Targeting Tyrosine Phosphatases: Time to End the Stigma
Stanford, Stephanie M, Bottini, Nunzio
Published in Trends in pharmacological sciences (Regular ed.) (01.06.2017)
Published in Trends in pharmacological sciences (Regular ed.) (01.06.2017)
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Journal Article
The Contribution of PTPN22 to Rheumatic Disease
Mustelin, Tomas, Bottini, Nunzio, Stanford, Stephanie M.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.04.2019)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.04.2019)
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Journal Article
PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis
Sacchetti, Cristiano, Bai, Yunpeng, Stanford, Stephanie M, Di Benedetto, Paola, Cipriani, Paola, Santelli, Eugenio, Piera-Velazquez, Sonsoles, Chernitskiy, Vladimir, Kiosses, William B, Ceponis, Arnold, Kaestner, Klaus H, Boin, Francesco, Jimenez, Sergio A, Giacomelli, Roberto, Zhang, Zhong-Yin, Bottini, Nunzio
Published in Nature communications (20.10.2017)
Published in Nature communications (20.10.2017)
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Journal Article
Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity
Szodoray, Peter, Andersen, Tor Kristian, Heinzelbecker, Julia, Imbery, John F., Huszthy, Peter C., Stanford, Stephanie M., Bogen, Bjarne, Landsverk, Ole B., Bottini, Nunzio, Tveita, Anders, Munthe, Ludvig A., Nakken, Britt
Published in Cell reports (Cambridge) (10.08.2021)
Published in Cell reports (Cambridge) (10.08.2021)
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Journal Article
T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity
Szodoray, Peter, MD, PhD, Stanford, Stephanie M., PhD, Molberg, Øyvind, MD, PhD, Munthe, Ludvig A., MD, PhD, Bottini, Nunzio, MD, PhD, Nakken, Britt, PhD
Published in Journal of allergy and clinical immunology (01.09.2016)
Published in Journal of allergy and clinical immunology (01.09.2016)
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Journal Article
Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy
Doody, Karen M, Stanford, Stephanie M, Sacchetti, Cristiano, Svensson, Mattias N D, Coles, Charlotte H, Mitakidis, Nikolaos, Kiosses, William B, Bartok, Beatrix, Fos, Camille, Cory, Esther, Sah, Robert L, Liu-Bryan, Ru, Boyle, David L, Arnett, Heather A, Mustelin, Tomas, Corr, Maripat, Esko, Jeffrey D, Tremblay, Michel L, Firestein, Gary S, Aricescu, A Radu, Bottini, Nunzio
Published in Science translational medicine (20.05.2015)
Published in Science translational medicine (20.05.2015)
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Journal Article
Gold(I)-Mediated Inhibition of Protein Tyrosine Phosphatases: A Detailed in Vitro and Cellular Study
Krishnamurthy, Divya, Karver, Mark R, Fiorillo, Edoardo, Orrú, Valeria, Stanford, Stephanie M, Bottini, Nunzio, Barrios, Amy M
Published in Journal of medicinal chemistry (14.08.2008)
Published in Journal of medicinal chemistry (14.08.2008)
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Journal Article
Protein Tyrosine Phosphatase Expression Profile of Rheumatoid Arthritis Fibroblast‐like Synoviocytes: A Novel Role of SH2 Domain–Containing Phosphatase 2 as a Modulator of Invasion and Survival
Stanford, Stephanie M., Maestre, Michael F., Campbell, Amanda M., Bartok, Beatrix, Kiosses, William B., Boyle, David L., Arnett, Heather A., Mustelin, Tomas, Firestein, Gary S., Bottini, Nunzio
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.05.2013)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.05.2013)
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Journal Article
Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue
Fiorillo, Edoardo, Orrú, Valeria, Stanford, Stephanie M., Liu, Yingge, Salek, Mogjiborahman, Rapini, Novella, Schenone, Aaron D., Saccucci, Patrizia, Delogu, Lucia G., Angelini, Federica, Manca Bitti, Maria Luisa, Schmedt, Christian, Chan, Andrew C., Acuto, Oreste, Bottini, Nunzio
Published in The Journal of biological chemistry (20.08.2010)
Published in The Journal of biological chemistry (20.08.2010)
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Journal Article
Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells
Wu, Dennis J, Zhou, Wenbo, Enouz, Sarah, Orrú, Valeria, Stanford, Stephanie M, Maine, Christian J, Rapini, Novella, Sawatzke, Kristy, Engel, Isaac, Fiorillo, Edoardo, Sherman, Linda A, Kronenberg, Mitch, Zehn, Dietmar, Peterson, Erik, Bottini, Nunzio
Published in PloS one (03.02.2014)
Published in PloS one (03.02.2014)
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Journal Article
High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45
Stanford, Stephanie M, Panchal, Rekha G, Walker, Logan M, Wu, Dennis J, Falk, Matthew D, Mitra, Sayantan, Damle, Sagar S, Ruble, David, Kaltcheva, Teodora, Zhang, Sheng, Zhang, Zhong-Yin, Bavari, Sina, Barrios, Amy M, Bottini, Nunzio
Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2012)
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Journal Article
Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy
Wade, Fallou, Quijada, Pearl, Al-Haffar, Kamar Mohamed Adib, Awad, Salma Mahmoud, Kunhi, Muhammad, Toko, Haruhiro, Marashly, Qussay, Belhaj, Karim, Zahid, Israa, Al-Mohanna, Falah, Stanford, Stephanie M, Alvarez, Roberto, Liu, Yingge, Colak, Dilek, Jordan, Maria C, Roos, Kenneth P, Assiri, Abdullah, Al-Habeeb, Waleed, Sussman, Mark, Bottini, Nunzio, Poizat, Coralie
Published in The Journal of pathology (01.12.2015)
Published in The Journal of pathology (01.12.2015)
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Journal Article
Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase
Stanford, Stephanie M, Aleshin, Alexander E, Zhang, Vida, Ardecky, Robert J, Hedrick, Michael P, Zou, Jiwen, Ganji, Santhi R, Bliss, Matthew R, Yamamoto, Fusayo, Bobkov, Andrey A, Kiselar, Janna, Liu, Yingge, Cadwell, Gregory W, Khare, Shilpi, Yu, Jinghua, Barquilla, Antonio, Chung, Thomas D Y, Mustelin, Tomas, Schenk, Simon, Bankston, Laurie A, Liddington, Robert C, Pinkerton, Anthony B, Bottini, Nunzio
Published in Nature chemical biology (27.03.2017)
Published in Nature chemical biology (27.03.2017)
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Journal Article
Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays
Kiris, Erkan, Nuss, Jonathan E, Stanford, Stephanie M, Wanner, Laura M, Cazares, Lisa, Maestre, Michael F, Du, Hao T, Gomba, Glenn Y, Burnett, James C, Gussio, Rick, Bottini, Nunzio, Panchal, Rekha G, Kane, Christopher D, Tessarollo, Lino, Bavari, Sina
Published in PloS one (10.06.2015)
Published in PloS one (10.06.2015)
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Journal Article
Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation
Maeshima, Keisuke, Stanford, Stephanie M, Hammaker, Deepa, Sacchetti, Cristiano, Zeng, Li-Fan, Ai, Rizi, Zhang, Vida, Boyle, David L, Aleman Muench, German R, Feng, Gen-Sheng, Whitaker, John W, Zhang, Zhong-Yin, Wang, Wei, Bottini, Nunzio, Firestein, Gary S
Published in JCI insight (19.05.2016)
Published in JCI insight (19.05.2016)
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Journal Article
RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain
Wen, Yutao, Yang, Shen, Wakabayashi, Kuninobu, Svensson, Mattias N.D., Stanford, Stephanie M., Santelli, Eugenio, Bottini, Nunzio
Published in The Journal of biological chemistry (10.04.2020)
Published in The Journal of biological chemistry (10.04.2020)
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