DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras
Zhang, Xiaoyu, Luukkonen, Lena M, Eissler, Christie L, Crowley, Vincent M, Yamashita, Yu, Schafroth, Michael A, Kikuchi, Shota, Weinstein, David S, Symons, Kent T, Nordin, Brian E, Rodriguez, Joe L, Wucherpfennig, Thomas G, Bauer, Ludwig G, Dix, Melissa M, Stamos, Dean, Kinsella, Todd M, Simon, Gabriel M, Baltgalvis, Kristen A, Cravatt, Benjamin F
Published in Journal of the American Chemical Society (07.04.2021)
Published in Journal of the American Chemical Society (07.04.2021)
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Orchestrated Triple CH Activation Reactions Using Two Directing Groups: Rapid Assembly of Complex Pyrazoles
Yang, Weibo, Ye, Shengqing, Fanning, Dewey, Coon, Timothy, Schmidt, Yvonne, Krenitsky, Paul, Stamos, Dean, Yu, Jin-Quan
Published in Angewandte Chemie International Edition (16.02.2015)
Published in Angewandte Chemie International Edition (16.02.2015)
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A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy
Bot, Ilze, Ortiz Zacarías, Natalia V., de Witte, Wilhelmus E. A., de Vries, Henk, van Santbrink, Peter J., van der Velden, Daniël, Kröner, Mara J., van der Berg, Dirk-Jan, Stamos, Dean, de Lange, Elizabeth C. M., Kuiper, Johan, IJzerman, Adriaan P., Heitman, Laura H.
Published in Scientific reports (03.03.2017)
Published in Scientific reports (03.03.2017)
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Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Stucture−Activity Relationships
Charifson, Paul S, Grillot, Anne-Laure, Grossman, Trudy H, Parsons, Jonathan D, Badia, Michael, Bellon, Steve, Deininger, David D, Drumm, Joseph E, Gross, Christian H, LeTiran, Arnaud, Liao, Yusheng, Mani, Nagraj, Nicolau, David P, Perola, Emanuele, Ronkin, Steven, Shannon, Dean, Swenson, Lora L, Tang, Qing, Tessier, Pamela R, Tian, Ski-Kai, Trudeau, Martin, Wang, Tiansheng, Wei, Yunyi, Zhang, Hong, Stamos, Dean
Published in Journal of medicinal chemistry (11.09.2008)
Published in Journal of medicinal chemistry (11.09.2008)
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Journal Article
Multiple binding sites for small-molecule antagonists at the CC chemokine receptor 2
Zweemer, Annelien J M, Nederpelt, Indira, Vrieling, Hilde, Hafith, Sarah, Doornbos, Maarten L J, de Vries, Henk, Abt, Jeffrey, Gross, Raymond, Stamos, Dean, Saunders, John, Smit, Martine J, Ijzerman, Adriaan P, Heitman, Laura H
Published in Molecular pharmacology (01.10.2013)
Published in Molecular pharmacology (01.10.2013)
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Journal Article
Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase
Ronkin, Steven M., Badia, Michael, Bellon, Steve, Grillot, Anne-Laure, Gross, Christian H., Grossman, Trudy H., Mani, Nagraj, Parsons, Jonathan D., Stamos, Dean, Trudeau, Martin, Wei, Yunyi, Charifson, Paul S.
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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Journal Article
When structure–affinity relationships meet structure–kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists
Vilums, Maris, Zweemer, Annelien J.M., Barmare, Farhana, van der Gracht, Anouk M.F., Bleeker, Dave C.T., Yu, Zhiyi, de Vries, Henk, Gross, Raymond, Clemens, Jeremy, Krenitsky, Paul, Brussee, Johannes, Stamos, Dean, Saunders, John, Heitman, Laura H., IJzerman, Adriaan P.
Published in European journal of medicinal chemistry (26.03.2015)
Published in European journal of medicinal chemistry (26.03.2015)
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Journal Article
Dual Targeting of GyrB and ParE by a Novel Aminobenzimidazole Class of Antibacterial Compounds
GROSSMAN, Trudy H, BARTELS, Douglas J, MANI, Nagraj, MULLIN, Steve, GROSS, Christian H, PARSONS, Jonathan D, YUSHENG LIAO, GRILLOT, Anne-Laure, STAMOS, Dean, OLSON, Eric R, CHARIFSON, Paul S
Published in Antimicrobial Agents and Chemotherapy (01.02.2007)
Published in Antimicrobial Agents and Chemotherapy (01.02.2007)
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Journal Article
In Vitro Characterization of the Antibacterial Spectrum of Novel Bacterial Type II Topoisomerase Inhibitors of the Aminobenzimidazole Class
MANI, Nagraj, GROSS, Christian H, GROSSMAN, Trudy H, PARSONS, Jonathan D, HANZELKA, Brian, MÜH, Ute, MULLIN, Steve, YUSHENG LIAO, GRILLOT, Anne-Laure, STAMOS, Dean, CHARIFSON, Paul S
Published in Antimicrobial Agents and Chemotherapy (01.04.2006)
Published in Antimicrobial Agents and Chemotherapy (01.04.2006)
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Journal Article
Evaluation of (4-Arylpiperidin-1-yl)cyclopentanecarboxamides As High-Affinity and Long-Residence-Time Antagonists for the CCR2 Receptor
Vilums, Maris, Zweemer, Annelien J. M., Dilanchian, Arian, van Veldhoven, Jacobus P. D., de Vries, Henk, Brussee, Johannes, Saunders, John, Stamos, Dean, Heitman, Laura H., IJzerman, Adriaan P.
Published in ChemMedChem (01.07.2015)
Published in ChemMedChem (01.07.2015)
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Journal Article
Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists
Zheng, Yi, Qin, Ling, Zacarías, Natalia V. Ortiz, de Vries, Henk, Han, Gye Won, Gustavsson, Martin, Dabros, Marta, Zhao, Chunxia, Cherney, Robert J., Carter, Percy, Stamos, Dean, Abagyan, Ruben, Cherezov, Vadim, Stevens, Raymond C., IJzerman, Adriaan P., Heitman, Laura H., Tebben, Andrew, Kufareva, Irina, Handel, Tracy M.
Published in Nature (London) (15.12.2016)
Published in Nature (London) (15.12.2016)
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Palladium (II)‐Catalyzed C−H Activation with Bifunctional Ligands: From Curiosity to Industrialization
Wu, Kevin, Lam, Nelson, Strassfeld, Daniel A., Fan, Zhoulong, Qiao, Jennifer X., Liu, Tao, Stamos, Dean, Yu, Jin‐Quan
Published in Angewandte Chemie International Edition (06.05.2024)
Published in Angewandte Chemie International Edition (06.05.2024)
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Journal Article
Ligand-Promoted C(sp3)−H Olefination en Route to Multi-functionalized Pyrazoles
Yang, Weibo, Ye, Shengqing, Schmidt, Yvonne, Stamos, Dean, Yu, Jin-Quan
Published in Chemistry : a European journal (17.05.2016)
Published in Chemistry : a European journal (17.05.2016)
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Journal Article
Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity-Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases
Ernst, Justin T, Liu, Michael, Zuccola, Harmon, Neubert, Timothy, Beaumont, Kevin, Turnbull, Amy, Kallel, Adam, Vought, Bryan, Stamos, Dean
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
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