Identification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4
Mohd, Saif, Oder, Andreas, Specker, Edgar, Neuenschwander, Martin, Von Kries, Jens Peter, Daumke, Oliver
Published in PloS one (29.07.2024)
Published in PloS one (29.07.2024)
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Journal Article
Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1
Juneja, Manisha, Kobelt, Dennis, Walther, Wolfgang, Voss, Cynthia, Smith, Janice, Specker, Edgar, Neuenschwander, Martin, Gohlke, Björn-Oliver, Dahlmann, Mathias, Radetzki, Silke, Preissner, Robert, von Kries, Jens Peter, Schlag, Peter Michael, Stein, Ulrike
Published in PLoS biology (01.06.2017)
Published in PLoS biology (01.06.2017)
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Journal Article
Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells
Plastira, Ioanna, Joshi, Lisha, Bernhart, Eva, Schoene, Jens, Specker, Edgar, Nazare, Marc, Sattler, Wolfgang
Published in Frontiers in cellular neuroscience (29.11.2019)
Published in Frontiers in cellular neuroscience (29.11.2019)
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Journal Article
Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation
Jordan, Philipp, Costa, Amanda, Specker, Edgar, Popp, Oliver, Volkamer, Andrea, Piske, Regina, Obrusnik, Tessa, Kleissle, Sabrina, Stuke, Kevin, Rex, Andre, Neuenschwander, Martin, von Kries, Jens Peter, Nazare, Marc, Mertins, Phillip, Kettenmann, Helmut, Wolf, Susanne A
Published in PloS one (06.02.2023)
Published in PloS one (06.02.2023)
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Journal Article
Neurotoxin II Bound to Acetylcholine Receptors in Native Membranes Studied by Dynamic Nuclear Polarization NMR
Linden, Arne H, Lange, Sascha, Franks, W. Trent, Akbey, Ümit, Specker, Edgar, van Rossum, Barth-Jan, Oschkinat, Hartmut
Published in Journal of the American Chemical Society (07.12.2011)
Published in Journal of the American Chemical Society (07.12.2011)
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Journal Article
Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity
Wetzel, Christiane, Pifferi, Simone, Picci, Cristina, Gök, Caglar, Hoffmann, Diana, Bali, Kiran K, Lampe, André, Lapatsina, Liudmila, Fleischer, Raluca, Smith, Ewan St John, Bégay, Valérie, Moroni, Mirko, Estebanez, Luc, Kühnemund, Johannes, Walcher, Jan, Specker, Edgar, Neuenschwander, Martin, von Kries, Jens Peter, Haucke, Volker, Kuner, Rohini, Poulet, James F A, Schmoranzer, Jan, Poole, Kate, Lewin, Gary R
Published in Nature neuroscience (01.02.2017)
Published in Nature neuroscience (01.02.2017)
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Journal Article
Discovery of tetrazolo-pyridazine-based small molecules as inhibitors of MACC1-driven cancer metastasis
Yan, Shixian, Schöpe, Paul Curtis, Lewis, Joe, Putzker, Kerstin, Uhrig, Ulrike, Specker, Edgar, von Kries, Jens Peter, Lindemann, Peter, Omran, Anahid, Sanchez-Ibarra, Hector E., Unger, Anke, Zischinsky, Mia-Lisa, Klebl, Bert, Walther, Wolfgang, Nazaré, Marc, Kobelt, Dennis, Stein, Ulrike
Published in Biomedicine & pharmacotherapy (01.12.2023)
Published in Biomedicine & pharmacotherapy (01.12.2023)
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Journal Article
Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway
Klein, Wolfgang, Rutz, Claudia, Eckhard, Jamina, Provinciael, Becky, Specker, Edgar, Neuenschwander, Martin, Kleinau, Gunnar, Scheerer, Patrick, von Kries, Jens-Peter, Nazaré, Marc, Vermeire, Kurt, Schülein, Ralf
Published in PloS one (13.12.2018)
Published in PloS one (13.12.2018)
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Journal Article
Temperature dependence of cross-effect dynamic nuclear polarization in rotating solids: advantages of elevated temperatures
Geiger, Michel-Andreas, Orwick-Rydmark, Marcella, Märker, Katharina, Franks, W Trent, Akhmetzyanov, Dmitry, Stöppler, Daniel, Zinke, Maximilian, Specker, Edgar, Nazaré, Marc, Diehl, Anne, van Rossum, Barth-Jan, Aussenac, Fabien, Prisner, Thomas, Akbey, Ümit, Oschkinat, Hartmut
Published in Physical chemistry chemical physics : PCCP (01.01.2016)
Published in Physical chemistry chemical physics : PCCP (01.01.2016)
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Journal Article
Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis
Bonnekoh, Hanna, Vera, Carolina, Abad‐Perez, Angela, Radetzki, Silke, Neuenschwander, Martin, Specker, Edgar, Mahnke, Niklas Amadeus, Frischbutter, Stefan, Latz, Eicke, Nazaré, Marc, Kries, Jens v., Maurer, Marcus, Scheffel, Jörg, Krause, Karoline
Published in Clinical and translational allergy (01.07.2021)
Published in Clinical and translational allergy (01.07.2021)
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Journal Article
Dde-protected PNA monomers, orthogonal to Fmoc, for the synthesis of PNA–peptide conjugates
Bialy, Laurent, Díaz-Mochón, Juan José, Specker, Edgar, Keinicke, Lise, Bradley, Mark
Published in Tetrahedron (22.08.2005)
Published in Tetrahedron (22.08.2005)
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Journal Article
A Small-Molecule Antagonist of the β-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis
Fang, Liang, Zhu, Qionghua, Neuenschwander, Martin, Specker, Edgar, Wulf-Goldenberg, Annika, Weis, William I, von Kries, Jens P, Birchmeier, Walter
Published in Cancer research (Chicago, Ill.) (15.02.2016)
Published in Cancer research (Chicago, Ill.) (15.02.2016)
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Journal Article
Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer
Carter, David M, Specker, Edgar, Małecki, Piotr H, Przygodda, Jessica, Dudaniec, Krystyna, Weiss, Manfred S, Heinemann, Udo, Nazaré, Marc, Gohlke, Ulrich
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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Journal Article
A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy
Marcinkowski, Patrick, Hoyer, Inna, Specker, Edgar, Furkert, Jens, Rutz, Claudia, Neuenschwander, Martin, Sobottka, Sebastian, Sun, Han, Nazare, Marc, Berchner-Pfannschmidt, Utta, von Kries, Jens Peter, Eckstein, Anja, Schülein, Ralf, Krause, Gerd
Published in Thyroid (New York, N.Y.) (01.01.2019)
Published in Thyroid (New York, N.Y.) (01.01.2019)
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Journal Article
Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors
Specker, Edgar, Wesolowski, Radoslaw, Schuetz, Anja, Matthes, Susann, Mallow, Keven, Wasinska-Kalwa, Malgorzata, Winkler, Lars, Oder, Andreas, Alenina, Natalia, Pleimes, Dirk, von Kries, Jens Peter, Heinemann, Udo, Bader, Michael, Nazare, Marc
Published in Journal of medicinal chemistry (09.11.2023)
Published in Journal of medicinal chemistry (09.11.2023)
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Journal Article
Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors
Specker, Edgar, Matthes, Susann, Wesolowski, Radoslaw, Schütz, Anja, Grohmann, Maik, Alenina, Natalia, Pleimes, Dirk, Mallow, Keven, Neuenschwander, Martin, Gogolin, Angelina, Weise, Marie, Pfeifer, Jochen, Ziebart, Nandor, Heinemann, Udo, von Kries, Jens Peter, Nazaré, Marc, Bader, Michael
Published in Journal of medicinal chemistry (25.08.2022)
Published in Journal of medicinal chemistry (25.08.2022)
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Journal Article
CellFy: A Cell-Based Fragment Screen against C‑Type Lectins
Schulze, Jessica, Baukmann, Hannes, Wawrzinek, Robert, Fuchsberger, Felix F, Specker, Edgar, Aretz, Jonas, Nazaré, Marc, Rademacher, Christoph
Published in ACS chemical biology (21.12.2018)
Published in ACS chemical biology (21.12.2018)
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Journal Article
NMR quality control of fragment libraries for screening
Sreeramulu, Sridhar, Richter, Christian, Kuehn, Till, Azzaoui, Kamal, Blommers, Marcel Jules José, Del Conte, Rebecca, Fragai, Marco, Trieloff, Nils, Schmieder, Peter, Nazaré, Marc, Specker, Edgar, Ivanov, Vladimir, Oschkinat, Hartmut, Banci, Lucia, Schwalbe, Harald
Published in Journal of biomolecular NMR (01.11.2020)
Published in Journal of biomolecular NMR (01.11.2020)
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Journal Article