Search Results - "STAMMERS TIMOTHY" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay

Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay

by Stammers, Timothy A., Coulombe, René, Duplessis, Martin, Fazal, Gulrez, Gagnon, Alexandre, Garneau, Michel, Goulet, Sylvie, Jakalian, Araz, LaPlante, Steven, Rancourt, Jean, Thavonekham, Bounkham, Wernic, Dominik, Kukolj, George, Beaulieu, Pierre L.
Published in Bioorganic & medicinal chemistry letters (15.12.2013)

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Journal Article

Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: Discovery of a quinazolinone chemotype

Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: Discovery of a quinazolinone chemotype

by Beaulieu, Pierre L., Coulombe, René, Duan, Jianmin, Fazal, Gulrez, Godbout, Cédrickx, Hucke, Oliver, Jakalian, Araz, Joly, Marc-André, Lepage, Olivier, Llinàs-Brunet, Montse, Naud, Julie, Poirier, Martin, Rioux, Nathalie, Thavonekham, Bounkham, Kukolj, George, Stammers, Timothy A.
Published in Bioorganic & medicinal chemistry letters (15.07.2013)

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Journal Article

Enantiomeric Atropisomers Inhibit HCV Polymerase and/or HIV Matrix: Characterizing Hindered Bond Rotations and Target Selectivity

Enantiomeric Atropisomers Inhibit HCV Polymerase and/or HIV Matrix: Characterizing Hindered Bond Rotations and Target Selectivity

by LaPlante, Steven R., Forgione, Pat, Boucher, Colette, Coulombe, René, Gillard, James, Hucke, Oliver, Jakalian, Araz, Joly, Marc-André, Kukolj, George, Lemke, Christopher, McCollum, Robert, Titolo, Steve, Beaulieu, Pierre L., Stammers, Timothy
Published in Journal of medicinal chemistry (13.03.2014)

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Journal Article

Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency

Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency

by Hucke, Oliver, Coulombe, René, Bonneau, Pierre, Bertrand-Laperle, Mégan, Brochu, Christian, Gillard, James, Joly, Marc-André, Landry, Serge, Lepage, Olivier, Llinàs-Brunet, Montse, Pesant, Marc, Poirier, Martin, Poirier, Maude, McKercher, Ginette, Marquis, Martin, Kukolj, George, Beaulieu, Pierre L., Stammers, Timothy A.
Published in Journal of medicinal chemistry (13.03.2014)

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Journal Article

Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors

Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors

by Stammers, Timothy A., Coulombe, René, Rancourt, Jean, Thavonekham, Bounkham, Fazal, Gulrez, Goulet, Sylvie, Jakalian, Araz, Wernic, Dominic, Tsantrizos, Youla, Poupart, Marc-André, Bös, Michael, McKercher, Ginette, Thauvette, Louise, Kukolj, George, Beaulieu, Pierre L.
Published in Bioorganic & medicinal chemistry letters (01.05.2013)

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Journal Article

Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: From benzimidazole to indole scaffolds

Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: From benzimidazole to indole scaffolds

by Beaulieu, Pierre L., Gillard, James, Bykowski, Darren, Brochu, Christian, Dansereau, Nathalie, Duceppe, Jean-Simon, Haché, Bruno, Jakalian, Araz, Lagacé, Lisette, LaPlante, Steven, McKercher, Ginette, Moreau, Elaine, Perreault, Stéphane, Stammers, Timothy, Thauvette, Louise, Warrington, Jeff, Kukolj, George
Published in Bioorganic & medicinal chemistry letters (01.10.2006)

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Journal Article

Indole 5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase with nanomolar potency in cell-based subgenomic replicons (part 2): Central amino acid linker and right-hand-side SAR studies

Indole 5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase with nanomolar potency in cell-based subgenomic replicons (part 2): Central amino acid linker and right-hand-side SAR studies

by Beaulieu, Pierre L., Chabot, Catherine, Duan, Jianmin, Garneau, Michel, Gillard, James, Jolicoeur, Eric, Poirier, Martin, Poupart, Marc-André, Stammers, Timothy A., Kukolj, George, Tsantrizos, Youla S.
Published in Bioorganic & medicinal chemistry letters (15.06.2011)

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Journal Article

Oxabicyclo[3.2.1]oct-6-enes as templates for the stereoselective synthesis of polypropionates: Total synthesis of callystatin A and C19-epi-callystatin A

Oxabicyclo[3.2.1]oct-6-enes as templates for the stereoselective synthesis of polypropionates: Total synthesis of callystatin A and C19-epi-callystatin A

by Lautens, M, Stammers, TA
Published in Synthesis (Stuttgart) (01.01.2002)

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Journal Article

Enantioselective Synthesis of α-Hydroxy and α-Amino Phosphonates via Catalytic Asymmetric Hydrogenation

Enantioselective Synthesis of α-Hydroxy and α-Amino Phosphonates via Catalytic Asymmetric Hydrogenation

by Burk, Mark J, Stammers, Timothy A, Straub, Judith A
Published in Organic letters (12.08.1999)

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Journal Article

Allosteric N-acetamide-indole-6-carboxylic acid thumb pocket 1 inhibitors of hepatitis C virus NS5B polymerase — Acylsulfonamides and acylsulfamides as carboxylic acid replacements

Allosteric N-acetamide-indole-6-carboxylic acid thumb pocket 1 inhibitors of hepatitis C virus NS5B polymerase — Acylsulfonamides and acylsulfamides as carboxylic acid replacements

by Beaulieu, Pierre L., Coulombe, Rene, Gillard, James, Brochu, Christian, Duan, Jianmin, Garneau, Michel, Jolicoeur, Eric, Kuhn, Peter, Poupart, Marc-Andre, Rancourt, Jean, Stammers, Timothy A., Thavonekham, Bounkham, Kukolj, George
Published in Canadian journal of chemistry (01.01.2013)

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Journal Article

Immunotherapy for the First-Line Treatment of Patients with Metastatic Non-Small Cell Lung Cancer

Immunotherapy for the First-Line Treatment of Patients with Metastatic Non-Small Cell Lung Cancer

by Martinez, Pablo, Peters, Solange, Stammers, Timothy, Soria, Jean-Charles
Published in Clinical cancer research (01.05.2019)

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Journal Article

Aza follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 1: Mitigating the genotoxic liability of an aniline metabolite

Aza follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 1: Mitigating the genotoxic liability of an aniline metabolite

by Beaulieu, Pierre L., Bolger, Gordon, Duplessis, Martin, Gagnon, Alexandre, Garneau, Michel, Stammers, Timothy, Kukolj, George, Duan, Jianmin
Published in Bioorganic & medicinal chemistry letters (01.03.2015)

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Journal Article

Conformation-Based Restrictions and Scaffold Replacements in the Design of Hepatitis C Virus Polymerase Inhibitors: Discovery of Deleobuvir (BI 207127)

Conformation-Based Restrictions and Scaffold Replacements in the Design of Hepatitis C Virus Polymerase Inhibitors: Discovery of Deleobuvir (BI 207127)

by LaPlante, Steven R., Bös, Michael, Brochu, Christian, Chabot, Catherine, Coulombe, René, Gillard, James R., Jakalian, Araz, Poirier, Martin, Rancourt, Jean, Stammers, Timothy, Thavonekham, Bounkham, Beaulieu, Pierre L., Kukolj, George, Tsantrizos, Youla S.
Published in Journal of medicinal chemistry (13.03.2014)

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Journal Article

A prodrug strategy for the oral delivery of a poorly soluble HCV NS5B thumb pocket 1 polymerase inhibitor using self-emulsifying drug delivery systems (SEDDS)

A prodrug strategy for the oral delivery of a poorly soluble HCV NS5B thumb pocket 1 polymerase inhibitor using self-emulsifying drug delivery systems (SEDDS)

by Beaulieu, Pierre L., De Marte, Josie, Garneau, Michel, Luo, Laibin, Stammers, Timothy, Telang, Chitra, Wernic, Dominik, Kukolj, George, Duan, Jianmin
Published in Bioorganic & medicinal chemistry letters (15.01.2015)

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Journal Article

Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity

Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity

by Beaulieu, Pierre L., Bolger, Gordon, Deon, Dan, Duplessis, Martin, Fazal, Gulrez, Gagnon, Alexandre, Garneau, Michel, LaPlante, Steven, Stammers, Timothy, Kukolj, George, Duan, Jianmin
Published in Bioorganic & medicinal chemistry letters (01.03.2015)

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Journal Article

Discovery of BI 207524, an Indole Diamide NS5B Thumb Pocket 1 Inhibitor with Improved Potency for the Potential Treatment of Chronic Hepatitis C Virus Infection

Discovery of BI 207524, an Indole Diamide NS5B Thumb Pocket 1 Inhibitor with Improved Potency for the Potential Treatment of Chronic Hepatitis C Virus Infection

by Beaulieu, Pierre L, Anderson, Paul C, Bethell, Richard, Bös, Michael, Bousquet, Yves, Brochu, Christian, Cordingley, Michael G, Fazal, Gulrez, Garneau, Michel, Gillard, James R, Kawai, Stephen, Marquis, Martin, McKercher, Ginette, Poupart, Marc-André, Stammers, Timothy, Thavonekham, Bounkham, Wernic, Dominik, Duan, Jianmin, Kukolj, George
Published in Journal of medicinal chemistry (11.12.2014)

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Journal Article

Techniques to facilitate data stream routing and entitlement

Techniques to facilitate data stream routing and entitlement

by Stammers, Timothy Peter
Year of Publication 11.04.2023

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Patent

N-Acetamideindolecarboxylic acid allosteric ‘finger-loop’ inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies

N-Acetamideindolecarboxylic acid allosteric ‘finger-loop’ inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies

by Beaulieu, Pierre L., Jolicoeur, Eric, Gillard, James, Brochu, Christian, Coulombe, René, Dansereau, Nathalie, Duan, Jianmin, Garneau, Michel, Jakalian, Araz, Kühn, Peter, Lagacé, Lisette, LaPlante, Steven, McKercher, Ginette, Perrault, Stéphane, Poirier, Martin, Poupart, Marc-André, Stammers, Timothy, Thauvette, Louise, Thavonekham, Bounkham, Kukolj, George
Published in Bioorganic & medicinal chemistry letters (01.02.2010)

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Journal Article

TECHNIQUES TO FACILITATE DATA STREAM ROUTING AND ENTITLEMENT

TECHNIQUES TO FACILITATE DATA STREAM ROUTING AND ENTITLEMENT

by Stammers, Timothy Peter
Year of Publication 19.05.2022

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Patent

PROVIDING A ROAMING POLICY FEDERATION IN A THIRD GENERATION PARTNERSHIP PROJECT (3GPP) NETWORK ENVIRONMENT

PROVIDING A ROAMING POLICY FEDERATION IN A THIRD GENERATION PARTNERSHIP PROJECT (3GPP) NETWORK ENVIRONMENT

by GRAYSON, Mark, STAMMERS, Timothy Peter
Year of Publication 12.07.2023

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Patent

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