Sirtuin activators and inhibitors: Promises, achievements, and challenges
Dai, Han, Sinclair, David A., Ellis, James L., Steegborn, Clemens
Published in Pharmacology & therapeutics (Oxford) (01.08.2018)
Published in Pharmacology & therapeutics (Oxford) (01.08.2018)
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Journal Article
Sirt4: A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer
Tomaselli, Daniela, Steegborn, Clemens, Mai, Antonello, Rotili, Dante
Published in Frontiers in oncology (15.04.2020)
Published in Frontiers in oncology (15.04.2020)
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Journal Article
Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives
You, Weijie, Zheng, Wei, Weiss, Sandra, Chua, Katrin F, Steegborn, Clemens
Published in Scientific reports (16.12.2019)
Published in Scientific reports (16.12.2019)
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Journal Article
Ex-527 inhibits Sirtuins by exploiting their unique NAD⁺-dependent deacetylation mechanism
Gertz, Melanie, Fischer, Frank, Nguyen, Giang Thi Tuyet, Lakshminarasimhan, Mahadevan, Schutkowski, Mike, Weyand, Michael, Steegborn, Clemens
Published in Proceedings of the National Academy of Sciences - PNAS (23.07.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (23.07.2013)
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Journal Article
Crystal structure analysis of human Sirt2 and its ADP-ribose complex
Moniot, Sébastien, Schutkowski, Mike, Steegborn, Clemens
Published in Journal of structural biology (01.05.2013)
Published in Journal of structural biology (01.05.2013)
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Journal Article
Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features
Pannek, Martin, Simic, Zeljko, Fuszard, Matthew, Meleshin, Marat, Rotili, Dante, Mai, Antonello, Schutkowski, Mike, Steegborn, Clemens
Published in Nature communications (15.11.2017)
Published in Nature communications (15.11.2017)
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Journal Article
Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5
Schlicker, Christine, Gertz, Melanie, Papatheodorou, Panagiotis, Kachholz, Barbara, Becker, Christian F.W., Steegborn, Clemens
Published in Journal of molecular biology (10.10.2008)
Published in Journal of molecular biology (10.10.2008)
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Journal Article
Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism
Schweizer, Ulrich, Schlicker, Christine, Braun, Doreen, Köhrle, Josef, Steegborn, Clemens
Published in Proceedings of the National Academy of Sciences - PNAS (22.07.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (22.07.2014)
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Journal Article
A molecular mechanism for direct sirtuin activation by resveratrol
Gertz, Melanie, Nguyen, Giang Thi Tuyet, Fischer, Frank, Suenkel, Benjamin, Schlicker, Christine, Fränzel, Benjamin, Tomaschewski, Jana, Aladini, Firouzeh, Becker, Christian, Wolters, Dirk, Steegborn, Clemens
Published in PloS one (21.11.2012)
Published in PloS one (21.11.2012)
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Journal Article
SIRT5 regulation of ammonia-induced autophagy and mitophagy
Polletta, Lucia, Vernucci, Enza, Carnevale, Ilaria, Arcangeli, Tania, Rotili, Dante, Palmerio, Silvia, Steegborn, Clemens, Nowak, Theresa, Schutkowski, Mike, Pellegrini, Laura, Sansone, Luigi, Villanova, Lidia, Runci, Alessandra, Pucci, Bruna, Morgante, Emanuela, Fini, Massimo, Mai, Antonello, Russo, Matteo A, Tafani, Marco
Published in Autophagy (01.02.2015)
Published in Autophagy (01.02.2015)
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Journal Article
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site
Rumpf, Tobias, Schiedel, Matthias, Karaman, Berin, Roessler, Claudia, North, Brian J, Lehotzky, Attila, Oláh, Judit, Ladwein, Kathrin I, Schmidtkunz, Karin, Gajer, Markus, Pannek, Martin, Steegborn, Clemens, Sinclair, David A, Gerhardt, Stefan, Ovádi, Judit, Schutkowski, Mike, Sippl, Wolfgang, Einsle, Oliver, Jung, Manfred
Published in Nature communications (12.02.2015)
Published in Nature communications (12.02.2015)
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Journal Article
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate
Kleinboelting, Silke, Diaz, Ana, Moniot, Sebastien, van den Heuvel, Joop, Weyand, Michael, Levin, Lonny R., Buck, Jochen, Steegborn, Clemens
Published in Proceedings of the National Academy of Sciences - PNAS (11.03.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (11.03.2014)
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Journal Article
On-demand male contraception via acute inhibition of soluble adenylyl cyclase
Balbach, Melanie, Rossetti, Thomas, Ferreira, Jacob, Ghanem, Lubna, Ritagliati, Carla, Myers, Robert W, Huggins, David J, Steegborn, Clemens, Miranda, Ileana C, Meinke, Peter T, Buck, Jochen, Levin, Lonny R
Published in Nature communications (14.02.2023)
Published in Nature communications (14.02.2023)
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Journal Article
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
de Oliveira, Rita Machado, Vicente Miranda, Hugo, Francelle, Laetitia, Pinho, Raquel, Szegö, Éva M, Martinho, Renato, Munari, Francesca, Lázaro, Diana F, Moniot, Sébastien, Guerreiro, Patrícia, Fonseca-Ornelas, Luis, Marijanovic, Zrinka, Antas, Pedro, Gerhardt, Ellen, Enguita, Francisco Javier, Fauvet, Bruno, Penque, Deborah, Pais, Teresa Faria, Tong, Qiang, Becker, Stefan, Kügler, Sebastian, Lashuel, Hilal Ahmed, Steegborn, Clemens, Zweckstetter, Markus, Outeiro, Tiago Fleming
Published in PLoS biology (03.03.2017)
Published in PLoS biology (03.03.2017)
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