Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation
Hurlburt, Nicholas K., Seydoux, Emilie, Wan, Yu-Hsin, Edara, Venkata Viswanadh, Stuart, Andrew B., Feng, Junli, Suthar, Mehul S., McGuire, Andrew T., Stamatatos, Leonidas, Pancera, Marie
Published in Nature communications (27.10.2020)
Published in Nature communications (27.10.2020)
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mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection
Stamatatos, Leonidas, Czartoski, Julie, Wan, Yu-Hsin, Homad, Leah J, Rubin, Vanessa, Glantz, Hayley, Neradilek, Moni, Seydoux, Emilie, Jennewein, Madeleine F, MacCamy, Anna J, Feng, Junli, Mize, Gregory, De Rosa, Stephen C, Finzi, Andrés, Lemos, Maria P, Cohen, Kristen W, Moodie, Zoe, McElrath, M Juliana, McGuire, Andrew T
Published in Science (25.06.2021)
Published in Science (25.06.2021)
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Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
Jardine, Joseph, Julien, Jean-Philippe, Menis, Sergey, Ota, Takayuki, Kalyuzhniy, Oleksandr, McGuire, Andrew, Sok, Devin, Huang, Po-Ssu, MacPherson, Skye, Jones, Meaghan, Nieusma, Travis, Mathison, John, Baker, David, Ward, Andrew B., Burton, Dennis R., Stamatatos, Leonidas, Nemazee, David, Wilson, Ian A., Schief, William R.
Published in Science (American Association for the Advancement of Science) (10.05.2013)
Published in Science (American Association for the Advancement of Science) (10.05.2013)
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HIV-specific humoral immune responses by CRISPR/Cas9-edited B cells
Hartweger, Harald, McGuire, Andrew T, Horning, Marcel, Taylor, Justin J, Dosenovic, Pia, Yost, Daniel, Gazumyan, Anna, Seaman, Michael S, Stamatatos, Leonidas, Jankovic, Mila, Nussenzweig, Michel C
Published in The Journal of experimental medicine (03.06.2019)
Published in The Journal of experimental medicine (03.06.2019)
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Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques
Escolano, Amelia, Gristick, Harry B., Abernathy, Morgan E., Merkenschlager, Julia, Gautam, Rajeev, Oliveira, Thiago Y., Pai, Joy, West, Anthony P., Barnes, Christopher O., Cohen, Alexander A., Wang, Haoqing, Golijanin, Jovana, Yost, Daniel, Keeffe, Jennifer R., Wang, Zijun, Zhao, Peng, Yao, Kai-Hui, Bauer, Jens, Nogueira, Lilian, Gao, Han, Voll, Alisa V., Montefiori, David C., Seaman, Michael S., Gazumyan, Anna, Silva, Murillo, McGuire, Andrew T., Stamatatos, Leonidas, Irvine, Darrell J., Wells, Lance, Martin, Malcolm A., Bjorkman, Pamela J., Nussenzweig, Michel C.
Published in Nature (London) (01.06.2019)
Published in Nature (London) (01.06.2019)
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Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies
McGuire, Andrew T, Hoot, Sam, Dreyer, Anita M, Lippy, Adriana, Stuart, Andrew, Cohen, Kristen W, Jardine, Joseph, Menis, Sergey, Scheid, Johannes F, West, Anthony P, Schief, William R, Stamatatos, Leonidas
Published in The Journal of experimental medicine (08.04.2013)
Published in The Journal of experimental medicine (08.04.2013)
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Anti–HIV-1 B cell responses are dependent on B cell precursor frequency and antigen-binding affinity
Dosenovic, Pia, Kara, Ervin E., Pettersson, Anna-Klara, McGuire, Andrew T., Gray, Matthew, Hartweger, Harald, Thientosapol, Eddy S., Stamatatos, Leonidas, Nussenzweig, Michel C.
Published in Proceedings of the National Academy of Sciences - PNAS (01.05.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (01.05.2018)
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Evaluation of Cell-Based and Surrogate SARS-CoV-2 Neutralization Assays
Sholukh, Anton M, Fiore-Gartland, Andrew, Ford, Emily S, Miner, Maurine D, Hou, Yixuan J, Tse, Longping V, Kaiser, Hannah, Zhu, Haiying, Lu, Joyce, Madarampalli, Bhanupriya, Park, Arnold, Lempp, Florian A, St Germain, Russell, Bossard, Emily L, Kee, Jia Jin, Diem, Kurt, Stuart, Andrew B, Rupert, Peter B, Brock, Chance, Buerger, Matthew, Doll, Margaret K, Randhawa, April Kaur, Stamatatos, Leonidas, Strong, Roland K, McLaughlin, Colleen, Huang, Meei-Li, Jerome, Keith R, Baric, Ralph S, Montefiori, David, Corey, Lawrence
Published in Journal of clinical microbiology (20.09.2021)
Published in Journal of clinical microbiology (20.09.2021)
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Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice
McGuire, Andrew T., Gray, Matthew D., Dosenovic, Pia, Gitlin, Alexander D., Freund, Natalia T., Petersen, John, Correnti, Colin, Johnsen, William, Kegel, Robert, Stuart, Andrew B., Glenn, Jolene, Seaman, Michael S., Schief, William R., Strong, Roland K., Nussenzweig, Michel C., Stamatatos, Leonidas
Published in Nature communications (24.02.2016)
Published in Nature communications (24.02.2016)
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Factors Associated with the Development of Cross-Reactive Neutralizing Antibodies during Human Immunodeficiency Virus Type 1 Infection
SATHER, D. Noah, ARMANN, Jakob, STAMATATOS, Leonidas, CHINE, Lance K, MAVRANTONI, Angeliki, SELLHORN, George, CALDWELL, Zachary, XUESONG YU, WOOD, Blake, SELF, Steve, KALAMS, Spyros
Published in Journal of Virology (01.01.2009)
Published in Journal of Virology (01.01.2009)
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Diverse Recombinant HIV-1 Envs Fail To Activate B Cells Expressing the Germline B Cell Receptors of the Broadly Neutralizing Anti-HIV-1 Antibodies PG9 and 447-52D
McGuire, Andrew T, Glenn, Jolene A, Lippy, Adriana, Stamatatos, Leonidas
Published in Journal of Virology (01.03.2014)
Published in Journal of Virology (01.03.2014)
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Characteristics of the earliest cross-neutralizing antibody response to HIV-1
Mikell, Iliyana, Sather, D Noah, Kalams, Spyros A, Altfeld, Marcus, Alter, Galit, Stamatatos, Leonidas
Published in PLoS pathogens (01.01.2011)
Published in PLoS pathogens (01.01.2011)
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Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice
Dosenovic, Pia, von Boehmer, Lotta, Escolano, Amelia, Jardine, Joseph, Freund, Natalia T., Gitlin, Alexander D., McGuire, Andrew T., Kulp, Daniel W., Oliveira, Thiago, Scharf, Louise, Pietzsch, John, Gray, Matthew D., Cupo, Albert, van Gils, Marit J., Yao, Kai-Hui, Liu, Cassie, Gazumyan, Anna, Seaman, Michael S., Björkman, Pamela J., Sanders, Rogier W., Moore, John P., Stamatatos, Leonidas, Schief, William R., Nussenzweig, Michel C.
Published in Cell (18.06.2015)
Published in Cell (18.06.2015)
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Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo
Medina-Ramírez, Max, Garces, Fernando, Escolano, Amelia, Skog, Patrick, de Taeye, Steven W, Del Moral-Sanchez, Ivan, McGuire, Andrew T, Yasmeen, Anila, Behrens, Anna-Janina, Ozorowski, Gabriel, van den Kerkhof, Tom L G M, Freund, Natalia T, Dosenovic, Pia, Hua, Yuanzi, Gitlin, Alexander D, Cupo, Albert, van der Woude, Patricia, Golabek, Michael, Sliepen, Kwinten, Blane, Tanya, Kootstra, Neeltje, van Breemen, Mariëlle J, Pritchard, Laura K, Stanfield, Robyn L, Crispin, Max, Ward, Andrew B, Stamatatos, Leonidas, Klasse, Per Johan, Moore, John P, Nemazee, David, Nussenzweig, Michel C, Wilson, Ian A, Sanders, Rogier W
Published in The Journal of experimental medicine (04.09.2017)
Published in The Journal of experimental medicine (04.09.2017)
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Journal Article
Isolation and characterization of cross-neutralizing coronavirus antibodies from COVID-19+ subjects
Jennewein, Madeleine F., MacCamy, Anna J., Akins, Nicholas R., Feng, Junli, Homad, Leah J., Hurlburt, Nicholas K., Seydoux, Emilie, Wan, Yu-Hsin, Stuart, Andrew B., Edara, Venkata Viswanadh, Floyd, Katharine, Vanderheiden, Abigail, Mascola, John R., Doria-Rose, Nicole, Wang, Lingshu, Yang, Eun Sung, Chu, Helen Y., Torres, Jonathan L., Ozorowski, Gabriel, Ward, Andrew B., Whaley, Rachael E., Cohen, Kristen W., Pancera, Marie, McElrath, M. Juliana, Englund, Janet A., Finzi, Andrés, Suthar, Mehul S., McGuire, Andrew T., Stamatatos, Leonidas
Published in Cell reports (Cambridge) (13.07.2021)
Published in Cell reports (Cambridge) (13.07.2021)
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Journal Article
Structural basis for germline antibody recognition of HIV-1 immunogens
Scharf, Louise, West, Anthony P, Sievers, Stuart A, Chen, Courtney, Jiang, Siduo, Gao, Han, Gray, Matthew D, McGuire, Andrew T, Scheid, Johannes F, Nussenzweig, Michel C, Stamatatos, Leonidas, Bjorkman, Pamela J
Published in eLife (21.03.2016)
Published in eLife (21.03.2016)
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Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation
Zhou, Tongqing, Doria-Rose, Nicole A., Cheng, Cheng, Stewart-Jones, Guillaume B.E., Chuang, Gwo-Yu, Chambers, Michael, Druz, Aliaksandr, Geng, Hui, McKee, Krisha, Kwon, Young Do, O’Dell, Sijy, Sastry, Mallika, Schmidt, Stephen D., Xu, Kai, Chen, Lei, Chen, Rita E., Louder, Mark K., Pancera, Marie, Wanninger, Timothy G., Zhang, Baoshan, Zheng, Anqi, Farney, S. Katie, Foulds, Kathryn E., Georgiev, Ivelin S., Joyce, M. Gordon, Lemmin, Thomas, Narpala, Sandeep, Rawi, Reda, Soto, Cinque, Todd, John-Paul, Shen, Chen-Hsiang, Tsybovsky, Yaroslav, Yang, Yongping, Zhao, Peng, Haynes, Barton F., Stamatatos, Leonidas, Tiemeyer, Michael, Wells, Lance, Scorpio, Diana G., Shapiro, Lawrence, McDermott, Adrian B., Mascola, John R., Kwong, Peter D.
Published in Cell reports (Cambridge) (25.04.2017)
Published in Cell reports (Cambridge) (25.04.2017)
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Journal Article
Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs
Hoot, Sam, McGuire, Andrew T, Cohen, Kristen W, Strong, Roland K, Hangartner, Lars, Klein, Florian, Diskin, Ron, Scheid, Johannes F, Sather, D Noah, Burton, Dennis R, Stamatatos, Leonidas
Published in PLoS pathogens (01.01.2013)
Published in PLoS pathogens (01.01.2013)
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Journal Article
Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit
Hurlburt, Nicholas K., Homad, Leah J., Sinha, Irika, Jennewein, Madeleine F., MacCamy, Anna J., Wan, Yu-Hsin, Boonyaratanakornkit, Jim, Sholukh, Anton M., Jackson, Abigail M., Zhou, Panpan, Burton, Dennis R., Andrabi, Raiees, Ozorowski, Gabriel, Ward, Andrew B., Stamatatos, Leonidas, Pancera, Marie, McGuire, Andrew T.
Published in Communications biology (11.04.2022)
Published in Communications biology (11.04.2022)
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