Mechanistic Studies of the Inactivation of TEM-1 and P99 by NXL104, a Novel Non-β-Lactam β-Lactamase Inhibitor
STACHYRA, Thérèse, PECHEREAU, Marie-Claude, BRUNEAU, Jean-Michel, CLAUDON, Monique, FRERE, Jean-Marie, MIOSSEC, Christine, COLEMAN, Kenneth, BLACK, Michael T
Published in Antimicrobial Agents and Chemotherapy (01.12.2010)
Published in Antimicrobial Agents and Chemotherapy (01.12.2010)
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Journal Article
Mechanism of Action of the Antibiotic NXL101, a Novel Nonfluoroquinolone Inhibitor of Bacterial Type II Topoisomerases
Black, Michael T, Stachyra, Thérèse, Platel, Denis, Girard, Anne-Marie, Claudon, Monique, Bruneau, Jean-Michel, Miossec, Christine
Published in Antimicrobial Agents and Chemotherapy (01.09.2008)
Published in Antimicrobial Agents and Chemotherapy (01.09.2008)
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Journal Article
In vitro activity of the β-lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases
Stachyra, Thérèse, Levasseur, Premavathy, Péchereau, Marie-Claude, Girard, Anne-Marie, Claudon, Monique, Miossec, Christine, Black, Michael T.
Published in Journal of antimicrobial chemotherapy (01.08.2009)
Published in Journal of antimicrobial chemotherapy (01.08.2009)
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Journal Article
In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor
Vaupel, Andrea, Holzer, Philipp, Ferretti, Stephane, Guagnano, Vito, Kallen, Joerg, Mah, Robert, Masuya, Keiichi, Ruetz, Stephan, Rynn, Caroline, Schlapbach, Achim, Stachyra, Thérèse, Stutz, Stefan, Todorov, Milen, Jeay, Sébastien, Furet, Pascal
Published in Bioorganic & medicinal chemistry letters (01.11.2018)
Published in Bioorganic & medicinal chemistry letters (01.11.2018)
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Journal Article
In vitro activity of AVE1330A, an innovative broad-spectrum non-β-lactam β-lactamase inhibitor
Bonnefoy, Alain, Dupuis-Hamelin, Claudine, Steier, Valérie, Delachaume, Carole, Seys, Catherine, Stachyra, Thérèse, Fairley, Monique, Guitton, Michèle, Lampilas, Maxime
Published in Journal of antimicrobial chemotherapy (01.08.2004)
Published in Journal of antimicrobial chemotherapy (01.08.2004)
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Journal Article
Fluorescence Detection-Based Functional Assay for High-Throughput Screening for MraY
STACHYRA, Thérèse, DINI, Christophe, FERRARI, Paul, BOUHSS, Ahmed, VAN HEIJENOORT, Jean, MENGIN-LECREULX, Dominique, BLANOT, Didier, BITON, Jacques, LE BELLER, Dominique
Published in Antimicrobial Agents and Chemotherapy (01.03.2004)
Published in Antimicrobial Agents and Chemotherapy (01.03.2004)
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Journal Article
Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201
Jeay, Sébastien, Ferretti, Stéphane, Holzer, Philipp, Fuchs, Jeanette, Chapeau, Emilie A, Wartmann, Markus, Sterker, Dario, Romanet, Vincent, Murakami, Masato, Kerr, Grainne, Durand, Eric Y, Gaulis, Swann, Cortes-Cros, Marta, Ruetz, Stephan, Stachyra, Therese-Marie, Kallen, Joerg, Furet, Pascal, Würthner, Jens, Guerreiro, Nelson, Halilovic, Ensar, Jullion, Astrid, Kauffmann, Audrey, Kuriakose, Emil, Wiesmann, Marion, Jensen, Michael R, Hofmann, Francesco, Sellers, William R
Published in Cancer research (Chicago, Ill.) (01.11.2018)
Published in Cancer research (Chicago, Ill.) (01.11.2018)
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Journal Article
DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance
Schröder, Martin, Renatus, Martin, Liang, Xiaoyou, Meili, Fabian, Zoller, Thomas, Ferrand, Sandrine, Gauter, Francois, Li, Xiaoyan, Sigoillot, Frederic, Gleim, Scott, Stachyra, Therese-Marie, Thomas, Jason R, Begue, Damien, Khoshouei, Maryam, Lefeuvre, Peggy, Andraos-Rey, Rita, Chung, BoYee, Ma, Renate, Pinch, Benika, Hofmann, Andreas, Schirle, Markus, Schmiedeberg, Niko, Imbach, Patricia, Gorses, Delphine, Calkins, Keith, Bauer-Probst, Beatrice, Maschlej, Magdalena, Niederst, Matt, Maher, Rob, Henault, Martin, Alford, John, Ahrne, Erik, Tordella, Luca, Hollingworth, Greg, Thomä, Nicolas H, Vulpetti, Anna, Radimerski, Thomas, Holzer, Philipp, Carbonneau, Seth, Thoma, Claudio R
Published in Nature communications (04.01.2024)
Published in Nature communications (04.01.2024)
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Journal Article
Abstract 1239: NVP-HDM201: Biochemical and biophysical profile of a novel highly potent and selective PPI inhibitor of p53-Mdm2
Stachyra-Valat, Thérèse, Baysang, Frédéric, D’Alessandro, Anne-Cécile, Dirk, Erdmann, Furet, Pascal, Guagnano, Vito, Kallen, Joerg, Leder, Lukas, Mah, Robert, Masuya, Keiichi, Stutz, Stefan, Vaupel, Andrea, Hofmann, Francesco, Chène, Patrick, Jeay, Sébastien, Holzer, Philipp
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes
Kallen, Joerg, Izaac, Aude, Chau, Suzanne, Wirth, Emmanuelle, Schoepfer, Joseph, Mah, Robert, Schlapbach, Achim, Stutz, Stefan, Vaupel, Andrea, Guagnano, Vito, Masuya, Keiichi, Stachyra, Therese‐Marie, Salem, Bahaa, Chene, Patrick, Gessier, Francois, Holzer, Philipp, Furet, Pascal
Published in ChemMedChem (17.07.2019)
Published in ChemMedChem (17.07.2019)
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Journal Article
Bioorthogonal Probes for the Study of MDM2-p53 Inhibitors in Cells and Development of High-Content Screening Assays for Drug Discovery
D'Alessandro, Pier Luca, Buschmann, Nicole, Kaufmann, Markus, Furet, Pascal, Baysang, Frederic, Brunner, Reto, Marzinzik, Andreas, Vorherr, Thomas, Stachyra, Therese-Marie, Ottl, Johannes, Lizos, Dimitrios E., Cobos-Correa, Amanda
Published in Angewandte Chemie (International ed.) (23.12.2016)
Published in Angewandte Chemie (International ed.) (23.12.2016)
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Journal Article
Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field
Vulpetti, Anna, Holzer, Philipp, Schmiedeberg, Niko, Imbach-Weese, Patricia, Pissot-Soldermann, Carole, Hollingworth, Gregory J., Radimerski, Thomas, Thoma, Claudio R., Stachyra, Therese-Marie, Wojtynek, Matthias, Maschlej, Magdalena, Chau, Suzanne, Schuffenhauer, Ansgar, Fernández, César, Schröder, Martin, Renatus, Martin
Published in ACS medicinal chemistry letters (13.07.2023)
Published in ACS medicinal chemistry letters (13.07.2023)
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Journal Article
The central valine concept provides an entry in a new class of non peptide inhibitors of the p53–MDM2 interaction
Furet, Pascal, Chène, Patrick, De Pover, Alain, Valat, Thérèse Stachyra, Lisztwan, Joanna Hergovich, Kallen, Joerg, Masuya, Keiichi
Published in Bioorganic & medicinal chemistry letters (15.05.2012)
Published in Bioorganic & medicinal chemistry letters (15.05.2012)
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Journal Article
Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors
Holzer, Philipp, Masuya, Keiichi, Furet, Pascal, Kallen, Joerg, Valat-Stachyra, Therese, Ferretti, Stéphane, Berghausen, Joerg, Bouisset-Leonard, Michèle, Buschmann, Nicole, Pissot-Soldermann, Carole, Rynn, Caroline, Ruetz, Stephan, Stutz, Stefan, Chène, Patrick, Jeay, Sébastien, Gessier, Francois
Published in Journal of medicinal chemistry (27.08.2015)
Published in Journal of medicinal chemistry (27.08.2015)
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Journal Article
Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors
Schneider, Anselm F L, Kallen, Joerg, Ottl, Johannes, Reid, Patrick C, Ripoche, Sebastien, Ruetz, Stephan, Stachyra, Therese-Marie, Hintermann, Samuel, Dumelin, Christoph E, Hackenberger, Christian P R, Marzinzik, Andreas L
Published in RSC chemical biology (02.12.2021)
Published in RSC chemical biology (02.12.2021)
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Journal Article
Author Correction: DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance
Schröder, Martin, Renatus, Martin, Liang, Xiaoyou, Meili, Fabian, Zoller, Thomas, Ferrand, Sandrine, Gauter, Francois, Li, Xiaoyan, Sigoillot, Frederic, Gleim, Scott, Stachyra, Therese-Marie, Thomas, Jason R, Begue, Damien, Khoshouei, Maryam, Lefeuvre, Peggy, Andraos-Rey, Rita, Chung, BoYee, Ma, Renate, Pinch, Benika, Hofmann, Andreas, Schirle, Markus, Schmiedeberg, Niko, Imbach, Patricia, Gorses, Delphine, Calkins, Keith, Bauer-Probst, Beatrice, Maschlej, Magdalena, Niederst, Matt, Maher, Rob, Henault, Martin, Alford, John, Ahrne, Erik, Tordella, Luca, Hollingworth, Greg, Thomä, Nicolas H, Vulpetti, Anna, Radimerski, Thomas, Holzer, Philipp, Carbonneau, Seth, Thoma, Claudio R
Published in Nature communications (19.08.2024)
Published in Nature communications (19.08.2024)
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Journal Article
Bioorthogonal Probes for the Study of MDM2-p53 Inhibitors in Cells and Development of High-Content Screening Assays for Drug Discovery
D'Alessandro, Pier Luca, Buschmann, Nicole, Kaufmann, Markus, Furet, Pascal, Baysang, Frederic, Brunner, Reto, Marzinzik, Andreas, Vorherr, Thomas, Stachyra, Therese-Marie, Ottl, Johannes, Lizos, Dimitrios E., Cobos-Correa, Amanda
Published in Angewandte Chemie (23.12.2016)
Published in Angewandte Chemie (23.12.2016)
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Journal Article
Discovery of a novel class of highly potent inhibitors of the p53–MDM2 interaction by structure-based design starting from a conformational argument
Furet, Pascal, Masuya, Keiichi, Kallen, Joerg, Stachyra-Valat, Thérèse, Ruetz, Stephan, Guagnano, Vito, Holzer, Philipp, Mah, Robert, Stutz, Stefan, Vaupel, Andrea, Chène, Patrick, Jeay, Sébastien, Schlapbach, Achim
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
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Journal Article
Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53–MDM2 interaction with a distinct binding mode
Gessier, François, Kallen, Joerg, Jacoby, Edgar, Chène, Patrick, Stachyra-Valat, Thérèse, Ruetz, Stephan, Jeay, Sébastien, Holzer, Philipp, Masuya, Keiichi, Furet, Pascal
Published in Bioorganic & medicinal chemistry letters (01.09.2015)
Published in Bioorganic & medicinal chemistry letters (01.09.2015)
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Journal Article
Tetra-substituted imidazoles as a new class of inhibitors of the p53–MDM2 interaction
Vaupel, Andrea, Bold, Guido, De Pover, Alain, Stachyra-Valat, Thérèse, Hergovich Lisztwan, Joanna, Kallen, Joerg, Masuya, Keiichi, Furet, Pascal
Published in Bioorganic & medicinal chemistry letters (01.05.2014)
Published in Bioorganic & medicinal chemistry letters (01.05.2014)
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