Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemia
Sanjuan-Pla, Alejandra, Bueno, Clara, Prieto, Cristina, Acha, Pamela, Stam, Ronald W., Marschalek, Rolf, Menéndez, Pablo
Published in Blood (17.12.2015)
Published in Blood (17.12.2015)
Get full text
Journal Article
Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis
Agraz-Doblas, Antonio, Bueno, Clara, Bashford-Rogers, Rachael, Roy, Anindita, Schneider, Pauline, Bardini, Michela, Ballerini, Paola, Cazzaniga, Gianni, Moreno, Thaidy, Revilla, Carlos, Gut, Marta, Valsecchi, Maria G, Roberts, Irene, Pieters, Rob, De Lorenzo, Paola, Varela, Ignacio, Menendez, Pablo, Stam, Ronald W
Published in Haematologica (Roma) (01.06.2019)
Published in Haematologica (Roma) (01.06.2019)
Get full text
Journal Article
Partner independent fusion gene detection by multiplexed CRISPR-Cas9 enrichment and long read nanopore sequencing
Stangl, Christina, de Blank, Sam, Renkens, Ivo, Westera, Liset, Verbeek, Tamara, Valle-Inclan, Jose Espejo, González, Rocio Chamorro, Henssen, Anton G., van Roosmalen, Markus J., Stam, Ronald W., Voest, Emile E., Kloosterman, Wigard P., van Haaften, Gijs, Monroe, Glen R.
Published in Nature communications (05.06.2020)
Published in Nature communications (05.06.2020)
Get full text
Journal Article
Trametinib inhibits RAS -mutant MLL -rearranged acute lymphoblastic leukemia at specific niche sites and reduces ERK phosphorylation in vivo
Kerstjens, Mark, Pinhancos, Sandra S, Castro, Patricia Garrido, Schneider, Pauline, Wander, Priscilla, Pieters, Rob, Stam, Ronald W
Published in Haematologica (Roma) (01.04.2018)
Published in Haematologica (Roma) (01.04.2018)
Get full text
Journal Article
The clinical and biological characteristics of NUP98-KDM5A in pediatric acute myeloid leukemia
Noort, Sanne, Wander, Priscilla, Alonzo, Todd A, Smith, Jenny, Ries, Rhonda E, Gerbing, Robert B, Dolman, M Emmy M, Locatelli, Franco, Reinhardt, Dirk, Baruchel, Andre, Stary, Jan, Molenaar, Jan J, Stam, Ronald W, van den Heuvel-Eibrink, Marry M, Zwaan, Michel C, Meshinchi, Soheil
Published in Haematologica (Roma) (01.02.2021)
Published in Haematologica (Roma) (01.02.2021)
Get full text
Journal Article
NUTM1 is a recurrent fusion gene partner in B-cell precursor acute lymphoblastic leukemia associated with increased expression of genes on chromosome band 10p12.31-12.2
Hormann, Femke M, Hoogkamer, Alex Q, Beverloo, H Berna, Boeree, Aurélie, Dingjan, Ilse, Wattel, Moniek M, Stam, Ronald W, Escherich, Gabriele, Pieters, Rob, den Boer, Monique L, Boer, Judith M
Published in Haematologica (Roma) (01.10.2019)
Published in Haematologica (Roma) (01.10.2019)
Get full text
Journal Article
Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study
Boer, Judith M, Valsecchi, Maria Grazia, Hormann, Femke M, Antić, Željko, Zaliova, Marketa, Schwab, Claire, Cazzaniga, Giovanni, Arfeuille, Chloé, Cavé, Hélène, Attarbaschi, Andishe, Strehl, Sabine, Escherich, Gabriele, Imamura, Toshihiko, Ohki, Kentaro, Grüber, Tanja A, Sutton, Rosemary, Pastorczak, Agata, Lammens, Tim, Lambert, Frédéric, Li, Chi Kong, Carrillo de Santa Pau, Enrique, Hoffmann, Steve, Möricke, Anja, Harrison, Christine J, Den Boer, Monique L, De Lorenzo, Paola, Stam, Ronald W, Bergmann, Anke K, Pieters, Rob
Published in Leukemia (01.10.2021)
Published in Leukemia (01.10.2021)
Get full text
Journal Article
Editorial: Harnessing chemotherapy resistance and development of novel therapeutic strategies for acute leukemia with KMT2A (MLL)-gene rearrangements
Esposito, Maria Teresa, Hagström-Andersson, Anna, Stam, Ronald W., Bortoluzzi, Stefania
Published in Frontiers in pharmacology (08.08.2022)
Published in Frontiers in pharmacology (08.08.2022)
Get full text
Journal Article
Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLL-rearranged B cell acute lymphoblastic leukemia
Tejedor, Juan Ramón, Bueno, Clara, Vinyoles, Meritxell, Petazzi, Paolo, Agraz-Doblas, Antonio, Cobo, Isabel, Torres-Ruiz, Raúl, Bayón, Gustavo F, Pérez, Raúl F, López-Tamargo, Sara, Gutierrez-Agüera, Francisco, Santamarina-Ojeda, Pablo, Ramírez-Orellana, Manuel, Bardini, Michela, Cazzaniga, Giovanni, Ballerini, Paola, Schneider, Pauline, Stam, Ronald W, Varela, Ignacio, Fraga, Mario F, Fernández, Agustín F, Menéndez, Pablo
Published in The Journal of clinical investigation (01.07.2021)
Published in The Journal of clinical investigation (01.07.2021)
Get full text
Journal Article
Identification and characterization of relapse-initiating cells in MLL-rearranged infant ALL by single-cell transcriptomics
Candelli, Tito, Schneider, Pauline, Garrido Castro, Patricia, Jones, Luke A, Bodewes, Eduard, Rockx-Brouwer, Dedeke, Pieters, Rob, Holstege, Frank C P, Margaritis, Thanasis, Stam, Ronald W
Published in Leukemia (01.01.2022)
Published in Leukemia (01.01.2022)
Get full text
Journal Article
Distinct Responses to Menin Inhibition and Synergy with DOT1L Inhibition in KMT2A-Rearranged Acute Lymphoblastic and Myeloid Leukemia
Adriaanse, Fabienne R. S, Schneider, Pauline, Arentsen-Peters, Susan T. C. J. M, Fonseca, Ana M. Neves da, Stutterheim, Janine, Pieters, Rob, Zwaan, C. Michel, Stam, Ronald W
Published in International journal of molecular sciences (01.06.2024)
Published in International journal of molecular sciences (01.06.2024)
Get full text
Journal Article
In Childhood Acute Lymphoblastic Leukemia, Blasts at Different Stages of Immunophenotypic Maturation Have Stem Cell Properties
le Viseur, Christoph, Hotfilder, Marc, Bomken, Simon, Wilson, Kerrie, Röttgers, Silja, Schrauder, André, Rosemann, Annegret, Irving, Julie, Stam, Ronald W., Shultz, Leonard D., Harbott, Jochen, Jürgens, Heribert, Schrappe, Martin, Pieters, Rob, Vormoor, Josef
Published in Cancer cell (08.07.2008)
Published in Cancer cell (08.07.2008)
Get full text
Journal Article
Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance
Wei, Guo, Twomey, David, Lamb, Justin, Schlis, Krysta, Agarwal, Jyoti, Stam, Ronald W., Opferman, Joseph T., Sallan, Stephen E., den Boer, Monique L., Pieters, Rob, Golub, Todd R., Armstrong, Scott A.
Published in Cancer cell (01.10.2006)
Published in Cancer cell (01.10.2006)
Get full text
Journal Article
CRISPR-Cas9 Library Screening Identifies Novel Molecular Vulnerabilities in KMT2A-Rearranged Acute Lymphoblastic Leukemia
Schneider, Pauline, Wander, Priscilla, Arentsen-Peters, Susan T. C. J. M., Vrenken, Kirsten S., Rockx-Brouwer, Dedeke, Adriaanse, Fabienne R. S., Hoeve, Veerle, Paassen, Irene, Drost, Jarno, Pieters, Rob, Stam, Ronald W.
Published in International journal of molecular sciences (01.09.2023)
Published in International journal of molecular sciences (01.09.2023)
Get full text
Journal Article
MEK inhibition is a promising therapeutic strategy for MLL-rearranged infant acute lymphoblastic leukemia patients carrying RAS mutations
Kerstjens, Mark, Driessen, Emma M C, Willekes, Merel, Pinhanços, Sandra S, Schneider, Pauline, Pieters, Rob, Stam, Ronald W
Published in Oncotarget (28.02.2017)
Published in Oncotarget (28.02.2017)
Get full text
Journal Article
NG2 is a target gene of MLL-AF4 and underlies glucocorticoid resistance in MLL-r B-ALL by regulating NR3C1 expression
Lopez-Millan, Belén, Rubio-Gayarre, Alba, Vinyoles, Meritxell, Trincado, Juan L., Fraga, Mario F., Fernandez-Fuentes, Narcís, Guerrero-Murillo, Mercedes, Martinez, Alba, Velasco-Hernandez, Talia, Falgàs, Aïda, Panisello, Carla, Valcarcel, Gemma, Sardina, José Luis, López-Martí, Paula, Javierre, Biola M., Del Valle-Pérez, Beatriz, García de Herreros, Antonio, Locatelli, Franco, Pieters, Rob, Bardini, Michela, Cazzaniga, Giovanni, Rodríguez-Manzaneque, Juan Carlos, Hanewald, Thomas, Marschalek, Rolf, Milne, Thomas A., Stam, Ronald W., Tejedor, Juan Ramón, Menendez, Pablo, Bueno, Clara
Published in Blood (02.08.2024)
Published in Blood (02.08.2024)
Get full text
Journal Article
Activated KRAS Cooperates with MLL-AF4 to Promote Extramedullary Engraftment and Migration of Cord Blood CD34+ HSPC But Is Insufficient to Initiate Leukemia
Prieto, Cristina, Stam, Ronald W, Agraz-Doblas, Antonio, Ballerini, Paola, Camos, Mireia, Castaño, Julio, Marschalek, Rolf, Bursen, Aldeheid, Varela, Ignacio, Bueno, Clara, Menendez, Pablo
Published in Cancer research (Chicago, Ill.) (15.04.2016)
Published in Cancer research (Chicago, Ill.) (15.04.2016)
Get full text
Journal Article