Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions
Teixeira, Vitor H., Pipinikas, Christodoulos P., Pennycuick, Adam, Lee-Six, Henry, Chandrasekharan, Deepak, Beane, Jennifer, Morris, Tiffany J., Karpathakis, Anna, Feber, Andrew, Breeze, Charles E., Ntolios, Paschalis, Hynds, Robert E., Falzon, Mary, Capitanio, Arrigo, Carroll, Bernadette, Durrenberger, Pascal F., Hardavella, Georgia, Brown, James M., Lynch, Andy G., Farmery, Henry, Paul, Dirk S., Chambers, Rachel C., McGranahan, Nicholas, Navani, Neal, Thakrar, Ricky M., Swanton, Charles, Beck, Stephan, George, Phillip Jeremy, Spira, Avrum, Campbell, Peter J., Thirlwell, Christina, Janes, Sam M.
Published in Nature medicine (01.03.2019)
Published in Nature medicine (01.03.2019)
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Journal Article
A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer
Silvestri, Gerard A, Vachani, Anil, Whitney, Duncan, Elashoff, Michael, Porta Smith, Kate, Ferguson, J. Scott, Parsons, Ed, Mitra, Nandita, Brody, Jerome, Lenburg, Marc E, Spira, Avrum
Published in The New England journal of medicine (16.07.2015)
Published in The New England journal of medicine (16.07.2015)
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Journal Article
Biomarkers in Lung Cancer Screening: Achievements, Promises, and Challenges
Seijo, Luis M., Peled, Nir, Ajona, Daniel, Boeri, Mattia, Field, John K., Sozzi, Gabriella, Pio, Ruben, Zulueta, Javier J., Spira, Avrum, Massion, Pierre P., Mazzone, Peter J., Montuenga, Luis M.
Published in Journal of thoracic oncology (01.03.2019)
Published in Journal of thoracic oncology (01.03.2019)
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Journal Article
Early Events in the Molecular Pathogenesis of Lung Cancer
Kadara, Humam, Scheet, Paul, Wistuba, Ignacio I, Spira, Avrum E
Published in Cancer prevention research (Philadelphia, Pa.) (01.07.2016)
Published in Cancer prevention research (Philadelphia, Pa.) (01.07.2016)
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Journal Article
Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease
Christenson, Stephanie A, Steiling, Katrina, van den Berge, Maarten, Hijazi, Kahkeshan, Hiemstra, Pieter S, Postma, Dirkje S, Lenburg, Marc E, Spira, Avrum, Woodruff, Prescott G
Published in American journal of respiratory and critical care medicine (01.04.2015)
Published in American journal of respiratory and critical care medicine (01.04.2015)
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Journal Article
Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions
Beane, Jennifer E., Mazzilli, Sarah A., Campbell, Joshua D., Duclos, Grant, Krysan, Kostyantyn, Moy, Christopher, Perdomo, Catalina, Schaffer, Michael, Liu, Gang, Zhang, Sherry, Liu, Hanqiao, Vick, Jessica, Dhillon, Samjot S., Platero, Suso J., Dubinett, Steven M., Stevenson, Christopher, Reid, Mary E., Lenburg, Marc E., Spira, Avrum E.
Published in Nature communications (23.04.2019)
Published in Nature communications (23.04.2019)
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Journal Article
The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection
Billatos, Ehab, Vick, Jessica L, Lenburg, Marc E, Spira, Avrum E
Published in Clinical cancer research (01.07.2018)
Published in Clinical cancer research (01.07.2018)
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Journal Article
Genomic Landscape of Atypical Adenomatous Hyperplasia Reveals Divergent Modes to Lung Adenocarcinoma
Sivakumar, Smruthy, Lucas, F Anthony San, McDowell, Tina L, Lang, Wenhua, Xu, Li, Fujimoto, Junya, Zhang, Jianjun, Futreal, P Andrew, Fukuoka, Junya, Yatabe, Yasushi, Dubinett, Steven M, Spira, Avrum E, Fowler, Jerry, Hawk, Ernest T, Wistuba, Ignacio I, Scheet, Paul, Kadara, Humam
Published in Cancer research (Chicago, Ill.) (15.11.2017)
Published in Cancer research (Chicago, Ill.) (15.11.2017)
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Journal Article
Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression
Beane, Jennifer, Mazzilli, Sarah A, Tassinari, Anna M, Liu, Gang, Zhang, Xiaohui, Liu, Hanqiao, Buncio, Anne Dy, Dhillon, Samjot S, Platero, Suso J, Lenburg, Marc E, Reid, Mary E, Lam, Stephen, Spira, Avrum E
Published in Clinical cancer research (01.09.2017)
Published in Clinical cancer research (01.09.2017)
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Journal Article
Network Analysis of Lung Transcriptomics Reveals a Distinct B-Cell Signature in Emphysema
Faner, Rosa, Cruz, Tamara, Casserras, Teresa, López-Giraldo, Alejandra, Noell, Guillaume, Coca, Ignacio, Tal-Singer, Ruth, Miller, Bruce, Rodriguez-Roisin, Roberto, Spira, Avrum, Kalko, Susana G, Agustí, Alvar
Published in American journal of respiratory and critical care medicine (01.06.2016)
Published in American journal of respiratory and critical care medicine (01.06.2016)
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Journal Article
Precancer Atlas to Drive Precision Prevention Trials
Spira, Avrum, Yurgelun, Matthew B, Alexandrov, Ludmil, Rao, Anjana, Bejar, Rafael, Polyak, Kornelia, Giannakis, Marios, Shilatifard, Ali, Finn, Olivera J, Dhodapkar, Madhav, Kay, Neil E, Braggio, Esteban, Vilar, Eduardo, Mazzilli, Sarah A, Rebbeck, Timothy R, Garber, Judy E, Velculescu, Victor E, Disis, Mary L, Wallace, Douglas C, Lippman, Scott M
Published in Cancer research (Chicago, Ill.) (01.04.2017)
Published in Cancer research (Chicago, Ill.) (01.04.2017)
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Journal Article
Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease
Sze, Marc A, Dimitriu, Pedro A, Suzuki, Masaru, McDonough, John E, Campbell, Josh D, Brothers, John F, Erb-Downward, John R, Huffnagle, Gary B, Hayashi, Shizu, Elliott, W Mark, Cooper, Joel, Sin, Don D, Lenburg, Marc E, Spira, Avrum, Mohn, William W, Hogg, James C
Published in American journal of respiratory and critical care medicine (15.08.2015)
Published in American journal of respiratory and critical care medicine (15.08.2015)
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Journal Article
Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airways
Xu, Ke, Shi, Xingyi, Husted, Christopher, Hong, Rui, Wang, Yichen, Ning, Boting, Sullivan, Travis B., Rieger-Christ, Kimberly M., Duan, Fenghai, Marques, Helga, Gower, Adam C., Xiao, Xiaohui, Liu, Hanqiao, Liu, Gang, Duclos, Grant, Platt, Michael, Spira, Avrum E., Mazzilli, Sarah A., Billatos, Ehab, Lenburg, Marc E., Campbell, Joshua D., Beane, Jennifer E.
Published in Scientific reports (28.10.2022)
Published in Scientific reports (28.10.2022)
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Journal Article
The Importance of the Biological Impact of Exposure to the Concept of the Exposome
Dennis, Kristine K, Auerbach, Scott S, Balshaw, David M, Cui, Yuxia, Fallin, Margaret Daniele, Smith, Martyn T, Spira, Avrum, Sumner, Susan, Miller, Gary W
Published in Environmental health perspectives (01.10.2016)
Published in Environmental health perspectives (01.10.2016)
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Journal Article
Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis
Kusko, Rebecca L, Brothers, 2nd, John F, Tedrow, John, Pandit, Kusum, Huleihel, Luai, Perdomo, Catalina, Liu, Gang, Juan-Guardela, Brenda, Kass, Daniel, Zhang, Sherry, Lenburg, Marc, Martinez, Fernando, Quackenbush, John, Sciurba, Frank, Limper, Andrew, Geraci, Mark, Yang, Ivana, Schwartz, David A, Beane, Jennifer, Spira, Avrum, Kaminski, Naftali
Published in American journal of respiratory and critical care medicine (15.10.2016)
Published in American journal of respiratory and critical care medicine (15.10.2016)
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Journal Article
Relationship of DNA methylation and gene expression in idiopathic pulmonary fibrosis
Yang, Ivana V, Pedersen, Brent S, Rabinovich, Einat, Hennessy, Corinne E, Davidson, Elizabeth J, Murphy, Elissa, Guardela, Brenda Juan, Tedrow, John R, Zhang, Yingze, Singh, Mandal K, Correll, Mick, Schwarz, Marvin I, Geraci, Mark, Sciurba, Frank C, Quackenbush, John, Spira, Avrum, Kaminski, Naftali, Schwartz, David A
Published in American journal of respiratory and critical care medicine (01.12.2014)
Published in American journal of respiratory and critical care medicine (01.12.2014)
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Journal Article
Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates
Chitsazzadeh, Vida, Coarfa, Cristian, Drummond, Jennifer A., Nguyen, Tri, Joseph, Aaron, Chilukuri, Suneel, Charpiot, Elizabeth, Adelmann, Charles H., Ching, Grace, Nguyen, Tran N., Nicholas, Courtney, Thomas, Valencia D., Migden, Michael, MacFarlane, Deborah, Thompson, Erika, Shen, Jianjun, Takata, Yoko, McNiece, Kayla, Polansky, Maxim A., Abbas, Hussein A., Rajapakshe, Kimal, Gower, Adam, Spira, Avrum, Covington, Kyle R., Xiao, Weimin, Gunaratne, Preethi, Pickering, Curtis, Frederick, Mitchell, Myers, Jeffrey N., Shen, Li, Yao, Hui, Su, Xiaoping, Rapini, Ronald P., Wheeler, David A., Hawk, Ernest T., Flores, Elsa R., Tsai, Kenneth Y.
Published in Nature communications (30.08.2016)
Published in Nature communications (30.08.2016)
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Journal Article
The Case for a Pre-Cancer Genome Atlas (PCGA)
Campbell, Joshua D, Mazzilli, Sarah A, Reid, Mary E, Dhillon, Samjot S, Platero, Suso, Beane, Jennifer, Spira, Avrum E
Published in Cancer prevention research (Philadelphia, Pa.) (01.02.2016)
Published in Cancer prevention research (Philadelphia, Pa.) (01.02.2016)
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Journal Article