Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors
Blake, James F, Xu, Rui, Bencsik, Josef R, Xiao, Dengming, Kallan, Nicholas C, Schlachter, Stephen, Mitchell, Ian S, Spencer, Keith L, Banka, Anna L, Wallace, Eli M, Gloor, Susan L, Martinson, Matthew, Woessner, Richard D, Vigers, Guy P.A, Brandhuber, Barbara J, Liang, Jun, Safina, Brian S, Li, Jun, Zhang, Birong, Chabot, Christine, Do, Steven, Lee, Leslie, Oeh, Jason, Sampath, Deepak, Lee, Brian B, Lin, Kui, Liederer, Bianca M, Skelton, Nicholas J
Published in Journal of medicinal chemistry (27.09.2012)
Published in Journal of medicinal chemistry (27.09.2012)
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Synthesis of Akt Inhibitor Ipatasertib. Part 2. Total Synthesis and First Kilogram Scale-up
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Published in Organic process research & development (19.12.2014)
Published in Organic process research & development (19.12.2014)
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Synthesis of Akt Inhibitor Ipatasertib. Part 1. Route Scouting and Early Process Development of a Challenging Cyclopentylpyrimidine Intermediate
Lane, Jonathan W, Spencer, Keith L, Shakya, Sagar R, Kallan, Nicholas C, Stengel, Peter J, Remarchuk, Travis
Published in Organic process research & development (19.12.2014)
Published in Organic process research & development (19.12.2014)
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Discovery of pyrrolopyrimidine inhibitors of Akt
Blake, James F., Kallan, Nicholas C., Xiao, Dengming, Xu, Rui, Bencsik, Josef R., Skelton, Nicholas J., Spencer, Keith L., Mitchell, Ian S., Woessner, Richard D., Gloor, Susan L., Risom, Tyler, Gross, Stefan D., Martinson, Matthew, Morales, Tony H., Vigers, Guy P.A., Brandhuber, Barbara J.
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
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Discovery and SAR of spirochromane Akt inhibitors
Kallan, Nicholas C., Spencer, Keith L., Blake, James F., Xu, Rui, Heizer, Justin, Bencsik, Josef R., Mitchell, Ian S., Gloor, Susan L., Martinson, Matthew, Risom, Tyler, Gross, Stefan D., Morales, Tony H., Wu, Wen-I, Vigers, Guy P.A., Brandhuber, Barbara J., Skelton, Nicholas J.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors
Bencsik, Josef R., Xiao, Dengming, Blake, James F., Kallan, Nicholas C., Mitchell, Ian S., Spencer, Keith L., Xu, Rui, Gloor, Susan L., Martinson, Matthew, Risom, Tyler, Woessner, Richard D., Dizon, Faith, Wu, Wen-I, Vigers, Guy P.A., Brandhuber, Barbara J., Skelton, Nicholas J., Prior, Wei Wei, Murray, Lesley J.
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA
Xu, Rui, Banka, Anna, Blake, James F., Mitchell, Ian S., Wallace, Eli M., Bencsik, Josef R., Kallan, Nicholas C., Spencer, Keith L., Gloor, Susan L., Martinson, Matthew, Risom, Tyler, Gross, Stefan D., Morales, Tony H., Wu, Wen-I, Vigers, Guy P.A., Brandhuber, Barbara J., Skelton, Nicholas J.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6
Fraley, Mark E., Steen, Justin T., Brnardic, Edward J., Arrington, Kenneth L., Spencer, Keith L., Hanney, Barbara A., Kim, Yuntae, Hartman, George D., Stirdivant, Steven M., Drakas, Bob A., Rickert, Keith, Walsh, Eileen S., Hamilton, Kelly, Buser, Carolyn A., Hardwick, James, Tao, Weikang, Beck, Stephen C., Mao, Xianzhi, Lobell, Robert B., Sepp-Lorenzino, Laura, Yan, Youwei, Ikuta, Mari, Munshi, Sanjeev K., Kuo, Lawrence C., Kreatsoulas, Constantine
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
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Year of Publication 25.10.2017
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Year of Publication 25.10.2017
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Year of Publication 20.04.2016
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PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS
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Year of Publication 07.08.2015
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PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS
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Year of Publication 04.08.2015
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AKT PROTEIN KINASE INHIBITORS
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PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS
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HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR
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Year of Publication 28.09.2010
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PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS
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Year of Publication 30.04.2010
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