Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS
Hodges, Timothy R, Abbott, Jason R, Little, Andrew J, Sarkar, Dhruba, Salovich, James M, Howes, Jennifer E, Akan, Denis T, Sai, Jiqing, Arnold, Allison L, Browning, Carrie, Burns, Michael C, Sobolik, Tammy, Sun, Qi, Beesetty, Yugandhar, Coker, Jesse A, Scharn, Dirk, Stadtmueller, Heinz, Rossanese, Olivia W, Phan, Jason, Waterson, Alex G, McConnell, Darryl B, Fesik, Stephen W
Published in Journal of medicinal chemistry (11.10.2018)
Published in Journal of medicinal chemistry (11.10.2018)
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Journal Article
Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors
Engelhardt, Harald, Böse, Dietrich, Petronczki, Mark, Scharn, Dirk, Bader, Gerd, Baum, Anke, Bergner, Andreas, Chong, Eugene, Döbel, Sandra, Egger, Georg, Engelhardt, Christian, Ettmayer, Peter, Fuchs, Julian E, Gerstberger, Thomas, Gonnella, Nina, Grimm, Andreas, Grondal, Elisabeth, Haddad, Nizar, Hopfgartner, Barbara, Kousek, Roland, Krawiec, Mariusz, Kriz, Monika, Lamarre, Lyne, Leung, Joyce, Mayer, Moriz, Patel, Nitinchandra D, Simov, Biljana Peric, Reeves, Jonathan T, Schnitzer, Renate, Schrenk, Andreas, Sharps, Bernadette, Solca, Flavio, Stadtmüller, Heinz, Tan, Zhulin, Wunberg, Tobias, Zoephel, Andreas, McConnell, Darryl B
Published in Journal of medicinal chemistry (27.11.2019)
Published in Journal of medicinal chemistry (27.11.2019)
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A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation
Waizenegger, Irene C, Baum, Anke, Steurer, Steffen, Stadtmüller, Heinz, Bader, Gerd, Schaaf, Otmar, Garin-Chesa, Pilar, Schlattl, Andreas, Schweifer, Norbert, Haslinger, Christian, Colbatzky, Florian, Mousa, Sien, Kalkuhl, Arno, Kraut, Norbert, Adolf, Günther R
Published in Molecular cancer therapeutics (01.03.2016)
Published in Molecular cancer therapeutics (01.03.2016)
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Palladium-catalyzed iodine-zinc exchange reactions. A new palladium-mediated intramolecular carbozincation of alkenes
Stadtmueller, Heinz, Lentz, Ruth, Tucker, Charles E, Stuedemann, Thomas, Doerner, Wolfgang, Knochel, Paul
Published in Journal of the American Chemical Society (01.07.1993)
Published in Journal of the American Chemical Society (01.07.1993)
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Abstract C133: Effective targeting of KRAS-driven tumors by the first-in-class, orally bioavailable SOS1::KRAS inhibitor BI-3406
Hofmann, Marco H, Gmachl, Michael, Ramharter, Jürgen, Savarese, Fabio, Sanderson, Michael P, Gerlach, Daniel, Trapani, Francesca, Botesteanu, Dana-Adriana, Kessler, Dirk, Ettmayer, Peter, Arnhof, Heribert, Gerstberger, Thomas, Schnitzer, Renate, Kofink, Christiane, Stadtmueller, Heinz, Wunberg, Tobias, O’Connell, Jonathan C., Mendes, Rachel L, Richard, David, Saldanha, Adrian S, Moll, Juergen, Pearson, Mark, McConnell, Darryl B, Kraut, Norbert
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Journal Article
Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype
Hirt, Ulrich A., Waizenegger, Irene C., Schweifer, Norbert, Haslinger, Christian, Gerlach, Daniel, Braunger, Jürgen, Weyer-Czernilofsky, Ulrike, Stadtmüller, Heinz, Sapountzis, Ioannis, Bader, Gerd, Zoephel, Andreas, Bister, Bojan, Baum, Anke, Quant, Jens, Kraut, Norbert, Garin-Chesa, Pilar, Adolf, Günther R.
Published in Oncogenesis (New York, NY) (23.02.2018)
Published in Oncogenesis (New York, NY) (23.02.2018)
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암 치료를 위한 고리형 2-아미노-3-시아노 티오펜 및 유도체
GOLLNER ANDREAS, STADTMUELLER HEINZ, TREU MATTHIAS, LITTLE ANDREW, MANTOULIDIS ANDREAS, CUI JIANWEN, HODGES TIM, PHAN JASON, HERDEIS LORENZ, SMETHURST CHRISTIAN ALAN PAUL, WUNBERG TOBIAS, SARKAR DHRUBA, SOKOL KEVIN, WILDING BIRGIT, FUCHS JULIAN, WATERSON ALEX, FESIK STEPHEN W, BROEKER JOACHIM, RAMHARTER JUERGEN, ABBOTT JASON, SUN QI
Year of Publication 27.08.2024
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Year of Publication 27.08.2024
Patent
SOS1 억제제로서의 신규 벤질아미노 치환 피리도피리미디논 및 유도체
STADTMUELLER HEINZ, GMACHL MICHAEL, GOEPPER STEFAN, HOFMANN MARCO HANS, GILLE ANNIKA, WUNBERG TOBIAS, RUDOLPH DOROTHEA INGRID, FRANK MARKUS, WIPPICH JULIAN, OSTERMEIER MARKUS, KOFINK CHRISTIANE, BAUM ANKE, RAMHARTER JUERGEN, SANTAGOSTINO MARCO, SAVARESE FABIO
Year of Publication 28.09.2020
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Year of Publication 28.09.2020
Patent
Abstract A249: BI 853520, a potent and highly selective inhibitor of protein tyrosine kinase 2 (focal adhesion kinase), shows efficacy in multiple xenograft models of human cancer
Hirt, Ulrich A., Braunger, Juergen, Schleicher, Michael, Weyer-Czernilofsky, Ulrike, Garin-Chesa, Pilar, Bister, Bojan, Stadtmueller, Heinz, Sapountzis, Ioannis, Kraut, Norbert, Adolf, Guenther R.
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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