Diversity-oriented synthesis as a tool for identifying new modulators of mitosis
Ibbeson, Brett M., Laraia, Luca, Alza, Esther, O' Connor, Cornelius J., Tan, Yaw Sing, Davies, Huw M.L., McKenzie, Grahame, Venkitaraman, Ashok R., Spring, David R.
Published in Nature communications (01.01.2014)
Published in Nature communications (01.01.2014)
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Journal Article
Linear Aliphatic Dialkynes as Alternative Linkers for Double-Click Stapling of p53-Derived Peptides
Lau, Yu Heng, de Andrade, Peterson, McKenzie, Grahame J., Venkitaraman, Ashok R., Spring, David R.
Published in Chembiochem : a European journal of chemical biology (15.12.2014)
Published in Chembiochem : a European journal of chemical biology (15.12.2014)
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Journal Article
Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa
McVey, Alyssa C, Medarametla, Prasanthi, Chee, Xavier, Bartlett, Sean, Poso, Antti, Spring, David R, Rahman, Taufiq, Welch, Martin
Published in Biochemistry (Easton) (17.10.2017)
Published in Biochemistry (Easton) (17.10.2017)
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Journal Article
Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells
Russell, David A, Bridges, Hannah R, Serreli, Riccardo, Kidd, Sarah L, Mateu, Natalia, Osberger, Thomas J, Sore, Hannah F, Hirst, Judy, Spring, David R
Published in Journal of natural products (Washington, D.C.) (26.06.2020)
Published in Journal of natural products (Washington, D.C.) (26.06.2020)
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Journal Article
Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents
Pettigrew, Talia R, Porter, Rachel J, Walsh, Stephen J, Housden, Michael P, Lam, Nelson Y. S, Carroll, Jason S, Parker, Jeremy S, Spring, David R, Paterson, Ian
Published in Chemical communications (Cambridge, England) (04.02.2020)
Published in Chemical communications (Cambridge, England) (04.02.2020)
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Journal Article
An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds
Stewart, Hannah L, Hanby, Abigail R, King, Thomas A, Bond, Andrew D, Moss, Thomas A, Sore, Hannah F, Spring, David R
Published in Chemical communications (Cambridge, England) (23.06.2020)
Published in Chemical communications (Cambridge, England) (23.06.2020)
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Journal Article
Investigating peptide sequence variations for 'double-click' stapled p53 peptides
Lau, Yu Heng, de Andrade, Peterson, Sköld, Niklas, McKenzie, Grahame J, Venkitaraman, Ashok R, Verma, Chandra, Lane, David P, Spring, David R
Published in Organic & biomolecular chemistry (28.06.2014)
Published in Organic & biomolecular chemistry (28.06.2014)
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Journal Article
Fsp 3 -rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery
Hanby, Abigail R, Troelsen, Nikolaj S, Osberger, Thomas J, Kidd, Sarah L, Mortensen, Kim T, Spring, David R
Published in Chemical communications (Cambridge, England) (20.02.2020)
Published in Chemical communications (Cambridge, England) (20.02.2020)
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Journal Article
Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design
Curran, Peter R, Radoux, Chris J, Smilova, Mihaela D, Sykes, Richard A, Higueruelo, Alicia P, Bradley, Anthony R, Marsden, Brian D, Spring, David R, Blundell, Tom L, Leach, Andrew R, Pitt, William R, Cole, Jason C
Published in Journal of chemical information and modeling (27.04.2020)
Published in Journal of chemical information and modeling (27.04.2020)
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Journal Article
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
Sharma, Pooja, Mahen, Robert, Rossmann, Maxim, Stokes, Jamie E., Hardwick, Bryn, Huggins, David J., Emery, Amy, Kunciw, Dominique L., Hyvönen, Marko, Spring, David R., McKenzie, Grahame J., Venkitaraman, Ashok R.
Published in Scientific reports (04.11.2019)
Published in Scientific reports (04.11.2019)
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Journal Article
Stapled peptides as a new technology to investigate protein-protein interactions in human platelets
Iegre, Jessica, Ahmed, Niaz S., Gaynord, Josephine S., Wu, Yuteng, Herlihy, Kara M., Tan, Yaw Sing, Lopes-Pires, Maria E., Jha, Rupam, Lau, Yu Heng, Sore, Hannah F., Verma, Chandra, O'Donovan, Daniel H., Pugh, Nicholas, Spring, David R.
Published in Chemical science (Cambridge) (28.05.2018)
Published in Chemical science (Cambridge) (28.05.2018)
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Journal Article
Identification of macrocyclic peptides which activate bacterial cylindrical proteases
Walther, Raoul, Westermann, Linda M, Carmali, Sheiliza, Jackson, Sophie E, Brötz-Oesterhelt, Heike, Spring, David R
Published in MedChemComm (22.06.2023)
Published in MedChemComm (22.06.2023)
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Journal Article
Specific inhibition of CK2α from an anchor outside the active site
Brear, Paul, De Fusco, Claudia, Hadje Georgiou, Kathy, Francis-Newton, Nicola J, Stubbs, Christopher J, Sore, Hannah F, Venkitaraman, Ashok R, Abell, Chris, Spring, David R, Hyvönen, Marko
Published in Chemical science (Cambridge) (01.01.2016)
Published in Chemical science (Cambridge) (01.01.2016)
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Journal Article
Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance
Nicolescu, Radu Costin Bizga, Maylin, Zoe R., Pérez‐Areales, Francisco Javier, Iegre, Jessica, Pandha, Hardev S., Asim, Mohammad, Spring, David R.
Published in ChemMedChem (17.01.2023)
Published in ChemMedChem (17.01.2023)
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Journal Article
Bioinspired Total Synthesis of Bussealin E
Twigg, David G, Baldassarre, Leonardo, Frye, Elizabeth C, Galloway, Warren R. J. D, Spring, David R
Published in Organic letters (16.03.2018)
Published in Organic letters (16.03.2018)
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Journal Article
Discovery of a highly selective turn-on fluorescent probe for Ag
ZHAOCHAO XU, SHAOJUN ZHENG, JUYOUNG YOON, SPRING, David R
Published in Analyst (London) (01.01.2010)
Published in Analyst (London) (01.01.2010)
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