Spirocycles as Rigidified sp3‑Rich Scaffolds for a Fragment Collection
Sveiczer, Attila, North, Andrew J. P, Mateu, Natalia, Kidd, Sarah L, Sore, Hannah F, Spring, David R
Published in Organic letters (21.06.2019)
Published in Organic letters (21.06.2019)
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Journal Article
Spirocycles as Rigidified sp 3 -Rich Scaffolds for a Fragment Collection
Sveiczer, Attila, North, Andrew J P, Mateu, Natalia, Kidd, Sarah L, Sore, Hannah F, Spring, David R
Published in Organic letters (21.06.2019)
Published in Organic letters (21.06.2019)
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Journal Article
A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action
Brear, Paul, De Fusco, Claudia, Atkinson, Eleanor L, Iegre, Jessica, Francis-Newton, Nicola J, Venkitaraman, Ashok R, Hyvönen, Marko, Spring, David R
Published in MedChemComm (16.11.2022)
Published in MedChemComm (16.11.2022)
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Journal Article
The Synthesis of Quinolone Natural Products from Pseudonocardia sp
Salvaggio, Flavia, Hodgkinson, James T., Carro, Laura, Geddis, Stephen M., Galloway, Warren R. J. D., Welch, Martin, Spring, David R.
Published in European Journal of Organic Chemistry (01.01.2016)
Published in European Journal of Organic Chemistry (01.01.2016)
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Book Review
Journal Article
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction
Cole, Daniel J, Janecek, Matej, Stokes, Jamie E, Rossmann, Maxim, Faver, John C, McKenzie, Grahame J, Venkitaraman, Ashok R, Hyvönen, Marko, Spring, David R, Huggins, David J, Jorgensen, William L
Published in Chemical communications (Cambridge, England) (17.08.2017)
Published in Chemical communications (Cambridge, England) (17.08.2017)
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Journal Article
Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling
Wu, Yuteng, Olsen, Lasse B., Lau, Yu Heng, Jensen, Claus Hatt, Rossmann, Maxim, Baker, Ysobel R., Sore, Hannah F., Collins, Súil, Spring, David R.
Published in Chembiochem : a European journal of chemical biology (15.04.2016)
Published in Chembiochem : a European journal of chemical biology (15.04.2016)
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Journal Article
Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell
Chattopadhyay, Anasuya, O’Connor, Cornelius J., Zhang, Fengzhi, Galvagnion, Celine, Galloway, Warren R. J. D., Tan, Yaw Sing, Stokes, Jamie E., Rahman, Taufiq, Verma, Chandra, Spring, David R., Itzhaki, Laura S.
Published in Scientific reports (05.04.2016)
Published in Scientific reports (05.04.2016)
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Journal Article
Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics
Morkunas, Bernardas, Galloway, Warren R. J. D., Wright, Megan, Ibbeson, Brett M., Hodgkinson, James T., O'Connell, Kieron M. G., Bartolucci, Noemi, Della Valle, Martina, Welch, Martin, Spring, David R.
Published in Organic & biomolecular chemistry (14.11.2012)
Published in Organic & biomolecular chemistry (14.11.2012)
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Journal Article
Small molecules in biology
Tavassoli, Ali, Hamilton, Andrew D, Spring, David R
Published in Chemical Society reviews (01.08.2011)
Published in Chemical Society reviews (01.08.2011)
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Journal Article
Studies Towards the Synthesis of the Core of Endiandric Acid H
Zheng, Shaojun, Yang, Dandan, Zhu, Rui, Spring, David R.
Published in Chemistry of natural compounds (01.03.2018)
Published in Chemistry of natural compounds (01.03.2018)
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Journal Article
An expedient strategy for the diversity-oriented synthesis of macrocyclic compounds with natural product-like characteristics
Ciardiello, Joe J., Galloway, Warren R.J.D., O'Connor, Cornelius J., Sore, Hannah F., Stokes, Jamie E., Wu, Yuteng, Spring, David R.
Published in Tetrahedron (23.06.2016)
Published in Tetrahedron (23.06.2016)
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Journal Article
Stereocontrolled semi-syntheses of deguelin and tephrosin
Russell, David A., Freudenreich, Julien J., Ciardiello, Joe J., Sore, Hannah F., Spring, David R.
Published in Organic & biomolecular chemistry (21.02.2017)
Published in Organic & biomolecular chemistry (21.02.2017)
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Journal Article
Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides
Wu, Yuteng, Kaur, Amandeep, Fowler, Elaine, Wiedmann, Mareike M, Young, Reginald, Galloway, Warren R. J. D, Olsen, Lasse, Sore, Hannah F, Chattopadhyay, Anasuya, Kwan, Terence T.-L, Xu, Wenshu, Walsh, Stephen J, de Andrade, Peterson, Janecek, Matej, Arumugam, Senthil, Itzhaki, Laura S, Lau, Yu Heng, Spring, David R
Published in ACS chemical biology (15.03.2019)
Published in ACS chemical biology (15.03.2019)
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Journal Article
Virulence in Pectobacterium atrosepticum is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)ppGpp
Bowden, Steven D., Eyres, Alison, Chung, Jade C. S., Monson, Rita E., Thompson, Arthur, Salmond, George P. C., Spring, David R., Welch, Martin
Published in Molecular microbiology (01.11.2013)
Published in Molecular microbiology (01.11.2013)
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Journal Article
Stereocontrolled Semisyntheses of Elliptone and 12aβ-Hydroxyelliptone
Russell, David A, Fong, Winston J. S, Twigg, David G, Sore, Hannah F, Spring, David R
Published in Journal of natural products (Washington, D.C.) (27.10.2017)
Published in Journal of natural products (Washington, D.C.) (27.10.2017)
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Journal Article
Which microbial factors really are important in Pseudomonas aeruginosa infections?
Crousilles, Audrey, Maunders, Eve, Bartlett, Sean, Fan, Catherine, Ukor, Emem-Fong, Abdelhamid, Yassmin, Baker, Ysobel, Floto, Andres, Spring, David R, Welch, Martin
Published in Future microbiology (01.01.2015)
Published in Future microbiology (01.01.2015)
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Journal Article
Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa
Hodgkinson, James T., Galloway, Warren R. J. D., Wright, Megan, Mati, Ioulia K., Nicholson, Rebecca L., Welch, Martin, Spring, David R.
Published in Organic & biomolecular chemistry (14.08.2012)
Published in Organic & biomolecular chemistry (14.08.2012)
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Journal Article
Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence
Wiedmann, Mareike M., Aibara, Shintaro, Spring, David R., Stewart, Murray, Brenton, James D.
Published in Journal of structural biology (01.09.2016)
Published in Journal of structural biology (01.09.2016)
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Journal Article
Synthesis and biological evaluation of 1,2-disubstituted 4-quinolone analogues of Pseudonocardia sp. natural products
Geddis, Stephen M, Coroama, Teodora, Forrest, Suzanne, Hodgkinson, James T, Welch, Martin, Spring, David R
Published in Beilstein journal of organic chemistry (19.10.2018)
Published in Beilstein journal of organic chemistry (19.10.2018)
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Journal Article