Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: A randomized clinical trial
Kelsen, Steven G., Agache, Ioana O., Soong, Weily, Israel, Elliot, Chupp, Geoffrey L., Cheung, Dorothy S., Theess, Wiebke, Yang, Xiaoying, Staton, Tracy L., Choy, David F., Fong, Alice, Dash, Ajit, Dolton, Michael, Pappu, Rajita, Brightling, Christopher E.
Published in Journal of allergy and clinical immunology (01.09.2021)
Published in Journal of allergy and clinical immunology (01.09.2021)
Get full text
Journal Article
A targeted amplicon next-generation sequencing assay for tryptase genotyping to support personalized therapy in mast cell-related disorders
Li, Olga, Hackney, Jason A, Choy, David F, Chang, Diana, Nersesian, Rhea, Staton, Tracy L, Cai, Fang, Toghi Eshghi, Shadi
Published in PloS one (09.02.2024)
Published in PloS one (09.02.2024)
Get full text
Journal Article
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma
Maun, Henry R., Jackman, Janet K., Choy, David F., Loyet, Kelly M., Staton, Tracy L., Jia, Guiquan, Dressen, Amy, Hackney, Jason A., Bremer, Meire, Walters, Benjamin T., Vij, Rajesh, Chen, Xiaocheng, Trivedi, Neil N., Morando, Ashley, Lipari, Michael T., Franke, Yvonne, Wu, Xiumin, Zhang, Juan, Liu, John, Wu, Ping, Chang, Diana, Orozco, Luz D., Christensen, Erin, Wong, Manda, Corpuz, Racquel, Hang, Julie Q., Lutman, Jeff, Sukumaran, Siddharth, Wu, Yan, Ubhayakar, Savita, Liang, Xiaorong, Schwartz, Lawrence B., Babina, Magda, Woodruff, Prescott G., Fahy, John V., Ahuja, Rahul, Caughey, George H., Kusi, Aija, Dennis, Mark S., Eigenbrot, Charles, Kirchhofer, Daniel, Austin, Cary D., Wu, Lawren C., Koerber, James T., Lee, Wyne P., Yaspan, Brian L., Alatsis, Kathila R., Arron, Joseph R., Lazarus, Robert A., Yi, Tangsheng
Published in Cell (03.10.2019)
Published in Cell (03.10.2019)
Get full text
Journal Article
Airway tryptase levels inform the lack of clinical efficacy of the tryptase inhibitor MTPS9579A in asthma
Rhee, Horace, Henderson, Lindsay M, Bauer, Rebecca N, Wong, Kit, Staton, Tracy L, Choy, David F, Banerjee, Prajna, Poon, Victor, Yoshida, Kenta, Chen, Chen, Long, Keyi, Sperinde, Gizette, Laing, Steven T, Jones, Nicholas S, Glickstein, Sara B, Dayal, Parul, Fong, Alice, Dash, Ajit, Pulka, Grazyna, Leaker, Brian, Singh, Dave, Bradding, Peter
Published in Allergy (Copenhagen) (09.09.2024)
Published in Allergy (Copenhagen) (09.09.2024)
Get full text
Journal Article
Seasonal Variability of Severe Asthma Exacerbations and Clinical Benefit from Lebrikizumab
Staton, Tracy L., PhD, Arron, Joseph R., MD, PhD, Olsson, Julie, MD, MS, Holweg, Cécile TJ., PhD, Matthews, John G., MB, BS, PhD, Choy, David F., BS
Published in Journal of allergy and clinical immunology (01.05.2017)
Published in Journal of allergy and clinical immunology (01.05.2017)
Get full text
Journal Article
Nod/Ripk2 signaling in dendritic cells activates IL-17A–secreting innate lymphoid cells and drives colitis in T-bet⁻/⁻.Rag2⁻/⁻ (TRUC) mice
Ermann, Joerg, Staton, Tracy, Glickman, Jonathan N, de Waal Malefyt, Rene, Glimcher, Laurie H
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2014)
Get full text
Journal Article
A whole genome sequencing study of moderate to severe asthma identifies a lung function locus associated with asthma risk
Chang, Diana, Hunkapiller, Julie, Bhangale, Tushar, Reeder, Jens, Mukhyala, Kiran, Tom, Jennifer, Cowgill, Amy, Vogel, Jan, Forrest, William F., Khan, Zia, Stockwell, Amy, McCarthy, Mark I., Staton, Tracy L., Olsson, Julie, Holweg, Cecile T. J., Cheung, Dorothy S., Chen, Hubert, Brauer, Matthew J., Graham, Robert R., Behrens, Timothy, Wilson, Mark S., Arron, Joseph R., Choy, David F., Yaspan, Brian L.
Published in Scientific reports (02.04.2022)
Published in Scientific reports (02.04.2022)
Get full text
Journal Article
Measurement of IL-17AA and IL-17FF as Pharmacodynamic Biomarkers to Demonstrate Target Engagement in the Phase I Study of MCAF5352A
Peng, Kun, Wang, Yehong, Siradze, Ketevan, Erickson, Rich, Fischer, Saloumeh K., Staton, Tracy L.
Published in The AAPS journal (01.01.2019)
Published in The AAPS journal (01.01.2019)
Get full text
Journal Article
The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells
Glimcher, Laurie H, Lazarevic, Vanja, Zullo, Alfred J, Gallo, Elena M, Crabtree, Gerald R, Staton, Tracy L, Schweitzer, Michelle N
Published in Nature immunology (01.03.2009)
Published in Nature immunology (01.03.2009)
Get full text
Journal Article
A phase I, randomized, observer-blinded, single and multiple ascending-dose study to investigate the safety, pharmacokinetics, and immunogenicity of BITS7201A, a bispecific antibody targeting IL-13 and IL-17, in healthy volunteers
Staton, Tracy L, Peng, Kun, Owen, Ryan, Choy, David F, Cabanski, Christopher R, Fong, Alice, Brunstein, Flavia, Alatsis, Kathila R, Chen, Hubert
Published in BMC pulmonary medicine (07.01.2019)
Published in BMC pulmonary medicine (07.01.2019)
Get full text
Journal Article
A mechanistic PK/PD model to enable dose selection of the potent anti‐tryptase antibody (MTPS9579A) in patients with moderate‐to‐severe asthma
Rymut, Sharon M., Henderson, Lindsay M., Poon, Victor, Staton, Tracy L., Cai, Fang, Sukumaran, Siddharth, Rhee, Horace, Owen, Ryan, Ramanujan, Saroja, Yoshida, Kenta
Published in Clinical and translational science (01.04.2023)
Published in Clinical and translational science (01.04.2023)
Get full text
Journal Article
Dose‐dependent inactivation of airway tryptase with a novel dissociating anti‐tryptase antibody (MTPS9579A) in healthy participants: A randomized trial
Rymut, Sharon M., Sukumaran, Siddharth, Sperinde, Gizette, Bremer, Meire, Galanter, Joshua, Yoshida, Kenta, Smith, Jordan, Banerjee, Prajna, Sverkos, Viyia, Cai, Fang, Steffen, Verena, Henderson, Lindsay M., Rhee, Horace, Belloni, Paula N., Lin, Joseph H., Staton, Tracy L.
Published in Clinical and translational science (01.02.2022)
Published in Clinical and translational science (01.02.2022)
Get full text
Journal Article
Development of a multi-matrix LC–MS/MS method for urea quantitation and its application in human respiratory disease studies
Wang, Jianshuang, Gao, Yang, Dorshorst, Drew W., Cai, Fang, Bremer, Meire, Milanowski, Dennis, Staton, Tracy L., Cape, Stephanie S., Dean, Brian, Ding, Xiao
Published in Journal of pharmaceutical and biomedical analysis (30.01.2017)
Published in Journal of pharmaceutical and biomedical analysis (30.01.2017)
Get full text
Journal Article
Integrated systems modeling of severe asthma: Exploration of IL‐33/ST2 antagonism
Gadkar, Kapil, Feigelman, Justin, Sukumaran, Siddharth, Rodrigo, Manoj C., Staton, Tracy, Cai, Fang, Bauer, Rebecca N., Choy, David F., Stokes, Cynthia L., Scheerens, Heleen, Ramanujan, Saroja
Published in CPT: pharmacometrics and systems pharmacology (01.09.2022)
Published in CPT: pharmacometrics and systems pharmacology (01.09.2022)
Get full text
Journal Article
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma
Maun, Henry R., Jackman, Janet K., Choy, David F., Loyet, Kelly M., Staton, Tracy L., Jia, Guiquan, Dressen, Amy, Hackney, Jason A., Bremer, Meire, Walters, Benjamin T., Vij, Rajesh, Chen, Xiaocheng, Trivedi, Neil N., Morando, Ashley, Lipari, Michael T., Franke, Yvonne, Wu, Xiumin, Zhang, Juan, Liu, John, Wu, Ping, Chang, Diana, Orozco, Luz D., Christensen, Erin, Wong, Manda, Corpuz, Racquel, Hang, Julie Q., Lutman, Jeff, Sukumaran, Siddharth, Wu, Yan, Ubhayakar, Savita, Liang, Xiaorong, Schwartz, Lawrence B., Babina, Magda, Woodruff, Prescott G., Fahy, John V., Ahuja, Rahul, Caughey, George H., Kusi, Aija, Dennis, Mark S., Eigenbrot, Charles, Kirchhofer, Daniel, Austin, Cary D., Wu, Lawren C., Koerber, James T., Lee, Wyne P., Yaspan, Brian L., Alatsis, Kathila R., Arron, Joseph R., Lazarus, Robert A., Yi, Tangsheng
Published in Cell (23.01.2020)
Published in Cell (23.01.2020)
Get full text
Journal Article
Dampening of death pathways by schnurri-2 is essential for T-cell development
Staton, Tracy L., Lazarevic, Vanja, Jones, Dallas C., Lanser, Amanda J., Takagi, Tsuyoshi, Ishii, Shunsuke, Glimcher, Laurie H.
Published in Nature (London) (07.04.2011)
Published in Nature (London) (07.04.2011)
Get full text
Journal Article
Population repeated time‐to‐event analysis of exacerbations in asthma patients: A novel approach for predicting asthma exacerbations based on biomarkers, spirometry, and diaries/questionnaires
Svensson, Robin J, Ribbing, Jakob, Kotani, Naoki, Dolton, Michael, Vadhavkar, Shweta, Cheung, Dorothy, Staton, Tracy, Choy, David F, Putnam, Wendy, Jin, Jin, Budha, Nageshwar, Karlsson, Mats O., Quartino, Angelica, Zhu, Rui
Published in CPT: pharmacometrics and systems pharmacology (01.10.2021)
Published in CPT: pharmacometrics and systems pharmacology (01.10.2021)
Get full text
Journal Article
CD8 + recent thymic emigrants home to and efficiently repopulate the small intestine epithelium
Butcher, Eugene C, Staton, Tracy L, Habtezion, Aida, Winslow, Monte M, Sato, Tohru, Love, Paul E
Published in Nature immunology (01.05.2006)
Published in Nature immunology (01.05.2006)
Get full text
Journal Article