The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade
Schaer, David A., Beckmann, Richard P., Dempsey, Jack A., Huber, Lysiane, Forest, Amelie, Amaladas, Nelusha, Li, Yanxia, Wang, Ying Cindy, Rasmussen, Erik R., Chin, Darin, Capen, Andrew, Carpenito, Carmine, Staschke, Kirk A., Chung, Linda A., Litchfield, Lacey M., Merzoug, Farhana F., Gong, Xueqian, Iversen, Philip W., Buchanan, Sean, de Dios, Alfonso, Novosiadly, Ruslan D., Kalos, Michael
Published in Cell reports (Cambridge) (13.03.2018)
Published in Cell reports (Cambridge) (13.03.2018)
Get full text
Journal Article
Identification of druggable cancer driver genes amplified across TCGA datasets
Chen, Ying, McGee, Jeremy, Chen, Xianming, Doman, Thompson N, Gong, Xueqian, Zhang, Youyan, Hamm, Nicole, Ma, Xiwen, Higgs, Richard E, Bhagwat, Shripad V, Buchanan, Sean, Peng, Sheng-Bin, Staschke, Kirk A, Yadav, Vipin, Yue, Yong, Kouros-Mehr, Hosein
Published in PloS one (29.05.2014)
Published in PloS one (29.05.2014)
Get full text
Journal Article
GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
Cordova, Ricardo A, Misra, Jagannath, Amin, Parth H, Klunk, Anglea J, Damayanti, Nur P, Carlson, Kenneth R, Elmendorf, Andrew J, Kim, Hyeong-Geug, Mirek, Emily T, Elzey, Bennet D, Miller, Marcus J, Dong, X Charlie, Cheng, Liang, Anthony, Tracy G, Pili, Roberto, Wek, Ronald C, Staschke, Kirk A
Published in eLife (15.09.2022)
Published in eLife (15.09.2022)
Get full text
Journal Article
PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma
Pytel, Dariusz, Gao, Yan, Mackiewicz, Katarzyna, Katlinskaya, Yuliya V, Staschke, Kirk A, Paredes, Maria C G, Yoshida, Akihiro, Qie, Shuo, Zhang, Gao, Chajewski, Olga S, Wu, Lawrence, Majsterek, Ireneusz, Herlyn, Meenhard, Fuchs, Serge Y, Diehl, J Alan
Published in PLoS genetics (01.12.2016)
Published in PLoS genetics (01.12.2016)
Get full text
Journal Article
Activation of the integrated stress response (ISR) pathways in response to Ref-1 inhibition in human pancreatic cancer and its tumor microenvironment
Mijit, Mahmut, Boner, Megan, Cordova, Ricardo A, Gampala, Silpa, Kpenu, Eyram, Klunk, Angela J, Zhang, Chi, Kelley, MarK R, Staschke, Kirk A, Fishel, Melissa L
Published in Frontiers in medicine (27.04.2023)
Published in Frontiers in medicine (27.04.2023)
Get full text
Journal Article
IRAK4 Kinase Activity Is Required for Th17 Differentiation and Th17-Mediated Disease
Staschke, Kirk A, Dong, Sucai, Saha, Joy, Zhao, Jingyong, Brooks, Nathan A, Hepburn, Deena L, Xia, Jinqi, Gulen, Muhammet F, Kang, Zizhen, Altuntas, Cengiz Z, Tuohy, Vincent K, Gilmour, Raymond, Li, Xiaoxia, Na, Songqing
Published in The Journal of immunology (1950) (01.07.2009)
Published in The Journal of immunology (1950) (01.07.2009)
Get full text
Journal Article
Surviving and Adapting to Stress: Translational Control and the Integrated Stress Response
Wek, Ronald C, Anthony, Tracy G, Staschke, Kirk A
Published in Antioxidants & redox signaling (01.08.2023)
Published in Antioxidants & redox signaling (01.08.2023)
Get more information
Journal Article
Activation of Gcn2 by small molecules designed to be inhibitors
Carlson, Kenneth R., Georgiadis, Millie M., Tameire, Feven, Staschke, Kirk A., Wek, Ronald C.
Published in The Journal of biological chemistry (01.04.2023)
Published in The Journal of biological chemistry (01.04.2023)
Get full text
Journal Article
Effects of PERK eIF2α Kinase Inhibitor against Toxoplasma gondii
Augusto, Leonardo, Martynowicz, Jennifer, Staschke, Kirk A, Wek, Ronald C, Sullivan, Jr, William J
Published in Antimicrobial agents and chemotherapy (01.11.2018)
Published in Antimicrobial agents and chemotherapy (01.11.2018)
Get full text
Journal Article
PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors
Stokes, Michael E, Calvo, Veronica, Fujisawa, Sho, Dudgeon, Crissy, Huang, Sharon, Ballal, Nupur, Shen, Leyi, Gasparek, Jennifer, Betzenhauser, Matthew, Taylor, Simon J, Staschke, Kirk A, Rigby, Alan C, Mulvihill, Mark J, Bose, Nandita, Lightcap, Eric S, Surguladze, David
Published in Clinical cancer research (01.12.2023)
Published in Clinical cancer research (01.12.2023)
Get full text
Journal Article
A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response-Dependent Survival of Quiescent Cancer Cells
Calvo, Veronica, Zheng, Wei, Adam-Artigues, Anna, Staschke, Kirk A, Huang, Xin, Cheung, Julie F, Nobre, Ana Rita, Fujisawa, Sho, Liu, David, Fumagalli, Maria, Surguladze, David, Stokes, Michael E, Nowacek, Ari, Mulvihill, Mark, Farias, Eduardo F, Aguirre-Ghiso, Julio A
Published in Clinical cancer research (15.12.2023)
Published in Clinical cancer research (15.12.2023)
Get full text
Journal Article
TFE3-Splicing Factor Fusions Represent Functional Drivers and Druggable Targets in Translocation Renal Cell Carcinoma
Damayanti, Nur P, Cordova, Ricardo A, Rupert, Christopher, Delle Fontane, Ilaria, Shen, Li, Orsi, Sabrina, Klunk, Angela J, Linehan, W Marston, Staschke, Kirk A, Hollenhorst, Peter C, Heppner, David E, Pili, Roberto
Published in Cancer research (Chicago, Ill.) (15.04.2024)
Published in Cancer research (Chicago, Ill.) (15.04.2024)
Get full text
Journal Article
GCN2 is required to maintain core body temperature in mice during acute cold
Levy, Jordan L, Mirek, Emily T, Rodriguez, Esther M, Zalma, Brian, Burns, Jeffrey, Jonsson, William O, Sampath, Harini, Staschke, Kirk A, Wek, Ronald C, Anthony, Tracy G
Published in American journal of physiology: endocrinology and metabolism (01.11.2023)
Published in American journal of physiology: endocrinology and metabolism (01.11.2023)
Get full text
Journal Article
Asparagine bioavailability regulates the translation of MYC oncogene
Srivastava, Sankalp, Jiang, Jie, Misra, Jagannath, Seim, Gretchen, Staschke, Kirk A., Zhong, Minghua, Zhou, Leonardo, Liu, Yu, Chen, Chong, Davé, Utpal, Kapur, Reuben, Batra, Sandeep, Zhang, Chi, Zhou, Jiehao, Fan, Jing, Wek, Ronald C., Zhang, Ji
Published in Oncogene (28.10.2022)
Published in Oncogene (28.10.2022)
Get full text
Journal Article
Obtaining Functional Proteomics Insights From Thermal Proteome Profiling Through Optimized Melt Shift Calculation and Statistical Analysis With InflectSSP
McCracken, Neil A., Liu, Hao, Runnebohm, Avery M., Wijeratne, H.R. Sagara, Wijeratne, Aruna B., Staschke, Kirk A., Mosley, Amber L.
Published in Molecular & cellular proteomics (01.09.2023)
Published in Molecular & cellular proteomics (01.09.2023)
Get full text
Journal Article
Inhibition of the eukaryotic initiation factor-2-α kinase PERK decreases risk of autoimmune diabetes in mice
Muralidharan, Charanya, Huang, Fei, Enriquez, Jacob R, Wang, Jiayi E, Nelson, Jennifer B, Nargis, Titli, May, Sarah C, Chakraborty, Advaita, Figatner, Kayla T, Navitskaya, Svetlana, Anderson, Cara M, Calvo, Veronica, Surguladze, David, Mulvihill, Mark J, Yi, Xiaoyan, Sarkar, Soumyadeep, Oakes, Scott A, Webb-Robertson, Bobbie-Jo M, Sims, Emily K, Staschke, Kirk A, Eizirik, Decio L, Nakayasu, Ernesto S, Stokes, Michael E, Tersey, Sarah A, Mirmira, Raghavendra G
Published in The Journal of clinical investigation (18.06.2024)
Published in The Journal of clinical investigation (18.06.2024)
Get full text
Journal Article
Targeting GCN2 Regulation of Amino Acid Homeostasis in Prostate Cancer
Cordova, Ricardo, Misra, Jagannath, Amin, Parth H, Damayanti, Nur P, Carlson, Kenneth R, Klunk, Angela J, Mirek, Emily T, Miller, Marcus J, Anthony, Tracy G, Pili, Roberto, Wek, Ronald C, Staschke, Kirk A
Published in The FASEB journal (01.05.2022)
Published in The FASEB journal (01.05.2022)
Get more information
Journal Article