Discovery of an Oral Respiratory Syncytial Virus (RSV) Fusion Inhibitor (GS-5806) and Clinical Proof of Concept in a Human RSV Challenge Study
Mackman, Richard L, Sangi, Michael, Sperandio, David, Parrish, Jay P, Eisenberg, Eugene, Perron, Michel, Hui, Hon, Zhang, Lijun, Siegel, Dustin, Yang, Hai, Saunders, Oliver, Boojamra, Constantine, Lee, Gary, Samuel, Dharmaraj, Babaoglu, Kerim, Carey, Anne, Gilbert, Brian E, Piedra, Pedro A, Strickley, Robert, Iwata, Quynh, Hayes, Jaclyn, Stray, Kirsten, Kinkade, April, Theodore, Dorothy, Jordan, Robert, Desai, Manoj, Cihlar, Tomas
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
Get full text
Journal Article
Design, synthesis, and anti-HIV activity of 4′-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors
Boojamra, Constantine G., Parrish, Jay P., Sperandio, David, Gao, Ying, Petrakovsky, Oleg V., Lee, Sharon K., Markevitch, David Y., Vela, Jennifer E., Laflamme, Genevieve, Chen, James M., Ray, Adrian S., Barron, Abraham C., Sparacino, Mark L., Desai, Manoj C., Kim, Choung U., Cihlar, Tomas, Mackman, Richard L.
Published in Bioorganic & medicinal chemistry (15.02.2009)
Published in Bioorganic & medicinal chemistry (15.02.2009)
Get full text
Journal Article
The Structure of the Extracellular Region of Human Hepsin Reveals a Serine Protease Domain and a Novel Scavenger Receptor Cysteine-Rich (SRCR) Domain
Somoza, John R, Ho, Joseph D, Luong, Christine, Ghate, Manjiri, Sprengeler, Paul A, Mortara, Kyle, Shrader, William D, Sperandio, David, Chan, Hedy, McGrath, Mary E, Katz, Bradley A
Published in Structure (London) (01.09.2003)
Published in Structure (London) (01.09.2003)
Get full text
Journal Article
Bmf-500: An Orally Bioavailable Covalent Inhibitor of FLT3 with High Selectivity and Potent Antileukemic Activity in FLT3-Mutated AML
Law, Brian, Rughwani, Tripta, Archer, Tenley C., Kumar, Lekha, Lu, Daniel, Somanath, Priyanka, Ma, Yan, Wang, Xiaodong, Sperandio, David, Morris, Steve, Kirschberg, Thorsten, Balakrishnan, Mini, Butler, Thomas
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
Get full text
Journal Article
Novel series of tunable μOR modulators with enhanced brain penetration for the treatment of opioid use disorder, pain and neuropsychiatric indications
Nerurkar, Alok, Nguyen, Thomas, Wang, Sheldon, Bhatt, Ulhas, Li, Kevin, Li, Yihong, Ding, Pingyu, Seidl, Frederick J., Holan, Martin, Lee, John, Widjaja, Tien, Wei, Zhi-Liang, Sadlowski, Corinne, Sperandio, David, McGee, Lawrence R., Youngblood, Beth, Schwartz, Neil, Gehlert, Donald, Medina, Julio C.
Published in Bioorganic & medicinal chemistry letters (15.08.2023)
Published in Bioorganic & medicinal chemistry letters (15.08.2023)
Get full text
Journal Article
Novel series of tunable µOR modulators with enhanced brain penetration for the treatment of opioid use disorder, pain and neuropsychiatric indications
Nerurkar, Alok, Nguyen, Thomas, Wang, Sheldon, Bhatt, Ulhas, Li, Kevin, Li, Yihong, Ding, Pingyu, Seidl, Frederick J., Holan, Martin, Lee, John, Widjaja, Tien, Wei, Zhi-Liang, Sadlowski, Corinne, Sperandio, David, McGee, Lawrence R., Youngblood, Beth, Schwartz, Neil, Gehlert, Donald, Medina, Julio C.
Published in Bioorganic & medicinal chemistry letters (15.08.2023)
Published in Bioorganic & medicinal chemistry letters (15.08.2023)
Get full text
Journal Article
Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms
Shi, Xiarong, Mihaylova, Valia T, Kuruvilla, Leena, Chen, Fang, Viviano, Stephen, Baldassarre, Massimiliano, Sperandio, David, Martinez, Ruben, Yue, Peng, Bates, Jamie G, Breckenridge, David G, Schlessinger, Joseph, Turk, Benjamin E, Calderwood, David A
Published in Proceedings of the National Academy of Sciences - PNAS (02.08.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (02.08.2016)
Get full text
Journal Article
Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle
Mackman, Richard L, Steadman, Victoria A, Dean, David K, Jansa, Petr, Poullennec, Karine G, Appleby, Todd, Austin, Carol, Blakemore, Caroline A, Cai, Ruby, Cannizzaro, Carina, Chin, Gregory, Chiva, Jean-Yves C, Dunbar, Neil A, Fliri, Hans, Highton, Adrian J, Hui, Hon, Ji, Mingzhe, Jin, Haolun, Karki, Kapil, Keats, Andrew J, Lazarides, Linos, Lee, Yu-Jen, Liclican, Albert, Mish, Michael, Murray, Bernard, Pettit, Simon B, Pyun, Peter, Sangi, Michael, Santos, Rex, Sanvoisin, Jonathan, Schmitz, Uli, Schrier, Adam, Siegel, Dustin, Sperandio, David, Stepan, George, Tian, Yang, Watt, Gregory M, Yang, Hai, Schultz, Brian E
Published in Journal of medicinal chemistry (08.11.2018)
Published in Journal of medicinal chemistry (08.11.2018)
Get full text
Journal Article
GS-5806 inhibits pre- to postfusion conformational changes of the respiratory syncytial virus fusion protein
Samuel, Dharmaraj, Xing, Weimei, Niedziela-Majka, Anita, Wong, Jinny S, Hung, Magdeleine, Brendza, Katherine M, Perron, Michel, Jordan, Robert, Sperandio, David, Liu, Xiaohong, Mackman, Richard, Sakowicz, Roman
Published in Antimicrobial agents and chemotherapy (01.11.2015)
Published in Antimicrobial agents and chemotherapy (01.11.2015)
Get full text
Journal Article
Abstract 4976: Preclinical characterization of BGI-9004, a covalent TEAD inhibitor with exceptional anti-cancer activity and combination potential
Guo, Shirley, Shrishrimal, Shashank, Cui, Jason, Wang, Guoqing, Zhang, Vivian, Deng, Ning, Dong, Iris, Chen, Anna, Luo, Steve, Sperandio, David, Cao, Ping, Wiedemeyer, Wolf R.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Get full text
Journal Article
Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor
Sperandio, David, Aktoudianakis, Vangelis, Babaoglu, Kerim, Chen, Xiaowu, Elbel, Kristyna, Chin, Gregory, Corkey, Britton, Du, Jinfa, Jiang, Bob, Kobayashi, Tetsuya, Mackman, Richard, Martinez, Ruben, Yang, Hai, Zablocki, Jeff, Kusam, Saritha, Jordan, Kim, Webb, Heather, Bates, Jamie G., Lad, Latesh, Mish, Michael, Niedziela-Majka, Anita, Metobo, Sammy, Sapre, Annapurna, Hung, Magdeleine, Jin, Debi, Fung, Wanchi, Kan, Elaine, Eisenberg, Gene, Larson, Nate, Newby, Zachary E.R., Lansdon, Eric, Tay, Chin, Neve, Richard M., Shevick, Sophia L., Breckenridge, David G.
Published in Bioorganic & medicinal chemistry (01.02.2019)
Published in Bioorganic & medicinal chemistry (01.02.2019)
Get full text
Journal Article
FLT3의 억제제로서의 피라진 화합물
SQUIRES NEIL HOWARD, KIRSCHBERG THORSTEN A, LIN NAN HORNG, ADAM AMNA TRINITY TURJUMAN, BUTLER THOMAS, PALMER JAMES T, SU YONGLI, SPERANDIO DAVID, UPASANI RAVINDRA B, WANG XIAODONG, UNGASHE SOLOMON B, PHAN THU
Year of Publication 27.08.2024
Get full text
Year of Publication 27.08.2024
Patent
술피닐아미노벤즈아미드 및 술포닐아미노벤즈아미드 유도체
SANGI MICHAEL, SPERANDIO DAVID, FARAND JULIE, KAPLAN JOSHUA A, NOTTE GREGORY, OLEN CASEY LOCKWOOD
Year of Publication 28.01.2021
Get full text
Year of Publication 28.01.2021
Patent
Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYCand TGF-β–dependent mechanisms
Shi, Xiarong, Mihaylova, Valia T., Kuruvilla, Leena, Chen, Fang, Viviano, Stephen, Baldassarre, Massimiliano, Sperandio, David, Martinez, Ruben, Yue, Peng, Bates, Jamie G., Breckenridge, David G., Schlessinger, Joseph, Turk, Benjamin E., Calderwood, David A.
Published in Proceedings of the National Academy of Sciences - PNAS (02.08.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (02.08.2016)
Get full text
Journal Article
Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-[Beta]-dependent mechanisms
Shi, Xiarong, Mihaylova, Valia T, Kuruvilla, Leena, Chen, Fang, Viviano, Stephen, Baldassarre, Massimiliano, Sperandio, David, Martinez, Ruben, Yue, Peng, Bates, Jamie G, Breckenridge, David G, Schlessinger, Joseph, Turk, Benjamin E, Calderwood, David A
Published in Proceedings of the National Academy of Sciences - PNAS (02.08.2016)
Get full text
Published in Proceedings of the National Academy of Sciences - PNAS (02.08.2016)
Journal Article
플루오로알킬-옥사디아졸 및 이의 용도
BHATT ULHAS, DING PINGYU, LI YIHONG, WIDJAJA TIEN, MEDINA JULIO, HOLAN MARTIN, LEE JOHN, NERURKAR ALOK, SPERANDIO DAVID, SEIDL FREDERICK, MANDEGAR MOHAMMAD A, PATEL SNAHEL
Year of Publication 30.08.2022
Get full text
Year of Publication 30.08.2022
Patent
항바이러스 화합물
CHIN GREGORY F, GOYAL BINDU, SIEGEL DUSTIN S, SPERANDIO DAVID, MISH MICHAEL R, ZHANG LIJUN, HUI HON C, JANSA PETR, MACKMAN RICHARD L, CLARKE MICHAEL O, YANG HAI, CHUN BYOUNG KWON, BYUN DANIEL H
Year of Publication 20.10.2022
Get full text
Year of Publication 20.10.2022
Patent