Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets
Cassetta, Luca, Fragkogianni, Stamatina, Sims, Andrew H., Swierczak, Agnieszka, Forrester, Lesley M., Zhang, Hui, Soong, Daniel Y.H., Cotechini, Tiziana, Anur, Pavana, Lin, Elaine Y., Fidanza, Antonella, Lopez-Yrigoyen, Martha, Millar, Michael R., Urman, Alexandra, Ai, Zhichao, Spellman, Paul T., Hwang, E. Shelley, Dixon, J. Michael, Wiechmann, Lisa, Coussens, Lisa M., Smith, Harriet O., Pollard, Jeffrey W.
Published in Cancer cell (15.04.2019)
Published in Cancer cell (15.04.2019)
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Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes
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Published in Cell (15.04.2021)
Published in Cell (15.04.2021)
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Circulating-tumor DNA as an early detection and diagnostic tool
Butler, Timothy M, Spellman, Paul T, Gray, Joe
Published in Current opinion in genetics & development (01.02.2017)
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Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer
Risom, Tyler, Langer, Ellen M, Chapman, Margaret P, Rantala, Juha, Fields, Andrew J, Boniface, Christopher, Alvarez, Mariano J, Kendsersky, Nicholas D, Pelz, Carl R, Johnson-Camacho, Katherine, Dobrolecki, Lacey E, Chin, Koei, Aswani, Anil J, Wang, Nicholas J, Califano, Andrea, Lewis, Michael T, Tomlin, Claire J, Spellman, Paul T, Adey, Andrew, Gray, Joe W, Sears, Rosalie C
Published in Nature communications (19.09.2018)
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Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
Verhaak, Roel G.W., Hoadley, Katherine A., Purdom, Elizabeth, Wang, Victoria, Qi, Yuan, Wilkerson, Matthew D., Miller, C. Ryan, Ding, Li, Golub, Todd, Mesirov, Jill P., Alexe, Gabriele, Lawrence, Michael, O'Kelly, Michael, Tamayo, Pablo, Weir, Barbara A., Gabriel, Stacey, Winckler, Wendy, Gupta, Supriya, Jakkula, Lakshmi, Feiler, Heidi S., Hodgson, J. Graeme, James, C. David, Sarkaria, Jann N., Brennan, Cameron, Kahn, Ari, Spellman, Paul T., Wilson, Richard K., Speed, Terence P., Gray, Joe W., Meyerson, Matthew, Getz, Gad, Perou, Charles M., Hayes, D. Neil
Published in Cancer cell (19.01.2010)
Published in Cancer cell (19.01.2010)
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Exome Sequencing of Cell-Free DNA from Metastatic Cancer Patients Identifies Clinically Actionable Mutations Distinct from Primary Disease
Butler, Timothy M, Johnson-Camacho, Katherine, Peto, Myron, Wang, Nicholas J, Macey, Tara A, Korkola, James E, Koppie, Theresa M, Corless, Christopher L, Gray, Joe W, Spellman, Paul T
Published in PloS one (28.08.2015)
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FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer
Fu, Xiaoyong, Jeselsohn, Rinath, Pereira, Resel, Hollingsworth, Emporia F., Creighton, Chad J., Li, Fugen, Shea, Martin, Nardone, Agostina, De Angelis, Carmine, Heiser, Laura M., Anur, Pavana, Wang, Nicholas, Grasso, Catherine S., Spellman, Paul T., Griffith, Obi L., Tsimelzon, Anna, Gutierrez, Carolina, Huang, Shixia, Edwards, Dean P., Trivedi, Meghana V., Rimawi, Mothaffar F., Lopez-Terrada, Dolores, Hilsenbeck, Susan G., Gray, Joe W., Brown, Myles, Osborne, C. Kent, Schiff, Rachel
Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2016)
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Subtype and pathway specific responses to anticancer compounds in breast cancer
Heiser, Laura M, Sadanandam, Anguraj, Kuo, Wen-Lin, Benz, Stephen C, Goldstein, Theodore C, Ng, Sam, Gibb, William J, Wang, Nicholas J, Ziyad, Safiyyah, Tong, Frances, Bayani, Nora, Hu, Zhi, Billig, Jessica I, Dueregger, Andrea, Lewis, Sophia, Jakkula, Lakshmi, Korkola, James E, Durinck, Steffen, Pepin, François, Guan, Yinghui, Purdom, Elizabeth, Neuvial, Pierre, Bengtsson, Henrik, Wood, Kenneth W, Smith, Peter G, Vassilev, Lyubomir T, Hennessy, Bryan T, Greshock, Joel, Bachman, Kurtis E, Hardwicke, Mary Ann, Park, John W, Marton, Laurence J, Wolf, Denise M, Collisson, Eric A, Neve, Richard M, Mills, Gordon B, Speed, Terence P, Feiler, Heidi S, Wooster, Richard F, Haussler, David, Stuart, Joshua M, Gray, Joe W, Spellman, Paul T
Published in Proceedings of the National Academy of Sciences - PNAS (21.02.2012)
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Integrated analysis of germline and somatic variants in ovarian cancer
Kanchi, Krishna L, Johnson, Kimberly J, Lu, Charles, McLellan, Michael D, Leiserson, Mark D M, Wendl, Michael C, Zhang, Qunyuan, Koboldt, Daniel C, Xie, Mingchao, Kandoth, Cyriac, McMichael, Joshua F, Wyczalkowski, Matthew A, Larson, David E, Schmidt, Heather K, Miller, Christopher A, Fulton, Robert S, Spellman, Paul T, Mardis, Elaine R, Druley, Todd E, Graubert, Timothy A, Goodfellow, Paul J, Raphael, Benjamin J, Wilson, Richard K, Ding, Li
Published in Nature communications (01.01.2014)
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Epigenetic loss of heterogeneity from low to high grade localized prostate tumours
Eksi, Sebnem Ece, Chitsazan, Alex, Sayar, Zeynep, Thomas, George V, Fields, Andrew J, Kopp, Ryan P, Spellman, Paul T, Adey, Andrew C
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Wang, Nicholas J, Sanborn, Zachary, Arnett, Kelly L, Bayston, Laura J, Liao, Wilson, Proby, Charlotte M, Leigh, Irene M, Collisson, Eric A, Gordon, Patricia B, Jakkula, Lakshmi, Pennypacker, Sally, Zou, Yong, Sharma, Mimansa, North, Jeffrey P, Vemula, Swapna S, Mauro, Theodora M, Neuhaus, Isaac M, LeBoit, Philip E, Hur, Joe S, Park, Kyunghee, Huh, Nam, Kwok, Pui-Yan, Arron, Sarah T, Massion, Pierre P, Bale, Allen E, Haussler, David, Cleaver, James E, Gray, Joe W, Spellman, Paul T, South, Andrew P, Aster, Jon C, Blacklow, Stephen C, Cho, Raymond J
Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2011)
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ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins
Thayer, Mathew, Heskett, Michael B, Smith, Leslie G, Spellman, Paul T, Yates, Phillip A
Published in eLife (18.06.2024)
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A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma
Collisson, Eric A, Trejo, Christy L, Silva, Jillian M, Gu, Shenda, Korkola, James E, Heiser, Laura M, Charles, Roch-Philippe, Rabinovich, Brian A, Hann, Byron, Dankort, David, Spellman, Paul T, Phillips, Wayne A, Gray, Joe W, McMahon, Martin
Published in Cancer discovery (01.08.2012)
Published in Cancer discovery (01.08.2012)
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Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination
Sanborn, J. Zachary, Chung, Jongsuk, Purdom, Elizabeth, Wang, Nicholas J., Kakavand, Hojabr, Wilmott, James S., Butler, Timothy, Thompson, John F., Mann, Graham J., Haydu, Lauren E., Saw, Robyn P. M., Busam, Klaus J., Lo, Roger S., Collisson, Eric A., Hur, Joe S., Spellman, Paul T., Cleaver, James E., Gray, Joe W., Huh, Nam, Murali, Rajmohan, Scolyer, Richard A., Bastian, Boris C., Cho, Raymond J.
Published in Proceedings of the National Academy of Sciences - PNAS (01.09.2015)
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Genomic and transcriptional aberrations linked to breast cancer pathophysiologies
Chin, Koei, DeVries, Sandy, Fridlyand, Jane, Spellman, Paul T., Roydasgupta, Ritu, Kuo, Wen-Lin, Lapuk, Anna, Neve, Richard M., Qian, Zuwei, Ryder, Tom, Chen, Fanqing, Feiler, Heidi, Tokuyasu, Taku, Kingsley, Chris, Dairkee, Shanaz, Meng, Zhenhang, Chew, Karen, Pinkel, Daniel, Jain, Ajay, Ljung, Britt Marie, Esserman, Laura, Albertson, Donna G., Waldman, Frederic M., Gray, Joe W.
Published in Cancer cell (01.12.2006)
Published in Cancer cell (01.12.2006)
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A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
Neve, Richard M., Chin, Koei, Fridlyand, Jane, Yeh, Jennifer, Baehner, Frederick L., Fevr, Tea, Clark, Laura, Bayani, Nora, Coppe, Jean-Philippe, Tong, Frances, Speed, Terry, Spellman, Paul T., DeVries, Sandy, Lapuk, Anna, Wang, Nick J., Kuo, Wen-Lin, Stilwell, Jackie L., Pinkel, Daniel, Albertson, Donna G., Waldman, Frederic M., McCormick, Frank, Dickson, Robert B., Johnson, Michael D., Lippman, Marc, Ethier, Stephen, Gazdar, Adi, Gray, Joe W.
Published in Cancer cell (01.12.2006)
Published in Cancer cell (01.12.2006)
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Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability
Heskett, Michael B, Vouzas, Athanasios E, Smith, Leslie G, Yates, Phillip A, Boniface, Christopher, Bouhassira, Eric E, Spellman, Paul T, Gilbert, David M, Thayer, Mathew J
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Published in Nature communications (22.10.2022)
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Basal Subtype and MAPK/ERK Kinase (MEK)-Phosphoinositide 3-Kinase Feedback Signaling Determine Susceptibility of Breast Cancer Cells to MEK Inhibition
MIRZOEVA, Olga K, DAS, Debopriya, ZHI HU, KNIGHT, Zachary, FEILER, Heidi S, GASCARD, Philippe, PARVIN, Bahram, SPELLMAN, Paul T, SHOKAT, Kevan M, WYROBEK, Andrew J, BISSELL, Mina J, MCCORMICK, Frank, HEISER, Laura M, KUO, Wen-Lin, MILLS, Gordon B, GRAY, Joe W, KORN, W. Michael, BHATTACHARYA, Sanchita, SIWAK, Doris, GENDELMAN, Rina, BAYANI, Nora, WANG, Nicholas J, NEVE, Richard M, YINGHUI GUAN
Published in Cancer research (Chicago, Ill.) (15.01.2009)
Published in Cancer research (Chicago, Ill.) (15.01.2009)
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