Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies
Steckel, Michael, Molina-Arcas, Miriam, Weigelt, Britta, Marani, Michaela, Warne, Patricia H, Kuznetsov, Hanna, Kelly, Gavin, Saunders, Becky, Howell, Michael, Downward, Julian, Hancock, David C
Published in Cell research (01.08.2012)
Published in Cell research (01.08.2012)
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Journal Article
The GATA2 Transcriptional Network Is Requisite for RAS Oncogene-Driven Non-Small Cell Lung Cancer
Kumar, Madhu S., Hancock, David C., Molina-Arcas, Miriam, Steckel, Michael, East, Phillip, Diefenbacher, Markus, Armenteros-Monterroso, Elena, Lassailly, François, Matthews, Nik, Nye, Emma, Stamp, Gordon, Behrens, Axel, Downward, Julian
Published in Cell (27.04.2012)
Published in Cell (27.04.2012)
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Journal Article
Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia
Brzezinka, Krzysztof, Nevedomskaya, Ekaterina, Lesche, Ralf, Steckel, Michael, Eheim, Ashley L, Haegebarth, Andrea, Stresemann, Carlo
Published in Journal of hematology and oncology (28.06.2019)
Published in Journal of hematology and oncology (28.06.2019)
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Journal Article
Functional inhibition of acid sphingomyelinase by Fluphenazine triggers hypoxia-specific tumor cell death
Klutzny, Saskia, Lesche, Ralf, Keck, Matthias, Kaulfuss, Stefan, Schlicker, Andreas, Christian, Sven, Sperl, Carolyn, Neuhaus, Roland, Mowat, Jeffrey, Steckel, Michael, Riefke, Björn, Prechtl, Stefan, Parczyk, Karsten, Steigemann, Patrick
Published in Cell death & disease (30.03.2017)
Published in Cell death & disease (30.03.2017)
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Journal Article
Identification of Small Molecules that Modulate Mutant p53 Condensation
Lemos, Clara, Schulze, Luise, Weiske, Joerg, Meyer, Hanna, Braeuer, Nico, Barak, Naomi, Eberspächer, Uwe, Werbeck, Nicolas, Stresemann, Carlo, Lange, Martin, Lesche, Ralf, Zablowsky, Nina, Juenemann, Katrin, Kamburov, Atanas, Luh, Laura Martina, Leissing, Thomas Markus, Mortier, Jeremie, Steckel, Michael, Steuber, Holger, Eis, Knut, Eheim, Ashley, Steigemann, Patrick
Published in iScience (25.09.2020)
Published in iScience (25.09.2020)
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Journal Article
Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis
Ding, Zhaobing, Ericksen, Russell E., Escande-Beillard, Nathalie, Lee, Qian Yi, Loh, Abigail, Denil, Simon, Steckel, Michael, Haegebarth, Andrea, Wai Ho, Timothy Shen, Chow, Pierce, Toh, Han Chong, Reversade, Bruno, Gruenewald, Sylvia, Han, Weiping
Published in Journal of hepatology (01.04.2020)
Published in Journal of hepatology (01.04.2020)
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Journal Article
Abstract 3790: Targeting the one-carbon metabolism protein MTHFD2 for cancer therapy: Exploiting the unique redox status of cancer cells
Glasauer, Andrea, Steckel, Michael, Haegebarth, Andrea, Bauser, Marcus, Toschi, Luisella
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 3477: Metabolic pathway analyses identify proline biosynthesis as a promoter of liver carcinogenesis
Ding, Zhaobing, Ericksen, Russell E., Steckel, Michael, Haegebarth, Andrea, Gruenewald, Sylvia, Han, Weiping
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
Shim, Jae-Hyuck, Xiao, Changchun, Paschal, Amber E, Bailey, Shannon T, Rao, Ping, Hayden, Matthew S, Lee, Ki-Young, Bussey, Crystal, Steckel, Michael, Tanaka, Nobuyuki, Yamada, Gen, Akira, Shizuo, Matsumoto, Kunihiro, Ghosh, Sankar
Published in Genes & development (15.11.2005)
Published in Genes & development (15.11.2005)
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Journal Article
Abstract 4460: Targeting the redox-protective protein MTH1 for cancer therapy: A novel way to exploit the unique redox status of cancer cells
Glasauer, Andrea, Irlbacher, Horst, Richter, Anja, Toschi, Luisella, Steckel, Michael, Haegebarth, Andrea
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract 4163: Determination of synthetic lethal interactions in KRAS oncogene dependent cancer cells reveals novel therapeutic targeting strategies
Molina-Arcas, Miriam, Hancock, David, Steckel, Michael, Downward, Julian
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Functional Genomics in Pharmaceutical Drug Discovery
Adams, Robert, Steckel, Michael, Nicke, Barbara
Published in Handbook of experimental pharmacology (01.01.2016)
Published in Handbook of experimental pharmacology (01.01.2016)
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Journal Article
Abstract 3355: Inhibiting glyoxylase 1 as a strategy to target highly glycolytic cancer cells
Gruenewald, Sylvia, Steckel, Michael, Timmermann, Andreas, Rehwinkel, Hartmut, Steigemann, Patrick, Zacharias, Sylvia, Walter, Alexander, Bauser, Marcus, Haegebarth, Andrea
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Abstract 1163: Phosphoserine aminotransferase 1 (PSAT1) as a novel anti-tumor target in hepatocellular carcinoma
Ding, Zhaobing, Wee, Kenneth, Kim, Eung-Sam, Samanta, Animesh, Steckel, Michael, Raschke, Marian, Velan, Sendhil, Chang, Young-Tae, Haegebarth, Andrea, Ziegelbauer, Karl, Gruenewald, Sylvia, Han, Weiping
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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