Which Hydroxy? Evidence for Species Differences in the Regioselectivity of Glucuronidation in Rat, Dog, and Human in Vitro Systems and Dog in Vivo
MARTIN, Iain J, LEWIS, Richard J, BERNSTEIN, Michael A, BEATTIE, Iain G, MARTIN, Craig A, RILEY, Robert J, SPRINGTHORPE, Brian
Published in Drug metabolism and disposition (01.09.2006)
Published in Drug metabolism and disposition (01.09.2006)
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Journal Article
Overcoming Undesirable hERG Potency of Chemokine Receptor Antagonists Using Baseline Lipophilicity Relationships
Shamovsky, Igor, Connolly, Stephen, David, Laurent, Ivanova, Svetlana, Nordén, Bo, Springthorpe, Brian, Urbahns, Klaus
Published in Journal of medicinal chemistry (13.03.2008)
Published in Journal of medicinal chemistry (13.03.2008)
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Journal Article
From ATP to AZD6140 : The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis
SPRINGTHORPE, Brian, BAILEY, Andrew, HUNT, Simon F, INCE, Francis, INGALL, Anthony H, KIRK, Ian P, LEESON, Paul D, LEFF, Paul, LEWIS, Richard J, MARTIN, Barrie P, MCGINNITY, Dermot F, MORTIMORE, Michael P, BARTON, Patrick, PAINE, Stuart W, PAIRAUDEAU, Garry, PATEL, Anil, RIGBY, Aaron J, RILEY, Robert J, TEOBALD, Barry J, TOMLINSON, Wendy, WEBBORN, Peter J. H, WILLIS, Paul A, BIRKINSHAW, Timothy N, BONNERT, Roger V, BROWN, Roger C, CHAPMAN, David, DIXON, John, GUILE, Simon D, HUMPHRIES, Robert G
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
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Journal Article
Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092
Bahl, Ash, Barton, Patrick, Bowers, Keith, Caffrey, Moya V., Denton, Rebecca, Gilmour, Peter, Hawley, Shaun, Linannen, Tero, Luckhurst, Christopher A., Mochel, Tobias, Perry, Matthew W.D., Riley, Robert J., Roe, Emma, Springthorpe, Brian, Stein, Linda, Webborn, Peter
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
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Journal Article
The discovery of CCR3/H-1 dual antagonists with reduced hERG risk
Bahl, Ash, Barton, Patrick, Bowers, Keith, Brough, Steven, Evans, Richard, Luckhurst, Christopher A., Mochel, Tobias, Perry, Matthew W. D., Rigby, Aaron, Riley, Robert J., Sanganee, Hitesh, Sisson, Adam, Springthorpe, Brian
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
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Journal Article
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H-1 antagonists. Part II: Optimising in vivo clearance
Furber, Mark, Alcaraz, Lilian, Luckhurst, Christopher, Bahl, Ash, Beaton, Haydn, Bowers, Keith, Collington, John, Denton, Rebecca, Donald, David, Kinchin, Elizabeth, MacDonald, Cathy, Rigby, Aaron, Riley, Rob, Soars, Matt, Springthorpe, Brian, Webborn, Peter
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H-1 antagonists. Part I
Furber, Mark, Alcaraz, Lilian, Luckhurst, Christopher, Bahl, Ash, Beaton, Haydn, Bowers, Keith, Collington, John, Denton, Rebecca, Donald, David, Kinchin, Elizabeth, MacDonald, Cathy, Rigby, Aaron, Riley, Rob, Soars, Matt, Springthorpe, Brian, Webborn, Peter
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part II: Optimising in vivo clearance
Furber, Mark, Alcaraz, Lilian, Luckhurst, Christopher, Bahl, Ash, Beaton, Haydn, Bowers, Keith, Collington, John, Denton, Rebecca, Donald, David, Kinchin, Elizabeth, MacDonald, Cathy, Rigby, Aaron, Riley, Rob, Soars, Matt, Springthorpe, Brian, Webborn, Peter
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part I
Furber, Mark, Alcaraz, Lilian, Luckhurst, Christopher, Bahl, Ash, Beaton, Haydn, Bowers, Keith, Collington, John, Denton, Rebecca, Donald, David, Kinchin, Elizabeth, MacDonald, Cathy, Rigby, Aaron, Riley, Rob, Soars, Matt, Springthorpe, Brian, Webborn, Peter
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
The discovery of CCR3/H1 dual antagonists with reduced hERG risk
Bahl, Ash, Barton, Patrick, Bowers, Keith, Brough, Steven, Evans, Richard, Luckhurst, Christopher A., Mochel, Tobias, Perry, Matthew W.D., Rigby, Aaron, Riley, Robert J., Sanganee, Hitesh, Sisson, Adam, Springthorpe, Brian
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
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Journal Article
Drug disposition and cardiac toxicity: A litterature-based review
Hammond, Tim, Bowes, Joanne, Boyer, Scott, Burnham, Matthew B., Cook, David, Gavaghan, Glaire, Hance, Mark, Haywood, Martin, Matis, Sherri, Roberts, Stephanie, Springthorpe, Brian, Valentin, Jean-Pierre
Published in Journal of pharmacological and toxicological methods (01.07.2011)
Published in Journal of pharmacological and toxicological methods (01.07.2011)
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Journal Article
From ATP to AZD6140: The discovery of an orally active reversible P2Y 12 receptor antagonist for the prevention of thrombosis
Springthorpe, Brian, Bailey, Andrew, Barton, Patrick, Birkinshaw, Timothy N., Bonnert, Roger V., Brown, Roger C., Chapman, David, Dixon, John, Guile, Simon D., Humphries, Robert G., Hunt, Simon F., Ince, Francis, Ingall, Anthony H., Kirk, Ian P., Leeson, Paul D., Leff, Paul, Lewis, Richard J., Martin, Barrie P., McGinnity, Dermot F., Mortimore, Michael P., Paine, Stuart W., Pairaudeau, Garry, Patel, Anil, Rigby, Aaron J., Riley, Robert J., Teobald, Barry J., Tomlinson, Wendy, Webborn, Peter J.H., Willis, Paul A.
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Journal Article
Triazolo(4,5-D)pyrimidine compounds
Ingall Anthony, Willis Paul, Guile Simon, Springthorpe Brian, Hardem David
Year of Publication 17.01.2017
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Year of Publication 17.01.2017
Patent
"composto de triazolo [ 4,5-d] pirimidina, e, composição farmacêutica"
Paul Willis, Simon Guile, Anthony Ingall, Brian Springthorpe, David Hardern
Year of Publication 25.05.2021
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Year of Publication 25.05.2021
Patent