Development of Serine Protease Inhibitors Displaying a Multicentered Short (<2.3 Å) Hydrogen Bond Binding Mode: Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa
Verner, Erik, Katz, Bradley A, Spencer, Jeffrey R, Allen, Darin, Hataye, Jason, Hruzewicz, Witold, Hui, Hon C, Kolesnikov, Aleksandr, Li, Yong, Luong, Christine, Martelli, Arnold, Radika, Kesavan, Rai, Roopa, She, Miles, Shrader, William, Sprengeler, Paul A, Trapp, Sean, Wang, Jing, Young, Wendy B, Mackman, Richard L
Published in Journal of medicinal chemistry (16.08.2001)
Published in Journal of medicinal chemistry (16.08.2001)
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Journal Article
Erythropoietin and small molecule agonists of the tissue-protective erythropoietin receptor increase FXN expression in neuronal cells in vitro and in Fxn-deficient KIKO mice in vivo
Miller, James L., Rai, Myriam, Frigon, Normand L., Pandolfo, Massimo, Punnonen, Juha, Spencer, Jeffrey R.
Published in Neuropharmacology (01.09.2017)
Published in Neuropharmacology (01.09.2017)
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Journal Article
Evaluation of antitumor properties of novel saframycin analogs in vitro and in vivo
Spencer, Jeffrey R., Sendzik, Martin, Oeh, Jason, Sabbatini, Peter, Dalrymple, Stacie A., Magill, Catherine, Kim, Hyunjin M., Zhang, Penglie, Squires, Neil, Moss, Katherine G., Sukbuntherng, Juthamas, Graupe, Doris, Eksterowicz, John, Young, Peter R., Myers, Andrew G., Green, Michael J.
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
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Journal Article
Discovery and Characterization of Nonpeptidyl Agonists of the Tissue-Protective Erythropoietin Receptor
Miller, James L, Church, Timothy J, Leonoudakis, Dmitri, Lariosa-Willingham, Karen, Frigon, Normand L, Tettenborn, Connie S, Spencer, Jeffrey R, Punnonen, Juha
Published in Molecular pharmacology (01.08.2015)
Published in Molecular pharmacology (01.08.2015)
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Journal Article
Antitumor activity of tetrahydroisoquinoline analogues 3- epi-jorumycin and 3- epi-renieramycin G
Lane, Jonathan W., Estevez, Alberto, Mortara, Kyle, Callan, Ondine, Spencer, Jeffrey R., Williams, Robert M.
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
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Journal Article
Discovery of 5-(4-hydroxy-6-methyl-2-oxo-2 H-pyran-3-yl)-7-phenyl-( E)-2,3,6,7-tetrahydro-1,4-thiazepines as a new series of apoptosis inducers using a cell- and caspase-based HTS assay
Drewe, John, Kasibhatla, Shailaja, Tseng, Ben, Shelton, Emma, Sperandio, David, Yee, Robert M., Litvak, Joane, Sendzik, Martin, Spencer, Jeffrey R., Cai, Sui Xiong
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
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Journal Article
Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors
Palmer, James T., Rydzewski, Robert M., Mendonca, Rohan V., Sperandio, David, Spencer, Jeffrey R., Hirschbein, Bernard L., Lohman, Julia, Beltman, Jeri, Nguyen, Margaret, Liu, Liang
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
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Journal Article
Discovery of novel hydroxy pyrazole based factor IXa inhibitor
Vijaykumar, Dange, Sprengeler, Paul A., Shaghafi, Michael, Spencer, Jeffrey R., Katz, Brad A., Yu, Christine, Rai, Roopa, Young, Wendy B., Schultz, Brian, Janc, James
Published in Bioorganic & medicinal chemistry letters (15.05.2006)
Published in Bioorganic & medicinal chemistry letters (15.05.2006)
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Journal Article
Discovery and structure–activity relationship of 2-phenyl-oxazole-4-carboxamide derivatives as potent apoptosis inducers
Tai, Vincent W.-F., Sperandio, David, Shelton, Emma J., Litvak, Joane, Pararajasingham, Keith, Cebon, Ben, Lohman, Julia, Eksterowicz, John, Kantak, Seema, Sabbatini, Peter, Brown, Cindy, Zeitz, Jennifer, Reed, Chris, Maske, Bill, Graupe, Doris, Estevez, Alberto, Oeh, Jason, Wong, Darren, Ni, Yong, Sprengeler, Paul, Yee, Robert, Magill, Catherine, Neri, Anthony, Cai, Sui Xiong, Drewe, John, Qiu, Ling, Herich, John, Tseng, Ben, Kasibhatla, Shailaja, Spencer, Jeffrey R.
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
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Journal Article
Design of novel, potent, and selective human β-tryptase inhibitors based on α-keto-[1,2,4]-oxadiazoles
Lee, Chang-Sun, Liu, Weili, Sprengeler, Paul A., Somoza, John R., Janc, James W., Sperandio, David, Spencer, Jeffrey R., Green, Michael J., McGrath, Mary E.
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
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Journal Article
Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors
Katz, Bradley A., Elrod, Kyle, Verner, Erik, Mackman, Richard L., Luong, Christine, Shrader, William D., Sendzik, Martin, Spencer, Jeffrey R., Sprengeler, Paul A., Kolesnikov, Aleks, Tai, Vincent W.-F., Hui, Hon C., Guy Breitenbucher, J., Allen, Darin, Janc, James W.
Published in Journal of molecular biology (23.05.2003)
Published in Journal of molecular biology (23.05.2003)
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Journal Article
Novel, potent, selective, and orally bioavailable human βII-tryptase inhibitors
Sperandio, David, Tai, Vincent W.-F., Lohman, Julia, Hirschbein, Bernie, Mendonca, Rohan, Lee, Chang-Sun, Spencer, Jeffrey R., Janc, James, Nguyen, Margaret, Beltman, Jerlyn, Sprengeler, Paul, Scheerens, Heleen, Lin, Tong, Liu, Liang, Gadre, Ashwini, Kellogg, Alisha, Green, Michael J., McGrath, Mary E.
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
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Journal Article
Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease
Sperandio, David, Gangloff, Anthony R., Litvak, Joane, Goldsmith, Richard, Hataye, Jason M., Wang, Vivian R., Shelton, Emma J., Elrod, Kyle, Janc, James W., Clark, James M., Rice, Ken, Weinheimer, Steve, Yeung, Kap-Sun, Meanwell, Nicholas A., Hernandez, Dennis, Staab, Andrew J., Venables, Brian L., Spencer, Jeffrey R.
Published in Bioorganic & medicinal chemistry letters (04.11.2002)
Published in Bioorganic & medicinal chemistry letters (04.11.2002)
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Journal Article
Contribution of Multicentered Short Hydrogen Bond Arrays to Potency of Active Site-Directed Serine Protease Inhibitors
Katz, Bradley A, Spencer, Jeffrey R, Elrod, Kyle, Luong, Christine, Mackman, Richard L, Rice, Mark, Sprengeler, Paul A, Allen, Darin, Janc, James
Published in Journal of the American Chemical Society (02.10.2002)
Published in Journal of the American Chemical Society (02.10.2002)
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Journal Article
2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors
MACKMAN, Richard L, HUI, Hon C, SPRENGELER, Paul A, TARIO, James, VERNER, Erik, JING WANG, BREITENBUCHER, J. Guy, KATZ, Bradley A, LUONG, Christine, MARTELLI, Arnold, MCGEE, Danny, RADIKA, Kesavan, SENDZIK, Martin, SPENCER, Jeffrey R
Published in Bioorganic & medicinal chemistry letters (05.08.2002)
Published in Bioorganic & medicinal chemistry letters (05.08.2002)
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Journal Article
4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors
Spencer, Jeffrey R, McGee, Danny, Allen, Darin, Katz, Bradley A, Luong, Christine, Sendzik, Martin, Squires, Neil, Mackman, Richard L
Published in Bioorganic & medicinal chemistry letters (05.08.2002)
Published in Bioorganic & medicinal chemistry letters (05.08.2002)
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Journal Article
Structural and Functional Characterization of a Constrained Asx-Turn Motif
Imperiali, Barbara, Spencer, Jeffrey R, Struthers, Mary D
Published in Journal of the American Chemical Society (01.09.1994)
Published in Journal of the American Chemical Society (01.09.1994)
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Journal Article
Unusual peptide bond cleavage reactions during acidolytic deprotection reactions
Spencer, Jeffrey R, Delaet, Nancy G. J, Toy-Palmer, Anna, Antonenko, Valery V, Goodman, Murray
Published in Journal of organic chemistry (01.03.1993)
Published in Journal of organic chemistry (01.03.1993)
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