ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance
Jang, Su Chul, Economides, Kyriakos D., Moniz, Raymond J., Sia, Chang Ling, Lewis, Nuruddeen, McCoy, Christine, Zi, Tong, Zhang, Kelvin, Harrison, Rane A., Lim, Joanne, Dey, Joyoti, Grenley, Marc, Kirwin, Katherine, Ross, Nikki L., Bourdeau, Raymond, Villiger-Oberbek, Agata, Estes, Scott, Xu, Ke, Sanchez-Salazar, Jorge, Dooley, Kevin, Dahlberg, William K., Williams, Douglas E., Sathyanarayanan, Sriram
Published in Communications biology (22.04.2021)
Published in Communications biology (22.04.2021)
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Journal Article
Characterization of immune regulatory molecules B7-H4 and PD-L1 in low and high grade endometrial tumors
Bregar, Amy, Deshpande, Amit, Grange, Chris, Zi, Tong, Stall, Jennifer, Hirsch, Heather, Reeves, Jason, Sathyanarayanan, Sriram, Growdon, Whitfield B, Rueda, Bo R
Published in Gynecologic oncology (01.06.2017)
Published in Gynecologic oncology (01.06.2017)
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Journal Article
ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models
Hanson, Amanda, Elpek, Kutlu, Duong, Ellen, Shallberg, Lindsey, Fan, Martin, Johnson, Calvin, Wallace, Matthew, Mabry, George R., Sazinsky, Stephen, Pepper, Lauren, Shu, Chengyi J., Sathyanarayanan, Sriram, Zuerndorfer, Sarah, Simpson, Tyler, Gostissa, Monica, Briskin, Michael, Law, Deborah, Michaelson, Jennifer, Harvey, Christopher J.
Published in PloS one (24.09.2020)
Published in PloS one (24.09.2020)
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Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma
Stoeck, Alexander, Lejnine, Serguei, Truong, Andrew, Pan, Li, Wang, Hongfang, Zang, Chongzhi, Yuan, Jing, Ware, Chris, MacLean, John, Garrett-Engele, Philip W, Kluk, Michael, Laskey, Jason, Haines, Brian B, Moskaluk, Christopher, Zawel, Leigh, Fawell, Stephen, Gilliland, Gary, Zhang, Theresa, Kremer, Brandon E, Knoechel, Birgit, Bernstein, Bradley E, Pear, Warren S, Liu, X Shirley, Aster, Jon C, Sathyanarayanan, Sriram
Published in Cancer discovery (01.10.2014)
Published in Cancer discovery (01.10.2014)
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Journal Article
Combination of the mTOR inhibitor ridaforolimus and the anti-IGF1R monoclonal antibody dalotuzumab: preclinical characterization and phase I clinical trial
Di Cosimo, Serena, Sathyanarayanan, Sriram, Bendell, Johanna C, Cervantes, Andrés, Stein, Mark N, Braña, Irene, Roda, Desamparados, Haines, Brian B, Zhang, Theresa, Winter, Christopher G, Jha, Sharda, Xu, Youyuan, Frazier, Jason, Klinghoffer, Richard A, Leighton-Swayze, Ann, Song, Yang, Ebbinghaus, Scot, Baselga, José
Published in Clinical cancer research (01.01.2015)
Published in Clinical cancer research (01.01.2015)
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Journal Article
mCRY1 and mCRY2 Are Essential Components of the Negative Limb of the Circadian Clock Feedback Loop
Kume, Kazuhiko, Zylka, Mark J, Sriram, Sathyanarayanan, Shearman, Lauren P, Weaver, David R, Jin, Xiaowei, Maywood, Elizabeth S, Hastings, Michael H, Reppert, Steven M
Published in Cell (23.07.1999)
Published in Cell (23.07.1999)
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Interacting Molecular Loops in the Mammalian Circadian Clock
Shearman, Lauren P., Sriram, Sathyanarayanan, Weaver, David R., Maywood, Elizabeth S., Chaves, Inẽs, Zheng, Binhai, Kume, Kazuhiko, Lee, Cheng Chi, Gijsbertus T. J. van der Horst, Hastings, Michael H., Reppert, Steven M.
Published in Science (American Association for the Advancement of Science) (12.05.2000)
Published in Science (American Association for the Advancement of Science) (12.05.2000)
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Journal Article
Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen
Sathyanarayanan, Sriram, Zheng, Xiangzhong, Kumar, Shailesh, Chen, Chun-Hong, Chen, Dechun, Hay, Bruce, Sehgal, Amita
Published in Genes & development (01.06.2008)
Published in Genes & development (01.06.2008)
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Journal Article
761 exoSTING demonstrates potent anti-tumor activity in a mouse model of leptomeningeal disease
Feng, Xudong, Lin, John, Jang, Su Chul, Lule, Sevda, Sanchez-Jauregui, Paloma, Kirwin, Katherine, Zi, Tong, Kasera, Samuel, Siso, Silvia, Zhang, Kelvin, Patel, Shil, Sathyanarayanan, Sriram, Economides, Kyriakos, Broom, Wendy
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
703 Engineered exosomes with altered cellular tropism achieve targeted STING agonist delivery and single-agent tumor control in vivo
Kauke, Monique, Ross, Nikki, Burzyn, Dalia, Martin, Shelly, Xu, Ke, Lewis, Nuruddeen, Leng, Charan, Jang, Su Chul, McCoy, Christine, Yu, Stephanie, Dooley, Kevin, Sathyanarayanan, Sriram, Finn, Jonathan
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
Development of a High-Throughput Gene Expression Screen for Modulators of RAS-MAPK Signaling in a Mutant RAS Cellular Context
Severyn, Bryan, Nguyen, Thi, Altman, Michael D., Li, Lixia, Nagashima, Kumiko, Naumov, George N., Sathyanarayanan, Sriram, Cook, Erica, Morris, Erick, Ferrer, Marc, Arthur, Bill, Benita, Yair, Watters, Jim, Loboda, Andrey, Hermes, Jeff, Gilliland, D. Gary, Cleary, Michelle A., Carroll, Pamela M., Strack, Peter, Tudor, Matt, Andersen, Jannik N.
Published in Journal of biomolecular screening (01.10.2016)
Published in Journal of biomolecular screening (01.10.2016)
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A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties
Dooley, Kevin, McConnell, Russell E., Xu, Ke, Lewis, Nuruddeen D., Haupt, Sonya, Youniss, Madeleine R., Martin, Shelly, Sia, Chang Ling, McCoy, Christine, Moniz, Raymond J., Burenkova, Olga, Sanchez-Salazar, Jorge, Jang, Su Chul, Choi, Bryan, Harrison, Rane A., Houde, Damian, Burzyn, Dalia, Leng, Charan, Kirwin, Katherine, Ross, Nikki L., Finn, Jonathan D., Gaidukov, Leonid, Economides, Kyriakos D., Estes, Scott, Thornton, James E., Kulman, John D., Sathyanarayanan, Sriram, Williams, Douglas E.
Published in Molecular therapy (05.05.2021)
Published in Molecular therapy (05.05.2021)
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Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity
Kamerkar, Sushrut, Leng, Charan, Burenkova, Olga, Jang, Su Chul, McCoy, Christine, Zhang, Kelvin, Dooley, Kevin, Kasera, Samuel, Zi, Tong, Sisó, Sílvia, Dahlberg, William, Sia, Chang Ling, Patel, Shil, Schmidt, Karl, Economides, Kyriakos, Soos, Timothy, Burzyn, Dalia, Sathyanarayanan, Sriram
Published in Science advances (18.02.2022)
Published in Science advances (18.02.2022)
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Journal Article
Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12
Lewis, Nuruddeen D, Sia, Chang Ling, Kirwin, Katherine, Haupt, Sonya, Mahimkar, Gauri, Zi, Tong, Xu, Ke, Dooley, Kevin, Jang, Su Chul, Choi, Bryan, Boutin, Adam, Grube, Andrew, McCoy, Christine, Sanchez-Salazar, Jorge, Doherty, Michael, Gaidukov, Leonid, Estes, Scott, Economides, Kyriakos D, Williams, Douglas E, Sathyanarayanan, Sriram
Published in Molecular cancer therapeutics (01.03.2021)
Published in Molecular cancer therapeutics (01.03.2021)
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Abstract CT114: Randomized placebo-controlled Phase 1 trial in healthy volunteers investigating safety, PK and PD of exoIL-12 - a novel engineered exosome therapeutic candidate
Mitchell, James, Scarisbrick, Julia, De Francesco, Irene, Cowan, Richard, McKay, Pam, Osborne, Wendy, Sathyanarayanan, Sriram, Ascolillo, Luke, Gow, Irene, Hill, Wendy, Lorch, Ulrike, Sorensen, Benny
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Interaction Between Sleep and the Immune Response in Drosophila: A Role for the NFκB Relish
Williams, Julie A., Sathyanarayanan, Sriram, Hendricks, Joan C., Sehgal, Amita
Published in Sleep (New York, N.Y.) (01.04.2007)
Published in Sleep (New York, N.Y.) (01.04.2007)
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Abstract 1792: Engineered exosome- mediated STAT6 knockdown in tumor associated macrophages (TAMs) results in potent single agent activity in a hepatocellular carcinoma (HCC) model
Kamerkar, Sushrut, Leng, Charan, Burenkova, Olga, Jang, Su Chul, McCoy, Christine, Zhang, Kelvin, Dahlberg, William, Leblanc, Marie, Quillery, Hugo, Maubant, Sylvie, Duchamp, Olivier, Economides, Kyriakos, Soos, Timothy, Burzyn, Dalia, Sathyanarayanan, Sriram
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
ICOS agonism by JTX-2011
Hanson, Amanda, Elpek, Kutlu, Duong, Ellen, Shallberg, Lindsey, Fan, Martin, Johnson, Calvin, Wallace, Matthew, Mabry, George R, Sazinsky, Stephen, Pepper, Lauren, Shu, Chengyi J, Sathyanarayanan, Sriram, Zuerndorfer, Sarah, Simpson, Tyler, Gostissa, Monica, Briskin, Michael, Law, Deborah, Michaelson, Jennifer, Harvey, Christopher J
Published in PloS one (24.09.2020)
Published in PloS one (24.09.2020)
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