liu, Jun, Caponigro, Giordano, Barretina, Jordi, Cooke, Vesselina G, Mullighan, Charles, Carr, Steven A, Downing, James R, Garraway, Levi A, Stegmeier, Frank
Published in Nature genetics (01.11.2013)
Published in Nature genetics (01.11.2013)
Get full text
Journal Article
A Lentiviral MicroRNA-Based System for Single-Copy Polymerase II-Regulated RNA Interference in Mammalian Cells
Stegmeier, Frank, Hu, Guang, Rickles, Richard J., Hannon, Gregory J., Elledge, Stephen J.
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2005)
Get full text
Journal Article
Inhibition of Casein Kinase 1 Alpha Prevents Acquired Drug Resistance to Erlotinib in EGFR-Mutant Non-Small Cell Lung Cancer
Lantermann, Alexandra B, Chen, Dongshu, McCutcheon, Kaitlin, Hoffman, Greg, Frias, Elizabeth, Ruddy, David, Rakiec, Daniel, Korn, Joshua, McAllister, Gregory, Stegmeier, Frank, Meyer, Matthew J, Sharma, Sreenath V
Published in Cancer research (Chicago, Ill.) (15.11.2015)
Published in Cancer research (Chicago, Ill.) (15.11.2015)
Get full text
Journal Article
Clonal populations of a human TNBC model display significant functional heterogeneity and divergent growth dynamics in distinct contexts
Kuiken, Hendrik J., Dhakal, Sabin, Selfors, Laura M., Friend, Chandler M., Zhang, Tian, Callari, Maurizio, Schackmann, Ron C. J., Gray, G. Kenneth, Crowdis, Jett, Bhang, Hyo-eun C., Baslan, Timour, Stegmeier, Frank, Gygi, Steven P., Caldas, Carlos, Brugge, Joan S.
Published in Oncogene (03.01.2022)
Published in Oncogene (03.01.2022)
Get full text
Journal Article
Protein Kinase C Inhibitor Sotrastaurin Selectively Inhibits the Growth of CD79 Mutant Diffuse Large B-Cell Lymphomas
NAYLOR, Tara L, HUAPING TANG, YAO, Yung-Mae, WARMUTH, Markus, LENZ, Georg, STEGMEIER, Frank, RATSCH, Boris A, ENNS, Andreas, LOO, Alice, LIQING CHEN, LENZ, Peter, WATERS, Nigel J, SCHULER, Walter, DÖRKEN, Bernd
Published in Cancer research (Chicago, Ill.) (01.04.2011)
Published in Cancer research (Chicago, Ill.) (01.04.2011)
Get full text
Journal Article
Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/β-catenin signaling
Scholer-Dahirel, Alix, Schlabach, Michael R, Loo, Alice, Bagdasarian, Linda, Meyer, Ronald, Guo, Ribo, Woolfenden, Steve, Yu, Kristine K, Markovits, Judit, Killary, Karen, Sonkin, Dmitry, Yao, Yung-Mae, Warmuth, Markus, Sellers, William R, Schlegel, Robert, Stegmeier, Frank, Mosher, Rebecca E, McLaughlin, Margaret E
Published in Proceedings of the National Academy of Sciences - PNAS (11.10.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (11.10.2011)
Get full text
Journal Article
tumor suppressor CYLD regulates entry into mitosis
Stegmeier, Frank, Sowa, Mathew E, Nalepa, Grzegorz, Gygi, Steven P, Harper, J. Wade, Elledge, Stephen J
Published in Proceedings of the National Academy of Sciences - PNAS (22.05.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (22.05.2007)
Get full text
Journal Article
Correction: MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells
Wang, Yubao, Li, Young-Mi, Baitsch, Lukas, Huang, Alan, Xiang, Yi, Tong, Haoxuan, Lako, Ana, Von, Thanh, Choi, Christine, Lim, Elgene, Min, Junxia, Li, Li, Stegmeier, Frank, Schlegel, Robert, Eck, Michael J, Gray, Nathanael S, Mitchison, Timothy J, Zhao, Jean J
Published in eLife (12.03.2018)
Published in eLife (12.03.2018)
Get full text
Journal Article