The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE3Leiden.CETP mice
Landlinger, Christine, Pouwer, Marianne G, Juno, Claudia, van der Hoorn, José W A, Pieterman, Elsbet J, Jukema, J Wouter, Staffler, Guenther, Princen, Hans M G, Galabova, Gergana
Published in European heart journal (21.08.2017)
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Peptide-based anti-PCSK9 vaccines - an approach for long-term LDLc management
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Published in PloS one (04.12.2014)
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Active immunization against complement factor C5a: a new therapeutic approach for Alzheimer's disease
Landlinger, Christine, Oberleitner, Lisa, Gruber, Petra, Noiges, Birgit, Yatsyk, Kristyna, Santic, Radmila, Mandler, Markus, Staffler, Guenther
Published in Journal of neuroinflammation (16.08.2015)
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Inhibiting cellular uptake of mutant huntingtin using a monoclonal antibody: Implications for the treatment of Huntington's disease
Bartl, Stefan, Oueslati, Abid, Southwell, Amber L., Siddu, Alberto, Parth, Michela, David, Linda Suzanne, Maxan, Alexander, Salhat, Nina, Burkert, Markus, Mairhofer, Andreas, Friedrich, Theresa, Pankevych, Halyna, Balazs, Katja, Staffler, Guenther, Hayden, Michael R., Cicchetti, Francesca, Smrzka, Oskar W.
Published in Neurobiology of disease (01.07.2020)
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Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance
Lemos, Miguel, Venezia, Serena, Refolo, Violetta, Heras-Garvin, Antonio, Schmidhuber, Sabine, Giese, Armin, Leonov, Andrei, Ryazanov, Sergey, Griesinger, Christian, Galabova, Gergana, Staffler, Guenther, Wenning, Gregor Karl, Stefanova, Nadia
Published in Translational neurodegeneration (24.09.2020)
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Identification of matrix metalloproteinase-12 as a candidate molecule for prevention and treatment of cardiometabolic disease
Amor, M, Moreno Viedma, V, Sarabi, A, Grün, N G, Itariu, B, Leitner, L, Steiner, I, Bilban, M, Kodama, K, Butte, A J, Staffler, G, Zeyda, M, Stulnig, T M
Published in Molecular medicine (Cambridge, Mass.) (01.01.2016)
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NMR Characterization of Surface Receptor Protein Interactions in Live Cells Using Methylcellulose Hydrogels
Mateos, Borja, Sealey‐Cardona, Marco, Balazs, Katja, Konrat, Judith, Staffler, Guenther, Konrat, Robert
Published in Angewandte Chemie International Edition (02.03.2020)
Published in Angewandte Chemie International Edition (02.03.2020)
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A phase I study assessing the safety, tolerability, immunogenicity, and low-density lipoprotein cholesterol-lowering activity of immunotherapeutics targeting PCSK9
Zeitlinger, Markus, Bauer, Martin, Reindl-Schwaighofer, Roman, Stoekenbroek, Robert M., Lambert, Gilles, Berger-Sieczkowski, Evelyn, Lagler, Heimo, Oesterreicher, Zoe, Wulkersdorfer, Beatrix, Lührs, Petra, Galabova, Gergana, Schwenke, Carsten, Mader, Robert M., Medori, Rossella, Landlinger, Christine, Kutzelnigg, Alexandra, Staffler, Günther
Published in European journal of clinical pharmacology (01.10.2021)
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Safety and Tolerability of Active Immunotherapy Targeting α-Synuclein with PD03A in Patients with Early Parkinson’s Disease: A Randomized, Placebo-Controlled, Phase 1 Study
Poewe, Werner, Volc, Dieter, Seppi, Klaus, Medori, Rossella, Lührs, Petra, Kutzelnigg, Alexandra, Djamshidian, Atbin, Thun-Hohenstein, Caroline, Meissner, Wassilios G., Rascol, Olivier, Schneeberger, Achim, Staffler, Günther, Poewe, Werner, deMarzi, Roberto, Heim, Beatrice, Mangesius, Stephanie, Stolz, Raphaela, Wachowicz, Katarzyna, Riha, Constanze, Schneeberger, Achim, Bürger, Vera, Galabova, Gergana
Published in Journal of Parkinson's disease (01.01.2021)
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Osteopontin affects macrophage polarization promoting endocytic but not inflammatory properties
Schuch, Karina, Wanko, Bettina, Ambroz, Katharina, Castelo‐Rosa, Alexandra, Moreno‐Viedma, Verónica, Grün, Nicole G., Leitner, Lukas, Staffler, Günther, Zeyda, Maximilian, Stulnig, Thomas M.
Published in Obesity (Silver Spring, Md.) (01.07.2016)
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Antibody-mediated targeting of cleavage-specific OPN-T cell interactions
Wanko, Bettina, Tardelli, Matteo, Jürets, Alexander, Neuhofer, Angelika, Prager, Gerhard, Morser, John, Leung, Lawrence L, Staffler, Günther, Zeyda, Maximilian, Stulnig, Thomas M
Published in PloS one (05.04.2019)
Published in PloS one (05.04.2019)
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An accelerated mouse model for atherosclerosis and adipose tissue inflammation
Neuhofer, Angelika, Wernly, Bernhard, Leitner, Lukas, Sarabi, Alisina, Sommer, Nicole G, Staffler, Günther, Zeyda, Maximilian, Stulnig, Thomas M
Published in Cardiovascular diabetology (17.01.2014)
Published in Cardiovascular diabetology (17.01.2014)
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Immunological blockade of adipocyte inflammation caused by increased matrix metalloproteinase‐cleaved osteopontin in obesity
Leitner, Lukas, Schuch, Karina, Jürets, Alexander, Itariu, Bianca K., Keck, Maike, Grablowitz, Viktor, Aszmann, Oskar C., Prager, Gerhard, Staffler, Günther, Zeyda, Maximilian, Stulnig, Thomas M.
Published in Obesity (Silver Spring, Md.) (01.04.2015)
Published in Obesity (Silver Spring, Md.) (01.04.2015)
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Inhibition of Cellular Adhesion by Immunological Targeting of Osteopontin Neoepitopes Generated through Matrix Metalloproteinase and Thrombin Cleavage
Jürets, Alexander, Le Bras, Marie, Staffler, Günther, Stein, Gesine, Leitner, Lukas, Neuhofer, Angelika, Tardelli, Matteo, Turkof, Edvin, Zeyda, Maximilian, Stulnig, Thomas M
Published in PloS one (03.02.2016)
Published in PloS one (03.02.2016)
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Abstract 15205: Atheroprotective Effect of the AFFITOPE®-based Anti-PCSK9 Vaccine (AT04A) in APOE3Leiden.CETP Mice
Galabova, Gergana, Juno, Claudia, Mairhofer, Andreas, van der Hoorn, José W, Pieterman, Elsbet J, Pouwer, Marianne, Jukema, J W, Princen, Hans M, Schneeberger, Achim, Staffler, Guenther
Published in Circulation (New York, N.Y.) (10.11.2015)
Published in Circulation (New York, N.Y.) (10.11.2015)
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Peptide-based vaccination against OPN integrin binding sites does not improve cardio-metabolic disease in mice
Grün, Nicole G, Strohmeier, Karin, Moreno-Viedma, Veronica, Le Bras, Marie, Landlinger, Christine, Zeyda, Karina, Wanko, Bettina, Leitner, Lukas, Staffler, Günther, Zeyda, Maximilian, Stulnig, Thomas M
Published in Immunology letters (01.11.2016)
Published in Immunology letters (01.11.2016)
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