Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
Heidorn, Sonja J., Milagre, Carla, Whittaker, Steven, Nourry, Arnaud, Niculescu-Duvas, Ion, Dhomen, Nathalie, Hussain, Jahan, Reis-Filho, Jorge S., Springer, Caroline J., Pritchard, Catrin, Marais, Richard
Published in Cell (22.01.2010)
Published in Cell (22.01.2010)
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Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF
Wan, Paul T.C, Garnett, Mathew J, Roe, S.Mark, Lee, Sharlene, Niculescu-Duvaz, Dan, Good, Valerie M, Project, Cancer Genome, Jones, C.Michael, Marshall, Christopher J, Springer, Caroline J, Barford, David, Marais, Richard
Published in Cell (19.03.2004)
Published in Cell (19.03.2004)
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Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes
Pedersen, Malin, Küsters-Vandevelde, Heidi V N, Viros, Amaya, Groenen, Patricia J T A, Sanchez-Laorden, Berta, Gilhuis, Jacobus H, van Engen-van Grunsven, Ilse A, Renier, Willy, Schieving, Jolanda, Niculescu-Duvaz, Ion, Springer, Caroline J, Küsters, Benno, Wesseling, Pieter, Blokx, Willeke A M, Marais, Richard
Published in Cancer discovery (01.04.2013)
Published in Cancer discovery (01.04.2013)
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Attenuated Salmonella Targets Prodrug Activating Enzyme Carboxypeptidase G2 to Mouse Melanoma and Human Breast and Colon Carcinomas for Effective Suicide Gene Therapy
FRIEDLOS, Frank, LEHOURITIS, Panos, OGILVIE, Lesley, MEDLEY, Douglas, DAVIES, Lawrence, BERMUDES, David, KING, Ivan, MARTIN, Jan, MARAIS, Richard, SPRINGER, Caroline J
Published in Clinical cancer research (01.07.2008)
Published in Clinical cancer research (01.07.2008)
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A Phase I Study of Single Administration of Antibody-Directed Enzyme Prodrug Therapy with the Recombinant Anti–Carcinoembryonic Antigen Antibody-Enzyme Fusion Protein MFECP1 and a Bis-Iodo Phenol Mustard Prodrug
Mayer, Astrid, Francis, Roslyn J, Sharma, Surinder K, Tolner, Berend, Springer, Caroline J, Martin, Jan, Boxer, Geoff M, Bell, James, Green, Alan J, Hartley, John A, Cruickshank, Clare, Wren, Julie, Chester, Kerry A, Begent, Richard H J
Published in Clinical cancer research (01.11.2006)
Published in Clinical cancer research (01.11.2006)
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BRAF as a therapeutic target: a patent review (2006 - 2012)
Zambon, Alfonso, Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Marais, Richard, Springer, Caroline J
Published in Expert opinion on therapeutic patents (01.02.2013)
Published in Expert opinion on therapeutic patents (01.02.2013)
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Investigating the Contribution of Collagen to the Tumor Biomechanical Phenotype with Noninvasive Magnetic Resonance Elastography
Li, Jin, Zormpas-Petridis, Konstantinos, Boult, Jessica K R, Reeves, Emma L, Heindl, Andreas, Vinci, Maria, Lopes, Filipa, Cummings, Craig, Springer, Caroline J, Chesler, Louis, Jones, Chris, Bamber, Jeffrey C, Yuan, Yinyin, Sinkus, Ralph, Jamin, Yann, Robinson, Simon P
Published in Cancer research (Chicago, Ill.) (15.11.2019)
Published in Cancer research (Chicago, Ill.) (15.11.2019)
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Small molecule inhibitors of BRAF in clinical trials
Zambon, Alfonso, Niculescu-Duvaz, Ion, Niculescu-Duvaz, Dan, Marais, Richard, Springer, Caroline J
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of V600EBRAF
WHITTAKER, Steven, MENARD, Delphine, LAMBROS, Maryou, REIS-FILHO, Jorge S, MARAIS, Richard, SPRINGER, Caroline J, KIRK, Ruth, OGILVIE, Lesley, HEDLEY, Douglas, ZAMBON, Alfonso, LOPES, Filipa, PREECE, Natasha, MANNE, Helen, RANA, Sareena
Published in Cancer research (Chicago, Ill.) (15.10.2010)
Published in Cancer research (Chicago, Ill.) (15.10.2010)
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Hyperpolarized 13C magnetic resonance detection of carboxypeptidase G2 activity
Jamin, Yann, Gabellieri, Cristina, Smyth, Lynette, Reynolds, Steven, Robinson, Simon P., Springer, Caroline J., Leach, Martin O., Payne, Geoffrey S., Eykyn, Thomas R.
Published in Magnetic resonance in medicine (01.11.2009)
Published in Magnetic resonance in medicine (01.11.2009)
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Preclinical Evidence That Trametinib Enhances the Response to Antiangiogenic Tyrosine Kinase Inhibitors in Renal Cell Carcinoma
Bridgeman, Victoria L, Wan, Elaine, Foo, Shane, Nathan, Mark R, Welti, Jonathan C, Frentzas, Sophia, Vermeulen, Peter B, Preece, Natasha, Springer, Caroline J, Powles, Thomas, Nathan, Paul D, Larkin, James, Gore, Martin, Vasudev, Naveen S, Reynolds, Andrew R
Published in Molecular cancer therapeutics (01.01.2016)
Published in Molecular cancer therapeutics (01.01.2016)
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Novel Fluorinated Prodrugs for Activation by Carboxypeptidase G2 Showing Good in Vivo Antitumor Activity in Gene-Directed Enzyme Prodrug Therapy
Davies, Lawrence C, Friedlos, Frank, Hedley, Douglas, Martin, Jan, Ogilvie, Lesley M, Scanlon, Ian J, Springer, Caroline J
Published in Journal of medicinal chemistry (11.08.2005)
Published in Journal of medicinal chemistry (11.08.2005)
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B-RAF is a therapeutic target in melanoma
KARASARIDES, Maria, CHILOECHES, Antonio, SPRINGER, Caroline J, MARAIS, Richard, HAYWARD, Robert, NICULESCU-DUVAZ, Dan, SCANLON, Ian, FRIEDLOS, Frank, OGILVIE, Lesley, HEDLEY, Douglas, MARTIN, Jan, MARSHALL, Christopher J
Published in Oncogene (19.08.2004)
Published in Oncogene (19.08.2004)
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Contrasting effects of sunitinib within in vivo models of metastasis
Welti, Jonathan C., Powles, Thomas, Foo, Shane, Gourlaouen, Morgane, Preece, Natasha, Foster, Julie, Frentzas, Sophia, Bird, Demelza, Sharpe, Kevin, van Weverwijk, Antoinette, Robertson, David, Soffe, Julie, Erler, Janine T., Pili, Roberto, Springer, Caroline J., Mather, Stephen J., Reynolds, Andrew R.
Published in Angiogenesis (London) (01.12.2012)
Published in Angiogenesis (London) (01.12.2012)
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Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents
Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Suijkerbuijk, Bart M.J.M., Ménard, Delphine, Zambon, Alfonso, Davies, Lawrence, Pons, Jean-Francois, Whittaker, Steven, Marais, Richard, Springer, Caroline J.
Published in Bioorganic & medicinal chemistry (01.03.2013)
Published in Bioorganic & medicinal chemistry (01.03.2013)
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Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2
SCHEPELMANN, Silke, OGILVIE, Lesley M, HEDLEY, Douglas, FRIEDLOS, Frank, MARTIN, Janet, SCANLON, Ian, PING CHEN, MARAIS, Richard, SPRINGER, Caroline J
Published in Cancer research (Chicago, Ill.) (15.05.2007)
Published in Cancer research (Chicago, Ill.) (15.05.2007)
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Detection of the Prodrug-Activating Enzyme Carboxypeptidase G2 Activity with Chemical Exchange Saturation Transfer Magnetic Resonance
Jamin, Yann, Eykyn, Thomas R., Poon, Evon, Springer, Caroline J., Robinson, Simon P.
Published in Molecular imaging and biology (01.04.2014)
Published in Molecular imaging and biology (01.04.2014)
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