Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease
McQuade, Amanda, Kang, You Jung, Hasselmann, Jonathan, Jairaman, Amit, Sotelo, Alexandra, Coburn, Morgan, Shabestari, Sepideh Kiani, Chadarevian, Jean Paul, Fote, Gianna, Tu, Christina H., Danhash, Emma, Silva, Jorge, Martinez, Eric, Cotman, Carl, Prieto, G. Aleph, Thompson, Leslie M., Steffan, Joan S., Smith, Ian, Davtyan, Hayk, Cahalan, Michael, Cho, Hansang, Blurton-Jones, Mathew
Published in Nature communications (23.10.2020)
Published in Nature communications (23.10.2020)
Get full text
Journal Article
Potential function for the Huntingtin protein as a scaffold for selective autophagy
Ochaba, Joseph, Lukacsovich, Tamás, Csikos, George, Zheng, Shuqiu, Margulis, Julia, Salazar, Lisa, Mao, Kai, Lau, Alice L., Yeung, Sylvia Y., Humbert, Sandrine, Saudou, Frédéric, Klionsky, Daniel J., Finkbeiner, Steven, Zeitlin, Scott O., Marsh, J. Lawrence, Housman, David E., Thompson, Leslie M., Steffan, Joan S.
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.2014)
Get full text
Journal Article
PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo
Ochaba, Joseph, Monteys, Alex Mas, O’Rourke, Jacqueline G., Reidling, Jack C., Steffan, Joan S., Davidson, Beverly L., Thompson, Leslie M.
Published in Neuron (Cambridge, Mass.) (04.05.2016)
Published in Neuron (Cambridge, Mass.) (04.05.2016)
Get full text
Journal Article
Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice
Gu, Xiaofeng, Greiner, Erin R., Mishra, Rakesh, Kodali, Ravindra, Osmand, Alex, Finkbeiner, Steven, Steffan, Joan S., Thompson, Leslie Michels, Wetzel, Ronald, Yang, X. William
Published in Neuron (Cambridge, Mass.) (24.12.2009)
Published in Neuron (Cambridge, Mass.) (24.12.2009)
Get full text
Journal Article
Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau
Green, Kim N, Steffan, Joan S, Martinez-Coria, Hilda, Sun, Xuemin, Schreiber, Steven S, Thompson, Leslie Michels, LaFerla, Frank M
Published in The Journal of neuroscience (05.11.2008)
Published in The Journal of neuroscience (05.11.2008)
Get full text
Journal Article
Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice
Di Pardo, Alba, Maglione, Vittorio, Alpaugh, Melanie, Horkey, Melanie, Atwal, Randy S, Sassone, Jenny, Ciammola, Andrea, Steffan, Joan S, Fouad, Karim, Truant, Ray, Sipione, Simonetta
Published in Proceedings of the National Academy of Sciences - PNAS (28.02.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (28.02.2012)
Get full text
Journal Article
Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease
Pallos, Judit, Bodai, Laszlo, Lukacsovich, Tamas, Purcell, Judith M., Steffan, Joan S., Thompson, Leslie Michels, Marsh, J. Lawrence
Published in Human molecular genetics (01.12.2008)
Published in Human molecular genetics (01.12.2008)
Get full text
Journal Article
SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation
O’Rourke, Jacqueline Gire, Gareau, Jaclyn R., Ochaba, Joseph, Song, Wan, Raskó, Tamás, Reverter, David, Lee, John, Monteys, Alex Mas, Pallos, Judit, Mee, Lisa, Vashishtha, Malini, Apostol, Barbara L., Nicholson, Thomas Peter, Illes, Katalin, Zhu, Ya-Zhen, Dasso, Mary, Bates, Gillian P., Difiglia, Marian, Davidson, Beverly, Wanker, Erich E., Marsh, J. Lawrence, Lima, Christopher D., Steffan, Joan S., Thompson, Leslie M.
Published in Cell reports (Cambridge) (25.07.2013)
Published in Cell reports (Cambridge) (25.07.2013)
Get full text
Journal Article
Author Correction: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease
McQuade, Amanda, Kang, You Jung, Hasselmann, Jonathan, Jairaman, Amit, Sotelo, Alexandra, Coburn, Morgan, Shabestari, Sepideh Kiani, Chadarevian, Jean Paul, Fote, Gianna, Tu, Christina H., Danhash, Emma, Silva, Jorge, Martinez, Eric, Cotman, Carl, Prieto, G. Aleph, Thompson, Leslie M., Steffan, Joan S., Smith, Ian, Davtyan, Hayk, Cahalan, Michael, Cho, Hansang, Blurton-Jones, Mathew
Published in Nature communications (02.03.2023)
Published in Nature communications (02.03.2023)
Get full text
Journal Article
Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models
Schulze-Krebs, Anja, Canneva, Fabio, Stemick, Judith, Plank, Anne-Christine, Harrer, Julia, Bates, Gillian P, Aeschlimann, Daniel, Steffan, Joan S, von Hörsten, Stephan
Published in International journal of molecular sciences (18.08.2021)
Published in International journal of molecular sciences (18.08.2021)
Get full text
Journal Article
Serine 421 regulates mutant huntingtin toxicity and clearance in mice
Kratter, Ian H, Zahed, Hengameh, Lau, Alice, Tsvetkov, Andrey S, Daub, Aaron C, Weiberth, Kurt F, Gu, Xiaofeng, Saudou, Frédéric, Humbert, Sandrine, Yang, X William, Osmand, Alex, Steffan, Joan S, Masliah, Eliezer, Finkbeiner, Steven
Published in The Journal of clinical investigation (01.09.2016)
Published in The Journal of clinical investigation (01.09.2016)
Get full text
Journal Article
The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis
Rockabrand, Erica, Slepko, Natalia, Pantalone, Antonello, Nukala, Vidya N., Kazantsev, Aleksey, Marsh, J. Lawrence, Sullivan, Patrick G., Steffan, Joan S., Sensi, Stefano L., Thompson, Leslie Michels
Published in Human molecular genetics (01.01.2007)
Published in Human molecular genetics (01.01.2007)
Get full text
Journal Article
Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice
Reidling, Jack C., Relaño-Ginés, Aroa, Holley, Sandra M., Ochaba, Joseph, Moore, Cindy, Fury, Brian, Lau, Alice, Tran, Andrew H., Yeung, Sylvia, Salamati, Delaram, Zhu, Chunni, Hatami, Asa, Cepeda, Carlos, Barry, Joshua A., Kamdjou, Talia, King, Alvin, Coleal-Bergum, Dane, Franich, Nicholas R., LaFerla, Frank M., Steffan, Joan S., Blurton-Jones, Mathew, Meshul, Charles K., Bauer, Gerhard, Levine, Michael S., Chesselet, Marie-Francoise, Thompson, Leslie M.
Published in Stem cell reports (09.01.2018)
Published in Stem cell reports (09.01.2018)
Get full text
Journal Article
SUMO Modification of Huntingtin and Huntington'S Disease Pathology
Steffan, Joan S., Agrawal, Namita, Pallos, Judit, Rockabrand, Erica, Trotman, Lloyd C., Slepko, Natalia, Illes, Katalin, Lukacsovich, Tamas, Zhu, Ya-Zhen, Cattaneo, Elena, Pandolfi, Pier Paolo, Thompson, Leslie Michels, Marsh, J. Lawrence
Published in Science (American Association for the Advancement of Science) (02.04.2004)
Published in Science (American Association for the Advancement of Science) (02.04.2004)
Get full text
Journal Article
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
Thompson, Leslie M, Steffan, Joan S, Bodai, Laszlo, Pallos, Judit, Poelman, Marnix, McCampbell, Alexander, Apostol, Barbara L, Kazantsev, Alexsey, Schmidt, Emily, Zhu, Ya-Zhen, Greenwald, Marilee, Kurokawa, Riki, Housman, David E, Jackson, George R, Marsh, J. Lawrence
Published in Nature (London) (18.10.2001)
Published in Nature (London) (18.10.2001)
Get full text
Journal Article
Suberoylanilide Hydroxamic Acid, a Histone Deacetylase Inhibitor, Ameliorates Motor Deficits in a Mouse Model of Huntington's Disease
Hockly, Emma, Richon, Victoria M., Woodman, Benjamin, Smith, Donna L., Zhou, Xianbo, Rosa, Eddie, Sathasivam, Kirupa, Ghazi-Noori, Shabnam, Mahal, Amarbirpal, Philip A. S. Lowden, Steffan, Joan S., Marsh, J. Lawrence, Thompson, Leslie M., Lewis, Cathryn M., Marks, Paul A., Bates, Gillian P.
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2003)
Get full text
Journal Article