Studies on Cytochrome P-450-Mediated Bioactivation of Diclofenac in Rats and in Human Hepatocytes: Identification of Glutathione Conjugated Metabolites
WEI TANG, STEARNS, R. A, STRAUSS, J. R, KWEI, G. Y, RUSHMORE, T. H, CHIU, S.-H. L, BAILLIE, T. A, BANDIERA, S. M, YONG ZHANG, RAAB, C, BRAUN, M. P, DEAN, D. C, JIANMEI PANG, LEUNG, K. H, DOSS, G. A
Published in Drug metabolism and disposition (01.03.1999)
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Published in Drug metabolism and disposition (01.03.1999)
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Bioactivation of diclofenac via benzoquinone imine intermediates-identification of urinary mercapturic acid derivatives in rats and humans
POON, Grace K, QING CHEN, BAILLIE, Thomas A, WEI TANG, TEFFERA, Yohannes, NGUI, Jason S, GRIFFIN, Patrick R, BRAUN, Mathew P, DOSS, George A, FREEDEN, Christopher, STEARNS, Ralph A, EVANS, David C
Published in Drug metabolism and disposition (01.12.2001)
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Published in Drug metabolism and disposition (01.12.2001)
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Influence of different recombinant systems on the cooperativity exhibited by cytochrome P4503A4
Zhang, Z., Li, Y., Shou, M., Zhang, Y., Ngui, J. S., Stearns, R. A., Evans, D. C., Baillie, T. A., Tang, W.
Published in Xenobiotica (01.05.2004)
Published in Xenobiotica (01.05.2004)
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Metabolites of L-735,524, a potent HIV-1 protease inhibitor, in human urine
Balani, S K, Arison, B H, Mathai, L, Kauffman, L R, Miller, R R, Stearns, R A, Chen, I W, Lin, J H
Published in Drug metabolism and disposition (01.02.1995)
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Published in Drug metabolism and disposition (01.02.1995)
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Determination of brain and plasma drug concentrations by liquid chromatography/tandem mass spectrometry
Tamvakopoulos, C. S., Colwell, L. F., Barakat, K., Fenyk-Melody, J., Griffin, P. R., Nargund, R., Palucki, B., Sebhat, I., Shen, X., Stearns, R. A.
Published in Rapid communications in mass spectrometry (01.01.2000)
Published in Rapid communications in mass spectrometry (01.01.2000)
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Metabolic activation of a pentafluorophenylethylamine derivative: Formation of glutathione conjugates in vitro in the rat
Shang, J., Xu, S., Teffera, Y., Doss, G. A., Stearns, R. A., Edmonson, S., Beconi, M. G.
Published in Xenobiotica (01.07.2005)
Published in Xenobiotica (01.07.2005)
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Disposition of L-732,531, a Potent Immunosuppressant, in Rats and Baboons
KARANAM, B. V, MILLER, R. R, VINCENT, S. H, COLLETTI, A, MONTGOMERY, T, CAREY, K. D, HAWKINS, T, TANG, Y. S, LAVIN, M, STEARNS, R. A, CHIU, S. H. L
Published in Drug metabolism and disposition (01.10.1998)
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Published in Drug metabolism and disposition (01.10.1998)
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In vitro and in vivo metabolism of a novel cannabinoid-1 receptor inverse agonist, taranabant, in rats and monkeys
Reddy, V.B.G., Doss, G.A., Karanam, B.V., Samuel, K., Lanza Jr, T.J., Lin, L.S., Yu, N.X., Zhang, A.S., Raab, C.E., Stearns, R.A., Kumar, S.
Published in Xenobiotica (01.09.2010)
Published in Xenobiotica (01.09.2010)
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Journal Article
Cytochrome P450 3A4-Mediated Bioactivation of Raloxifene: Irreversible Enzyme Inhibition and Thiol Adduct Formation
Chen, Qing, Ngui, Jason S, Doss, George A, Wang, Regina W, Cai, Xiaoxin, DiNinno, Frank P, Blizzard, Timothy A, Hammond, Milton L, Stearns, Ralph A, Evans, David C, Baillie, Thomas A, Tang, Wei
Published in Chemical research in toxicology (01.07.2002)
Published in Chemical research in toxicology (01.07.2002)
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Evidence for a novel heme adduct generated by the in vitro reaction of 2,4,6-trinitrotoluene with human hemoglobin using electrospray ionization mass spectrometry
Bakbtiar, R., Leung, K.H., Stearns, R.A., Hop, C.E.C.A.
Published in Journal of inorganic biochemistry (01.12.1997)
Published in Journal of inorganic biochemistry (01.12.1997)
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Importance of mechanistic drug metabolism studies in support of drug discovery: A case study with an N -sulfonylated dipeptide VLA-4 antagonist in rats
Tang, W., Stearns, R. A., Chen, Q., Bleasby, K., Teffera, Y., Colletti, A., Hafey, M., Evers, R., Dean, D. C., Magriotis, P. A., Lanza, T. J., Lin, L. S., Hagmann, W. K., Baillie, T. A.
Published in Xenobiotica (01.02.2008)
Published in Xenobiotica (01.02.2008)
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In Vitro Bioactivation of Dihydrobenzoxathiin Selective Estrogen Receptor Modulators by Cytochrome P450 3A4 in Human Liver Microsomes: Formation of Reactive Iminium and Quinone Type Metabolites
Zhang, Zhoupeng, Chen, Qing, Li, Ying, Doss, George A, Dean, Brian J, Ngui, Jason S, Silva Elipe, Maria, Kim, Seongkon, Wu, Jane Y, DiNinno, Frank, Hammond, Milton L, Stearns, Ralph A, Evans, David C, Baillie, Thomas A, Tang, Wei
Published in Chemical research in toxicology (01.04.2005)
Published in Chemical research in toxicology (01.04.2005)
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The role of drug metabolism in drug discovery: a case study in the selection of an oxytocin receptor antagonist for development
Chiu, S H, Thompson, K A, Vincent, S H, Alvaro, R F, Huskey, S W, Stearns, R A, Pettibone, D J
Published in Toxicologic pathology (01.03.1995)
Published in Toxicologic pathology (01.03.1995)
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Evidence for a 1,2-hydride shift in the microsomal metabolism of the heterocycle L-158,338, a nonpeptide angiotensin II receptor antagonist
Stearns, R A, Miller, R R, Arison, B H, Rosegay, A, Smith, J L, Mantlo, N B, Chiu, S H
Published in Drug metabolism and disposition (01.07.1993)
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Published in Drug metabolism and disposition (01.07.1993)
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